Frances Leslie

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Nicotinic receptors in addiction pathways
    Frances M Leslie
    Department of Pharmacology, University of California, Irvine, California 92617, USA
    Mol Pharmacol 83:753-8. 2013
  2. pmc Multigenerational epigenetic effects of nicotine on lung function
    Frances M Leslie
    Department of Pharmacology, School of Medicine, University of California, Irvine, CA 92697, USA
    BMC Med 11:27. 2013
  3. pmc Nicotine-induced brain metabolism associated with anger provocation
    JEAN G GEHRICKE
    Department of Psychiatry and Human Behavior, University of California, Irvine, 19722 MacArthur Blvd, Irvine, California 92612, USA
    Behav Brain Funct 5:19. 2009
  4. ncbi request reprint Opioid receptor and peptide mRNA expression in proliferative zones of fetal rat central nervous system
    F M Leslie
    Department of Pharmacology, College of Medicine, University of California, Irvine 92697, USA
    Can J Physiol Pharmacol 76:284-93. 1998
  5. ncbi request reprint Nicotinic acetylcholine receptor-mediated release of [3H]norepinephrine from developing and adult rat hippocampus: direct and indirect mechanisms
    F M Leslie
    Department of Pharmacology, College of Medicine, University of California, Irvine, CA 92697, USA
    Neuropharmacology 42:653-61. 2002
  6. ncbi request reprint Adolescent development of forebrain stimulant responsiveness: insights from animal studies
    Frances M Leslie
    Department of Pharmacology, College of Medicine, University of California, Irvine, CA 92697 4625, USA
    Ann N Y Acad Sci 1021:148-59. 2004
  7. ncbi request reprint Neonatal treatment with 192 IgG-saporin produces long-term forebrain cholinergic deficits and reduces dendritic branching and spine density of neocortical pyramidal neurons
    R T Robertson
    Department of Anatomy and Neurobiology, College of Medicine, University of California, Irvine, 92697 1275, USA
    Cereb Cortex 8:142-55. 1998
  8. ncbi request reprint Developmental regulation of nicotinic acetylcholine receptor-mediated [3H]norepinephrine release from rat cerebellum
    K T O'Leary
    Department of Anatomy and Neurobiology, College of Medicine, University of California, Irvine, CA 92697, USA
    J Neurochem 84:952-9. 2003
  9. ncbi request reprint Gender specific effect of neonatal handling on stress reactivity of adolescent rats
    M K Park
    Department of Pharmacology, College of Medicine and Transdisciplinary Tobacco Use Research Center, University of California, Irvine, CA 92697, USA
    J Neuroendocrinol 15:289-95. 2003
  10. ncbi request reprint Enhanced nicotinic acetylcholine receptor-mediated [3H]norepinephrine release from neonatal rat hypothalamus
    K T O'Leary
    Department of Anatomy and Neurobiology, College of Medicine, University of California, Irvine, 92697, USA
    Neuropharmacology 50:81-8. 2006

Research Grants

Collaborators

Detail Information

Publications17

  1. doi request reprint Nicotinic receptors in addiction pathways
    Frances M Leslie
    Department of Pharmacology, University of California, Irvine, California 92617, USA
    Mol Pharmacol 83:753-8. 2013
    ....
  2. pmc Multigenerational epigenetic effects of nicotine on lung function
    Frances M Leslie
    Department of Pharmacology, School of Medicine, University of California, Irvine, CA 92697, USA
    BMC Med 11:27. 2013
    ..Please see related article: http://www.biomedcentral.com/1741-7015/10/129...
  3. pmc Nicotine-induced brain metabolism associated with anger provocation
    JEAN G GEHRICKE
    Department of Psychiatry and Human Behavior, University of California, Irvine, 19722 MacArthur Blvd, Irvine, California 92612, USA
    Behav Brain Funct 5:19. 2009
    ..These findings reveal the underlying brain circuitry targeted by nicotine during anger provocation...
  4. ncbi request reprint Opioid receptor and peptide mRNA expression in proliferative zones of fetal rat central nervous system
    F M Leslie
    Department of Pharmacology, College of Medicine, University of California, Irvine 92697, USA
    Can J Physiol Pharmacol 76:284-93. 1998
    ..Given the segregated expression of proenkephalin mRNA in forebrain neuroepithelium and kappa receptor mRNA within hindbrain, different opioid mechanisms may regulate cell division in rostral and caudal brain regions...
  5. ncbi request reprint Nicotinic acetylcholine receptor-mediated release of [3H]norepinephrine from developing and adult rat hippocampus: direct and indirect mechanisms
    F M Leslie
    Department of Pharmacology, College of Medicine, University of California, Irvine, CA 92697, USA
    Neuropharmacology 42:653-61. 2002
    ..These findings are consistent with the hypothesis that nicotine-induced GABA release serves as an additional stimulus for [(3)H]norepinephrine secretion within rat hippocampus...
  6. ncbi request reprint Adolescent development of forebrain stimulant responsiveness: insights from animal studies
    Frances M Leslie
    Department of Pharmacology, College of Medicine, University of California, Irvine, CA 92697 4625, USA
    Ann N Y Acad Sci 1021:148-59. 2004
    ..Further efforts are required to overcome technical challenges in order to evaluate drug effects systematically in this age group...
  7. ncbi request reprint Neonatal treatment with 192 IgG-saporin produces long-term forebrain cholinergic deficits and reduces dendritic branching and spine density of neocortical pyramidal neurons
    R T Robertson
    Department of Anatomy and Neurobiology, College of Medicine, University of California, Irvine, 92697 1275, USA
    Cereb Cortex 8:142-55. 1998
    ..These results indicate a developmental or maintenance role for cholinergic afferents to cerebral cortical neurons...
  8. ncbi request reprint Developmental regulation of nicotinic acetylcholine receptor-mediated [3H]norepinephrine release from rat cerebellum
    K T O'Leary
    Department of Anatomy and Neurobiology, College of Medicine, University of California, Irvine, CA 92697, USA
    J Neurochem 84:952-9. 2003
    ..These data support recent findings of a possible functional role of nAChRs in regulating cerebellar ontogeny, and provides further support for the role of NA as a neurotrophic factor during development...
  9. ncbi request reprint Gender specific effect of neonatal handling on stress reactivity of adolescent rats
    M K Park
    Department of Pharmacology, College of Medicine and Transdisciplinary Tobacco Use Research Center, University of California, Irvine, CA 92697, USA
    J Neuroendocrinol 15:289-95. 2003
    ..The striking gender difference in the effect of early neonatal handling provides evidence that this must be considered as an important variable in subsequent stress responsivity induced by early manipulations...
  10. ncbi request reprint Enhanced nicotinic acetylcholine receptor-mediated [3H]norepinephrine release from neonatal rat hypothalamus
    K T O'Leary
    Department of Anatomy and Neurobiology, College of Medicine, University of California, Irvine, 92697, USA
    Neuropharmacology 50:81-8. 2006
    ....
  11. ncbi request reprint The urotensin II receptor is expressed in the cholinergic mesopontine tegmentum of the rat
    S D Clark
    Department of Developmental and Cell Biology, The University of California, Irvine, CA 92697-4625, USA
    Brain Res 923:120-7. 2001
    ..This distribution of UII-R in the cholinergic mesopontine area indicates that the UII system may be involved in sensory-motor integration and perhaps in central nervous system blood flow...
  12. ncbi request reprint Expression of the melanin-concentrating hormone (MCH) receptor mRNA in the rat brain
    Y Saito
    Department of Pharmacology, University of California, Irvine, Irvine, California 92697-4625, USA
    J Comp Neurol 435:26-40. 2001
    ..However, the extensive MCHR distribution throughout the brain suggests that this receptor may play a role in other functions, most notably reinforcement, arousal, sensorimotor integration, and autonomic control...
  13. pmc Brain monoglyceride lipase participating in endocannabinoid inactivation
    T P Dinh
    Department of Pharmacology, University of California, Irvine, CA 92697 4625, USA
    Proc Natl Acad Sci U S A 99:10819-24. 2002
    ..No such effect was observed on the accumulation of anandamide, another endocannabinoid lipid. The results suggest that hydrolysis by means of MGL is a primary mechanism for 2-AG inactivation in intact neurons...
  14. ncbi request reprint Vaccination against nicotine does not prevent nicotine-induced changes in fetal nicotinic receptor binding and c-fos mRNA expression in rats
    P R Pentel
    Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA
    Neurotoxicol Teratol 28:589-96. 2006
    ..The lack of effect of vaccination suggests that the cumulative exposure of fetal tissues to nicotine may influence the measured parameters to a greater extent than peak exposure levels...
  15. pmc Developmental regulation of nicotinic acetylcholine receptors within midbrain dopamine neurons
    L Azam
    Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112, USA
    Neuroscience 144:1347-60. 2007
    ..In males, but not females, there were significant changes in both nicotine potency and efficacy during this developmental period. These findings suggest that nAChRs may play critical functional roles throughout DA neuronal maturation...
  16. ncbi request reprint Regulation of Homer and group I metabotropic glutamate receptors by nicotine
    J K Kane
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Eur J Neurosci 21:1145-54. 2005
    ..These data provide further evidence for the involvement of nicotine in the glutamatergic neuronal synaptic activity in vivo, suggesting a role for the newly identified Homer proteins in this paradigm...
  17. ncbi request reprint Co-expression of alpha7 and beta2 nicotinic acetylcholine receptor subunit mRNAs within rat brain cholinergic neurons
    L Azam
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    Neuroscience 119:965-77. 2003
    ..There may also be differential nAChR regulation of cholinergic and non-cholinergic cells within the mesopontine tegmentum that are implicated in acquisition of nicotine self-administration...

Research Grants15

  1. NICOTINE REGULATION OF DEVELOPING BRAIN CATECHOLAMINES
    Frances Leslie; Fiscal Year: 1999
    ..It is anticipated that the proposed in vitro analysis will provide a substantial framework for interpreting data on the effects of chronic perinatal nicotine administration in vivo. ..
  2. NICOTINE REGULATION OF DEVELOPING BRAIN CATECHOLAMINES
    Frances Leslie; Fiscal Year: 2005
    ..These combined in vitro and in vivo approaches are designed to elucidate mechanisms underlying adaptive responses of central catecholamine neurons to chronic prenatal nicotine exposure. ..
  3. Role of Monoamine Oxidases in Tobacco Addiction
    Frances Leslie; Fiscal Year: 2006
    ....
  4. Mechanisms of Adolescent Vulnerability to Drugs of Abuse
    Frances Leslie; Fiscal Year: 2007
    ..abstract_text> ..