J Leserman

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Relation of lifetime trauma and depressive symptoms to mortality in HIV
    Jane Leserman
    Department of Psychiatry and Medicine, CB 7160, Medical School Wing C, Rm 233, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    Am J Psychiatry 164:1707-13. 2007
  2. ncbi request reprint How trauma, recent stressful events, and PTSD affect functional health status and health utilization in HIV-infected patients in the south
    Jane Leserman
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    Psychosom Med 67:500-7. 2005
  3. ncbi request reprint Sexual abuse history: prevalence, health effects, mediators, and psychological treatment
    Jane Leserman
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7160, USA
    Psychosom Med 67:906-15. 2005
  4. ncbi request reprint The effects of stressful life events, coping, and cortisol on HIV infection
    Jane Leserman
    Department of Psychiatry, CB 7160, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7160, USA
    CNS Spectr 8:25-30. 2003
  5. pmc Trauma, stressful life events and depression predict HIV-related fatigue
    J Leserman
    University of North Carolina at Chapel Hill, NC, USA
    AIDS Care 20:1258-65. 2008
  6. ncbi request reprint Identification of diagnostic subtypes of chronic pelvic pain and how subtypes differ in health status and trauma history
    Jane Leserman
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    Am J Obstet Gynecol 195:554-60; discussion 560-1. 2006
  7. ncbi request reprint Role of depression, stress, and trauma in HIV disease progression
    Jane Leserman
    Departments of Psychiatry and Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7160, USA
    Psychosom Med 70:539-45. 2008
  8. pmc Stressful life events and adherence in HIV
    Jane Leserman
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7160, USA
    AIDS Patient Care STDS 22:403-11. 2008
  9. ncbi request reprint Impact of stressful life events, depression, social support, coping, and cortisol on progression to AIDS
    J Leserman
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599 7160, USA
    Am J Psychiatry 157:1221-8. 2000
  10. ncbi request reprint Progression to AIDS: the effects of stress, depressive symptoms, and social support
    J Leserman
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599 7160, USA
    Psychosom Med 61:397-406. 1999

Detail Information

Publications51

  1. ncbi request reprint Relation of lifetime trauma and depressive symptoms to mortality in HIV
    Jane Leserman
    Department of Psychiatry and Medicine, CB 7160, Medical School Wing C, Rm 233, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    Am J Psychiatry 164:1707-13. 2007
    ..The authors hypothesized that these psychosocial variables would predict significantly faster HIV-specific and all-cause mortality...
  2. ncbi request reprint How trauma, recent stressful events, and PTSD affect functional health status and health utilization in HIV-infected patients in the south
    Jane Leserman
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    Psychosom Med 67:500-7. 2005
    ....
  3. ncbi request reprint Sexual abuse history: prevalence, health effects, mediators, and psychological treatment
    Jane Leserman
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7160, USA
    Psychosom Med 67:906-15. 2005
    ....
  4. ncbi request reprint The effects of stressful life events, coping, and cortisol on HIV infection
    Jane Leserman
    Department of Psychiatry, CB 7160, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7160, USA
    CNS Spectr 8:25-30. 2003
    ..Delineating the role of psychosocial factors and cortisol on HIV disease progression may aid in the development of new interventions for this devastating disease...
  5. pmc Trauma, stressful life events and depression predict HIV-related fatigue
    J Leserman
    University of North Carolina at Chapel Hill, NC, USA
    AIDS Care 20:1258-65. 2008
    ..Although stress and trauma have been related to fatigue in other populations, this is the first study to examine the effects of traumatic and recent stressful life events on fatigue in an HIV-infected sample...
  6. ncbi request reprint Identification of diagnostic subtypes of chronic pelvic pain and how subtypes differ in health status and trauma history
    Jane Leserman
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    Am J Obstet Gynecol 195:554-60; discussion 560-1. 2006
    ..We hypothesized that women with diffuse abdominal/pelvic pain would have greater health impairment and report more lifetime trauma than women with vulvovaginal pain or cyclic pain...
  7. ncbi request reprint Role of depression, stress, and trauma in HIV disease progression
    Jane Leserman
    Departments of Psychiatry and Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7160, USA
    Psychosom Med 70:539-45. 2008
    ..Given the high rates of depression and past trauma in persons living with HIV/AIDS, it is important for healthcare providers to address these problems as part of standard HIV care...
  8. pmc Stressful life events and adherence in HIV
    Jane Leserman
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7160, USA
    AIDS Patient Care STDS 22:403-11. 2008
    ..These findings underscore the importance of addressing the often chaotic and stressful lives of HIV infected persons within medical settings...
  9. ncbi request reprint Impact of stressful life events, depression, social support, coping, and cortisol on progression to AIDS
    J Leserman
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599 7160, USA
    Am J Psychiatry 157:1221-8. 2000
    ..This study examined prospectively the effects of stressful events, depressive symptoms, social support, coping methods, and cortisol levels on progression of HIV-1 infection...
  10. ncbi request reprint Progression to AIDS: the effects of stress, depressive symptoms, and social support
    J Leserman
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599 7160, USA
    Psychosom Med 61:397-406. 1999
    ..We examined the effects of stress, depressive symptoms, and social support on the progression of HIV infection...
  11. ncbi request reprint High versus low basal cortisol secretion in asymptomatic, medication-free HIV-infected men: differential effects of severe life stress on parameters of immune status
    J M Petitto
    Department of Psychiatry, University of Florida College of Medicine, Gainesville, USA
    Behav Med 25:143-51. 2000
    ..These data suggest that severe stress in combination with high glucocorticoid activity may modify select parameters of immune status in HIV-infected men...
  12. pmc Measuring fatigue in people living with HIV/AIDS: psychometric characteristics of the HIV-related fatigue scale
    B W Pence
    Sanford Institute of Public Policy, Duke University, Durham, NC, USA
    AIDS Care 20:829-37. 2008
    ..30 to 0.68 across the 8 SF-36 subscales with most >0.40). The HRFS is a promising tool to help facilitate research on the prevalence, etiology and consequences of fatigue in people living with HIV...
  13. ncbi request reprint Progression to AIDS, a clinical AIDS condition and mortality: psychosocial and physiological predictors
    J Leserman
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599 7160, USA
    Psychol Med 32:1059-73. 2002
    ....
  14. ncbi request reprint The effects of depression, stressful life events, social support, and coping on the progression of HIV infection
    J Leserman
    University of North Carolina School of Medicine, Department of Psychiatry, CB 7160, Chapel Hill, NC 27599 7160, USA
    Curr Psychiatry Rep 2:495-502. 2000
    ..Delineating the role of psychosocial factors on HIV disease progression may aid in the development of new interventions for this devastating disease...
  15. doi request reprint Psychosocial factors are more important than disease activity in determining gastrointestinal symptoms and health status in adults at a celiac disease referral center
    Spencer D Dorn
    Center for Functional GI and Motility Disorders, University of North Carolina, Chapel Hill, NC, USA
    Dig Dis Sci 55:3154-63. 2010
    ..In adult patients with (CD), we studied the relationships among demographics, psychosocial factors, and disease activity with health-related quality of life (HRQOL), health care utilization, and symptoms...
  16. ncbi request reprint Dysregulation of cardiovascular and neuroendocrine responses to stress in premenstrual dysphoric disorder
    S S Girdler
    Department of Psychiatry, The University of North Carolina at Chapel Hill, 27559, USA
    Psychiatry Res 81:163-78. 1998
    ..These results are interpreted as reflecting dysregulation of the stress response and may be related to histories of severe and/or chronic exposure to stress for a subgroup of PMDD women...
  17. ncbi request reprint Effects of coping on health outcome among women with gastrointestinal disorders
    D A Drossman
    Department of Medicine, University of North Carolina, Chapel Hill 27599 7080, USA
    Psychosom Med 62:309-17. 2000
    ..Studies have shown that the nature and quality of coping may positively or negatively affect health outcome; however, this relationship has not been well studied among patients with gastrointestinal (GI) disorders...
  18. doi request reprint Cognitive factors affect treatment response to medical and psychological treatments in functional bowel disorders
    Stephan R Weinland
    Division of Gastroenterology and Hepatology, UNC Center for Functional GI and Motility Disorders, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7080, USA
    Am J Gastroenterol 105:1397-406. 2010
    ..Factors that determine clinical response aside from treatment itself are unknown. The aim of this study was to determine what baseline and post-treatment factors affect treatment response...
  19. ncbi request reprint Predicting fatigue and depression in HIV-positive gay men
    Julie Barroso
    School of Nursing, Department of Biostatistics, Carrington Hall, University of North Carolina at Chapel Hill, NC 27599 7460, USA
    Psychosomatics 43:317-25. 2002
    ..5 years were used to develop logistic regression models for predicting fatigue and depression. Fatigue was predicted by both physiologic and psychological risk factors, whereas depression was predicted by only psychological risk factors...
  20. ncbi request reprint Antenatal thyroid correlates of postpartum depression
    Cort A Pedersen
    Department of Psychiatry CB 7160, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    Psychoneuroendocrinology 32:235-45. 2007
    ..Study of the relationships with antenatal thyroid status may provide new insights into the pathophysiology of perinatal mood disturbances...
  21. pmc Persistent alterations in biological profiles in women with abuse histories: influence of premenstrual dysphoric disorder
    Susan S Girdler
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Health Psychol 26:201-13. 2007
    ..To examine dysregulation in biological measures associated with histories of abuse in women and whether women with premenstrual dysphoric disorder (PMDD) differ in their dysregulation...
  22. ncbi request reprint Trauma and posttraumatic stress disorder in women with chronic pelvic pain
    Samantha Meltzer-Brody
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Obstet Gynecol 109:902-8. 2007
    ..To examine the effect of abuse history, other major trauma, and posttraumatic stress disorder (PTSD) on medical symptoms and health-related daily functioning in women with chronic pelvic pain...
  23. ncbi request reprint Relationship of abuse history to functional gastrointestinal disorders and symptoms: some possible mediating mechanisms
    Jane Leserman
    UNC School of Medicine, University of North Carolina at Chapel Hill, USA
    Trauma Violence Abuse 8:331-43. 2007
    ..Given the high prevalence of abuse and long-lasting health consequences, referral for psychiatric and psychological treatment makes sense for many patients with abuse history seen within medical settings...
  24. ncbi request reprint Alterations of brain activity associated with resolution of emotional distress and pain in a case of severe irritable bowel syndrome
    Douglas A Drossman
    UNC Center for Functional GI and Motility Disorders, Division of Digestive Diseases and Department of Radiology and Biomedical Engineering, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Gastroenterology 124:754-61. 2003
    ..We also found that clinical and psychosocial improvement was associated with reduced cingulate activation...
  25. doi request reprint Obsessional thoughts and compulsive behaviors in a sample of women with postpartum mood symptoms
    Jonathan S Abramowitz
    University of North Carolina at Chapel Hill, CB 3270, Chapel Hill, NC 27599, USA
    Arch Womens Ment Health 13:523-30. 2010
    ..Clinicians should assess for anxiety and obsessive-compulsive symptoms as routinely as they assess for depressive symptoms in the perinatal period...
  26. ncbi request reprint Historical sexual abuse and current thyroid axis profiles in women with premenstrual dysphoric disorder
    Susan S Girdler
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7175, USA
    Psychosom Med 66:403-10. 2004
    ....
  27. pmc International survey of patients with IBS: symptom features and their severity, health status, treatments, and risk taking to achieve clinical benefit
    Douglas A Drossman
    UNC Center for Functional GI and Motility Disorders, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7080, USA
    J Clin Gastroenterol 43:541-50. 2009
    ..These factors are not fully understood...
  28. ncbi request reprint Biological correlates of abuse in women with premenstrual dysphoric disorder and healthy controls
    Susan S Girdler
    Department of Psychiatry, University of North Carolina at Chapel Hill, North Carolina 27599 7175, USA
    Psychosom Med 65:849-56. 2003
    ..To examine the biological correlates associated with histories of sexual or physical abuse in women meeting DSM criteria for premenstrual dysphoric disorder (PMDD) and in healthy, non-PMDD controls...
  29. ncbi request reprint A prospective assessment of bowel habit in irritable bowel syndrome in women: defining an alternator
    Douglas A Drossman
    UNC Center for Functional GI and Motility Disorders, University of North Carolina at Chapel Hill, Room 1110 Burnett Womack CB 7080, Chapel Hill, North Carolina 27599 7080, USA
    Gastroenterology 128:580-9. 2005
    ..There is no standard definition of an alternator (IBS-A), in which bowel habit changes over time. Our aim was to use Rome II criteria to prospectively assess change in bowel habit for more than 1 year to understand IBS-A...
  30. ncbi request reprint Characterization of health related quality of life (HRQOL) for patients with functional bowel disorder (FBD) and its response to treatment
    Douglas Drossman
    The UNC Center for Functional GI and Motility Disorders, Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Am J Gastroenterol 102:1442-53. 2007
    ....
  31. ncbi request reprint Further characterization of painful constipation (PC): clinical features over one year and comparison with IBS
    Douglas A Drossman
    UNC Center for Functional GI and Motility Disorders, University of North Carolina at Chapel Hill, Room 4150 Burnett Womack CB No 7080, Chapel Hill, NC 27599 7080, USA
    J Clin Gastroenterol 42:1080-8. 2008
    ....
  32. ncbi request reprint Open-label trial of lamotrigine focusing on efficacy in vulvodynia
    Samantha E Meltzer-Brody
    Department of Psychiatry, University of North Carolina at Chapel Hill, Campus Box 7160, Chapel Hill, NC 27599, USA
    J Reprod Med 54:171-8. 2009
    ..Vulvodynia, a vulvar pain syndrome that includes vulvar vestibulitis, is the most common subtype of CPP. This study examined the efficacy of lamotrigine for the treatment of CPP using an open-label design...
  33. ncbi request reprint HIV disease progression: depression, stress, and possible mechanisms
    Jane Leserman
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    Biol Psychiatry 54:295-306. 2003
    ..More research is warranted to investigate how depression and stress might impact HIV disease progression and what types of interventions might mitigate the negative impact of chronic depression and trauma...
  34. ncbi request reprint Histories of sexual abuse are associated with differential effects of clonidine on autonomic function in women with premenstrual dysphoric disorder
    Robertas Bunevicius
    Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7175, Medical Research Bldg A, Chapel Hill, NC 27599 7175, USA
    Biol Psychol 69:281-96. 2005
    ....
  35. pmc Catastrophizing: a predictor of persistent pain among women with endometriosis at 1 year
    C E Martin
    Pelvic Pain Research Unit, Division of Advanced Laparoscopy and Pelvic Pain, Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Hum Reprod 26:3078-84. 2011
    ..Therefore, the objective of this study was to determine the biopsychosocial predictors of pain improvement among women with endometriosis...
  36. ncbi request reprint Characterizing and dating the onset of symptoms in psychotic illness: the Symptom Onset in Schizophrenia (SOS) inventory
    D O Perkins
    Department of Psychiatry, University of North Carolina, CB 7160, Chapel Hill, NC 27599, USA
    Schizophr Res 44:1-10. 2000
    ..Further study is underway to evaluate other psychometric properties of the SOS, including test-retest reliability and predictive validity...
  37. pmc Not all side effects associated with tricyclic antidepressant therapy are true side effects
    Syed Thiwan
    Division of Gastroenterology and Hepatology, University of North Carolina Center for Functional Gastrointestinal and Motility Disorders, University of North Carolina, Chapel Hill, North Carolina 27599 7080, USA
    Clin Gastroenterol Hepatol 7:446-51. 2009
    ....
  38. ncbi request reprint Changes in neuropsychological functioning with progression of HIV-1 infection: results of an 8-year longitudinal investigation
    Teri T Baldewicz
    Department of Clinical Operations, Inveresk, Cary, North Carolina, USA
    AIDS Behav 8:345-55. 2004
    ..Further research is needed to examine the effects of disease stage and depression on cognitive impairment in the era of new HIV treatments...
  39. pmc Prevalence of childhood sexual abuse and physical trauma in an HIV-positive sample from the deep south
    Kathryn Whetten
    Center for Health Policy, Law, and Management, Department of Public Policy, the Health Inequalities Program, Duke University, Durham, NC 27708, USA
    Am J Public Health 96:1028-30. 2006
    ..Abuse is related to increases in high-HIV-risk activities. The findings help explain why people engage in such high-risk activities and can provide guidance in designing improved care and prevention messages...
  40. ncbi request reprint Mood disorders in the medically ill: scientific review and recommendations
    Dwight L Evans
    School of Medicine, University of Pennsylvania, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Biol Psychiatry 58:175-89. 2005
    ....
  41. ncbi request reprint Depression and HIV infection: impact on immune function and disease progression
    Dean G Cruess
    Department of Psychology, University of Pennsylvania, 3815 Walnut Street, Philadelphia, PA 19104, USA
    CNS Spectr 8:52-8. 2003
    ..This paper will highlight studies examining the prevalence of depression during HIV infection and review some of the evidence examining the impact of depressive symptoms on immune function and HIV disease progression...
  42. doi request reprint A road well traveled (although not yet a super highway)
    Jane Leserman
    Psychosom Med 70:521-2. 2008
  43. ncbi request reprint Barriers to antiretroviral adherence: the importance of depression, abuse, and other traumatic events
    Michael Mugavero
    Department of Medicine, Division of Infectious Diseases and International Health, Health Inequalities Program, Duke University, Durham, North Carolina, USA
    AIDS Patient Care STDS 20:418-28. 2006
    ....
  44. pmc Demographic and illness-related variables associated with HIV-related fatigue
    James L Harmon
    Duke University School of Nursing, Durham, North Carolina, USA
    J Assoc Nurses AIDS Care 19:90-7. 2008
    ..These must be better understood to develop interventions to successfully ameliorate HIV-related fatigue...
  45. pmc Physiological correlates of HIV-related fatigue
    Julie Barroso
    Duke University School of Nursing, Durham, NC 27710, USA
    Clin Nurs Res 17:5-19. 2008
    ..It is possible that fatigue suffered by seropositive people is better predicted by other variables, which must be better understood to develop interventions to successfully ameliorate HIV-related fatigue...
  46. ncbi request reprint Minorities, the poor, and survivors of abuse: HIV-infected patients in the US deep South
    Brian Wells Pence
    Health Inequalities Program, Duke University, Center for Health Policy, Duke University, Durham, NC 27708, USA
    South Med J 100:1114-22. 2007
    ..The HIV/AIDS epidemic in the U.S. South is undergoing a marked shift toward a greater proportion of new HIV/AIDS cases in women, African-Americans, and through heterosexual transmission...
  47. ncbi request reprint Association of depression, CD8+ T lymphocytes, and natural killer cell activity: implications for morbidity and mortality in Human immunodeficiency virus disease
    Dean G Cruess
    Department of Psychology, University of Pennsylvania, 3815 Walnut Street, Philadelphia, PA 19104, USA
    Curr Psychiatry Rep 5:445-50. 2003
    ....
  48. ncbi request reprint Relationship of abuse history and other risk factors with obesity among female gastrointestinal patients
    Huanguang Jia
    Rehabilitation Outcomes Research Center, VA Medical Center, Gainesville, Florida 32608, USA
    Dig Dis Sci 49:872-7. 2004
    ..Physical abuse history and several demographic factors were significantly related to being overweight and obese in this clinical population...
  49. pmc Exploring lack of trust in care providers and the government as a barrier to health service use
    Kathryn Whetten
    Center for Health Policy, Box 90253, 125 Old Chemistry Bldg, Durham, NC 27708, USA
    Am J Public Health 96:716-21. 2006
    ..We examined associations between trust of health care providers and the government and health service use and outcomes...
  50. ncbi request reprint Stress, hostility, and disease parameters of benign prostatic hyperplasia
    Philip M Ullrich
    Department of Rehabilitation Medicine, University of Washington, Seattle, WA, USA
    Psychosom Med 67:476-82. 2005
    ..Associations between psychological stress and prostate function have not been directly examined. The objective of this study was to examine associations among stress, hostility, and BPH disease parameters...
  51. ncbi request reprint Predictors of AIDS-related morbidity and mortality in a southern U.S. Cohort
    Michael J Mugavero
    Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama, USA
    AIDS Patient Care STDS 21:681-90. 2007
    ..97, p = 0.04), who had lower baseline CD4 counts (HR = 0.48 per 100 cells/mm(3), p < 0.01), and who spent less time on antiretroviral therapy during follow-up (HR = 0.47, p = 0.02) were more likely to experience an HIV-related event...