Mark G LeSage

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Enhanced attenuation of nicotine discrimination in rats by combining nicotine-specific antibodies with a nicotinic receptor antagonist
    Mark G LeSage
    Department of Medicine, Minneapolis Medical Research Foundation, Minneapolis, MN, United States
    Pharmacol Biochem Behav 102:157-62. 2012
  2. pmc Current status of immunologic approaches to treating tobacco dependence: vaccines and nicotine-specific antibodies
    Mark G LeSage
    Minneapolis Medical Research Foundation, Department of Medicine, University of Minnesota Medical School, Minneapolis, USA
    AAPS J 8:E65-75. 2006
  3. pmc Passive immunization with a nicotine-specific monoclonal antibody decreases brain nicotine levels but does not precipitate withdrawal in nicotine-dependent rats
    SAMUEL A ROIKO
    Minneapolis Medical Research Foundation, Minneapolis, MN 55404, USA
    Pharmacol Biochem Behav 93:105-11. 2009
  4. pmc Delivery of nicotine in an extract of a smokeless tobacco product reduces its reinforcement-attenuating and discriminative stimulus effects in rats
    Andrew C Harris
    Minneapolis Medical Research Foundation, 914 South 8th St, S 3 Labs, 860, Minneapolis, MN 55404, USA
    Psychopharmacology (Berl) 220:565-76. 2012
  5. pmc Combined active and passive immunization against nicotine: minimizing monoclonal antibody requirements using a target antibody concentration strategy
    Katherine E Cornish
    Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
    Int Immunopharmacol 11:1809-15. 2011
  6. pmc Toward a nonhuman model of contingency management: effects of reinforcing abstinence from nicotine self-administration in rats with an alternative nondrug reinforcer
    Mark G LeSage
    Minneapolis Medical Research Foundation, 914 South 8th Street, D3 860, Minneapolis, MN, 55404, USA
    Psychopharmacology (Berl) 203:13-22. 2009
  7. ncbi request reprint Effects of a nicotine conjugate vaccine on the acquisition and maintenance of nicotine self-administration in rats
    Mark G LeSage
    Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    Psychopharmacology (Berl) 184:409-16. 2006
  8. ncbi request reprint Effects of pregnancy on nicotine self-administration and nicotine pharmacokinetics in rats
    Mark G LeSage
    Minneapolis Medical Research Foundation, 914 South 8th Street, D3 860, Minneapolis, MN 55404, USA
    Psychopharmacology (Berl) 194:413-21. 2007
  9. ncbi request reprint Prevalence, magnitude, and correlates of an extinction burst in drug-seeking behavior in rats trained to self-administer nicotine during unlimited access (23 h/day) sessions
    Andrew C Harris
    Minneapolis Medical Research Foundation, 914 South 8th St S 3 Labs, 860, Minneapolis, MN 55404, USA
    Psychopharmacology (Berl) 194:395-402. 2007
  10. pmc Nicotine self-administration in the rat: effects of hypocretin antagonists and changes in hypocretin mRNA
    Mark G LeSage
    Minneapolis Medical Research Foundation, 914 S 8th Street, Minneapolis, MN 55404, USA
    Psychopharmacology (Berl) 209:203-12. 2010

Collaborators

Detail Information

Publications29

  1. pmc Enhanced attenuation of nicotine discrimination in rats by combining nicotine-specific antibodies with a nicotinic receptor antagonist
    Mark G LeSage
    Department of Medicine, Minneapolis Medical Research Foundation, Minneapolis, MN, United States
    Pharmacol Biochem Behav 102:157-62. 2012
    ..These data demonstrate that nicotine-specific antibodies and MEC can work synergistically to suppress the subjective effects of nicotine and suggest that low doses of MEC may significantly enhance the efficacy of immunotherapy...
  2. pmc Current status of immunologic approaches to treating tobacco dependence: vaccines and nicotine-specific antibodies
    Mark G LeSage
    Minneapolis Medical Research Foundation, Department of Medicine, University of Minnesota Medical School, Minneapolis, USA
    AAPS J 8:E65-75. 2006
    ..Taken together, the work completed to date provides substantial evidence that immunologic interventions could play an important role in future treatment strategies for tobacco dependence...
  3. pmc Passive immunization with a nicotine-specific monoclonal antibody decreases brain nicotine levels but does not precipitate withdrawal in nicotine-dependent rats
    SAMUEL A ROIKO
    Minneapolis Medical Research Foundation, Minneapolis, MN 55404, USA
    Pharmacol Biochem Behav 93:105-11. 2009
    ..The Nic311 doses used have been shown to attenuate the behavioral effects of nicotine, suggesting that the use of passive immunization to treat nicotine addiction is not likely to precipitate withdrawal...
  4. pmc Delivery of nicotine in an extract of a smokeless tobacco product reduces its reinforcement-attenuating and discriminative stimulus effects in rats
    Andrew C Harris
    Minneapolis Medical Research Foundation, 914 South 8th St, S 3 Labs, 860, Minneapolis, MN 55404, USA
    Psychopharmacology (Berl) 220:565-76. 2012
    ..Models using tobacco extracts derived from tobacco products and containing a range of tobacco constituents might more accurately simulate tobacco exposure in humans...
  5. pmc Combined active and passive immunization against nicotine: minimizing monoclonal antibody requirements using a target antibody concentration strategy
    Katherine E Cornish
    Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
    Int Immunopharmacol 11:1809-15. 2011
    ..However, variability in serum NicAb levels with combination immunotherapy may make translation of this approach challenging...
  6. pmc Toward a nonhuman model of contingency management: effects of reinforcing abstinence from nicotine self-administration in rats with an alternative nondrug reinforcer
    Mark G LeSage
    Minneapolis Medical Research Foundation, 914 South 8th Street, D3 860, Minneapolis, MN, 55404, USA
    Psychopharmacology (Berl) 203:13-22. 2009
    ..Moreover, abstinence contingencies per se under free-operant conditions have not been examined...
  7. ncbi request reprint Effects of a nicotine conjugate vaccine on the acquisition and maintenance of nicotine self-administration in rats
    Mark G LeSage
    Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    Psychopharmacology (Berl) 184:409-16. 2006
    ..It is not known whether such a vaccine can attenuate nicotine's reinforcing effects...
  8. ncbi request reprint Effects of pregnancy on nicotine self-administration and nicotine pharmacokinetics in rats
    Mark G LeSage
    Minneapolis Medical Research Foundation, 914 South 8th Street, D3 860, Minneapolis, MN 55404, USA
    Psychopharmacology (Berl) 194:413-21. 2007
    ..Animal models could be useful for this purpose...
  9. ncbi request reprint Prevalence, magnitude, and correlates of an extinction burst in drug-seeking behavior in rats trained to self-administer nicotine during unlimited access (23 h/day) sessions
    Andrew C Harris
    Minneapolis Medical Research Foundation, 914 South 8th St S 3 Labs, 860, Minneapolis, MN 55404, USA
    Psychopharmacology (Berl) 194:395-402. 2007
    ..e., an "extinction burst"). However, the presence of an extinction burst in animal models of nicotine self-administration (NSA) has not been studied extensively...
  10. pmc Nicotine self-administration in the rat: effects of hypocretin antagonists and changes in hypocretin mRNA
    Mark G LeSage
    Minneapolis Medical Research Foundation, 914 S 8th Street, Minneapolis, MN 55404, USA
    Psychopharmacology (Berl) 209:203-12. 2010
    ..The hypocretin (hcrt) system has been implicated in addiction-relevant effects of several drugs, but its role in nicotine dependence has been little studied...
  11. pmc Comparison of the behavioral effects of cigarette smoke and pure nicotine in rats
    Andrew C Harris
    Minneapolis Medical Research Foundation, Minneapolis, MN 55404, United States
    Pharmacol Biochem Behav 96:217-27. 2010
    ....
  12. doi request reprint Compensatory nicotine self-administration in rats during reduced access to nicotine: an animal model of smoking reduction
    Andrew C Harris
    Minneapolis Medical Research Foundation, Minneapolis, MN 55404, USA
    Exp Clin Psychopharmacol 16:86-97. 2008
    ..This model may be useful for characterizing underlying factors and potential consequences of compensatory smoking...
  13. ncbi request reprint Effects of the selective dopamine D3 receptor antagonist SB-277011A on the reinforcing effects of nicotine as measured by a progressive-ratio schedule in rats
    Jason T Ross
    Minneapolis Medical Research Foundation, 914 South 8th Street, Minneapolis, MN 55404, USA
    Eur J Pharmacol 559:173-9. 2007
    ....
  14. pmc Effects of the nicotinic receptor partial agonists varenicline and cytisine on the discriminative stimulus effects of nicotine in rats
    Mark G LeSage
    Minneapolis Medical Research Foundation, 914 South Eighth Street, Minneapolis, MN 55404, USA
    Pharmacol Biochem Behav 91:461-7. 2009
    ..These results demonstrate that VCL and CYT partially generalize to and partially antagonize nicotine's discriminative stimulus effects, consistent with a partial agonist mechanism of action...
  15. doi request reprint Combined active and passive immunization enhances the efficacy of immunotherapy against nicotine in rats
    SAMUEL A ROIKO
    Minneapolis Medical Research Foundation, Minneapolis, Minnesota, USA
    J Pharmacol Exp Ther 325:985-93. 2008
    ..These data indicate that providing higher serum NicAb concentrations improves the efficacy of immunotherapy against nicotine and that supplementing vaccination with passive immunization is a potential strategy to accomplish this...
  16. pmc A lack of association between severity of nicotine withdrawal and individual differences in compensatory nicotine self-administration in rats
    Andrew C Harris
    Minneapolis Medical Research Foundation, 914 South 8th Street, S 3 Labs, 860, Minneapolis, MN 55404, USA
    Psychopharmacology (Berl) 217:153-66. 2011
    ..Compensatory smoking may represent an adverse consequence of smoking reduction or the use of reduced-nicotine tobacco products. Factors contributing to individual variability in compensation are poorly understood...
  17. ncbi request reprint Effects of nicotine withdrawal on performance under a progressive-ratio schedule of sucrose pellet delivery in rats
    Mark G LeSage
    Minneapolis Medical Research Foundation, 914 South 8th Street, D3 860, MN 55404, USA
    Pharmacol Biochem Behav 83:585-91. 2006
    ..Therefore, PR schedules of natural reinforcement may provide information on the motivational effects of nicotine withdrawal complimentary to that obtained from ICSS threshold studies...
  18. pmc Effects of maternal intravenous nicotine administration on locomotor behavior in pre-weanling rats
    Mark G LeSage
    Minneapolis Medical Research Foundation, 914 South 8th Street, D3 860, Minneapolis, MN 55404, USA
    Pharmacol Biochem Behav 85:575-83. 2006
    ....
  19. pmc Correlates of individual differences in compensatory nicotine self-administration in rats following a decrease in nicotine unit dose
    Andrew C Harris
    Minneapolis Medical Research Foundation, Minneapolis, MN 55404, USA
    Psychopharmacology (Berl) 205:599-611. 2009
    ..Characterizing factors contributing to the marked individual variability in compensation may be useful for understanding this phenomenon and assessing the feasibility of harm reduction interventions...
  20. ncbi request reprint Reinstatement of nicotine self-administration in rats by presentation of nicotine-paired stimuli, but not nicotine priming
    Mark G LeSage
    Minneapolis Medical Research Foundation, 914 South 8th Street, D3 860, Minneapolis, MN 55404, USA
    Pharmacol Biochem Behav 79:507-13. 2004
    ....
  21. ncbi request reprint Effects of continuous nicotine infusion on nicotine self-administration in rats: relationship between continuously infused and self-administered nicotine doses and serum concentrations
    Mark G LeSage
    Minneapolis Medical Research Foundation, D3 860, 914 South 8th Street, Minneapolis, MN 55404, USA
    Psychopharmacology (Berl) 170:278-86. 2003
    ..One reason for this limited efficacy may be that typical serum nicotine concentrations provided by NRT do not match the peak arterial nicotine concentrations achieved from smoking...
  22. doi request reprint Nicotine reduction revisited: science and future directions
    Dorothy K Hatsukami
    Tobacco Use Research Center, University of Minnesota, 717 Delaware St SE, Minneapolis, Minnesota 55414, USA
    Tob Control 19:e1-10. 2010
    ..This article provides an overview of the current science in the area of reduced nicotine content cigarettes and key conclusions and recommendations for research and policy that emerged from the deliberations of the meeting members...
  23. ncbi request reprint Reduced nicotine distribution from mother to fetal brain in rats vaccinated against nicotine: time course and influence of nicotine dosing regimen
    Daniel E Keyler
    Minneapolis Medical Research Foundation, Hennepin County Medical Center, Minneapolis, MN 55415, USA
    Biochem Pharmacol 69:1385-95. 2005
    ..These data comment on the safety of vaccination against nicotine during pregnancy, and suggest that vaccination may reduce the distribution of nicotine to fetal brain under some nicotine dosing conditions...
  24. doi request reprint Sex differences in nicotine self-administration in rats during progressive unit dose reduction: implications for nicotine regulation policy
    Patricia Grebenstein
    Department of Medicine, Minneapolis Medical Research Foundation, United States
    Pharmacol Biochem Behav 114:70-81. 2013
    ..These findings suggest that females may exhibit less compensatory smoking in response to nicotine reduction policies, even though their nicotine reinforcement threshold and elasticity of demand may not differ from males. ..
  25. doi request reprint New directions in nicotine vaccine design and use
    Paul R Pentel
    Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA Minneapolis Medical Research Foundation, Minneapolis, Minnesota, USA Electronic address
    Adv Pharmacol 69:553-80. 2014
    ..Next-generation immunotherapies are likely to be substantially more effective than first-generation vaccines. ..
  26. ncbi request reprint Continuous nicotine infusion reduces nicotine self-administration in rats with 23-h/day access to nicotine
    Mark G LeSage
    Minneapolis Medical Research Foundation, D 3 Lab, Mail Code 860, 825 South 8th Street, Minneapolis, MN 55415, USA
    Pharmacol Biochem Behav 72:279-89. 2002
    ..The highest nicotine infusion rate had no sustained effect on food-maintained responding, demonstrating its specificity for suppression of NSA. These data provide a model for studying NRT in the rat...
  27. ncbi request reprint Translational research in medication development for nicotine dependence
    Caryn Lerman
    Department of Psychiatry and Abramson Cancer Center, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Drug Discov 6:746-62. 2007
    ....
  28. ncbi request reprint Tobacco extract but not nicotine impairs the mechanical strength of fracture healing in rats
    Martin Skott
    Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Aarhus University Hospital, Norrebrogade 44, Building 1A, DK 8000 Aarhus C, Denmark
    J Orthop Res 24:1472-9. 2006
    ..Serum levels of nicotine were between 40-50 ng/mL in the group given nicotine alone and the group given tobacco extract plus nicotine (equivalent to serum levels observed in persons smoking one to two packs of cigarettes per day)...
  29. pmc Effects of anorectic drugs on food intake under progressive-ratio and free-access conditions in rats
    Mark G LeSage
    Louisiana State University Health Sciences Center in Shreveport, USA
    J Exp Anal Behav 82:275-92. 2004
    ..The present findings suggest that the effects of some anorectic drugs depend upon the access conditions for food; increasing the effort to obtain food may enhance their ability to decrease food-maintained behavior...