Caryn E Lerman

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc The public health utility of genome-wide association study results for smoking behavior
    Helena Furberg
    Department of Psychiatry and Behavioral Science, Memorial Sloan Kettering Cancer Center, 641 Lexington Ave, New York, NY 10022, USA
    Genome Med 2:26. 2010
  2. ncbi Attention-Deficit Hyperactivity Disorder (ADHD) symptoms and smoking patterns among participants in a smoking-cessation program
    C Lerman
    University of Pennsylvania, 3535 Market St, Suite 4100, Philadelphia, PA 19104, USA
    Nicotine Tob Res 3:353-9. 2001
  3. ncbi Nicotine metabolite ratio predicts efficacy of transdermal nicotine for smoking cessation
    Caryn Lerman
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Clin Pharmacol Ther 79:600-8. 2006
  4. ncbi Genetic testing for cancer susceptibility: the promise and the pitfalls
    Caryn Lerman
    Department of Psychiatry, Abramson Cancer Center, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Cancer 4:235-41. 2004
  5. ncbi The functional mu opioid receptor (OPRM1) Asn40Asp variant predicts short-term response to nicotine replacement therapy in a clinical trial
    C Lerman
    Department of Psychiatry, Abramson Cancer Center, University of Pennsylvania, Philadelphia, USA
    Pharmacogenomics J 4:184-92. 2004
  6. ncbi Role of functional genetic variation in the dopamine D2 receptor (DRD2) in response to bupropion and nicotine replacement therapy for tobacco dependence: results of two randomized clinical trials
    Caryn Lerman
    Department of Psychiatry and Abramson Cancer Center, Tobacco Use Research Center, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 31:231-42. 2006
  7. ncbi Changes in food reward following smoking cessation: a pharmacogenetic investigation
    Caryn Lerman
    Department of Psychiatry, Abramson Cancer Center, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, PA 19104, USA
    Psychopharmacology (Berl) 174:571-7. 2004
  8. pmc Genetics and smoking cessation improving outcomes in smokers at risk
    Caryn E Lerman
    Transdisciplinary Tobacco Use Research Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Prev Med 33:S398-405. 2007
  9. ncbi Treating tobacco dependence: state of the science and new directions
    Caryn Lerman
    Tobacco Use Research Center, 3535 Market St, Suite 4100, Philadelphia, PA 19104, USA
    J Clin Oncol 23:311-23. 2005
  10. ncbi Effects of dopamine transporter and receptor polymorphisms on smoking cessation in a bupropion clinical trial
    Caryn Lerman
    University of Pennsylvania, Dept of Psychiatry, Abramson Cancer Ctr, Philadelphia, PA 19104, USA
    Health Psychol 22:541-8. 2003

Research Grants

  1. Pharmacogenetic Investigation of Naltrexone
    Caryn Lerman; Fiscal Year: 2007
  2. Neural Substrates of Cognitive Deficits in Nicotine Withdrawal
    James Loughead; Fiscal Year: 2010
  3. BIOBEHAVIORAL LUNG CANCER PREVENTION PROGRAM
    Caryn Lerman; Fiscal Year: 2004
  4. BIOBEHAVIORAL LUNG CANCER PREVENTION PROGRAM
    Caryn Lerman; Fiscal Year: 1993
  5. BIOBEHAVIORAL LUNG CANCER PREVENTION PROGRAM
    Caryn Lerman; Fiscal Year: 2000
  6. Cognitive Training for Nicotine Dependence
    James Loughead; Fiscal Year: 2010

Collaborators

Detail Information

Publications87

  1. pmc The public health utility of genome-wide association study results for smoking behavior
    Helena Furberg
    Department of Psychiatry and Behavioral Science, Memorial Sloan Kettering Cancer Center, 641 Lexington Ave, New York, NY 10022, USA
    Genome Med 2:26. 2010
    ..The coordinated effort of multidisciplinary research teams will help reveal the circumstances under which we can translate genetic insights into clinical practice in the hope of reducing the burden of smoking in society...
  2. ncbi Attention-Deficit Hyperactivity Disorder (ADHD) symptoms and smoking patterns among participants in a smoking-cessation program
    C Lerman
    University of Pennsylvania, 3535 Market St, Suite 4100, Philadelphia, PA 19104, USA
    Nicotine Tob Res 3:353-9. 2001
    ..Future studies of the role of inattention symptoms in response to smoking treatment are warranted...
  3. ncbi Nicotine metabolite ratio predicts efficacy of transdermal nicotine for smoking cessation
    Caryn Lerman
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Clin Pharmacol Ther 79:600-8. 2006
    ..This study evaluated the utility of the 3-HC/cotinine ratio as a predictor of the efficacy of nicotine replacement therapy as an aid for smoking cessation...
  4. ncbi Genetic testing for cancer susceptibility: the promise and the pitfalls
    Caryn Lerman
    Department of Psychiatry, Abramson Cancer Center, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Cancer 4:235-41. 2004
  5. ncbi The functional mu opioid receptor (OPRM1) Asn40Asp variant predicts short-term response to nicotine replacement therapy in a clinical trial
    C Lerman
    Department of Psychiatry, Abramson Cancer Center, University of Pennsylvania, Philadelphia, USA
    Pharmacogenomics J 4:184-92. 2004
    ..Smokers who carry the OPRM1 Asp40 variant are likely to have a favorable response to TN and may benefit from extended therapy with the 21 mg dose...
  6. ncbi Role of functional genetic variation in the dopamine D2 receptor (DRD2) in response to bupropion and nicotine replacement therapy for tobacco dependence: results of two randomized clinical trials
    Caryn Lerman
    Department of Psychiatry and Abramson Cancer Center, Tobacco Use Research Center, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 31:231-42. 2006
    ..Study findings require confirmation in additional larger samples before they are applied in practice...
  7. ncbi Changes in food reward following smoking cessation: a pharmacogenetic investigation
    Caryn Lerman
    Department of Psychiatry, Abramson Cancer Center, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, PA 19104, USA
    Psychopharmacology (Berl) 174:571-7. 2004
    ..Despite the high prevalence and public health significance of weight gain following smoking cessation, little is known about the underlying bio-behavioral mechanisms or effective therapies...
  8. pmc Genetics and smoking cessation improving outcomes in smokers at risk
    Caryn E Lerman
    Transdisciplinary Tobacco Use Research Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Prev Med 33:S398-405. 2007
    ..However, additional trials including larger and more diverse populations are needed before such data can be translated to practice to reduce smoking prevalence and tobacco-related disease...
  9. ncbi Treating tobacco dependence: state of the science and new directions
    Caryn Lerman
    Tobacco Use Research Center, 3535 Market St, Suite 4100, Philadelphia, PA 19104, USA
    J Clin Oncol 23:311-23. 2005
    ..These discoveries could someday help practitioners to individualize the type, dosage, and duration of tobacco dependence treatment based on genotype, and maximize the efficacy...
  10. ncbi Effects of dopamine transporter and receptor polymorphisms on smoking cessation in a bupropion clinical trial
    Caryn Lerman
    University of Pennsylvania, Dept of Psychiatry, Abramson Cancer Ctr, Philadelphia, PA 19104, USA
    Health Psychol 22:541-8. 2003
    ..These results provide the first evidence from a prospective clinical trial that genes that alter dopamine function may influence smoking cessation and relapse during the treatment phase...
  11. ncbi Translational research in medication development for nicotine dependence
    Caryn Lerman
    Department of Psychiatry and Abramson Cancer Center, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Drug Discov 6:746-62. 2007
    ....
  12. ncbi Genetic testing: psychological aspects and implications
    Caryn Lerman
    Cancer Center, University of Pennsylvania, Philadelphia 19104 4283, USA
    J Consult Clin Psychol 70:784-97. 2002
    ....
  13. ncbi Mediating mechanisms for the impact of bupropion in smoking cessation treatment
    Caryn Lerman
    Cancer Center and Department of Psychiatry, University of Pennsylvania Health Sciences, 3535 Market Street, Suite 4100, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 67:219-23. 2002
    ..Laboratory-based paradigms may be useful to identify other mediators of bupropion's effects, thereby pointing to mechanisms of effect that can be bolstered in future treatment studies...
  14. ncbi Applying genetic approaches to the treatment of nicotine dependence
    Caryn Lerman
    Department of Psychiatry and Abramson Cancer Center, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, Pennsylvania, PA 19104, USA
    Oncogene 21:7412-20. 2002
    ..Such research has the potential to improve treatment outcome, thereby reducing morbidity and mortality from smoking-related disease...
  15. ncbi Pharmacogenetic investigation of smoking cessation treatment
    Caryn Lerman
    Department of Psychiatry, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA
    Pharmacogenetics 12:627-34. 2002
    ..Such research could ultimately enable practitioners to select the optimal type and dose of medication for individual smokers...
  16. ncbi Elucidating the role of genetic factors in smoking behavior and nicotine dependence
    Caryn Lerman
    Department of Psychiatry and Abramson Cancer Center, University of Pennsylvania Health Sciences, 3535 Market Street, Suite 1400, Philadelphia, PA 19104, USA
    Am J Med Genet B Neuropsychiatr Genet 118:48-54. 2003
    ..This article provides an overview of currently available data from genetics research on smoking behavior and discusses study design issues to be addressed to make progress in this line of research...
  17. doi Genetic variation in nicotine metabolism predicts the efficacy of extended-duration transdermal nicotine therapy
    C Lerman
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Clin Pharmacol Ther 87:553-7. 2010
    ..RMs of nicotine are candidates for extended transdermal nicotine therapy, whereas an alternative therapeutic approach may be needed for those with normal rates of nicotine metabolism...
  18. ncbi Effect of bupropion on depression symptoms in a smoking cessation clinical trial
    Caryn Lerman
    Department of Psychiatry, Abramson Family Cancer Research Institute, University of Pennsylvania Cancer Center, Philadelphia, PA, USA
    Psychol Addict Behav 18:362-6. 2004
    ....
  19. pmc Gene and gene by sex associations with initial sensitivity to nicotine in nonsmokers
    Kenneth A Perkins
    Department of Psychiatry, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Behav Pharmacol 19:630-40. 2008
    ....
  20. ncbi Pharmacotherapy and pharmacogenetics of nicotine dependence
    Wade H Berrettini
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Clinical Research Bldg, Room 111, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Am J Psychiatry 162:1441-51. 2005
    ....
  21. pmc Dopamine and opioid gene variants are associated with increased smoking reward and reinforcement owing to negative mood
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Behav Pharmacol 19:641-9. 2008
    ..These results warrant replication but provide the first evidence for genetic associations with the acute increase in smoking reward and reinforcement owing to negative mood...
  22. ncbi Helping smokers quit through pharmacogenetics
    Caryn Lerman
    Department of Psychiatry and the Annenberg Public Policy Center, University of Pennsylvania, USA
    LDI Issue Brief 11:1-4. 2006
    ..This Issue Brief reviews ongoing work at Penn's Transdisciplinary Tobacco Use Research Center (TTURC) to unravel the genetic factors that might affect smoking cessation and to develop more effective treatment strategies...
  23. ncbi Predictors of attendance in a randomized clinical trial of nicotine replacement therapy with behavioral counseling
    Freda Patterson
    University of Pennsylvania, Transdisciplinary Tobacco Use Research Center, 3535 Market Street, Suite 4100, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 72:123-31. 2003
    ..Additional research in this area would also be valuable to evaluate strategies to promote attendance in these high-risk groups...
  24. pmc Variability in initial nicotine sensitivity due to sex, history of other drug use, and parental smoking
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Drug Alcohol Depend 99:47-57. 2009
    ..They also suggest that parental smoking may not increase risk of nicotine dependence in offspring by altering initial nicotine sensitivity, and that cross-tolerance between other drugs and nicotine may not be robust in humans...
  25. pmc Convergent evidence that choline acetyltransferase gene variation is associated with prospective smoking cessation and nicotine dependence
    Riju Ray
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Neuropsychopharmacology 35:1374-82. 2010
    ..Additional sequencing and characterization of ChAT may reveal functional variants that contribute to nicotine dependence and smoking cessation...
  26. doi Effects of the alpha4beta2 partial agonist varenicline on brain activity and working memory in abstinent smokers
    James Loughead
    Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 67:715-21. 2010
    ..In rodents and humans, cognitive deficits can be reversed by treatment with the alpha4beta2 nicotinic receptor partial agonist varenicline. This neuroimaging study examined the neural mechanisms that underlie these effects...
  27. ncbi Gender differences in smoking cessation in a placebo-controlled trial of bupropion with behavioral counseling
    Bradley N Collins
    University of Pennsylvania, Tabacco Research Center, Philadelphia, PA 19104, USA
    Nicotine Tob Res 6:27-37. 2004
    ..These results suggest that bupropion treatment may reduce the gender disparity in prolonged abstinence rates among lighter smokers...
  28. doi Increase in anger symptoms after smoking cessation predicts relapse
    Freda Patterson
    Transdisciplinary Tobacco Use Research Center, University of Pennsylvania, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 95:173-6. 2008
    ..001). These data suggest that anger may be an important withdrawal symptom that influences liability to relapse. Future studies are needed to evaluate treatment strategies that effectively help smokers reduce and manage post-quit anger...
  29. pmc Varenicline improves mood and cognition during smoking abstinence
    Freda Patterson
    Department of Psychiatry, University of Pennsylvania, University of Pittsburgh Medical Center, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Biol Psychiatry 65:144-9. 2009
    ..Varenicline, a partial agonist at the alpha4beta2 nAChRs, is a new, efficacious medication for nicotine dependence. Its effects on the affective and cognitive dimensions of nicotine withdrawal have yet to be well characterized...
  30. ncbi Individualizing nicotine replacement therapy for the treatment of tobacco dependence: a randomized trial
    Caryn Lerman
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Ann Intern Med 140:426-33. 2004
    ....
  31. ncbi Genetic variation in mu-opioid-receptor-interacting proteins and smoking cessation in a nicotine replacement therapy trial
    Riju Ray
    Department of Pharmacology, and Transdisciplinary Tobacco Use Research Center, University of Pennsylvania, Philadelphia, PA, USA
    Nicotine Tob Res 9:1237-41. 2007
    ....
  32. pmc Working memory deficits predict short-term smoking resumption following brief abstinence
    Freda Patterson
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
    Drug Alcohol Depend 106:61-4. 2010
    ....
  33. ncbi Associations between relationship support and psychological reactions of participants and partners to BRCA1 and BRCA2 testing in a clinic-based sample
    Sharon Manne
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Ann Behav Med 28:211-25. 2004
    ....
  34. pmc Nicotine metabolite ratio predicts smoking topography and carcinogen biomarker level
    Andrew A Strasser
    Department of Psychiatry and Abramson Cancer Center, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, PA 19104 3309, USA
    Cancer Epidemiol Biomarkers Prev 20:234-8. 2011
    ..We hypothesized that faster NMR would be associated with greater cigarette puff volume and higher levels of total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), a carcinogen biomarker...
  35. doi Association of retrospective early smoking experiences with prospective sensitivity to nicotine via nasal spray in nonsmokers
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Nicotine Tob Res 10:1335-45. 2008
    ....
  36. ncbi Rate of nicotine onset from nicotine replacement therapy and acute responses in smokers
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Nicotine Tob Res 6:501-7. 2004
    ..patch differentially affected cardiovascular responses and perhaps craving but did not influence withdrawal, subjective ratings, and smoking reinforcement...
  37. ncbi Lower nicotine cigarettes may not lower harm
    Andrew A Strasser
    Transdisciplinary Tobacco Use Center, University of Pennsylvania, USA
    LDI Issue Brief 12:1-4. 2006
    ..These complementary studies send a cautionary signal about the ability of these new cigarettes to reduce the harmful effects of smoking...
  38. ncbi Pharmacogenetics and smoking cessation with nicotine replacement therapy
    Riju Ray
    Department of Psychiatry, The Transdisciplinary Tobacco Use Research Center and Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA
    CNS Drugs 21:525-33. 2007
    ..Larger-scale investigations that incorporate pathway-based or genome-wide analysis, as well as intermediate measures of nicotine dependence (i.e. 'endophenotypes'), may be necessary to capture the complexity of pharmacogenetic effects...
  39. ncbi Individual differences in nicotine intake per cigarette
    Freda Patterson
    Abramson Cancer Center and Department of Psychiatry, University of Pennsylvania Health Sciences and the Annenberg Public Policy Center, Philadelphia, Pennsylvania 19104, USA
    Cancer Epidemiol Biomarkers Prev 12:468-71. 2003
    ..Future research on individual differences in nicotine boost is warranted to clarify the role of psychological, physiological, and cigarette-related determinants...
  40. pmc Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior
    Stephen D Mague
    Department of Pharmacology, Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 106:10847-52. 2009
    ..Further cross-species analysis will allow us to investigate mechanisms and adaptations present in humans carrying this SNP...
  41. pmc Mouse model predicts effects of smoking and varenicline on event-related potentials in humans
    Noam D Rudnick
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nicotine Tob Res 12:589-97. 2010
    ..Nicotine alters auditory event-related potentials (ERPs) in rodents and humans and is an effective treatment for smoking cessation. Less is known about the effects of the partial nicotine agonist varenicline on ERPs...
  42. ncbi Treating tobacco dependence in women
    Robert A Schnoll
    The Transdisciplinary Tobacco Use Research Center, Department of Psychiatry, and Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Womens Health (Larchmt) 16:1211-8. 2007
    ..Greater attention to the unique needs of female smokers may allow healthcare providers to optimize delivery of pharmacotherapy and behavioral counseling to aid their female patients to quit smoking...
  43. pmc Nicotine metabolic rate predicts successful smoking cessation with transdermal nicotine: a validation study
    Robert A Schnoll
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Pharmacol Biochem Behav 92:6-11. 2009
    ..38, t[355]=-3.09, p<.05). These data support the value of the 3-HC/cotinine ratio as a biomarker to predict success with transdermal nicotine for smoking cessation...
  44. pmc Neural substrates of abstinence-induced cigarette cravings in chronic smokers
    Ze Wang
    Department of Neurology, Center for Functional Neuroimaging, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 27:14035-40. 2007
    ..These data suggest that increased activation in the brain's visuospatial and reward circuitry underlies abstinence-induced cravings to smoke, and thereby, may be important in relapse...
  45. doi Nicotine dependence: biology, behavior, and treatment
    Riju Ray
    Transdisciplinary Tobacco Use Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Annu Rev Med 60:247-60. 2009
    ..Enhanced understanding of these dimensions of nicotine dependence may help to advance progress toward lowering the prevalence rate of tobacco use in the U.S. and lowering the rate of tobacco-related morbidity and mortality...
  46. pmc Identification of pharmacogenetic markers in smoking cessation therapy
    Daniel F Heitjan
    Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Med Genet B Neuropsychiatr Genet 147:712-9. 2008
    ..In a panel of 43 randomly selected control SNPs, none is significant by either the Bayesian or the corrected frequentist test...
  47. pmc A placebo-controlled trial of modafinil for nicotine dependence
    Robert A Schnoll
    Department of Psychiatry, Abramson Cancer Center, and Annenberg Public Policy Center, University of Pennsylvania, Philadelphia, PA, United States
    Drug Alcohol Depend 98:86-93. 2008
    ..Modafinil (Provigil), a wakefulness medication shown to have efficacy for the treatment of cocaine addiction, was tested as a novel therapy for nicotine dependence in a double-blind placebo-controlled trial...
  48. doi Dosimetry of 11C-carfentanil, a micro-opioid receptor imaging agent
    Andrew B Newberg
    Department of Radiology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nucl Med Commun 30:314-8. 2009
    ..The study was conducted within a regulatory framework that required its pharmacological safety to be assessed simultaneously...
  49. pmc Neuroimaging, genetics and the treatment of nicotine addiction
    Riju Ray
    Trandisciplinary Tobacco Use Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Behav Brain Res 193:159-69. 2008
    ..The purpose of this review is to provide an outline of the work in neuroimaging, genetics, and nicotine dependence, and to explore the potential for increased integration of these approaches to improve nicotine dependence treatment...
  50. pmc Smoking cues, argument strength, and perceived effectiveness of antismoking PSAs
    Sungkyoung Lee
    Center of Excellence in Cancer Communication Research, Annenberg School of Communication, University of Pennsylvania, 3620 Walnut St, Philadelphia, PA 19104, USA
    Nicotine Tob Res 13:282-90. 2011
    ..Argument strength indicates smoker's judgments of perceived strength and persuasiveness of the arguments extracted from the PSAs...
  51. ncbi Which adolescents are most receptive to tobacco industry marketing? implications for counter-advertising campaigns
    Janet Audrain-McGovern
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Health Commun 15:499-513. 2003
    ..Counter-advertising messages should consider individual differences in novelty-seeking, because novelty-seekers may be most receptive to tobacco industry promotional campaigns...
  52. ncbi Dopamine transporter binding in smokers and nonsmokers
    Andrew Newberg
    Division of Nuclear Medicine, Department of Radiology, University of Pennsylvania Health System, Philadelphia, PA, USA
    Clin Nucl Med 32:452-5. 2007
    ..This study determined whether healthy current smokers and nonsmokers exhibit differences in dopamine transporter (DAT) binding measured by Tc-99m TRODAT SPECT...
  53. ncbi Predictors of participation in psychosocial telephone counseling following genetic testing for BRCA1 and BRCA2 mutations
    Chanita Hughes Halbert
    Department of Psychiatry and Abramson Cancer Center, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, PA 19104, USA
    Cancer Epidemiol Biomarkers Prev 13:875-81. 2004
    ....
  54. ncbi Recurrent event analysis of lapse and recovery in a smoking cessation clinical trial using bupropion
    E Paul Wileyto
    University of Pennsylvania, Tobacco Use Research Center, Philadelphia, PA 19104 3309, USA
    Nicotine Tob Res 7:257-68. 2005
    ..Further research disentangling lapse and recovery events from summary abstinence measures is needed to help us develop interventions that take advantage of bupropion at its best and that compensate where it is weak...
  55. ncbi Behavioral consequences of testing for obesity risk
    Dominick L Frosch
    Robert Wood Johnson Health and Society Scholars Program, Philadelphia, Pennsylvania, USA
    Cancer Epidemiol Biomarkers Prev 14:1485-9. 2005
    ..There is considerable hope that genetic susceptibility testing will motivate behavior that can prevent or reduce the risk of complex conditions such as obesity. This study examined potential behavioral consequences of such testing...
  56. ncbi Increases in hyperactive-impulsive symptoms predict relapse among smokers in nicotine replacement therapy
    Margaret Rukstalis
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Subst Abuse Treat 28:297-304. 2005
    ....
  57. pmc Association of catechol-O-methyltransferase with smoking cessation in two independent studies of women
    Susan Colilla
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pharmacogenet Genomics 15:393-8. 2005
    ..To determine if the lower activity Met allele of COMT was associated with smoking cessation in women, we used two independent studies: a population-based case--control study and a nicotine replacement clinical trial...
  58. ncbi Naltrexone reduces the relative reinforcing value of nicotine in a cigarette smoking choice paradigm
    Margaret Rukstalis
    Tobacco Use Research Center, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, PA 19104, USA
    Psychopharmacology (Berl) 180:41-8. 2005
    ..Naltrexone and bupropion have been shown to alter ad lib smoking behavior; however, medication effects on nicotine reward in a cigarette choice paradigm have yet to be investigated...
  59. ncbi Interacting effects of genetic predisposition and depression on adolescent smoking progression
    Janet Audrain-McGovern
    Department of Psychiatry, Abramson Cancer Center, University of Pennsylvania, Suite 4100, 3535 Market Street, Philadelphia, PA 19104, USA
    Am J Psychiatry 161:1224-30. 2004
    ..The goal of the present study was to identify specific genetic associations with smoking progression in adolescents and to determine whether these genetic effects on smoking practices are potentiated by depression symptoms...
  60. ncbi Effects of different nicotine replacement therapies on postcessation psychological responses
    Andrew A Strasser
    Tobacco Use Research Center, Department of Psychiatry, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, PA 19140 3309, USA
    Addict Behav 30:9-17. 2005
    ..These findings indicate that, although TN may enhance positive affect for smokers in treatment compared with NS, only changes in negative affect predict treatment outcome...
  61. ncbi Predictors of cognitive appraisals following genetic testing for BRCA1 and BRCA2 mutations
    Chanita Hughes Halbert
    Department of Psychiatry and Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Behav Med 27:373-92. 2004
    ..001). These results suggest that interventions designed to address perceptions of stress related to medical decision-making and familial concerns may need to be targeted to BRCA1/2 mutation carriers and individuals who are highly anxious...
  62. ncbi Smoking topography predicts abstinence following treatment with nicotine replacement therapy
    Andrew A Strasser
    Transdisciplinary Tobacco Use Research Center, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, PA 19104 3309, USA
    Cancer Epidemiol Biomarkers Prev 13:1800-4. 2004
    ..A secondary objective was to determine the relationship of smoking topography to carbon monoxide (CO) exposure...
  63. ncbi A randomized controlled trial of financial incentives for smoking cessation
    Kevin G Volpp
    CHERP, Philadelphia Veterans Affairs Medical Center, University and Woodland Ave, Philadelphia, PA 19104 6021, USA
    Cancer Epidemiol Biomarkers Prev 15:12-8. 2006
    ..The objective of this study was to determine whether modest financial incentives increase the rate of smoking cessation program enrollment, completion, and quit rates in a outpatient clinical setting...
  64. ncbi Colon cancer screening practices following genetic testing for hereditary nonpolyposis colon cancer (HNPCC) mutations
    Chanita Hughes Halbert
    Abramson Cancer Center, Department of Psychiatry, and Annenberg Public Policy Center, University of Pennsylvania, 19104, USA
    Arch Intern Med 164:1881-7. 2004
    ..This study investigated colonoscopy practices following genetic testing for HNPCC mutations...
  65. ncbi An association of CYP2A6 genotype and smoking topography
    Andrew A Strasser
    Transdisciplinary Tobacco Use Research Center, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nicotine Tob Res 9:511-8. 2007
    ..The results from this study also suggest a behavioral mechanism that may account for reduced cancer risk in slow metabolizers...
  66. ncbi Catechol-O-methyltransferase (COMT) gene variants predict response to bupropion therapy for tobacco dependence
    Wade H Berrettini
    Department of Psychiatry, Transdisciplinary Tobacco Use Research Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Biol Psychiatry 61:111-8. 2007
    ..We investigated variants in the catechol-O-methyltransferase (COMT) gene in a smoking cessation trial of bupropion...
  67. pmc Nicotine abstinence-induced cerebral blood flow changes by genotype
    Ze Wang
    Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, United States
    Neurosci Lett 438:275-80. 2008
    ..While preliminary, these results suggest a neural mechanism through which these genetic variants may be linked with nicotine dependence, and provide further support for increased biological vulnerability in these subgroups of smokers...
  68. ncbi New lower nicotine cigarettes can produce compensatory smoking and increased carbon monoxide exposure
    Andrew A Strasser
    Transdisciplinary Tobacco Use Research Center, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, PA 19104, United States
    Drug Alcohol Depend 86:294-300. 2007
    ..Although marketed as a PREP, increases in CO boost suggest this product can potentially be a harm-increasing product...
  69. ncbi Current and emerging pharmacotherapies for treating tobacco dependence
    Robert A Schnoll
    Department of Psychiatry, Transdisciplinary Tobacco Use Research Center, University of Pennsylvania, 3535 Market Street, 4th Floor, Philadelphia, PA 19104, USA
    Expert Opin Emerg Drugs 11:429-44. 2006
    ....
  70. ncbi Hemodynamic responses in neural circuitries for detection of visual target and novelty: An event-related fMRI study
    Ruben C Gur
    Department of Psychiatry, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Hum Brain Mapp 28:263-74. 2007
    ..Age was associated with reduced peak HRF in left frontal region. Thus, indices of the HRF can be used to better understand the relationship between hemodynamic changes and performance and can be sensitive to individual differences...
  71. pmc Ventrolateral prefrontal cortex and the effects of task demand context on facial affect appraisal in schizophrenia
    David I Leitman
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Soc Cogn Affect Neurosci 6:66-73. 2011
    ..In schizophrenia, reduced modulation of OFC/VLPFC by context coupled with reduced behavioural efficiency suggests impaired ventral prefrontal control mechanisms that optimize affective appraisal...
  72. ncbi Neurocognitive performance and clinical changes in olanzapine-treated patients with schizophrenia
    Raquel E Gur
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 28:2029-36. 2003
    ..These results suggest that some effects of olanzapine may impact both symptoms and cognitive performance...
  73. ncbi Acute effect of methadone maintenance dose on brain FMRI response to heroin-related cues
    Daniel D Langleben
    Department of Psychiatry, University of Pennsylvania, Treatment Research Center, Philadelphia, PA 19104, USA
    Am J Psychiatry 165:390-4. 2008
    ..The authors sought to identify the functional neuroanatomy of the brain response to visual heroin-related stimuli in methadone maintenance patients...
  74. pmc Multisensory integration of emotionally valenced olfactory-visual information in patients with schizophrenia and healthy controls
    Janina Seubert
    Department of Psychiatry and Psychotherapy, Rheinisch Westfalische Technische Hochschule, Aachen University, Germany
    J Psychiatry Neurosci 35:185-94. 2010
    ..We investigated whether this impairment is aggravated by difficulties relating the observed facial expression to contextual information, as is often provided by emotionally valenced crossmodal stimulation...
  75. pmc Alterations of fronto-temporal connectivity during word encoding in schizophrenia
    Daniel H Wolf
    University of Pennsylvania, Department of Psychiatry, Philadelphia, PA 19104, USA
    Psychiatry Res 154:221-32. 2007
    ..The results suggest that reduced temporal-DLPFC connectivity in schizophrenia could underlie encoding deficits, and increased temporal-VLPFC connectivity may represent an ineffective compensatory effort...
  76. doi Processing of disgusted faces is facilitated by odor primes: a functional MRI study
    Janina Seubert
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    Neuroimage 53:746-56. 2010
    ..These results indicate the presence of a central network with modality-specific and -unspecific components modulating emotional face recognition...
  77. doi Association of enhanced limbic response to threat with decreased cortical facial recognition memory response in schizophrenia
    Theodore D Satterthwaite
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Psychiatry 167:418-26. 2010
    ..The authors used an affective face recognition paradigm to examine possible interactions between cognitive and affective neural systems in schizophrenia...
  78. ncbi Quantification of facial expressions using high-dimensional shape transformations
    Ragini Verma
    Department of Radiology, Section of Biomedical Image Analysis, University of Pennsylvania, 3600 Market Street, Suite 380, Philadelphia, PA 19104, USA
    J Neurosci Methods 141:61-73. 2005
    ..A model for the average expression of specific emotions was also constructed using the RVD maps. This method can be applied in basic and clinical investigations of facial affect and its neural substrates...
  79. ncbi Functional magnetic resonance imaging of internal source monitoring in schizophrenia: recognition with and without recollection
    J Daniel Ragland
    Department of Psychiatry, Brain Behavior Laboratory, 3400 Spruce Street, University of Pennsylvania, Philadelphia, PA 19104, USA
    Schizophr Res 87:160-71. 2006
    ..Activation in these areas was associated with worse positive and negative symptoms, but did not correlate with performance, suggesting inefficient rather than compensatory activation...
  80. ncbi Levels-of-processing effect on frontotemporal function in schizophrenia during word encoding and recognition
    J Daniel Ragland
    Department of Psychiatry, 10th Floor Gates Bldg HUP, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Psychiatry 162:1840-8. 2005
    ..Patients with schizophrenia improve episodic memory accuracy when given organizational strategies through levels-of-processing paradigms. This study tested if improvement is accompanied by normalized frontotemporal function...
  81. ncbi Visual attention circuitry in schizophrenia investigated with oddball event-related functional magnetic resonance imaging
    Raquel E Gur
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Psychiatry 164:442-9. 2007
    ..Cerebral activity underlying abnormal attention can be examined with event-related functional magnetic resonance imaging...
  82. pmc Brain activation during eye gaze discrimination in stable schizophrenia
    Christian G Kohler
    Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
    Schizophr Res 99:286-93. 2008
    ..Earlier studies described gaze discrimination impairment in schizophrenia. The purpose of this study was to compare gaze discrimination abilities and associated brain activation in persons with stable schizophrenia and matched controls...
  83. doi Neural circuitry for accurate identification of facial emotions
    James Loughead
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Brain Res 1194:37-44. 2008
    ..Results indicate that the fusiform cortex and amygdala respond differentially in the four target conditions (happy, sad, angry and fearful) along the dimension of threat-relatedness...
  84. doi Frontolimbic responses to emotional face memory: the neural correlates of first impressions
    Theodore D Satterthwaite
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Hum Brain Mapp 30:3748-58. 2009
    ..The results indicate that a network of frontolimbic regions may provide emotional bias signals during facial recognition...
  85. ncbi Limbic activation associated with misidentification of fearful faces and flat affect in schizophrenia
    Raquel E Gur
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Arch Gen Psychiatry 64:1356-66. 2007
    ..Deficits in emotion processing are prominent in schizophrenia, and flat affect is resistant to treatment and portends poor outcome. Investigation of the underlying neural circuitry can elucidate affective dysfunction...
  86. pmc Abnormal superior temporal connectivity during fear perception in schizophrenia
    David I Leitman
    Department of Psychiatry Neuropsychiatry Program, Brain Behavior Laboratory, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Schizophr Bull 34:673-8. 2008
    ..Such abnormal integration may disrupt the evaluation of threat within fronto-cortical regions...
  87. ncbi Frontiers in cancer prevention research
    Anita L Sabichi
    Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Cancer Res 63:5649-55. 2003

Research Grants20

  1. Pharmacogenetic Investigation of Naltrexone
    Caryn Lerman; Fiscal Year: 2007
    ..The long-term objective of this research is to discover and develop new pharmacogenetic treatment models that can be readily translated to the clinical setting to individualize pharmacotherapy and maximize effectiveness. ..
  2. Neural Substrates of Cognitive Deficits in Nicotine Withdrawal
    James Loughead; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: This study will improve our understanding of the brain mechanisms that underlie abstinence-induced cognitive deficits which promote smoking relapse. ..
  3. BIOBEHAVIORAL LUNG CANCER PREVENTION PROGRAM
    Caryn Lerman; Fiscal Year: 2004
    ..The long-term objective is to provide information necessary to match smoking cessation treatments to individuals, based on their genetic predispositions. ..
  4. BIOBEHAVIORAL LUNG CANCER PREVENTION PROGRAM
    Caryn Lerman; Fiscal Year: 1993
    ..Finally, we will use regressive models to identify key variables and causal processes associated with progress through stages of smoking behavior change and cessation...
  5. BIOBEHAVIORAL LUNG CANCER PREVENTION PROGRAM
    Caryn Lerman; Fiscal Year: 2000
    ..Finally, we will use regressive models to identify key variables and causal processes associated with progress through stages of smoking behavior change and cessation. ..
  6. Cognitive Training for Nicotine Dependence
    James Loughead; Fiscal Year: 2010
    ..The novel web-based computerized cognitive training intervention is "portable" and can be easily translated to clinical practice for the treatment for nicotine dependence. ..