Robert F Lera

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc The final link: tapping the power of chemical genetics to connect the molecular and biologic functions of mitotic protein kinases
    Robert F Lera
    Graduate Program in Cellular and Molecular Biology, University of Wisconsin, Madison, WI 53705, USA
    Molecules 17:12172-86. 2012
  2. pmc High mitotic activity of Polo-like kinase 1 is required for chromosome segregation and genomic integrity in human epithelial cells
    Robert F Lera
    Department of Medicine and the University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Biol Chem 287:42812-25. 2012
  3. pmc Interphase cytofission maintains genomic integrity of human cells after failed cytokinesis
    Alka Choudhary
    University of Wisconsin Carbone Cancer Center, Hematology Oncology Division, Department of Medicine, and Department of Cell and Regenerative Medicine, University of Wisconsin, Madison, WI 53705
    Proc Natl Acad Sci U S A 110:13026-31. 2013

Collaborators

Detail Information

Publications3

  1. pmc The final link: tapping the power of chemical genetics to connect the molecular and biologic functions of mitotic protein kinases
    Robert F Lera
    Graduate Program in Cellular and Molecular Biology, University of Wisconsin, Madison, WI 53705, USA
    Molecules 17:12172-86. 2012
    ..We believe a complete "chemical genetic toolbox" will ultimately allow a comprehensive understanding of how protein kinases regulate mitosis...
  2. pmc High mitotic activity of Polo-like kinase 1 is required for chromosome segregation and genomic integrity in human epithelial cells
    Robert F Lera
    Department of Medicine and the University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Biol Chem 287:42812-25. 2012
    ..These results demonstrate that different thresholds of Plk1 activity can elicit distinct phenotypes, illustrating a general method for separating pleiotropic functions of a protein kinase even when these are executed close in time...
  3. pmc Interphase cytofission maintains genomic integrity of human cells after failed cytokinesis
    Alka Choudhary
    University of Wisconsin Carbone Cancer Center, Hematology Oncology Division, Department of Medicine, and Department of Cell and Regenerative Medicine, University of Wisconsin, Madison, WI 53705
    Proc Natl Acad Sci U S A 110:13026-31. 2013
    ..Thus, traction-mediated cytofission, originally observed in Dictyostelium, is relevant to human biology-where it seems to be an evolutionarily conserved mechanism that can preserve genomic integrity. ..