Robert F Lera
Affiliation: University of Wisconsin
- The final link: tapping the power of chemical genetics to connect the molecular and biologic functions of mitotic protein kinasesRobert F Lera
Graduate Program in Cellular and Molecular Biology, University of Wisconsin, Madison, WI 53705, USA
Molecules 17:12172-86. 2012..We believe a complete "chemical genetic toolbox" will ultimately allow a comprehensive understanding of how protein kinases regulate mitosis...
- Interphase cytofission maintains genomic integrity of human cells after failed cytokinesisAlka Choudhary
University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, WI 53705, USA
Proc Natl Acad Sci U S A 110:13026-31. 2013..Thus, traction-mediated cytofission, originally observed in Dictyostelium, is relevant to human biology--where it seems to be an evolutionarily conserved mechanism that can preserve genomic integrity...
- High mitotic activity of Polo-like kinase 1 is required for chromosome segregation and genomic integrity in human epithelial cellsRobert F Lera
Department of Medicine and the University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, Wisconsin 53705, USA
J Biol Chem 287:42812-25. 2012..These results demonstrate that different thresholds of Plk1 activity can elicit distinct phenotypes, illustrating a general method for separating pleiotropic functions of a protein kinase even when these are executed close in time...