- The final link: tapping the power of chemical genetics to connect the molecular and biologic functions of mitotic protein kinasesRobert F Lera
Graduate Program in Cellular and Molecular Biology, University of Wisconsin, Madison, WI 53705, USA
Molecules 17:12172-86. 2012..We believe a complete "chemical genetic toolbox" will ultimately allow a comprehensive understanding of how protein kinases regulate mitosis...
- High mitotic activity of Polo-like kinase 1 is required for chromosome segregation and genomic integrity in human epithelial cellsRobert F Lera
Department of Medicine and the University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, Wisconsin 53705, USA
J Biol Chem 287:42812-25. 2012..These results demonstrate that different thresholds of Plk1 activity can elicit distinct phenotypes, illustrating a general method for separating pleiotropic functions of a protein kinase even when these are executed close in time...
- Interphase cytofission maintains genomic integrity of human cells after failed cytokinesisAlka Choudhary
University of Wisconsin Carbone Cancer Center, Hematology Oncology Division, Department of Medicine, and Department of Cell and Regenerative Medicine, University of Wisconsin, Madison, WI 53705
Proc Natl Acad Sci U S A 110:13026-31. 2013..Thus, traction-mediated cytofission, originally observed in Dictyostelium, is relevant to human biology-where it seems to be an evolutionarily conserved mechanism that can preserve genomic integrity. ..