Research Topics
| Stanley P LeongSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Discordancy between clinical predictions vs lymphoscintigraphic and intraoperative mapping of sentinel lymph node drainage of primary melanomaS P Leong
Department of Surgery, University of California San Francisco Mount Zion Cancer Center, 94115, USA
Arch Dermatol 135:1472-6. 1999..To evaluate discordancy between clinical predictions and lymphatic drainage patterns of primary cutaneous melanoma as determined by preoperative lymphoscintigraphy and intraoperative lymphatic mapping of sentinel lymph nodes (SLNs)...- Future perspectives on malignant melanomaStanley P L Leong
Department of Surgery, University of California at San Francisco Comprehensive Cancer Center, 1600 Divisadero Street, San Francisco, CA 94143 1674, USA
Surg Clin North Am 83:453-6, x. 2003..If such mechanisms can be understood, potential therapeutic maneuvers can be developed to prevent the process of micrometastasis... - Sentinel lymph node mapping and selective lymphadenectomy: the standard of care for melanomaStanley P L Leong
Department of Surgery, University of California, San Francisco Mount Zion Medical Center and UCSF Comprehensive Cancer Center, 1600 Divisadero Street, Room C333, San Francisco, CA 94143, USA
Curr Treat Options Oncol 5:185-94. 2004..A complete LN dissection is performed if the SLN is positive. It is important to follow the clinical outcome of patients undergoing SSL, thus its role can be further defined... - Selective sentinel lymphadenectomy for breast cancer in the United StatesStanley P L Leong
Sentinel Lymph Node Program, Department of Surgery, University of California, San Francisco, CA 94143, USA
Asian J Surg 27:268-74. 2004..SSL is rapidly evolving into a standard approach for staging primary breast cancer in the United States, without the maturation of results from clinical trials... - Heterogeneous patterns of lymphatic drainage to sentinel lymph nodes by primary melanoma from different anatomic sitesStanley P L Leong
Department of Surgery, UCSF Comprehensive Cancer Center at Mount Zion, San Francisco, California 94143 1674, USA
Clin Nucl Med 30:150-8. 2005..Preoperative lymphoscintigraphy was used to identify and classify SLN drainage basins and patterns of drainage... - Clinical significance of occult metastatic melanoma in sentinel lymph nodes and other high-risk factors based on long-term follow-upStanley P L Leong
Department of Surgery, University of California, San Francisco, Medical Center at Mount Zion and CSF Comprehensive Cancer Center, 1600 Divisadero Street, Box 1674, San Francisco, California 94143, USA
World J Surg 29:683-91. 2005..CI 1.20,2.98), and age (HR= 1.26 95% CI 1.08, 1.47). SLN status was the most significant factor for melanoma recurrence and death. Other important predictors include tumor thickness, ulceration, lymphatic invasion, and mitotic index... - Impact of sentinel node status and other risk factors on the clinical outcome of head and neck melanoma patientsStanley P L Leong
Department of Surgery, University of California, San Francisco, CA 94115, USA
Arch Otolaryngol Head Neck Surg 132:370-3. 2006..To determine the impact of sentinel lymph node (SLN) status and other risk factors on recurrence and overall survival in head and neck melanoma patients... - Clinical patterns of metastasisStanley P L Leong
Department of Surgery, University of California, and UCSF Comprehensive Cancer Center, San Francisco, CA, USA
Cancer Metastasis Rev 25:221-32. 2006..Beyond the clinical patterns of metastasis, it is imperative to understand the biology of metastasis and to characterize patterns of metastasis perhaps due to heterogeneous clones based on their molecular signatures... - Paradigm shift of staging and treatment for early breast cancer in the sentinel lymph node eraStanley P L Leong
Department of Surgery, University of California and UCSF Comprehensive Cancer Center at Mount Zion, San Francisco, California 94143 1674, USA
Breast J 12:S128-33. 2006..The challenge in the future will be to dissect these different patterns of metastasis based on molecular or genetic markers. Such information will be critical to select high-risk patients for adjuvant therapy... - Selective sentinel lymphadenectomy for malignant melanomaStanley P L Leong
Department of Surgery, University of California at San Francisco, University of California at San Francisco Comprehensive Cancer Center at Mount Zion, 1600 Divisadero Street, San Francisco, CA 94143 1674, USA
Surg Clin North Am 83:157-85, vii. 2003..It is important for investigators involved with SSL to follow the clinical outcome of their patients so that the role of SSL can be further defined... - Delayed harvesting of sentinel lymph nodes after previous wide local excision of extremity melanomaStanley P L Leong
Department of Surgery, Melanoma Center, University of California, San Francisco Medical Center at Mount Zion, San Francisco, California, USA
Ann Surg Oncol 10:196-200. 2003..The aim of our study was to determine whether delayed SSL is useful in detecting micrometastasis to the regional basin in patients with previous WLE of an extremity melanoma... - Adverse reactions to isosulfan blue during selective sentinel lymph node dissection in melanomaS P Leong
Department of Surgery, University of California Mount Zion Medical Center, San Francisco 94143 1674, USA
Ann Surg Oncol 7:361-6. 2000..This procedure identifies the SLN either visually by injecting isosulfan blue dye around the primary melanoma site or by handheld gamma probe after radiocolloid injection... - The role of sentinel lymph nodes in malignant melanomaS P Leong
Department of Surgery, University of California, San Francisco School of Medicine, UCSF Comprehensive Cancer Center, 94115, USA
Surg Clin North Am 80:1741-57. 2000..Based on the clinical outcome data of selective sentinel lymph node dissection, micrometastasis to the SLNs carries a poor prognosis for patients with primary invasive melanoma... - Future perspectives on selective sentinel lymphadenectomyS P Leong
Department of Surgery, University of California, San Francisco School of Medicine, UCSF Comprehensive Cancer Center, 94115, USA
Surg Clin North Am 80:1839-44. 2000..The techniques of harvesting are being developed in other solid cancers, such as gynecologic and gastrointestinal cancer. Cellular and molecular techniques are being used to study the mechanism of micrometastasis... - Cytokine profiles of sentinel lymph nodes draining the primary melanomaStanley P L Leong
Department of Surgery, University of California at San Francisco Comprehensive Cancer Center Mount Zion, 94143 1674, USA
Ann Surg Oncol 9:82-7. 2002..The sentinel lymph node (SLN) draining the primary melanoma is the first echelon node where micrometastasis is established. SLNs may be the initial sites of antigen presentation associated with immune responses... - Paradigm of metastasis for melanoma and breast cancer based on the sentinel lymph node experienceStanley P L Leong
Department of Surgery, University of California, San Francisco, UCSF Comprehensive Cancer Center, and UCSF Medical Center at Mount Zion, San Francisco, California, USA
Ann Surg Oncol 11:192S-7S. 2004..Better understanding of the molecular and genetic mechanisms of metastasis will be critical to select high-risk patients for adjuvant therapy... 
Is it necessary to harvest additional lymph nodes after resection of the most radioactive sentinel lymph node in breast cancer?Liang Chih Liu
Department of Surgery and Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA
J Am Coll Surg 207:853-8. 2008..We hypothesized that the node with the highest radioactivity would have the strongest probability of being a positive SLN, and we sought to determine the lowest radioactive count of a node harboring cancer...- Intraoperative frozen section analysis of sentinel lymph nodes in breast cancer patients: a meta-analysis and single-institution experienceLiang Chih Liu
Department of Surgery, Helen Diller and Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California, USA
Cancer 117:250-8. 2011..The objective of the current study was to determine the accuracy of intraoperative frozen section (IFS) of SLNs during breast cancer surgery... - Melanoma patients with positive sentinel nodes who did not undergo completion lymphadenectomy: a multi-institutional studySandra L Wong
Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
Ann Surg Oncol 13:809-16. 2006..CONCLUSIONS: This study underscores the importance of ongoing prospective randomized trials in determining the therapeutic value of CLND after positive SLN biopsy in melanoma patients... - Prognostic implications of positive nonsentinel lymph nodes removed during selective sentinel lymphadenectomy for breast cancerJulie E Lang
Department of Surgery and UCSF Comprehensive Cancer Center, UCSF, San Francisco, CA 94143 1674, USA
Breast J 15:242-6. 2009..57), or overall survival (p = 0.70). Positive non-SLNs removed during SSL are not a significant risk factor for additional positive nodes on completion axillary nodal dissection (CALND) or for worse survival than positive SLNs... - Prognostic significance of nuclear receptor coactivator-3 overexpression in primary cutaneous melanomaJavier Rangel
Auerback Melanoma Research Laboratory, Cutaneous Oncology Program, University of California San Francisco Comprehensive Cancer Center, San Francisco, CA 94115, USA
J Clin Oncol 24:4565-9. 2006..To assess the prognostic significance of nuclear receptor coactivator-3 (NCOA3) overexpression in primary cutaneous melanoma... - Novel role for RGS1 in melanoma progressionJavier Rangel
Auerback Melanoma Research Laboratory, Cutaneous Oncology Program, UCSF Comprehensive Cancer Center, Department of Dermatology, University of California San Francisco, San Francisco, CA 94115, USA
Am J Surg Pathol 32:1207-12. 2008..0039). These results validate the role of RGS1 as a novel prognostic marker for melanoma given its impact on the survival associated with melanoma... 
Multivariate analysis of prognostic factors among 2,313 patients with stage III melanoma: comparison of nodal micrometastases versus macrometastasesCharles M Balch
Department of Surgery, Johns Hopkins Medical Institutions, 600 N Wolfe St, Osler 624, Baltimore, MD 21287, USA
J Clin Oncol 28:2452-9. 2010..To determine the survival rates and independent predictors of survival using a contemporary international cohort of patients with stage III melanoma...- Impact of multiple lymphatic channel drainage to a single nodal basin on outcomes in melanomaJames K Wall
Department of Surgery, UCSF, San Francisco, CA 94115, USA
Arch Surg 142:753-7; discussion 756-8. 2007..To determine the impact of multiple lymphatic channels (MLCs) on outcome in melanoma... - Selection of tumorigenic melanoma cells using ALDHJim B Boonyaratanakornkit
Department of Dermatology, University of California, San Francisco, San Francisco, California, USA
J Invest Dermatol 130:2799-808. 2010..Thus, ALDH(+) melanoma cells have enhanced tumorigenicity over ALDH(-) cells and superior self-renewal ability... - Accuracy of selective sentinel lymphadenectomy after neoadjuvant chemotherapy: effect of clinical node status at presentationJulie E Lang
Department of Surgery, University of California San Francisco, San Francisco, CA 94114, USA
J Am Coll Surg 199:856-62. 2004.... - Internal mammary sentinel lymph node mapping for invasive breast cancer: implications for staging and treatmentCatherine Park
Department of Radiation Oncology, University of California, Mount Zion Medical Center, the UCSF Comprehensive Cancer Center, San Francisco, California, USA
Breast J 11:29-33. 2005..These factors may aid in the selection of patients who might benefit from further staging or treatment of the IMNs... - Primary tumor characteristics predict sentinel lymph node macrometastasis in breast cancerYah-Yuen Tan
Department of Surgery, UCSF Medical Center at Mount Zion, San Francisco, California, USA
Breast J 11:338-43. 2005..These patients can be identified preoperatively based on imaging and biopsy criteria, allowing the option of selective intraoperative pathologic evaluation of the sentinel node and immediate completion axillary dissection as necessary... - Failure to harvest sentinel lymph nodes identified by preoperative lymphoscintigraphy in breast cancer patientsChen-Teng Wu
Department of Surgery, University of California, San Francisco (UCSF) Medical Center at Mount Zion, 94143-1674, USA
Breast J 9:86-90. 2003..The possibility of failure to get the SLN should be explained to patients before surgery. Axillary lymph node dissection (ALND) should be done if selective SLN dissection is not successful... - The effect of sentinel node tumor burden on non-sentinel node status and recurrence rates in breast cancerYang-Guo Fan
Department of Surgery, University of California San Francisco Medical Center at Mount Zion, San Francisco, 94143-1674, USA
Ann Surg Oncol 12:705-11. 2005..Higher recurrence rates are also seen in these patients. However, the role of routine ALND in patients with a low SLN tumor burden remains to be further determined by prospective randomized trials... - Selective sentinel lymph node mapping and dissection for malignant melanomaStanley P L Leong
Sentinel Lymph Node Program, Department of Surgery, University of California, San Francisco Medical Center at Mount Zion, UCSF Comprehensive Cancer Center, San Francisco, California, USA
Cancer Treat Res 111:39-64. 2002 - Prognostic significance of extent of ulceration in primary cutaneous melanomaHege Grande Sarpa
Melanoma Center, Cutaneous Oncology Program, Cancer Center, University of California, San Francisco, CA 94115, USA
Am J Surg Pathol 30:1396-400. 2006..These results suggest that no more than minimal ulceration is required to have a prognostic impact on melanoma survival... - Osteopontin as a molecular prognostic marker for melanomaJavier Rangel
Auerback Melanoma Research Laboratory, Cutaneous Oncology Program, University of California San Francisco Comprehensive Cancer Center, San Francisco, California 94115, USA
Cancer 112:144-50. 2008..Osteopontin has been suggested as a marker of disease progression in patients with melanoma because of its overexpression in recent microarray analyses. However, its prognostic role in melanoma has not been fully defined... - Coexisting tattoo pigment and metastatic melanoma in the same sentinel lymph nodeAdnan A Jaigirdar
Departments of Surgery and Pathology, University of California, San Francisco, UCSF Helen Diller Family Comprehensive Cancer Center, UCSF Medical Center at Mount Zion, San Francisco, CA 94115, USA
J Cutan Med Surg 13:321-5. 2009..We present two cases of melanoma arising within the setting of a tattoo where the sentinel lymph node contained both pigmented histiocytes and metastatic melanoma on gross inspection and histopathology... - A multimarker prognostic assay for primary cutaneous melanomaMohammed Kashani-Sabet
Auerback Melanoma Research Laboratory and Melanoma Center, Comprehensive Cancer Center, and Departments of Pathology, Surgery, and Urology, University of California San Francisco, San Francisco, California, USA
Clin Cancer Res 15:6987-92. 2009..To determine the prognostic significance of a multimarker assay incorporating expression levels of three molecular markers in primary cutaneous melanoma... - Prognostic factors in patients with thick cutaneous melanoma (> 4 mm)Elizabeth Zettersten
Melanoma Center, Cutaneous Oncology Program, University of California at San Francisco, Comprehensive Cancer Center, San Francisco, California 94115, USA
Cancer 94:1049-56. 2002..Consideration of these factors has important implications in the management of patients with T4 melanoma... - Selective sentinel lymph node mapping and dissection for breast cancerStanley P L Leong
Sentinel Lymph Node Program, Department of Surgery, University of California, San Francisco Medical Center at Mount Zion, UCSF Comprehensive Cancer Center, San Francisco, California, USA
Cancer Treat Res 111:65-79. 2002 - The gene expression signatures of melanoma progressionChristopher Haqq
Auerback Melanoma Research Laboratory, Melanoma Center and Department of Dermatology, Cutaneous Oncology Program, University of California at San Francisco UCSF Comprehensive Cancer Center, San Francisco, CA 94115, USA
Proc Natl Acad Sci U S A 102:6092-7. 2005..The gene expression signatures identified here provide the basis for developing new diagnostics and targeting therapies for patients with malignant melanoma... - Routine imaging of asymptomatic melanoma patients with metastasis to sentinel lymph nodes rarely identifies systemic diseaseEdward P Miranda
Department of Surgery, University of California San Francisco, 94143-1974, USA
Arch Surg 139:831-6; discussion 836-7. 2004..Routine imaging of asymptomatic patients at the time of selective sentinel lymphadenectomy is not indicated... - Selective sentinel lymphadenectomy for malignant melanoma, Merkel cell carcinoma, and squamous cell carcinomaStanley P L Leong
Department of Surgery, University of California, San Francisco Medical Center at Mount Zion, USA
Cancer Treat Res 127:39-76. 2005..It is important for investigators involved with the SSL to follow the clinical outcome of these patients, so that the role of SSL can be further defined... - The role of a positron- and high-energy gamma photon probe in intraoperative localization of recurrent melanomaBenjamin L Franc
Department of Radiology, University of California San Francisco, San Francisco, CA 94143 0252, USA
Clin Nucl Med 30:787-91. 2005.... - Ratio of positive to total number of sentinel nodes predicts nonsentinel node status in breast cancer patientsYah-Yuen Tan
Department of Surgery, UCSF Medical Center at Mount Zion and UCSF Comprehensive Cancer Center, San Francisco, California 94143-1674, USA
Breast J 11:248-53. 2005.... - Future perspectives and unanswered questions on cancer metastasis and the lymphovascular systemStanley P L Leong
University of California San Francisco, San Francisco, California, USA
Cancer Treat Res 135:293-6. 2007 - An isolated Merkel cell carcinoma metastasis at a distant cutaneous site presenting as a second 'primary' tumorIris Z Ahronowitz
Department of Dermatology, University of California San Francisco, San Francisco, CA, USA
J Cutan Pathol 38:801-7. 2011..Our data calls into question prior reports alleging multiple cutaneous primaries of this very rare tumor... - Detection of occult melanoma by preoperative positron emission tomography-computed tomography and intraoperative ultrasonographyBrenda A Shoo
Department of Dermatology, University of California San Francisco, CA 94143 1674, USA
J Cutan Med Surg 14:130-5. 2010..18F-Fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) has become a common imaging modality for detecting metastatic melanoma. However, the identification of lesions intraoperatively can be difficult... - Image of the month: angiosarcoma of the breastJustin Parekh
Department of Surgery, University of California-San Francisco, 1600 Divisadero Street, San Francisco, CA 94143, USA
Arch Surg 140:809-10. 2005 - Patterns of metastasis in human solid cancersStanley P L Leong
Department of Surgery, University of California San Francisco, California, USA
Cancer Treat Res 135:209-21. 2007 - Future perspectives for cancer metastasis and the lymphovascular systemStanley P L Leong
Department of Surgery, University of California, and UCSF Comprehensive Cancer Center, San Francisco, CA 94143-1674, USA
Cancer Metastasis Rev 25:293-4. 2006 - Getting to better cancer care: results of a society of surgical oncology surveySandra L Wong
Department of Surgery, Division of Surgical Oncology, University of Michigan, 1500 E Medical Center Drive, 3310 CCC, Ann Arbor, MI, 48109 5932, USA
Ann Surg Oncol 15:2363-71. 2008..A survey of its members was conducted to determine which domains of "outcomes" are important and relevant to surgical oncologists... - Laparoscopic surgery for melanoma metastases to the adrenal glandCord Sturgeon
University of Feinberg School of Medicine, Division of Gastrointestinal and Endocrine Surgery, Chicago, IL 60611 2908, USA
Expert Rev Anticancer Ther 4:837-41. 2004..However, the natural history of laparoscopic surgery for these lesions is still unknown. The indications for and limitations of laparoscopic adrenalectomy for metastatic melanoma are discussed... - Loss of the eukaryotic initiation factor 3f in melanomaAdriana Doldan
Department of Pathology, University of Arizona, Tucson, Arizona 85724, USA
Mol Carcinog 47:806-13. 2008..These data provide new insight into the understanding of the molecular pathogenesis of eIF3f during melanoma tumorigenesis... - Tumour-induced immune modulation of sentinel lymph nodesAlistair J Cochran
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at the University of California at Los Angeles, California 90095, USA
Nat Rev Immunol 6:659-70. 2006..Immune modulation of the lymph nodes can be reversed by granulocyte/macrophage colony-stimulating factor (GM-CSF), a finding that has implications for the future therapy of lymph-node metastases...
Research Grants
- Symposium on Cancer Metastasis and Lymphovascular SystemSTANLEY LEONG; Fiscal Year: 2004..abstract_text> ..
- International Symposium on Cancer Metastasis and the Lymphovascular SystemSTANLEY LEONG; Fiscal Year: 2007....