Sherry S Leonard

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi Smoking and schizophrenia: abnormal nicotinic receptor expression
    S Leonard
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Eur J Pharmacol 393:237-42. 2000
  2. ncbi Genetics of chromosome 15q13-q14 in schizophrenia
    Sherry Leonard
    Department of Psychiatry, University of Colorado at Denver and Health Sciences Center, Fitzsimmons Campus, Aurora, Colorado 80045, USA
    Biol Psychiatry 60:115-22. 2006
  3. ncbi Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia
    Sherry Leonard
    Department of Psychiatry, Campus Box C 268 71, University of Colorado Health Sciences Center, 4200 E Ninth Ave, Denver, CO 80262, USA
    Arch Gen Psychiatry 59:1085-96. 2002
  4. ncbi Neuronal nicotinic receptors: from structure to function
    S Leonard
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Nicotine Tob Res 3:203-23. 2001
  5. ncbi Smoking and mental illness
    S Leonard
    Department of Psychiatry, University of Colorado Health Sciences Center, Box C 268 71, 4200 East 9th Avenue, Denver, CO 80262, USA
    Pharmacol Biochem Behav 70:561-70. 2001
  6. ncbi Genomic organization and partial duplication of the human alpha7 neuronal nicotinic acetylcholine receptor gene (CHRNA7)
    J Gault
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado, 80262, USA
    Genomics 52:173-85. 1998
  7. ncbi Characterization of allelic variants at chromosome 15q14 in schizophrenia
    R Freedman
    Department of Psychiatry, Denver VA MIRECC, Denver, CO, USA
    Genes Brain Behav 5:14-22. 2006
  8. ncbi Evidence for the multigenic inheritance of schizophrenia
    R Freedman
    Department of Psychiatry, Denver VA Medical Center and University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Med Genet 105:794-800. 2001
  9. ncbi Linkage disequilibrium for schizophrenia at the chromosome 15q13-14 locus of the alpha7-nicotinic acetylcholine receptor subunit gene (CHRNA7)
    R Freedman
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver 80262, USA
    Am J Med Genet 105:20-2. 2001
  10. ncbi The alpha7-nicotinic acetylcholine receptor and the pathology of hippocampal interneurons in schizophrenia
    R Freedman
    Departments of Psychiatry and Pharmacology, University of Colorado Health Sciences Center and Denver VA Medical Center, Campus Box C 268 71, Room 3F10, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Chem Neuroanat 20:299-306. 2000

Detail Information

Publications16

  1. ncbi Smoking and schizophrenia: abnormal nicotinic receptor expression
    S Leonard
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Eur J Pharmacol 393:237-42. 2000
    ..The results of these studies suggest the presence of abnormal expression and function of the neuronal nicotinic receptor gene family in schizophrenia...
  2. ncbi Genetics of chromosome 15q13-q14 in schizophrenia
    Sherry Leonard
    Department of Psychiatry, University of Colorado at Denver and Health Sciences Center, Fitzsimmons Campus, Aurora, Colorado 80045, USA
    Biol Psychiatry 60:115-22. 2006
    ..Evidence from multiple studies supports a broad region of genetic linkage around the marker D15S1360...
  3. ncbi Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia
    Sherry Leonard
    Department of Psychiatry, Campus Box C 268 71, University of Colorado Health Sciences Center, 4200 E Ninth Ave, Denver, CO 80262, USA
    Arch Gen Psychiatry 59:1085-96. 2002
    ..This study presents DNA sequence analysis of the core promoter region for CHRNA7 in schizophrenic and control subjects...
  4. ncbi Neuronal nicotinic receptors: from structure to function
    S Leonard
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Nicotine Tob Res 3:203-23. 2001
    ..This review addresses current knowledge of nicotinic receptor structure, regulation of expression, and function, in both normal and psychiatric subjects...
  5. ncbi Smoking and mental illness
    S Leonard
    Department of Psychiatry, University of Colorado Health Sciences Center, Box C 268 71, 4200 East 9th Avenue, Denver, CO 80262, USA
    Pharmacol Biochem Behav 70:561-70. 2001
    ..The alpha 7 receptor is decreased in expression in schizophrenia. [(3)H]-Nicotine binding studies in postmortem brain indicate that high-affinity nicotinic receptors may also be affected in schizophrenia...
  6. ncbi Genomic organization and partial duplication of the human alpha7 neuronal nicotinic acetylcholine receptor gene (CHRNA7)
    J Gault
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado, 80262, USA
    Genomics 52:173-85. 1998
    ..Four novel exons are described, located in genomic clones containing the partially duplicated gene. The duplicated sequences, including the novel exons, are expressed in human brain...
  7. ncbi Characterization of allelic variants at chromosome 15q14 in schizophrenia
    R Freedman
    Department of Psychiatry, Denver VA MIRECC, Denver, CO, USA
    Genes Brain Behav 5:14-22. 2006
    ..Further sequencing in these two groups may yield more definitive identification of the molecular pathology...
  8. ncbi Evidence for the multigenic inheritance of schizophrenia
    R Freedman
    Department of Psychiatry, Denver VA Medical Center and University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Med Genet 105:794-800. 2001
    ....
  9. ncbi Linkage disequilibrium for schizophrenia at the chromosome 15q13-14 locus of the alpha7-nicotinic acetylcholine receptor subunit gene (CHRNA7)
    R Freedman
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver 80262, USA
    Am J Med Genet 105:20-2. 2001
    ..Replication of this result was found in an additional set of families. The results support this region as a chromosomal location involved in the genetic transmission of schizophrenia...
  10. ncbi The alpha7-nicotinic acetylcholine receptor and the pathology of hippocampal interneurons in schizophrenia
    R Freedman
    Departments of Psychiatry and Pharmacology, University of Colorado Health Sciences Center and Denver VA Medical Center, Campus Box C 268 71, Room 3F10, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Chem Neuroanat 20:299-306. 2000
    ..The alpha7-receptor is a ligand-gated ion channel that admits calcium ions into cells, and it has been proposed to have various developmental roles. Its malfunction may be part of the developmental pathogenesis of schizophrenia...
  11. ncbi Inhibitory neurophysiological deficit as a phenotype for genetic investigation of schizophrenia
    R Freedman
    Psychiatry and Pharmacology, University of Colorado, CO 80262, USA
    Am J Med Genet 97:58-64. 2000
    ..It is certain that there are many genetic factors in schizophrenia and bipolar disorder; what is needed is a complete and precise description of the contribution of each individual factor to the pathophysiology of these illnesses...
  12. ncbi The effect of nicotine and haloperidol co-treatment on nicotinic receptor levels in the rat brain
    M J Lee
    The Neuroscience Program, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Brain Res Mol Brain Res 86:115-24. 2001
    ..These results suggest that haloperidol is not likely to affect nicotinic receptor regulation by smoking in most brain regions...
  13. ncbi Brain pH has a significant impact on human postmortem hippocampal gene expression profiles
    S Mexal
    Department of Psychiatry, University of Colorado at Denver and Health Sciences Center, Mail Stop 8344, PO Box 6511, Aurora, CO 80045, USA
    Brain Res 1106:1-11. 2006
    ..The predictive value of brain pH in an independent sample set was also greater than the disease, demonstrating that pH represents one of the most important control parameters in human postmortem gene expression studies in schizophrenia...
  14. ncbi Differential modulation of gene expression in the NMDA postsynaptic density of schizophrenic and control smokers
    S Mexal
    Department of Psychiatry, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    Brain Res Mol Brain Res 139:317-32. 2005
    ..The biological mechanisms underlying chronic tobacco use are likely to differ substantially between these two groups...
  15. ncbi High-affinity epibatidine binding of functional, human alpha7-nicotinic acetylcholine receptors stably and heterologously expressed de novo in human SH-EP1 cells
    Jian Hong Peng
    Division of Neurobiology, Barrow Neurological Institute, 350 West Thomas Rd, Phoenix, AZ 85013, USA
    J Pharmacol Exp Ther 313:24-35. 2005
    ....
  16. pmc Permutation-based adjustments for the significance of partial regression coefficients in microarray data analysis
    Brandie D Wagner
    Department of Preventative Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Genet Epidemiol 32:1-8. 2008
    ..The application of a linear model is emphasized for data containing confounders and the permutation-based approaches are shown to be better suited for microarray data...

Research Grants18

  1. Regulation of Alpha 7 Nicotinic Receptor Assembly in Human Smokers
    Sherry Leonard; Fiscal Year: 2010
    ..This proposal will study mechanisms for cell surface expression of a nicotinic receptor that responds to the nicotine in tobacco. ..
  2. Regulation of the Human a7 Nicotinic Receptor Gene in Schizophrenia
    Sherry Leonard; Fiscal Year: 2010
    ..This proposal will investigate the regulation of the a7 nicotinic receptor gene in postmortem brain of control and schizophrenic smokers and non-smokers. ..
  3. Regulation of Alpha 7 Nicotinic Receptor Assembly in Human Smokers
    Sherry Leonard; Fiscal Year: 2007
    ..This proposal will study mechanisms for cell surface expression of a nicotinic receptor that responds to the nicotine in tobacco. ..
  4. HUMAN BRAIN NICOTINIC RECEPTORS AND NICOTINE ADDICTION
    Sherry Leonard; Fiscal Year: 2004
    ....
  5. Regulation of the Human a7 Nicotinic Receptor Gene in Schizophrenia
    Sherry Leonard; Fiscal Year: 2009
    ..This proposal will investigate the regulation of the a7 nicotinic receptor gene in postmortem brain of control and schizophrenic smokers and non-smokers. ..