Charles E Leonard

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi Effectiveness of a two-part educational intervention to improve hypertension control: a cluster-randomized trial
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Pharmacotherapy 26:1342-7. 2006
  2. pmc Observed association between antidepressant use and pneumonia risk was confounded by comorbidity measures
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Clin Epidemiol 60:911-8. 2007
  3. doi Unintended effects of a computerized physician order entry nearly hard-stop alert to prevent a drug interaction: a randomized controlled trial
    Brian L Strom
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Arch Intern Med 170:1578-83. 2010
  4. doi Proton pump inhibitors and traditional nonsteroidal anti-inflammatory drugs and the risk of acute interstitial nephritis and acute kidney injury
    Charles E Leonard
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 21:1155-72. 2012
  5. pmc A system for de-identifying medical message board text
    Adrian Benton
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    BMC Bioinformatics 12:S2. 2011
  6. doi Diagnostic E-codes for commonly used, narrow therapeutic index medications poorly predict adverse drug events
    Charles E Leonard
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Clin Epidemiol 61:561-71. 2008
  7. pmc Antidepressants and the risk of sudden cardiac death and ventricular arrhythmia
    Charles E Leonard
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, and Center for Education and Research on Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 20:903-13. 2011
  8. doi Increased risk of digoxin toxicity following hospitalization
    Kevin Haynes
    Program for the Reduction in Medication Errors, Department of Biostatistics and Epidemiology and School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 18:28-35. 2009
  9. pmc Validation of diagnostic codes for outpatient-originating sudden cardiac death and ventricular arrhythmia in Medicaid and Medicare claims data
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pharmacoepidemiol Drug Saf 19:555-62. 2010
  10. pmc Diagnostic codes for sudden cardiac death and ventricular arrhythmia functioned poorly to identify outpatient events in EPIC's General Practice Research Database
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 17:1131-6. 2008

Detail Information

Publications24

  1. ncbi Effectiveness of a two-part educational intervention to improve hypertension control: a cluster-randomized trial
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Pharmacotherapy 26:1342-7. 2006
    ..To measure the effectiveness of a multifaceted educational intervention to improve ambulatory hypertension control...
  2. pmc Observed association between antidepressant use and pneumonia risk was confounded by comorbidity measures
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Clin Epidemiol 60:911-8. 2007
    ..A prior study suggested that antidepressants might increase the risk of hospitalization for pneumonia in the elderly. This study sought to confirm or refute this hypothesis...
  3. doi Unintended effects of a computerized physician order entry nearly hard-stop alert to prevent a drug interaction: a randomized controlled trial
    Brian L Strom
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Arch Intern Med 170:1578-83. 2010
    ..The effectiveness of computerized physician order entry (CPOE) systems has been modest, largely because clinicians frequently override electronic alerts...
  4. doi Proton pump inhibitors and traditional nonsteroidal anti-inflammatory drugs and the risk of acute interstitial nephritis and acute kidney injury
    Charles E Leonard
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 21:1155-72. 2012
    ....
  5. pmc A system for de-identifying medical message board text
    Adrian Benton
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    BMC Bioinformatics 12:S2. 2011
    ....
  6. doi Diagnostic E-codes for commonly used, narrow therapeutic index medications poorly predict adverse drug events
    Charles E Leonard
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Clin Epidemiol 61:561-71. 2008
    ..We sought to examine the validity of specific hospital discharge codes in identifying drug toxicity precipitating hospitalization, among elderly users of high-risk medications...
  7. pmc Antidepressants and the risk of sudden cardiac death and ventricular arrhythmia
    Charles E Leonard
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, and Center for Education and Research on Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 20:903-13. 2011
    ..To examine the association between exposure to antidepressants and emergency department or inpatient admission for sudden cardiac death and ventricular arrhythmia (SD/VA), and to examine the impact of dose and cytochrome P-450 inhibition...
  8. doi Increased risk of digoxin toxicity following hospitalization
    Kevin Haynes
    Program for the Reduction in Medication Errors, Department of Biostatistics and Epidemiology and School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 18:28-35. 2009
    ..The objective of the study was to identify health care system factors that affect the risk of digoxin toxicity for older adults on digoxin...
  9. pmc Validation of diagnostic codes for outpatient-originating sudden cardiac death and ventricular arrhythmia in Medicaid and Medicare claims data
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pharmacoepidemiol Drug Saf 19:555-62. 2010
    ..This study examined the positive predictive value (PPV) of hospitalization and emergency department encounter diagnoses in identifying SD/VA events originating in the outpatient setting...
  10. pmc Diagnostic codes for sudden cardiac death and ventricular arrhythmia functioned poorly to identify outpatient events in EPIC's General Practice Research Database
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 17:1131-6. 2008
    ....
  11. pmc Patient reported receipt of medication instructions for warfarin is associated with reduced risk of serious bleeding events
    Joshua P Metlay
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Gen Intern Med 23:1589-94. 2008
    ..Adverse drug events are an important cause of preventable hospitalizations...
  12. doi Online discussion of drug side effects and discontinuation among breast cancer survivors
    Jun J Mao
    Department of Family Medicine and Community Health, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
    Pharmacoepidemiol Drug Saf 22:256-62. 2013
    ..We aim to understand the frequency and content of side effects and associated adherence behaviors discussed by breast cancer patients related to using aromatase inhibitors (AIs), with particular emphasis on AI-related arthralgia...
  13. pmc Randomized clinical trial of a customized electronic alert requiring an affirmative response compared to a control group receiving a commercial passive CPOE alert: NSAID--warfarin co-prescribing as a test case
    Brian L Strom
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Pennsylvania 19104 6021, USA
    J Am Med Inform Assoc 17:411-5. 2010
    ..Studies that have looked at the effectiveness of computerized decision support systems to prevent drug-drug interactions have reported modest results because of low response by the providers to the automated alerts...
  14. pmc Instantaneous preference was a stronger instrumental variable than 3- and 6-month prescribing preference for NSAIDs
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Clin Epidemiol 61:1285-8. 2008
    ..We sought to compare the correlations between different IV measures with exposure...
  15. doi Identifying potential adverse effects using the web: a new approach to medical hypothesis generation
    Adrian Benton
    University of Pennsylvania, School of Medicine, Center for Clinical Epidemiology and Biostatistics, Philadelphia, PA 19104 6021, United States
    J Biomed Inform 44:989-96. 2011
    ..Of the pairs identified by our system, 75-80% were documented on the drug labels. Some of the undocumented pairs may represent previously unidentified adverse drug effects...
  16. pmc Cisapride and ventricular arrhythmia
    Sean Hennessy
    Department of Biostatistics and Epidemiology, and Center for Education and Research on Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Br J Clin Pharmacol 66:375-85. 2008
    ..We aimed to examine the association between cisapride and ventricular arrhythmia, and examine the relationship to dose and CYP3A4 inhibitors...
  17. ncbi Quality of Medicaid and Medicare data obtained through Centers for Medicare and Medicaid Services (CMS)
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Med Care 45:1216-20. 2007
    ..The Centers for Medicare and Medicaid Services (CMS) now make data from the Medicaid and Medicare programs available for research. Prior research has identified important issues in Medicaid data obtained from a commercial vendor...
  18. pmc Detecting pregnancy use of non-hormonal category X medications in electronic medical records
    Brian L Strom
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6021, USA
    J Am Med Inform Assoc 18:i81-6. 2011
    ..To determine whether a rule-based algorithm applied to an outpatient electronic medical record (EMR) can identify patients who are pregnant and prescribed medications proved to cause birth defects...
  19. pmc Effectiveness of interventions in reducing antibiotic use for upper respiratory infections in ambulatory care practices
    Christopher Vinnard
    Division of Infectious Diseases and HIV Medicine, Department of Medicine, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
    Popul Health Manag 16:22-7. 2013
    ..Organizations that seek to reduce inappropriate use of antibiotics should use proven approaches, even when they are more expensive...
  20. pmc Identifying and quantifying medication errors: evaluation of rapidly discontinued medication orders submitted to a computerized physician order entry system
    Ross Koppel
    Department of Sociology, University of Pennsylvania, Philadelphia, PA, USA
    J Am Med Inform Assoc 15:461-5. 2008
    ..This measure offers a rapid, constant, inexpensive, and objective method to identify medication orders with a high probability of error. It may also serve as a screening and teaching mechanism for physicians-in-training...
  21. pmc Location, location, location: geographic clustering of lower-extremity amputation among Medicare beneficiaries with diabetes
    David J Margolis
    Department of Biostatistics and Epidemiology and the Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania
    Diabetes Care 34:2363-7. 2011
    ..S. overall, neighboring locations have unexpectedly similar amputation rates, some being uniformly high and others uniformly low...
  22. pmc The effect of a physician-targeted intervention on metoclopramide prescribing practice
    Yu Xiao Yang
    Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA, USA
    Ther Clin Risk Manag 7:359-65. 2011
    ..Metoclopramide use is associated with serious and potentially irreversible neurologic side effects. However, it is often used for questionable or unclear indications in clinical practice...
  23. pmc Natural supplements for H1N1 influenza: retrospective observational infodemiology study of information and search activity on the Internet
    Shawndra Hill
    Operations and Information Management, The Wharton School, University of Pennsylvania, 3730 Walnut Street, Philadelphia, PA 19104, USA
    J Med Internet Res 13:e36. 2011
    ..As the incidence of H1N1 increases, the lay public may turn to the Internet for information about natural supplements for prevention and treatment...
  24. ncbi Researchers and HIPAA
    Sean Hennessy
    Epidemiology 18:518. 2007