A S Leon

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Leisure time physical activity and the 16-year risks of mortality from coronary heart disease and all-causes in the Multiple Risk Factor Intervention Trial (MRFIT)
    A S Leon
    Division of Kinesiology, College of Education and Human Development, University of Minnesota, Minneapolis 55455, U S A
    Int J Sports Med 18:S208-15. 1997
  2. ncbi request reprint Exercise following myocardial infarction. Current recommendations
    A S Leon
    Department of Medicine, University of Minnesota, Minneapolis, USA
    Sports Med 29:301-11. 2000
  3. ncbi request reprint Response of blood lipids to exercise training alone or combined with dietary intervention
    A S Leon
    Laboratory of Physiological Hygiene and Exercise Science, Division of Kinesiology, College of Education and Human Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Med Sci Sports Exerc 33:S502-15; discussion S528-9. 2001
  4. ncbi request reprint Variability in the response of HDL cholesterol to exercise training in the HERITAGE Family Study
    A S Leon
    Laboratory of Physiological Hygiene and Exercise Science, Division of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA
    Int J Sports Med 23:1-9. 2002
  5. ncbi request reprint Physical activity and body weight: associations over ten years in the CARDIA study. Coronary Artery Risk Development in Young Adults
    K H Schmitz
    Division of Epidemiology, University of Minnesota, Minneapolis 55454, USA
    Int J Obes Relat Metab Disord 24:1475-87. 2000
  6. ncbi request reprint Independent and interactive effects of apolipoprotein E phenotype and cardiorespiratory fitness on plasma lipids
    K H Schmitz
    Division of Epidemiology, Minneapolis, MN 55454, USA
    Ann Epidemiol 11:94-103. 2001
  7. ncbi request reprint Changes in inflammatory biomarkers following one-year of moderate resistance training in overweight women
    T P Olson
    Mayo Clinic, Division of Cardiovascular Diseases, University of Minnesota, and Minneapolis Veterans Affairs Medical Center, MN, USA
    Int J Obes (Lond) 31:996-1003. 2007
  8. ncbi request reprint Strength training for obesity prevention in midlife women
    K H Schmitz
    Division of Epidemiology, University of Minnesota, Minneapolis, MN 55454, USA
    Int J Obes Relat Metab Disord 27:326-33. 2003
  9. ncbi request reprint Leptin and leptin receptor gene polymorphisms and changes in glucose homeostasis in response to regular exercise in nondiabetic individuals: the HERITAGE family study
    Timo A Lakka
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808 4124, USA
    Diabetes 53:1603-8. 2004
  10. ncbi request reprint Calcium intake is associated with adiposity in Black and White men and White women of the HERITAGE Family Study
    Ruth J F Loos
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA
    J Nutr 134:1772-8. 2004

Collaborators

Detail Information

Publications64

  1. ncbi request reprint Leisure time physical activity and the 16-year risks of mortality from coronary heart disease and all-causes in the Multiple Risk Factor Intervention Trial (MRFIT)
    A S Leon
    Division of Kinesiology, College of Education and Human Development, University of Minnesota, Minneapolis 55455, U S A
    Int J Sports Med 18:S208-15. 1997
    ..To examine the long-term association of leisure time physical activity (LTPA) and risk of death from coronary heart disease (CHD) and all-causes...
  2. ncbi request reprint Exercise following myocardial infarction. Current recommendations
    A S Leon
    Department of Medicine, University of Minnesota, Minneapolis, USA
    Sports Med 29:301-11. 2000
    ....
  3. ncbi request reprint Response of blood lipids to exercise training alone or combined with dietary intervention
    A S Leon
    Laboratory of Physiological Hygiene and Exercise Science, Division of Kinesiology, College of Education and Human Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Med Sci Sports Exerc 33:S502-15; discussion S528-9. 2001
    ..The purpose of this study is to review the effects of aerobic exercise training (AET) on blood lipids and assess dose-response relationships and diet interactions...
  4. ncbi request reprint Variability in the response of HDL cholesterol to exercise training in the HERITAGE Family Study
    A S Leon
    Laboratory of Physiological Hygiene and Exercise Science, Division of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA
    Int J Sports Med 23:1-9. 2002
    ..Thus, marked variability was found in the HDL-C response to the same endurance exercise training stimulus with only a modest amount of the response predictable by identified nongenetic factors...
  5. ncbi request reprint Physical activity and body weight: associations over ten years in the CARDIA study. Coronary Artery Risk Development in Young Adults
    K H Schmitz
    Division of Epidemiology, University of Minnesota, Minneapolis 55454, USA
    Int J Obes Relat Metab Disord 24:1475-87. 2000
    ..Hypothesis 2-those who attenuate weight gain because of a temporary increase in physical activity (PA) may maintain a lower body weight over time...
  6. ncbi request reprint Independent and interactive effects of apolipoprotein E phenotype and cardiorespiratory fitness on plasma lipids
    K H Schmitz
    Division of Epidemiology, Minneapolis, MN 55454, USA
    Ann Epidemiol 11:94-103. 2001
    ....
  7. ncbi request reprint Changes in inflammatory biomarkers following one-year of moderate resistance training in overweight women
    T P Olson
    Mayo Clinic, Division of Cardiovascular Diseases, University of Minnesota, and Minneapolis Veterans Affairs Medical Center, MN, USA
    Int J Obes (Lond) 31:996-1003. 2007
    ..This study examined the effects of 1 year of moderate-intensity RT on biomarkers of inflammation and adhesion in healthy, overweight women...
  8. ncbi request reprint Strength training for obesity prevention in midlife women
    K H Schmitz
    Division of Epidemiology, University of Minnesota, Minneapolis, MN 55454, USA
    Int J Obes Relat Metab Disord 27:326-33. 2003
    ....
  9. ncbi request reprint Leptin and leptin receptor gene polymorphisms and changes in glucose homeostasis in response to regular exercise in nondiabetic individuals: the HERITAGE family study
    Timo A Lakka
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808 4124, USA
    Diabetes 53:1603-8. 2004
    ..Similar interaction was observed in blacks (P = 0.046). Variations in the LEP and LEPR genes are associated with the magnitude of the effects of regular exercise on glucose homeostasis in nondiabetic individuals...
  10. ncbi request reprint Calcium intake is associated with adiposity in Black and White men and White women of the HERITAGE Family Study
    Ruth J F Loos
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA
    J Nutr 134:1772-8. 2004
    ..04). No significant associations were found in Black women. Low Ca(2+) intake may be associated with higher adiposity, particularly in men and White women...
  11. ncbi request reprint The effects of exercise training on abdominal visceral fat, body composition, and indicators of the metabolic syndrome in postmenopausal women with and without estrogen replacement therapy: the HERITAGE family study
    John S Green
    Department of Health and Kinesiology, Texas A and M University, College Station, TX 77845, USA
    Metabolism 53:1192-6. 2004
    ..Also exercise training did not improve the overall MS status of either group, as LDL-C status improved in the ERT group while TG decreased in the NHRT group...
  12. ncbi request reprint A genome-wide linkage scan for dietary energy and nutrient intakes: the Health, Risk Factors, Exercise Training, and Genetics (HERITAGE) Family Study
    Agron Collaku
    Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Am J Clin Nutr 79:881-6. 2004
    ..A poor diet is a risk factor for chronic diseases such as obesity, cardiovascular disease, hypertension, and some cancers. Twin and family studies suggest that genetic factors potentially influence energy and nutrient intakes...
  13. ncbi request reprint Fitness alters the associations of BMI and waist circumference with total and abdominal fat
    Ian Janssen
    Department of Community Health and Epidemiology, Division of Endocrinology and Metabolism, Queen s University, Kingston, Ontario, Canada
    Obes Res 12:525-37. 2004
    ....
  14. ncbi request reprint Association of apolipoprotein E polymorphism with blood lipids and maximal oxygen uptake in the sedentary state and after exercise training in the HERITAGE family study
    Arthur S Leon
    Laboratory of Physiological Hygiene and Exercise Science, Division of Kinesiology, University of Minnesota, Minneapolis 55455, USA
    Metabolism 53:108-16. 2004
    ..Apo E polymorphism was not found to be associated with Vo(2max) levels either in the sedentary state nor the Vo(2max) response to exercise training, contrary to previous reports...
  15. ncbi request reprint Race and sex similarities in exercise-induced changes in blood lipids and fatness
    Chris I Ardern
    School of Physical and Health Education, Department of Community Health and Epidemiology, Queen s University, Kingston, ON, Canada
    Med Sci Sports Exerc 36:1610-5. 2004
    ..This study explores sex and race differences in the association between changes in fat mass (FM), abdominal visceral fat (AVF), and abdominal subcutaneous fat (ASF) on blood lipid changes consequent to aerobic exercise training...
  16. ncbi request reprint Apolipoprotein AI- and AI:AII-containing lipoproteins in white men and women of the HERITAGE Family study: Associations with metabolic risk profile variables
    Charles Couillard
    Department of Food Sciences and Nutrition, Laval University, Ste Foy, Quebec, Canada
    Metabolism 52:1530-6. 2003
    ..Our results suggest that LpAI and HDL cholesterol levels are good correlates of the metabolic profile, but that HDL cholesterol concentrations could still represent a better index in CHD risk assessment...
  17. ncbi request reprint Effects of exercise training on glucose homeostasis: the HERITAGE Family Study
    Normand G Boule
    Division of Kinesiology, Laval University, Sainte Foy, Quebec, Canada
    Diabetes Care 28:108-14. 2005
    ..To determine the effect of a 20-week endurance training program in healthy, previously sedentary participants on measures derived from an intravenous glucose tolerance test (i.v.GTT)...
  18. ncbi request reprint Common genetic and environmental effects on lipid phenotypes: the HERITAGE family study
    Mary F Feitosa
    Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO 63110 1093, USA
    Hum Hered 59:34-40. 2005
    ..Our aim is to investigate pair-wise polygenic and environmental correlations among lipid-lipoprotein levels at baseline and in response to regular exercise in Whites and Blacks...
  19. ncbi request reprint Protein tyrosine phosphatase 1B variant associated with fat distribution and insulin metabolism
    Olavi Ukkola
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Obes Res 13:829-34. 2005
    ..Gene-gene interactions between the PTPN1 and leptin receptor genes contributed to the phenotypic variability of insulin sensitivity. The PTPN1 Pro387Leu variant was associated with lower glucose tolerance...
  20. ncbi request reprint Genome-wide linkage scan for submaximal exercise heart rate in the HERITAGE family study
    Nadine Spielmann
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Am J Physiol Heart Circ Physiol 293:H3366-71. 2007
    ..The most promising regions for fine mapping in the HERITAGE Family Study were found on 2q33 for HR50 training response in whites, on 10q25-26 for baseline HR60 in blacks, and on 18q21-22 for both baseline HR50 and DeltaHR60 in whites...
  21. ncbi request reprint Peroxisome proliferator-activated receptor-delta polymorphisms are associated with physical performance and plasma lipids: the HERITAGE Family Study
    Arto J Hautala
    Pennington Biomedical Research Center, Human Genomics Laboratory, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Am J Physiol Heart Circ Physiol 292:H2498-505. 2007
    ..DNA sequence variation in the PPARdelta locus is a potential modifier of changes in cardiorespiratory fitness and plasma HDL-C in healthy individuals in response to regular exercise...
  22. ncbi request reprint Pleiotropic QTL on chromosome 12q23-q24 influences triglyceride and high-density lipoprotein cholesterol levels: the HERITAGE family study
    Mary E Feitosa
    Division of Statistical Genomics in the Center for Genome Sciences, Washington University School of Medicine, Saint Louis, MO, USA
    Hum Biol 78:317-27. 2006
    ..Further investigation should confirm whether IGF1 or another nearby gene is responsible for the concomitant variation in TG and HDL-C levels...
  23. ncbi request reprint Effect of regular exercise on homocysteine concentrations: the HERITAGE Family Study
    Tomohiro Okura
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Eur J Appl Physiol 98:394-401. 2006
    ..Men exhibit racial differences for tHcy responses to exercise training. Regular aerobic exercise has favorable effects on individuals with hyperhomocysteinemia, but tHcy slightly increased in individuals within the normal range...
  24. ncbi request reprint Quantitative trait locus on chromosome 20q13 for plasma levels of C-reactive protein in healthy whites: the HERITAGE Family Study
    Timo A Lakka
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Physiol Genomics 27:103-7. 2006
    ..The present findings may be useful in the ongoing effort to search for genes contributing to inflammation and to identify individuals at an increased risk of chronic inflammatory diseases...
  25. ncbi request reprint The TNF-alpha G-308A polymorphism is associated with C-reactive protein levels: the HERITAGE Family Study
    Hanna Maaria Lakka
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, Louisiana 70808 4124, USA
    Vascul Pharmacol 44:377-83. 2006
    ..Pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha), stimulate the release of C-reactive protein (CRP). We investigated the association between the TNF-alpha G-308A polymorphism and plasma CRP levels...
  26. ncbi request reprint Evidence of QTLs on chromosomes 13q and 14q for triglycerides before and after 20 weeks of exercise training: the HERITAGE Family Study
    Mary F Feitosa
    Division of Biostatistics, Campus Box 8067 Washington University School of Medicine, 660 S Euclid, Saint Louis, MO 63110 1093, USA
    Atherosclerosis 182:349-60. 2005
    ..It is interesting that the strongest signals were found for the LDL-TG and HDL-TG subfractions, given their particular relationships with the atherogenic lipid profile including dense LDL and HDL particles...
  27. ncbi request reprint Effect of exercise training on plasma levels of C-reactive protein in healthy adults: the HERITAGE Family Study
    Timo A Lakka
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA
    Eur Heart J 26:2018-25. 2005
    ..To study the effect of exercise training on plasma C-reactive protein, a marker of inflammation...
  28. ncbi request reprint Hepatic lipase gene variant -514C>T is associated with lipoprotein and insulin sensitivity response to regular exercise: the HERITAGE Family Study
    Margarita Teran-Garcia
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes 54:2251-5. 2005
    ..The benefits from an exercise program on Si are likely to be substantial in the general population given the high frequency of the LIPC -514C allele, particularly in whites...
  29. ncbi request reprint Familial resemblance for muscle phenotypes in the HERITAGE Family Study
    Jesus Rico-Sanz
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, LA 70808, USA
    Med Sci Sports Exerc 35:1360-6. 2003
    ..We hypothesized that skeletal muscle histological and biochemical phenotypes aggregate within families...
  30. pmc The alpha 2-adrenergic receptor gene and body fat content and distribution: the HERITAGE Family Study
    Christophe Garenc
    Division of Kinesiology, Department of Preventive Medicine, Laval University, Ste Foy, Quebec, Canada
    Mol Med 8:88-94. 2002
    ..A C-1291G polymorphism is located in the alpha2-adrenergic receptor gene (ADRA2A) but no association with body fat accumulation has been reported yet...
  31. ncbi request reprint Genomewide linkage scan of resting blood pressure: HERITAGE Family Study. Health, Risk Factors, Exercise Training, and Genetics
    Treva Rice
    Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110, USA
    Hypertension 39:1037-43. 2002
    ....
  32. ncbi request reprint Familial resemblance for plasma leptin: sample homogeneity across adiposity and ethnic groups
    Treva Rice
    Division of Biostatistics, Departments of Genetics, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Obes Res 10:351-60. 2002
    ..Therefore, the purpose of this study was to investigate heterogeneity hypotheses across ethnic groups and by adiposity level, using the same statistical methods...
  33. ncbi request reprint Familial aggregation of blood lipid response to exercise training in the health, risk factors, exercise training, and genetics (HERITAGE) Family Study
    Treva Rice
    Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110, USA
    Circulation 105:1904-8. 2002
    ..Fasting levels of plasma lipids and lipoproteins are reported to improve with regular exercise training. However, little is known on whether the training responses are influenced by heritable factors...
  34. ncbi request reprint Genome-wide linkage scan for exercise stroke volume and cardiac output in the HERITAGE Family Study
    Tuomo Rankinen
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, Louisiana 70808 4124, USA
    Physiol Genomics 10:57-62. 2002
    ..3, 3q13.3, 12q13.2) and one for baseline SV50 and Q50 (10p14). All these chromosomal regions include several potential candidate genes and therefore warrant further studies in the HERITAGE cohort and other studies...
  35. ncbi request reprint Role of ghrelin polymorphisms in obesity based on three different studies
    Olavi Ukkola
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808 4124, USA
    Obes Res 10:782-91. 2002
    ..Associations between preproghrelin DNA variants and obesity-related phenotypes were studied in 3004 subjects from the Québec Family Study (QFS), the HERITAGE Family Study (HERITAGE), and the Swedish Obese Subjects (SOS) Study...
  36. ncbi request reprint Major gene effects on exercise ventilatory threshold: the HERITAGE Family Study
    Mary F Feitosa
    Division of Biostatistics, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    J Appl Physiol 93:1000-6. 2002
    ....
  37. ncbi request reprint Pleiotropic relationships between cortisol levels and adiposity: The HERITAGE Family Study
    Mary F Feitosa
    Division of Biostatistics, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Obes Res 10:1222-31. 2002
    ..To investigate familial basis for the relationship between cortisol adiposity at baseline and their training responses...
  38. ncbi request reprint Lack of pleiotropic genetic effects between adiposity and sex hormone-binding globulin concentrations before and after 20 weeks of exercise training: the HERITAGE family study
    Mary F Feitosa
    Division of Biostatistics, Department of Genetics, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Metabolism 52:35-41. 2003
    ....
  39. ncbi request reprint Menopause, estrogen, and training effects on exercise hemodynamics: the HERITAGE study
    John S Green
    Department of Health and Kinesiology, Texas A and M University, College Station, TX 77843 4243, USA
    Med Sci Sports Exerc 34:74-82. 2002
    ..To investigate the influences of menopause, hormone replacement, and endurance exercise training on cardiovascular hemodynamics and oxygen uptake parameters during exercise in women...
  40. ncbi request reprint A quantitative trait locus on 7q31 for the changes in plasma insulin in response to exercise training: the HERITAGE Family Study
    Timo A Lakka
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Diabetes 52:1583-7. 2003
    ..The present findings may be important in identifying individuals at increased risk of developing type 2 diabetes and who are most likely to benefit from a physically active lifestyle...
  41. ncbi request reprint Effects of beta2-adrenergic receptor gene variants on adiposity: the HERITAGE Family Study
    Christophe Garenc
    Department of Preventive Medicine, Laval University, Ste Foy, Quebec, Canada
    Obes Res 11:612-8. 2003
    ....
  42. ncbi request reprint Heritability of HR and BP response to exercise training in the HERITAGE Family Study
    Treva Rice
    Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110, USA
    Med Sci Sports Exerc 34:972-9. 2002
    ..The heritability of the response to exercise training in resting blood pressure (BP) and heart rate (HR) was assessed in 482 Caucasian individuals comprising 98 families participating in the HERITAGE Family Study...
  43. ncbi request reprint Uncoupling protein 3 gene is associated with body composition changes with training in HERITAGE study
    Christian Marc Lanouette
    Hôpital Laval and Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Sainte Foy, Quebec, Canada G1K 7P4
    J Appl Physiol 92:1111-8. 2002
    ..0006), with a borderline result for body mass index (P = 0.06). We concluded that UCP3 could be involved in body composition changes after regular exercise...
  44. ncbi request reprint A genomewide linkage scan for abdominal subcutaneous and visceral fat in black and white families: The HERITAGE Family Study
    Treva Rice
    Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Diabetes 51:848-55. 2002
    ..Additional work in an independent sample is needed to verify the linkages for baseline AVF as well as the response measures...
  45. ncbi request reprint A genetic study of cortisol measured before and after endurance training: the HERITAGE Family Study
    Mary F Feitosa
    Division of Biostatistics, and Department of Genetics, Washington University School of Medicine, Saint Louis, MO 63110 1093, USA
    Metabolism 51:360-5. 2002
    ..The putative major gene effects appear to explain most of the observed familial resemblance, this will motivate further linkage and association studies...
  46. ncbi request reprint Effect of exercise training on in vitro LDL oxidation and free radical-induced hemolysis: the HERITAGE Family Study
    Denis Blache
    INSERM U 498, Biochimie des Lipoprotéines et Interactions Vasculaires, and Faculté de Médecine, Universite de Bourgogne, Dijon, France
    Antioxid Redox Signal 9:123-30. 2007
    ..Further, smoking negates the beneficial effect of exercise training on erythrocyte resistance to free radical-induced hemolysis. These observations emphasize the importance of context in the evaluation of exercise and oxidant stress...
  47. ncbi request reprint CETP genotypes and HDL-cholesterol phenotypes in the HERITAGE Family Study
    Nadine Spielmann
    Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808 4124, USA
    Physiol Genomics 31:25-31. 2007
    ..The CETP and APOE genotypes account for up to 9% of the variance in HDL-c phenotypes in the HERITAGE Family Study...
  48. ncbi request reprint G protein beta 3 polymorphism and hemodynamic and body composition phenotypes in the HERITAGE Family Study
    Tuomo Rankinen
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, Louisiana 70808 4124, USA
    Physiol Genomics 8:151-7. 2002
    ..The GNB3 genotype may play a minor role in HR and body fatness regulation in blacks and in responsiveness of resting BP to endurance training in black women...
  49. ncbi request reprint Two ethnic-specific polymorphisms in the human Agouti-related protein gene are associated with macronutrient intake
    Ruth J F Loos
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 82:1097-101. 2005
    ..Exogenous administration of AGRP in rodents predisposes to high fat and high sugar intakes...
  50. ncbi request reprint Moderate resistance training and vascular health in overweight women
    Thomas P Olson
    University of Minnesota, Minneapolis, MN, USA
    Med Sci Sports Exerc 38:1558-64. 2006
    ..Thus, the aim of this study was to examine the effects of 1 yr of resistance training (RT) on vascular structure and function in overweight but otherwise healthy eumenorrheic women...
  51. ncbi request reprint Pleiotropic QTL on chromosome 19q13 for triglycerides and adiposity: the HERITAGE Family Study
    Mary F Feitosa
    Division of Biostatistics, Washington University School of Medicine, Campus Box 8067, 660 S Euclid, St Louis, MO 63110 1093, USA
    Atherosclerosis 185:426-32. 2006
    ..Polymorphisms in the APOE gene, and possibly LIPE gene, appear to be strong candidates for the source of this pleiotropic QTL...
  52. ncbi request reprint Adiponectin polymorphisms, adiposity and insulin metabolism: HERITAGE family study and Oulu diabetic study
    Olavi Ukkola
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge 70808 4124, USA
    Ann Med 37:141-50. 2005
    ..Adiponectin is an adipocytokine with lowered blood levels in obesity and Type 2 diabetes mellitus. We sought to define the specific effects of different alleles of the gene encoding adiponectin...
  53. ncbi request reprint Heart rate versus %VO2max: age, sex, race, initial fitness, and training response--HERITAGE
    James S Skinner
    Department of Kinesiology, Indiana University, Bloomington, IN, USA
    Med Sci Sports Exerc 35:1908-13. 2003
    ..Although we assumed that subjects were again working at the same %VO2max, there were no studies with a large heterogeneous population to determine whether this was correct...
  54. ncbi request reprint A dopamine D2 receptor gene polymorphism and physical activity in two family studies
    Riitta L Simonen
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Physiol Behav 78:751-7. 2003
    ..09, P=.023) and 27-33% lower work index (F=6.23, P=.004) than the CC homozygotes and CT heterozygotes. The results suggest that DNA sequence variation in the DRD2 gene is associated with physical activity levels among White women...
  55. ncbi request reprint Genomic scan of glucose and insulin metabolism phenotypes: the HERITAGE Family Study
    Ping An
    Division of Biostatistics, and the Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Metabolism 52:246-53. 2003
    ..Fine mapping and association studies of candidate genes within these genomic regions are warranted...
  56. pmc Acetylcholinesterase/paraoxonase genotype and expression predict anxiety scores in Health, Risk Factors, Exercise Training, and Genetics study
    Ella H Sklan
    Department of Biological Chemistry, Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Proc Natl Acad Sci U S A 101:5512-7. 2004
    ....
  57. ncbi request reprint Melanocortin 4 receptor sequence variations are seldom a cause of human obesity: the Swedish Obese Subjects, the HERITAGE Family Study, and a Memphis cohort
    Peter Jacobson
    Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 87:4442-6. 2002
    ..In conclusion, our results do not support the prevailing notion that sequence variation in the melanocortin 4 receptor gene is a frequent cause of human obesity...
  58. ncbi request reprint Genome-wide linkage scan for the metabolic syndrome in the HERITAGE Family Study
    Ruth J F Loos
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 88:5935-43. 2003
    ..Some of these chromosomal regions harbor promising potential candidate genes...
  59. ncbi request reprint Evidence of QTLs on chromosomes 1q42 and 8q24 for LDL-cholesterol and apoB levels in the HERITAGE family study
    Mary F Feitosa
    Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO, USA
    J Lipid Res 46:281-6. 2005
    ..As there are no known strong candidate genes in these regions for lipids, follow-up studies to determine the source of those signals are needed...
  60. ncbi request reprint Cardiac rehabilitation and secondary prevention of coronary heart disease: an American Heart Association scientific statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Cardiac Rehabilitation, and Prevention) and the Council on Nut
    Arthur S Leon
    Circulation 111:369-76. 2005
    ....
  61. ncbi request reprint A genome-wide linkage scan for steroids and SHBG levels in black and white families: the HERITAGE Family Study
    Olavi Ukkola
    Pennington Biomedical Research Center, Louisianan State University, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 87:3708-20. 2002
    ..3. Several genes encoding enzymes of the steroid biosynthesis pathways but also other potential candidate genes were located in the vicinity of the genomic regions showing evidence of linkage in this genomic scan...
  62. ncbi request reprint Titin is a candidate gene for stroke volume response to endurance training: the HERITAGE Family Study
    Tuomo Rankinen
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, Louisiana 70808 4124, USA
    Physiol Genomics 15:27-33. 2003
    ..Since TTN is the largest gene in the human genome, the challenge is to identify the DNA sequence variants contributing to the interindividual differences in cardiac adaptation to endurance training...
  63. ncbi request reprint Does long-term aerobic exercise slow progression of atherosclerosis?
    Arthur S Leon
    University of Minnesota, Minneapolis, Minnesota, USA
    Clin J Sport Med 15:285-6. 2005
  64. ncbi request reprint Effect of endothelin 1 genotype on blood pressure is dependent on physical activity or fitness levels
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Hypertension 50:1120-5. 2007
    ..Our study provides an illustrative example of how physical activity and fitness level modifies the associations between a candidate gene and outcome phenotype...