Research Topics
Genomes and GenesSpecies | Eric J LenzeSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
The course of functional decline in older people with persistently elevated depressive symptoms: longitudinal findings from the Cardiovascular Health StudyEric J Lenze
Intervention Research Center in Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
J Am Geriatr Soc 53:569-75. 2005..To examine the relationship between persistently high depressive symptoms and long-term changes in functional disability in elderly persons...
Does depression, apathy or cognitive impairment reduce the benefit of inpatient rehabilitation facilities for elderly hip fracture patients?Eric J Lenze
Department of Psychiatry, University of Pittsburgh School of Medicine, Advanced Center for Interventions and Services Research in Late Life Mood Disorders and John A Hartford Center of Excellence in Geriatric Psychiatry, PA 15213, USA
Gen Hosp Psychiatry 29:141-6. 2007....- Onset of depression in elderly persons after hip fracture: implications for prevention and early intervention of late-life depressionEric J Lenze
Advanced Center for Interventions and Services Research and John A Hartford Center of Excellence in Geriatric Psychiatry, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
J Am Geriatr Soc 55:81-6. 2007..To identify predictors of onset of major depressive disorder (MDD) and of depressive symptoms in subjects who suffered a hip fracture... - Generalized anxiety disorder in late life: lifetime course and comorbidity with major depressive disorderEric J Lenze
Intervention Research Center in Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh, PA 15213, USA
Am J Geriatr Psychiatry 13:77-80. 2005..The authors assessed the course and comorbidity of late-life GAD and MDD... - Somatic symptoms in late-life anxiety: treatment issuesEric J Lenze
Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA
J Geriatr Psychiatry Neurol 18:89-96. 2005..However, additional treatment and integrated approaches are likely to be necessary for many such individuals... - Association of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) genotype with depression in elderly persons after hip fractureEric J Lenze
Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, University of Pittsburg School of Medicine, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 13:428-32. 2005..The authors examined the serotonin transporter gene-linked polymorphic region (5-HTTLPR) as a predictor of major depressive disorder and depressive symptoms after hip fracture, a common stressful medical event... - Recovery from major depression in older adults receiving augmentation of antidepressant pharmacotherapyMary Amanda Dew
Department of Psychiatry, University of Pittsburgh School of Medicine and Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
Am J Psychiatry 164:892-9. 2007..The authors examined likelihood, speed, and predictors of recovery in older adults receiving augmentation pharmacotherapy after inadequate response to standardized treatment with paroxetine plus interpersonal psychotherapy... - Outcomes of late-life anxiety disorders during 32 weeks of citalopram treatmentStephen Blank
Intervention Research Center for Late-Life Mood Disorders, The Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Clin Psychiatry 67:468-72. 2006..CONCLUSIONS: In this 32-week study of citalopram for elderly persons with anxiety disorders, 60% responded. Those who received a full course of treatment experience significant improvements in quality of life and sleep quality... - Good treatment outcomes in late-life depression with comorbid anxietyEric J Lenze
The Intervention Research Center in Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
J Affect Disord 77:247-54. 2003..This study evaluated the impact of comorbid anxiety on response, dropouts, and side effects, in elderly subjects treated for depression... - Effect of comorbid anxiety on treatment response and relapse risk in late-life depression: controlled studyCarmen Andreescu
Western Psychiatric Institute and Clinic, 3811 O Hara Street, Room E 823, Pittsburgh, PA15213, USA
Br J Psychiatry 190:344-9. 2007..Comorbid anxiety is common in depressive disorders in both middle and late life, and it affects response to antidepressant treatment... - Pilot study of augmentation with aripiprazole for incomplete response in late-life depression: getting to remissionMeera Sheffrin
Advanced Center in Interventions and Services Research for Late Life Mood Disorders ACISR LLMD and the John A Hartford Center of Excellence in Geriatric Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
J Clin Psychiatry 70:208-13. 2009.... - Maintenance treatment of depression in old age: a randomized, double-blind, placebo-controlled evaluation of the efficacy and safety of donepezil combined with antidepressant pharmacotherapyCharles F Reynolds
Department of Psychiatry, University of Pittsburgh, PA 15213, USA
Arch Gen Psychiatry 68:51-60. 2011..Cognitive impairment in late-life depression is a core feature of the illness... - High worry severity is associated with poorer acute and maintenance efficacy of antidepressants in late-life depressionCarmen Andreescu
The Advanced Center in Interventions and Services Research for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Depress Anxiety 26:266-72. 2009..We explored the impact of the dimensions of worry and panic on acute and maintenance treatment outcomes in LLD... - Impact of prior treatment exposure on response to antidepressant treatment in late lifeJames D Tew
Advanced Center for Interventions and Services Research in Late-Life Mood Disorders, Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 14:957-65. 2006..Most TR and TI patients eventually respond, but TR patients may require more intensive and longer courses of treatment than TI and TN patients... - Efficacy and tolerability of citalopram in the treatment of late-life anxiety disorders: results from an 8-week randomized, placebo-controlled trialEric J Lenze
Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine and VA Healthcare System, PA, USA
Am J Psychiatry 162:146-50. 2005..Anxiety disorders are highly prevalent in elderly persons. However, to date, the efficacy of selective serotonin reuptake inhibitors (SSRIs) for the treatment of anxiety disorders in this age group has not been established... - Residual symptoms and recurrence during maintenance treatment of late-life depressionAlexandre Y Dombrovski
Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, United States
J Affect Disord 103:77-82. 2007..Our study assesses the impact of these residual symptoms on the risk of recurrence during maintenance treatment of late-life depression... 
Changes in neuropsychological functioning following treatment for late-life generalised anxiety disorderMeryl A Butters
Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
Br J Psychiatry 199:211-8. 2011..Aims We examined neuropsychological functioning in older adults with GAD in comparison with psychiatrically healthy older adults at baseline, and we examined changes following a 12-week placebo-controlled trial of escitalopram...- Predicting 6-week treatment response to escitalopram pharmacotherapy in late-life major depressive disorderRamin Saghafi
Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, USA
Int J Geriatr Psychiatry 22:1141-6. 2007..This study aims to characterize sociodemographic, clinical, and neuropsychologic correlates of full, partial, and non-response to escitalopram monotherapy of unipolar MDD in later life... - Elevated cortisol in older adults with generalized anxiety disorder is reduced by treatment: a placebo-controlled evaluation of escitalopramEric J Lenze
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Am J Geriatr Psychiatry 19:482-90. 2011..The authors examined whether treatment of GAD in older adults with a selective serotonin reuptake inhibitor (SSRI) corrects this HPA axis hyperactivity... - An open-label pilot study of acetylcholinesterase inhibitors to promote functional recovery in elderly cognitively impaired stroke patientsEllen M Whyte
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63108, USA
Cerebrovasc Dis 26:317-21. 2008..We investigated the feasibility of using acetylcholinesterase inhibitors in older patients with acute post-stroke cognitive impairment and examined their effects on functional recovery... - Apathy after hip fracture: a potential target for intervention to improve functional outcomesEric J Lenze
Department of Psychiatry, Washington University School of Medicine, USA
J Neuropsychiatry Clin Neurosci 21:271-8. 2009..Interventions to prevent or improve apathy in elderly persons deserve further attention... - Incomplete response in late-life depression: getting to remissionEric J Lenze
Washington University School of Medicine, Department of Psychiatry, St Louis, MO, USA
Dialogues Clin Neurosci 10:419-30. 2008..Such studies may advance us toward the goal of personalized treatment in late-life depression... - Risk factors for falls during treatment of late-life depressionJin H Joo
Intervention Research Center for Late-Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
J Clin Psychiatry 63:936-41. 2002..Additionally, augmenting paroxetine with bupropion may also increase the risk of falls, and this medication combination should be used with caution in elderly patients... - Treatment-related alteration of cortisol predicts change in neuropsychological function during acute treatment of late-life anxiety disorderEric J Lenze
Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
Int J Geriatr Psychiatry 27:454-62. 2012.... - Cognitive impairment in late-life generalized anxiety disorderRose C Mantella
Advanced Center in Interventions and Services Research for Late Life Mood Disorders and the John A Hartford Center of Excellence in Geriatric Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Am J Geriatr Psychiatry 15:673-9. 2007..This study sought to characterize cognitive functioning in elderly patients with generalized anxiety disorder (GAD), as compared with normal comparison subjects and patients with major depression... - Maintenance treatment for old-age depression preserves health-related quality of life: a randomized, controlled trial of paroxetine and interpersonal psychotherapyAlexandre Y Dombrovski
Western Psychiatric Institute and Clinic, Department of Psychiatry, School of Medicine, University of Pittsburgh, Pennsylvania, USA
J Am Geriatr Soc 55:1325-32. 2007..To determine whether maintenance antidepressant pharmacotherapy and interpersonal psychotherapy sustain gains in health-related quality of life (HR-QOL) achieved during short-term treatment in older patients with depression... - Comorbid anxiety disorder in late life depression: association with memory decline over four yearsAlison K DeLuca
The Intervention Research Center for Late-Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Int J Geriatr Psychiatry 20:848-54. 2005..The data also suggest that anxiety disorders with an onset later in life may be associated with cognitive impairment, although further study is needed to confirm this finding... - Somatic symptoms of depression in elderly patients with medical comorbiditiesRebecca A Drayer
Center for Research on Health Care, Division of General Internal Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Int J Geriatr Psychiatry 20:973-82. 2005..Rating scales emphasizing somatic symptoms associated with depression may provide a more accurate measure of depression severity than those excluding such symptoms... - Significance of poor patient participation in physical and occupational therapy for functional outcome and length of stayEric J Lenze
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Arch Phys Med Rehabil 85:1599-601. 2004..To determine the frequency of poor patient participation during inpatient physical (PT) and occupational therapy (OT) sessions and to examine the influence of poor participation on functional outcome and length of stay (LOS)... - Effect of rehabilitation site on functional recovery after hip fractureMichael C Munin
Department of Physical Medicine and Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Arch Phys Med Rehabil 86:367-72. 2005..To evaluate whether FIM instrument motor outcomes differ between hip fracture survivors undergoing rehabilitation in inpatient rehabilitation facilities (IRFs) and skilled nursing facilities (SNFs)... - Salivary cortisol is associated with diagnosis and severity of late-life generalized anxiety disorderRose C Mantella
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Psychoneuroendocrinology 33:773-81. 2008..These data demonstrate HPA axis dysfunction in late-life GAD and suggest the need for additional research on the influence of aging on HPA axis function in mood and anxiety disorders... - Adverse effects of depression and cognitive impairment on rehabilitation participation and recovery from hip fractureEric J Lenze
Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Int J Geriatr Psychiatry 19:472-8. 2004..Our goal was to determine whether any association of depression and cognitive impairment with rehabilitation outcome is accounted for by more immediate effects of these variables on rehabilitation participation... - Memantine for late-life depression and apathy after a disabling medical event: a 12-week, double-blind placebo-controlled pilot studyEric J Lenze
Department of Psychiatry, Washington University, St Louis, MO, USA
Int J Geriatr Psychiatry 27:974-80. 2012..Therefore, we examined whether memantine could reduce depressive symptoms and amotivation manifesting in older adults after a disabling medical event, thereby improving their functional recovery... - Cognitive and affective predictors of rehabilitation participation after strokeElizabeth R Skidmore
Department of Occupational Therapy, University of Pittsburgh, Pittsburgh, PA, USA
Arch Phys Med Rehabil 91:203-7. 2010..To examine associations between cognitive and affective impairments and rehabilitation participation during stroke rehabilitation... - Generalized anxiety disorder severity scale validation in older adultsCarmen Andreescu
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 16:813-8. 2008..Given the high prevalence of GAD in the elderly and the need for a validated scale to assess GAD severity in this age group, the authors examined the psychometric properties of the GADSS in the elderly... - Preventing depression in medical illness: a new lead?Charles F Reynolds
Advanced Center for Interventions and Services Research for Late Life Mood Disorders, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
Arch Gen Psychiatry 64:884-5. 2007 - Rescue pharmacotherapy with duloxetine for selective serotonin reuptake inhibitor nonresponders in late-life depression: outcome and tolerabilityJordan F Karp
Western Psychiatric Institute and Clinic, Advanced Center for Interventions and Services Research for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
J Clin Psychiatry 69:457-63. 2008.... - Time course of response to antidepressants in late-life major depression: therapeutic implicationsEllen M Whyte
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Drugs Aging 21:531-54. 2004..Better understanding of factors related to such differences may suggest new intervention strategies to accelerate response... - Achieving long-term optimal outcomes in geriatric depression and anxietyBenoit H Mulsant
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
CNS Spectr 8:27-34. 2003.... - Escitalopram for older adults with generalized anxiety disorder: a randomized controlled trialEric J Lenze
Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, Box 8134, St Louis, MO 63110, USA
JAMA 301:295-303. 2009..Selective serotonin reuptake inhibitors (SSRIs) are efficacious for younger adults with GAD, but benefits and risks may be different in older adults... - Relation of serotonin transporter genetic variation to efficacy of escitalopram for generalized anxiety disorder in older adultsEric J Lenze
Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, Box 8134, St Louis, MO 63110, USA
J Clin Psychopharmacol 30:672-7. 2010..We hypothesized that GAD patients with no La haplotypes (La⁻) have lower SSRI treatment efficacy than those with 1 to 2 La haplotypes (La+)... - Clinically relevant behaviors in elderly hip fracture inpatientsHelen H Dorra
University of Pittsburgh School of Medicine, USA
Int J Psychiatry Med 32:249-59. 2002..It is recommended that staff observations be routinely added to mental health evaluations. Additionally, routine mental health screening and required staff documentation of behaviors would improve case detection rate... - Effect of cerebrovascular risk factors on depression treatment outcome in later lifeMark D Miller
Intervention Research Center in Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Am J Geriatr Psychiatry 10:592-8. 2002..This study tested the relationship of cerebrovascular risk factors (CVRF) to clinical presentation and treatment outcome in 156 subjects enrolled in a long-term maintenance treatment study of late-life recurrent major depression... - Treatment considerations for anxiety in the elderlyEric J Lenze
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
CNS Spectr 8:6-13. 2003..Overall, the research in late-life anxiety has not caught up to the literature in late-life depression and, for the most part, treatment recommendations must be extrapolated from studies in young adults... - Anxiety symptoms in elderly patients with depression: what is the best approach to treatment?Eric J Lenze
Department of Psychiatry, Intervention Research Center in Late Life Mood Disorders, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Drugs Aging 19:753-60. 2002..Therefore, optimism should be maintained when treating the depressed elderly individual, even when comorbid anxiety is present... - Patient participation and physical activity during rehabilitation and future functional outcomes in patients after hip fractureJaime B Talkowski
Department of Physical Therapy, University of Pittsburgh, Pittsburgh, PA, USA
Arch Phys Med Rehabil 90:618-22. 2009..We hypothesized those participants who were more active during rehabilitation would have higher participation scores and better functional outcomes after hip fracture compared with those who were less active... - The Pittsburgh Rehabilitation Participation Scale: reliability and validity of a clinician-rated measure of participation in acute rehabilitationEric J Lenze
Intervention Research Center in Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Arch Phys Med Rehabil 85:380-4. 2004..To demonstrate interrater reliability and predictive validity of the Pittsburgh Rehabilitation Participation Scale (PRPS), a clinician-rated 6-point Likert-type item measuring patient participation in inpatient rehabilitation sessions... - Influence of rehabilitation site on hip fracture recovery in community-dwelling subjects at 6-month follow-upMichael C Munin
Department of Physical Medicine and Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Arch Phys Med Rehabil 87:1004-6. 2006..To evaluate whether postacute rehabilitation after hip fracture influences recovery of prefracture function as detected by the FIM instrument motor scale... - Stroke-related knowledge and health behaviors among poststroke patients in inpatient rehabilitationKris L Koenig
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Arch Phys Med Rehabil 88:1214-6. 2007..To measure stroke knowledge and prestroke personal health behaviors of stroke patients undergoing inpatient rehabilitation and their caregivers... - Predictors of adequacy of depression management in the primary care settingJin H Joo
Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
Psychiatr Serv 56:1524-8. 2005..These findings have implications for ways that primary care physicians could be trained to more adequately manage the spectrum of severity of depression... - A lifespan view of anxiety disordersEric J Lenze
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
Dialogues Clin Neurosci 13:381-99. 2011..Finally we describe optimal management of anxiety disorders across the lifespan, in "eight simple steps" for practitioners... - Do clinical rehabilitation education programs really improve stroke-related knowledge?Elizabeth R Skidmore
Department of Occupational Therapy, School of Rehabilitation Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Am J Phys Med Rehabil 87:637-41. 2008..We evaluated the effectiveness of a clinical stroke education program for improving stroke-related health knowledge after inpatient rehabilitation in a "real world" setting... - fMRI activation in late-life anxious depression: a potential biomarkerCarmen Andreescu
Department of Psychiatry, The Advanced Center in Interventions and Services Research for Late Life Mood Disorders, University of Pittsburgh School of Medicine and the John A Hartford Center of Excellence in Geriatric Psychiatry, Pittsburgh, PA, USA
Int J Geriatr Psychiatry 24:820-8. 2009..Subjects were trained on the Preparing to Overcome Prepotency (POP) task, which is an executive control task that reliably activates the lateral prefrontal cortex-anterior cingulate cortex (ACC) cognitive control circuit... - Evidence-based treatment of geriatric anxiety disordersJulie Loebach Wetherell
Department of Psychiatry, University of California San Diego, VA San Diego Healthcare System, 3350 La Jolla Village Drive (116B, San Diego, CA 92161, USA
Psychiatr Clin North Am 28:871-96, ix. 2005 - Physician office visits of adults for anxiety disorders in the United States, 1985-1998Jeffrey S Harman
Intervention Research Centers for Mid and Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
J Gen Intern Med 17:165-72. 2002..To determine the number of physician office visits by adults in which an anxiety disorder diagnosis was recorded and rates of treatment during these visits... - Aripiprazole prescribing patterns and side effects in elderly psychiatric inpatientsKim C Coley
University of Pittsburgh School of Pharmacy, Pittsburgh, PA 15261, USA
J Psychiatr Pract 15:150-3. 2009..This analysis examined dosing patterns and safety of aripiprazole in elderly inpatients... - Combined pharmacotherapy and psychotherapy as maintenance treatment for late-life depression: effects on social adjustmentEric J Lenze
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Am J Psychiatry 159:466-8. 2002..CONCLUSIONS: Treatment of late-life depression with nortriptyline and psychotherapy is more likely to maintain social adjustment than treatment with either alone. Combination therapy improves not only duration but quality of wellness... - Comorbidity of depression and anxiety in the elderlyEric J Lenze
Intervention Research Center in Late Life Mood Disorders, Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Room E1124, PA 15213, USA
Curr Psychiatry Rep 5:62-7. 2003..Future research areas are also addressed in this paper... - Enhanced medical rehabilitation increases therapy intensity and engagement and improves functional outcomes in postacute rehabilitation of older adults: a randomized-controlled trialEric J Lenze
Department of Psychiatry, Washington University, St Louis, MO, USA
J Am Med Dir Assoc 13:708-12. 2012..This study tested Enhanced Medical Rehabilitation, an intervention designed to increase patient engagement in, and intensity of, daily physical and occupational therapy sessions in postacute-care rehabilitation... - Comorbid anxiety and depression: bête noire or quick fix?Carmen Andreescu
Br J Psychiatry 200:179-81. 2012..The most recent evidence from genetics, neuropeptide systems and functional neuroimaging suggests a valid diagnostic construct...
Research Grants
- Pharmacotherapy of Latelife Generalized Anxiety DisorderMeryl Butters; Fiscal Year: 2007....