STEVEN LENTZ

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia
    S R Lentz
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA
    J Clin Invest 98:24-9. 1996
  2. ncbi request reprint Mechanisms of homocysteine-induced atherothrombosis
    S R Lentz
    Department of Internal Medicine, The University of Iowa, and Veterans Affairs Medical Center, Iowa City, IA 52242, USA
    J Thromb Haemost 3:1646-54. 2005
  3. ncbi request reprint Effect of hyperhomocysteinemia on protein C activation and activity
    Steven R Lentz
    Department of Internal Medicine, Veterans Affairs Medical Center, C303 GH, University of Iowa, Iowa City, IA 52242, USA
    Blood 100:2108-12. 2002
  4. ncbi request reprint Anticoagulant responses to thrombin are enhanced during regression of atherosclerosis in monkeys
    Steven R Lentz
    Veterans Affairs Medical Center, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Circulation 106:842-6. 2002
  5. ncbi request reprint Homocysteine: is it a clinically important cardiovascular risk factor?
    Steven R Lentz
    Department of Internal Medicine, University of Iowa, Iowa City 52242, USA
    Cleve Clin J Med 71:729-34. 2004
  6. ncbi request reprint Supplementation of atherogenic diet with B vitamins does not prevent atherosclerosis or vascular dysfunction in monkeys
    S R Lentz
    Veterans Affairs Medical Center, Departments of Internal Medicine, University of Iowa College of Medicine, Iowa City, USA
    Circulation 103:1006-11. 2001
  7. ncbi request reprint Folate dependence of hyperhomocysteinemia and vascular dysfunction in cystathionine beta-synthase-deficient mice
    S R Lentz
    Veterans Affairs Medical Center, Iowa City 52246, USA
    Am J Physiol Heart Circ Physiol 279:H970-5. 2000
  8. ncbi request reprint Impaired anticoagulant response to infusion of thrombin in atherosclerotic monkeys associated with acquired defects in the protein C system
    S R Lentz
    Veterans Affairs Medical Center, Departments of Internal Medicine and Pharmacology, University of Iowa College of Medicine, Iowa City, Iowa, USA
    Arterioscler Thromb Vasc Biol 19:1744-50. 1999
  9. ncbi request reprint Consequences of hyperhomocyst(e)inemia on vascular function in atherosclerotic monkeys
    S R Lentz
    Veterans Affairs Medical Center, Iowa City, Iowa, USA
    Arterioscler Thromb Vasc Biol 17:2930-4. 1997
  10. ncbi request reprint Homocysteine and vascular dysfunction
    S R Lentz
    Veterans Affairs Medical Center, Iowa City, IA 52246, USA
    Life Sci 61:1205-15. 1997

Collaborators

Detail Information

Publications53

  1. pmc Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia
    S R Lentz
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA
    J Clin Invest 98:24-9. 1996
    ..Thrombomodulin anticoagulant activity in aorta decreased by 34 +/- 15% in hyperhomocyst(e)inemic monkeys (P = 0.03). We conclude that diet-induced moderate hyperhomocyst(e)inemia is associated with altered vascular function...
  2. ncbi request reprint Mechanisms of homocysteine-induced atherothrombosis
    S R Lentz
    Department of Internal Medicine, The University of Iowa, and Veterans Affairs Medical Center, Iowa City, IA 52242, USA
    J Thromb Haemost 3:1646-54. 2005
    ....
  3. ncbi request reprint Effect of hyperhomocysteinemia on protein C activation and activity
    Steven R Lentz
    Department of Internal Medicine, Veterans Affairs Medical Center, C303 GH, University of Iowa, Iowa City, IA 52242, USA
    Blood 100:2108-12. 2002
    ..Our findings indicate that activation of protein C by thrombin and inactivation of plasma FVa by APC are not impaired during moderate hyperhomocysteinemia in vivo...
  4. ncbi request reprint Anticoagulant responses to thrombin are enhanced during regression of atherosclerosis in monkeys
    Steven R Lentz
    Veterans Affairs Medical Center, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Circulation 106:842-6. 2002
    ..We tested the hypothesis that anticoagulant responses to thrombin increase toward normal during regression of atherosclerosis...
  5. ncbi request reprint Homocysteine: is it a clinically important cardiovascular risk factor?
    Steven R Lentz
    Department of Internal Medicine, University of Iowa, Iowa City 52242, USA
    Cleve Clin J Med 71:729-34. 2004
    ..Until we know the results of ongoing clinical trials of homocysteine-lowering therapy, testing for and treating elevated homocysteine is probably justified only in patients with known cardiovascular disease or who are at high risk...
  6. ncbi request reprint Supplementation of atherogenic diet with B vitamins does not prevent atherosclerosis or vascular dysfunction in monkeys
    S R Lentz
    Veterans Affairs Medical Center, Departments of Internal Medicine, University of Iowa College of Medicine, Iowa City, USA
    Circulation 103:1006-11. 2001
    ..In many patients, hyperhomocysteinemia can be treated or prevented by dietary supplementation with B vitamins, but the clinical benefit of B vitamins for the prevention of vascular disease has not been proven...
  7. ncbi request reprint Folate dependence of hyperhomocysteinemia and vascular dysfunction in cystathionine beta-synthase-deficient mice
    S R Lentz
    Veterans Affairs Medical Center, Iowa City 52246, USA
    Am J Physiol Heart Circ Physiol 279:H970-5. 2000
    ..These data indicate that CBS-deficient mice are predisposed to hyperhomocysteinemia during dietary folate deficiency, and moderate hyperhomocysteinemia is associated with marked impairment of endothelial function in mice...
  8. ncbi request reprint Impaired anticoagulant response to infusion of thrombin in atherosclerotic monkeys associated with acquired defects in the protein C system
    S R Lentz
    Veterans Affairs Medical Center, Departments of Internal Medicine and Pharmacology, University of Iowa College of Medicine, Iowa City, Iowa, USA
    Arterioscler Thromb Vasc Biol 19:1744-50. 1999
    ..The blunted anticoagulant response to thrombin in hypercholesterolemic monkeys was not corrected by supplementation with B vitamins...
  9. ncbi request reprint Consequences of hyperhomocyst(e)inemia on vascular function in atherosclerotic monkeys
    S R Lentz
    Veterans Affairs Medical Center, Iowa City, Iowa, USA
    Arterioscler Thromb Vasc Biol 17:2930-4. 1997
    ....
  10. ncbi request reprint Homocysteine and vascular dysfunction
    S R Lentz
    Veterans Affairs Medical Center, Iowa City, IA 52246, USA
    Life Sci 61:1205-15. 1997
    ....
  11. ncbi request reprint Hyperhomocysteinemia, endothelial dysfunction, and cardiovascular risk: the potential role of ADMA
    Steven R Lentz
    Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Atheroscler Suppl 4:61-5. 2003
    ..Additional studies are required to determine the mechanisms by which ADMA accumulates in hyperhomocysteinemia and to define the importance of ADMA in the endothelial dysfunction of hyperhomocysteinemia in vivo...
  12. ncbi request reprint Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine beta-synthase-deficient mice
    S Dayal
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa, USA
    Circ Res 88:1203-9. 2001
    ..Endothelial dysfunction in CBS(+/-) mice was associated with increased tissue levels of SAH, which suggests that altered SAM-dependent methylation may contribute to vascular dysfunction in hyperhomocysteinemia...
  13. ncbi request reprint The benefits of excess EPCR
    T J Raife
    Department of Pathology, The University of Iowa, Iowa City, IA 52242, USA
    J Thromb Haemost 3:1349-50. 2005
  14. ncbi request reprint Effect of mechanical ventilation on carotid artery thrombosis induced by photochemical injury in mice
    K M Wilson
    Internal Medicine, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Thromb Haemost 1:2669-74. 2003
    ..Increasing use of transgenic and gene targeting techniques for the investigation of hemostasis and vascular biology has generated interest in experimental models of carotid artery thrombosis in mice...
  15. pmc Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice
    J L Clements
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Clin Invest 103:19-25. 1999
    ..These data provide one potential mechanism for the fetal hemorrhage observed in SLP-76-deficient mice and reveal that SLP-76 expression is required for optimal receptor-mediated signal transduction in platelets as well as T lymphocytes...
  16. pmc Expression of thrombomodulin and consequences of thrombomodulin deficiency during healing of cutaneous wounds
    J J Peterson
    Veterans Affairs Medical Center, Iowa City, Iowa
    Am J Pathol 155:1569-75. 1999
    ..Severe deficiency of thrombomodulin anticoagulant activity does not appear to alter reepithelialization but may influence collagen production by fibroblasts in the wound matrix...
  17. ncbi request reprint Deficiency of glutathione peroxidase-1 sensitizes hyperhomocysteinemic mice to endothelial dysfunction
    Sanjana Dayal
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA
    Arterioscler Thromb Vasc Biol 22:1996-2002. 2002
    ..We tested the hypothesis that deficiency of cellular glutathione peroxidase (GPx-1) enhances susceptibility to endothelial dysfunction in mice with moderate hyperhomocysteinemia...
  18. ncbi request reprint Influence of folate on arterial permeability and stiffness in the absence or presence of hyperhomocysteinemia
    J David Symons
    College of Health, University of Utah, Salt Lake City, Utah, USA
    Arterioscler Thromb Vasc Biol 26:814-8. 2006
    ....
  19. ncbi request reprint ADMA and hyperhomocysteinemia
    Sanjana Dayal
    Department of Internal Medicine, University of Iowa, Iowa City 52242, USA
    Vasc Med 10:S27-33. 2005
    ..The recent development of transgenic mice with altered ADMA metabolism should provide further mechanistic insights into the role of ADMA in hyperhomocysteinemia...
  20. ncbi request reprint Hyperhomocysteinemia increases arterial permeability and stiffness in mice
    Adam E Mullick
    Univ of Utah School of Medicine, Bldg 585, Rm 152, 30 N 2030 E, Salt Lake City, UT 84132 e mail
    Am J Physiol Regul Integr Comp Physiol 291:R1349-54. 2006
    ..05) by simultaneous incubation with DEANO or tiron. Thus, acute HHcy increases arterial permeability by generating O2- to an extent whereby nitric oxide bioavailability is reduced...
  21. pmc Enhanced susceptibility to arterial thrombosis in a murine model of hyperhomocysteinemia
    Sanjana Dayal
    Department of Internal Medicine, C32 GH, University of Iowa, Iowa City, IA 52242, USA
    Blood 108:2237-43. 2006
    ....
  22. ncbi request reprint A novel ELISA for mouse activated protein C in plasma
    Jose A Fernandez
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, United States
    J Immunol Methods 314:174-81. 2006
    ..The amount of complex APC:PCI is detected with an anti-human PCI monoclonal antibody. The assay shows improved sensitivity versus enzyme immunocapture assays commonly used to detect human APC and considerably reduces the processing time...
  23. ncbi request reprint Prothrombotic effects of hyperhomocysteinemia and hypercholesterolemia in ApoE-deficient mice
    Katina M Wilson
    Department of Internal Medicine, The University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Arterioscler Thromb Vasc Biol 27:233-40. 2007
    ..We tested the hypothesis that hyperhomocysteinemia and hypercholesterolemia promote arterial thrombosis in mice...
  24. ncbi request reprint Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation
    Estelle Sontag
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 27:2751-9. 2007
    ..The link between homocysteine, PPMT, PP2A methylation, and key CNS proteins involved in AD pathogenesis provides new mechanistic insights into this disorder...
  25. ncbi request reprint Cerebral vascular dysfunction during hypercholesterolemia
    Jiro Kitayama
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242 1081, USA
    Stroke 38:2136-41. 2007
    ..We tested the hypothesis that vasomotor function is impaired in cerebral arterioles during hypercholesterolemia through a mechanism that involves oxidative stress...
  26. ncbi request reprint Testosterone regulation of renal cystathionine beta-synthase: implications for sex-dependent differences in plasma homocysteine levels
    Victor Vitvitsky
    Redox Biology Center and the Biochemistry Dept, University of Nebraska, Lincoln, NE 68588 0664, USA
    Am J Physiol Renal Physiol 293:F594-600. 2007
    ..Our data suggest that testosterone-dependent regulation of human CBS in kidney may contribute to sex-dependent differences in homocysteine transsulfuration...
  27. ncbi request reprint Role of redox reactions in the vascular phenotype of hyperhomocysteinemic animals
    Sanjana Dayal
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa
    Antioxid Redox Signal 9:1899-909. 2007
    ....
  28. ncbi request reprint Hypermethylation of Fads2 and altered hepatic fatty acid and phospholipid metabolism in mice with hyperhomocysteinemia
    Angela M Devlin
    Nutrition Research Program, Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver V6H 3N1, Canada
    J Biol Chem 282:37082-90. 2007
    ..05), and lower Delta6-desaturase activity (p<0.001) in liver from mice with HHcy. These findings suggest that methylation silencing of liver Fads2 expression and changes in liver fatty acids may contribute to the pathology of HHcy...
  29. ncbi request reprint Overexpression of dimethylarginine dimethylaminohydrolase inhibits asymmetric dimethylarginine-induced endothelial dysfunction in the cerebral circulation
    Hayan Dayoub
    Department of Internal Medicine, E318 2 GH, University of Iowa, Carver College of Medicine, Iowa City, IA 52242 1081, USA
    Stroke 39:180-4. 2008
    ..ADMA is hydrolyzed by dimethylarginine dimethylaminohydrolases (DDAHs). The goal of this study was to determine whether overexpression of human DDAH-1 in transgenic (DDAH-1-Tg) mice inhibits the vascular effects of ADMA...
  30. pmc Glutathione peroxidase-1 plays a major role in protecting against angiotensin II-induced vascular dysfunction
    Sophocles Chrissobolis
    Department of Internal Medicine, Cardiovascular Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242 1081, USA
    Hypertension 51:872-7. 2008
    ..Thus, genetic and pharmacological evidence suggests a major role for glutathione peroxidase-1 and hydrogen peroxide in Ang II-induced effects on vascular function...
  31. pmc The homocysteine paradox
    Roman N Rodionov
    Arterioscler Thromb Vasc Biol 28:1031-3. 2008
  32. pmc Murine models of hyperhomocysteinemia and their vascular phenotypes
    Sanjana Dayal
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, USA
    Arterioscler Thromb Vasc Biol 28:1596-605. 2008
    ..We also summarize the major vascular phenotypes observed in these murine models...
  33. pmc Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia
    Sanjana Dayal
    Dept of Internal Medicine, Univ of Iowa, C32 GH, Iowa City, IA 52242, USA
    Am J Physiol Heart Circ Physiol 295:H816-25. 2008
    ..Our findings demonstrate that hyperhomocysteinemia causes tissue-specific decreases in DDAH expression without altering plasma ADMA levels in mice with endothelial dysfunction...
  34. ncbi request reprint Perturbations in homocysteine-linked redox homeostasis in a murine model for hyperhomocysteinemia
    Victor Vitvitsky
    Biochemistry Dept, Univ of Nebraska, Lincoln, NE 68588 0664, USA
    Am J Physiol Regul Integr Comp Physiol 287:R39-46. 2004
    ....
  35. ncbi request reprint Structure of cerebral arterioles in cystathionine beta-synthase-deficient mice
    Gary L Baumbach
    Department of Pathology, University of Iowa College of Medicine and Cardiovascular Center, Iowa City, Iowa 52242, USA
    Circ Res 91:931-7. 2002
    ..These findings suggest that hyperhomocysteinemia promotes cerebral vascular hypertrophy and altered cerebral vascular mechanics, both of which may contribute to the increased incidence of stroke associated with hyperhomocysteinemia...
  36. ncbi request reprint Role of the adapter protein SLP-76 in GPVI-dependent platelet procoagulant responses to collagen
    Lorie Leo
    Departments of Internal Medicine and Pediatrics, University of Iowa College of Medicine, and Veterans Affairs Medical Center, Iowa City, IA 52242, USA
    Blood 100:2839-44. 2002
    ..Thus, both GPVI-dependent and GPVI-independent pathways contribute to collagen-induced platelet procoagulant activity...
  37. ncbi request reprint Hyperhomocysteinemia, oxidative stress, and cerebral vascular dysfunction
    Frank M Faraci
    Department of Internal Medicine, Cardiovascular Center, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242 1081, USA
    Stroke 35:345-7. 2004
  38. ncbi request reprint Cerebral vascular dysfunction mediated by superoxide in hyperhomocysteinemic mice
    Sanjana Dayal
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    Stroke 35:1957-62. 2004
    ..We tested the hypothesis that chronic hyperhomocysteinemia in mice causes endothelial dysfunction in cerebral arterioles through a mechanism that involves superoxide...
  39. ncbi request reprint Platelet factor 4 enhances generation of activated protein C in vitro and in vivo
    Arne Slungaard
    Department of Medicine, Section of Hematology, Oncology and Transplantation, University of Minnesota, Mayo Mail Code 480, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Blood 102:146-51. 2003
    ..These findings suggest that PF4 may play a previously unsuspected physiologic role in enhancing APC generation...
  40. ncbi request reprint Association of multiple cellular stress pathways with accelerated atherosclerosis in hyperhomocysteinemic apolipoprotein E-deficient mice
    Ji Zhou
    Henderson Research Centre and McMaster University, Hamilton, Ontario, Canada
    Circulation 110:207-13. 2004
    ....
  41. ncbi request reprint Factor V Leiden: a genetic risk factor for thrombotic microangiopathy in patients with normal von Willebrand factor-cleaving protease activity
    Thomas J Raife
    The Blood Center of Southeastern Wisconsin, Milwaukee, USA
    Blood 99:437-42. 2002
    ..The prevalence of other thrombosis-associated alleles did not differ between TM patients and control subjects. These findings suggest that factor V Leiden may be a pathogenic risk factor in TM patients that have normal VWCP activity...
  42. ncbi request reprint Another lesson from the factor V Leiden mouse: thrombin generation drives arterial disease
    Steven R Lentz
    Circulation 111:1733-4. 2005
  43. ncbi request reprint Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemia
    Angela M Devlin
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Biol Chem 280:25506-11. 2005
    ..05, r = 0.620). We conclude that hyperhomocysteinemia produces tissue-specific changes in H19 DMD methylation and increased vascular expression of H19 in adult mice...
  44. ncbi request reprint Thrombosis of vein grafts: wall tension restrains thrombomodulin expression
    Steven R Lentz
    Circ Res 92:12-3. 2003
  45. ncbi request reprint Cerebral vascular dysfunction in methionine synthase-deficient mice
    Sanjana Dayal
    Department of Internal Medicine, University of Iowa, Carver College of Medicine, Iowa City, IA, USA
    Circulation 112:737-44. 2005
    ..We tested the hypothesis that deficiency of MS impairs endothelial function in mice heterozygous for disruption of the Mtr gene, which encodes MS...
  46. ncbi request reprint Mechanisms of the atherogenic effects of elevated homocysteine in experimental models
    Katina M Wilson
    Department of Internal Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
    Semin Vasc Med 5:163-71. 2005
    ....
  47. ncbi request reprint Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice
    Angela M Devlin
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City 52242, USA
    Blood 103:2624-9. 2004
    ..These findings demonstrate that the Mthfr(+/-) genotype sensitizes mice to diet-induced hyperhomocysteinemia and that hyperhomocysteinemia alters tissue methylation capacity and impairs endothelial function in cerebral microvessels...
  48. ncbi request reprint Platelet-mediated modulation of adaptive immunity. A communication link between innate and adaptive immune compartments
    Bennett D Elzey
    The University of Iowa, Department of Urology, Iowa City, IA 52242, USA
    Immunity 19:9-19. 2003
    ..Additionally, depletion of platelets in normal mice results in decreased antigen-specific antibody production...
  49. pmc Critical role for the mitochondrial permeability transition pore and cyclophilin D in platelet activation and thrombosis
    Shawn M Jobe
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, USA
    Blood 111:1257-65. 2008
    ..These results implicate CypD and the MPTP as critical regulators of platelet activation and suggest a novel CypD-dependent negative-feedback mechanism regulating arterial thrombosis...
  50. ncbi request reprint Rebuttal: Need for mechanical ventilation with murine thrombosis models
    Katina M Wilson
    Thromb Haemost 93:389; author reply 390. 2005
  51. ncbi request reprint Increased plasma oxidized phospholipid:apolipoprotein B-100 ratio with concomitant depletion of oxidized phospholipids from atherosclerotic lesions after dietary lipid-lowering: a potential biomarker of early atherosclerosis regression
    Sotirios Tsimikas
    Division of Cardiovascular Diseases, Department of Medicine, University of California San Diego, USA
    Arterioscler Thromb Vasc Biol 27:175-81. 2007
    ..We evaluated whether changes in plasma levels of OxPL associated with apolipoprotein B-100 (apoB-100) reflect changes in OxPL content in atherosclerotic plaques during dietary-induced atherosclerosis progression and regression...
  52. ncbi request reprint ApoA-I: a missing link between homocysteine and lipid metabolism?
    Angela M Devlin
    Circ Res 98:431-3. 2006
  53. pmc Role of FcRgamma and factor XIIIA in coated platelet formation
    Shawn M Jobe
    Department of Pediatrics, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Blood 106:4146-51. 2005
    ..We conclude that FcRgamma, but not factor XIIIA, is essential for formation of highly procoagulant coated platelets following dual stimulation with collagen and thrombin...

Research Grants10

  1. Vascular Mechanisms in Homocysteinemia and Atherosclerosis
    STEVEN LENTZ; Fiscal Year: 2009
    ..The goals of this project are to define the molecular mechanisms by which hyperhomocysteinemia and hypercholesterolemia, alone or in combination, lead to adverse vascular events, and to identify new targets for therapy. ..
  2. Program in Hematology:& Cell Biology Blood Cells
    STEVEN LENTZ; Fiscal Year: 2007
    ....
  3. MECHANISMS OF VASCULAR DYSFUNCTION IN HOMOCYSTEINEMIA
    STEVEN LENTZ; Fiscal Year: 2007
    ..This project has the potential to suggest novel therapeutic approaches to the prevention and treatment of vascular disease associated with hyperhomocysteinemia. ..
  4. MECHANISMS OF VASCULAR DYSFUNCTION IN HOMOCYSTEINEMIA
    STEVEN LENTZ; Fiscal Year: 2003
    ..Aim 2, will test the hypothesis that vascular dysfunction in hyperhomocysteinemic mice is caused by increased oxidative stress in vivo. Aim 3 will attempt to determine the mechanisms of elevation of ADMA in hyperhomocysteinemia. ..
  5. Vascular Mechanisms in Homocysteinemia and Atherosclerosis
    Steven R Lentz; Fiscal Year: 2010
    ..The goals of this project are to define the molecular mechanisms by which hyperhomocysteinemia and hypercholesterolemia, alone or in combination, lead to adverse vascular events, and to identify new targets for therapy. ..