R H Lenox

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Overview of the mechanism of action of lithium in the brain: fifty-year update
    R H Lenox
    Department of Psychiatry, University of Pennsylvania, Philadelphia 19104 6140, USA
    J Clin Psychiatry 61:5-15. 2000
  2. ncbi request reprint Differential regulation of primary protein kinase C substrate (MARCKS, MLP, GAP-43, RC3) mRNAs in the hippocampus during kainic acid-induced seizures and synaptic reorganization
    R K McNamara
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104 6140, USA
    J Neurosci Res 62:416-26. 2000
  3. ncbi request reprint Distribution of the protein kinase C substrates MARCKS and MRP in the postnatal developing rat brain
    R K McNamara
    Department of Psychiatry, University of Florida College of Medicine, Gainesville 32610 0256, USA
    J Comp Neurol 397:337-56. 1998
  4. ncbi request reprint Facial motor neuron regeneration induces a unique spatial and temporal pattern of myristoylated alanine-rich C kinase substrate expression
    R K McNamara
    Department of Psychiatry, University of Pennsylvania School of Medicine, Clinical Research Building, Philadelphia, PA 19104 6140, USA
    Neuroscience 97:581-9. 2000
  5. ncbi request reprint Signalling pathways in the brain: cellular transduction of mood stabilisation in the treatment of manic-depressive illness
    H K Manji
    Department of Psychiatry, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Aust N Z J Psychiatry 33:S65-83. 1999
  6. ncbi request reprint Transcriptional down-regulation of MARCKS gene expression in immortalized hippocampal cells by lithium
    L Wang
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurochem 79:816-25. 2001
  7. ncbi request reprint Molecular basis of lithium action: integration of lithium-responsive signaling and gene expression networks
    R H Lenox
    Molecular Neuropsychopharmacology Program, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Mol Psychiatry 8:135-44. 2003
  8. ncbi request reprint Differential subcellular redistribution of protein kinase C isozymes in the rat hippocampus induced by kainic acid
    R K McNamara
    Department of Psychiatry, University of Pennsylvania School of Medicine, Abramson Research Center, Philadelphia 19104, USA
    J Neurochem 72:1735-43. 1999
  9. pmc Effect of reduced myristoylated alanine-rich C kinase substrate expression on hippocampal mossy fiber development and spatial learning in mutant mice: transgenic rescue and interactions with gene background
    R K McNamara
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 95:14517-22. 1998
  10. ncbi request reprint Actin filament cross-linking by MARCKS: characterization of two actin-binding sites within the phosphorylation site domain
    E G Yarmola
    Departments of Medicine and Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida 32610, USA
    J Biol Chem 276:22351-8. 2001

Detail Information

Publications10

  1. ncbi request reprint Overview of the mechanism of action of lithium in the brain: fifty-year update
    R H Lenox
    Department of Psychiatry, University of Pennsylvania, Philadelphia 19104 6140, USA
    J Clin Psychiatry 61:5-15. 2000
    ..Future studies on long-term neuroplastic changes caused by lithium in the brain will set the stage for new drug-discovery opportunities...
  2. ncbi request reprint Differential regulation of primary protein kinase C substrate (MARCKS, MLP, GAP-43, RC3) mRNAs in the hippocampus during kainic acid-induced seizures and synaptic reorganization
    R K McNamara
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104 6140, USA
    J Neurosci Res 62:416-26. 2000
    ..The expression profiles following kainate seizures bear resemblance to those observed during postnatal hippocampal development, which may indicate the recruitment of common regulatory mechanisms...
  3. ncbi request reprint Distribution of the protein kinase C substrates MARCKS and MRP in the postnatal developing rat brain
    R K McNamara
    Department of Psychiatry, University of Florida College of Medicine, Gainesville 32610 0256, USA
    J Comp Neurol 397:337-56. 1998
    ....
  4. ncbi request reprint Facial motor neuron regeneration induces a unique spatial and temporal pattern of myristoylated alanine-rich C kinase substrate expression
    R K McNamara
    Department of Psychiatry, University of Pennsylvania School of Medicine, Clinical Research Building, Philadelphia, PA 19104 6140, USA
    Neuroscience 97:581-9. 2000
    ....
  5. ncbi request reprint Signalling pathways in the brain: cellular transduction of mood stabilisation in the treatment of manic-depressive illness
    H K Manji
    Department of Psychiatry, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Aust N Z J Psychiatry 33:S65-83. 1999
    ....
  6. ncbi request reprint Transcriptional down-regulation of MARCKS gene expression in immortalized hippocampal cells by lithium
    L Wang
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurochem 79:816-25. 2001
    ..Taken together, our data indicate that transcriptional inhibition of the Macs gene underlies the lithium-induced down-regulation of MARCKS expression in the immortalized hippocampal cells...
  7. ncbi request reprint Molecular basis of lithium action: integration of lithium-responsive signaling and gene expression networks
    R H Lenox
    Molecular Neuropsychopharmacology Program, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Mol Psychiatry 8:135-44. 2003
    ....
  8. ncbi request reprint Differential subcellular redistribution of protein kinase C isozymes in the rat hippocampus induced by kainic acid
    R K McNamara
    Department of Psychiatry, University of Pennsylvania School of Medicine, Abramson Research Center, Philadelphia 19104, USA
    J Neurochem 72:1735-43. 1999
    ..The subcellular redistribution of PKC isozymes may contribute to the histopathological sequelae produced by KA in the hippocampus and may model the pathogenesis associated with diseases involving glutamate-induced neurotoxicity...
  9. pmc Effect of reduced myristoylated alanine-rich C kinase substrate expression on hippocampal mossy fiber development and spatial learning in mutant mice: transgenic rescue and interactions with gene background
    R K McNamara
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 95:14517-22. 1998
    ....
  10. ncbi request reprint Actin filament cross-linking by MARCKS: characterization of two actin-binding sites within the phosphorylation site domain
    E G Yarmola
    Departments of Medicine and Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida 32610, USA
    J Biol Chem 276:22351-8. 2001
    ....