Research Topics
| Petar S LenertSummaryAffiliation: University of Iowa Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Structural characterization of the inhibitory DNA motif for the type A (D)-CpG-induced cytokine secretion and NK-cell lytic activity in mouse spleen cellsPetar Lenert
Division of Rheumatology, Department of Internal Medicine and Roy J and Lucille A Carver College of Medicine, University of Iowa, The Iowa City VA Medical Center, Iowa City, Iowa 52242, USA
DNA Cell Biol 22:621-31. 2003..These findings suggest that CpG regulation of innate immunity can itself be regulated by particular motifs, which could be of therapeutic benefit in autoimmune diseases...- Inhibitory oligodeoxynucleotides - therapeutic promise for systemic autoimmune diseases?P Lenert
Division of Rheumatology, Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
Clin Exp Immunol 140:1-10. 2005.... - DNA-like class R inhibitory oligonucleotides (INH-ODNs) preferentially block autoantigen-induced B-cell and dendritic cell activation in vitro and autoantibody production in lupus-prone MRL-Fas(lpr/lpr) mice in vivoPetar Lenert
Department of Internal Medicine and Pathology, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
Arthritis Res Ther 11:R79. 2009..Thus, strategies to preferentially block innate activation through TLRs in autoimmune B cells may be preferred over non-selective B-cell depletion... - Extended sequence preferences for oligodeoxyribonucleotide activityPetar Lenert
Division of Rheumatology, Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
Immunology 117:474-81. 2006.... - Targeting Toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupusPetar S Lenert
Division of Rheumatology, Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA
Arthritis Res Ther 8:203. 2006..Both classes of INH-ODNs can block animal lupus. Hence, therapeutic application of these novel INH-ODNs in human lupus, particularly class R INH-ODNs, may result in more selective and disease-specific immunosuppression... - Classification, mechanisms of action, and therapeutic applications of inhibitory oligonucleotides for Toll-like receptors (TLR) 7 and 9Petar S Lenert
Department of Internal Medicine, Division of Rheumatology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
Mediators Inflamm 2010:986596. 2010..Several short ODNs have already shown promise as pathway-specific therapeutics for animal lupus. We envision their future use in human SLE, microbial DNA-dependent sepsis, and in other autoinflammatory diseases... - TLR-9 activation of marginal zone B cells in lupus mice regulates immunity through increased IL-10 productionPetar Lenert
Division of Rheumatology, Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
J Clin Immunol 25:29-40. 2005..Therefore, B cells may contribute to the lupus pathogenesis in many different ways: as antigen-presenting cells for self antigens, as effector cells for autoantibody production, and as IL-10 secreting regulatory cells... - Inhibitory oligonucleotides block the induction of AP-1 transcription factor by stimulatory CpG oligonucleotides in B cellsPetar Lenert
Department of Internal Medicine, University of Iowa, College of Medicine, Iowa City, IA 52242, USA
Antisense Nucleic Acid Drug Dev 13:143-50. 2003..These data suggest that inhibitory ODNs block the CpG ODN-driven signaling pathway at a site proximal to AP-1 induction... - Innate immune responses in lupus-prone Palmerston North mice: differential responses to LPS and bacterial DNA/CpG oligonucleotidesPetar Lenert
Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
J Clin Immunol 23:202-13. 2003.... - Nucleic acid sensing receptors in systemic lupus erythematosus: development of novel DNA- and/or RNA-like analogues for treating lupusP Lenert
Department of Internal Medicine, Division of Rheumatology, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
Clin Exp Immunol 161:208-22. 2010..Several groups are exploring the possibility of translating these INH-ODNs into human therapeutics for treating SLE and bacterial DNA-induced sepsis... - CpG stimulation of primary mouse B cells is blocked by inhibitory oligodeoxyribonucleotides at a site proximal to NF-kappaB activationP Lenert
Department of Internal Medicine, University of Iowa, College of Medicine, Iowa City 52242, USA
Antisense Nucleic Acid Drug Dev 11:247-56. 2001.... - Aggregation and secondary loop structure of oligonucleotides do not determine their ability to inhibit TLR9Robert F Ashman
Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, United States
Int Immunopharmacol 11:1032-7. 2011..These results support the conclusion that certain features of the primary linear sequence are critical for TLR9 inhibition, but changes in secondary structure or in ODN aggregation are irrelevant... - Identification of methylated CpG motifs as inhibitors of the immune stimulatory CpG motifsY Chen
Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
Gene Ther 8:1024-32. 2001..Our results suggest that methylated DNA may be applied to alleviate the unwanted immune stimulation and inflammation in systemic inflammatory response syndrome and in gene therapy with plasmid DNA...
Research Grants
- Mechanism of Action of Inhibitory CpG OligonucleotidesPetar Lenert; Fiscal Year: 2007....
- Therapeutic use of inhibitory DNA sequences in animal models of lupusPetar Lenert; Fiscal Year: 2006..Future extension of these studies to humans may lead to the design of novel therapeutic agents for human SLE. ..
- Mechanism of Action of Inhibitory CpG OligonucleotidesPetar Lenert; Fiscal Year: 2009..abstract_text> ..