Petar S Lenert

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. ncbi request reprint Structural characterization of the inhibitory DNA motif for the type A (D)-CpG-induced cytokine secretion and NK-cell lytic activity in mouse spleen cells
    Petar Lenert
    Division of Rheumatology, Department of Internal Medicine and Roy J and Lucille A Carver College of Medicine, University of Iowa, The Iowa City VA Medical Center, Iowa City, Iowa 52242, USA
    DNA Cell Biol 22:621-31. 2003
  2. doi request reprint ANA (+) ANCA (+) systemic vasculitis associated with the use of minocycline: case-based review
    Petar Lenert
    Department of Internal Medicine, Carver College of Medicine, The University of Iowa, 200 Hawkins Drive, Iowa City, IA, USA
    Clin Rheumatol 32:1099-106. 2013
  3. pmc Classification, mechanisms of action, and therapeutic applications of inhibitory oligonucleotides for Toll-like receptors (TLR) 7 and 9
    Petar S Lenert
    Department of Internal Medicine, Division of Rheumatology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
    Mediators Inflamm 2010:986596. 2010
  4. pmc Nucleic acid sensing receptors in systemic lupus erythematosus: development of novel DNA- and/or RNA-like analogues for treating lupus
    P Lenert
    Department of Internal Medicine, Division of Rheumatology, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
    Clin Exp Immunol 161:208-22. 2010
  5. pmc DNA-like class R inhibitory oligonucleotides (INH-ODNs) preferentially block autoantigen-induced B-cell and dendritic cell activation in vitro and autoantibody production in lupus-prone MRL-Fas(lpr/lpr) mice in vivo
    Petar Lenert
    Department of Internal Medicine and Pathology, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
    Arthritis Res Ther 11:R79. 2009
  6. pmc Extended sequence preferences for oligodeoxyribonucleotide activity
    Petar Lenert
    Division of Rheumatology, Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
    Immunology 117:474-81. 2006
  7. pmc Targeting Toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus
    Petar S Lenert
    Division of Rheumatology, Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA
    Arthritis Res Ther 8:203. 2006
  8. pmc Inhibitory oligodeoxynucleotides - therapeutic promise for systemic autoimmune diseases?
    P Lenert
    Division of Rheumatology, Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
    Clin Exp Immunol 140:1-10. 2005
  9. ncbi request reprint TLR-9 activation of marginal zone B cells in lupus mice regulates immunity through increased IL-10 production
    Petar Lenert
    Division of Rheumatology, Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
    J Clin Immunol 25:29-40. 2005
  10. ncbi request reprint Inhibitory oligonucleotides block the induction of AP-1 transcription factor by stimulatory CpG oligonucleotides in B cells
    Petar Lenert
    Department of Internal Medicine, University of Iowa, College of Medicine, Iowa City, IA 52242, USA
    Antisense Nucleic Acid Drug Dev 13:143-50. 2003

Detail Information

Publications14

  1. ncbi request reprint Structural characterization of the inhibitory DNA motif for the type A (D)-CpG-induced cytokine secretion and NK-cell lytic activity in mouse spleen cells
    Petar Lenert
    Division of Rheumatology, Department of Internal Medicine and Roy J and Lucille A Carver College of Medicine, University of Iowa, The Iowa City VA Medical Center, Iowa City, Iowa 52242, USA
    DNA Cell Biol 22:621-31. 2003
    ..These findings suggest that CpG regulation of innate immunity can itself be regulated by particular motifs, which could be of therapeutic benefit in autoimmune diseases...
  2. doi request reprint ANA (+) ANCA (+) systemic vasculitis associated with the use of minocycline: case-based review
    Petar Lenert
    Department of Internal Medicine, Carver College of Medicine, The University of Iowa, 200 Hawkins Drive, Iowa City, IA, USA
    Clin Rheumatol 32:1099-106. 2013
    ..We additionally present a comprehensive review of biopsy-proven cases of vasculitis associated with chronic minocycline treatment focusing on its pathogenesis and clinical manifestations...
  3. pmc Classification, mechanisms of action, and therapeutic applications of inhibitory oligonucleotides for Toll-like receptors (TLR) 7 and 9
    Petar S Lenert
    Department of Internal Medicine, Division of Rheumatology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
    Mediators Inflamm 2010:986596. 2010
    ..Several short ODNs have already shown promise as pathway-specific therapeutics for animal lupus. We envision their future use in human SLE, microbial DNA-dependent sepsis, and in other autoinflammatory diseases...
  4. pmc Nucleic acid sensing receptors in systemic lupus erythematosus: development of novel DNA- and/or RNA-like analogues for treating lupus
    P Lenert
    Department of Internal Medicine, Division of Rheumatology, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
    Clin Exp Immunol 161:208-22. 2010
    ..Several groups are exploring the possibility of translating these INH-ODNs into human therapeutics for treating SLE and bacterial DNA-induced sepsis...
  5. pmc DNA-like class R inhibitory oligonucleotides (INH-ODNs) preferentially block autoantigen-induced B-cell and dendritic cell activation in vitro and autoantibody production in lupus-prone MRL-Fas(lpr/lpr) mice in vivo
    Petar Lenert
    Department of Internal Medicine and Pathology, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
    Arthritis Res Ther 11:R79. 2009
    ..Thus, strategies to preferentially block innate activation through TLRs in autoimmune B cells may be preferred over non-selective B-cell depletion...
  6. pmc Extended sequence preferences for oligodeoxyribonucleotide activity
    Petar Lenert
    Division of Rheumatology, Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
    Immunology 117:474-81. 2006
    ....
  7. pmc Targeting Toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus
    Petar S Lenert
    Division of Rheumatology, Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA
    Arthritis Res Ther 8:203. 2006
    ..Both classes of INH-ODNs can block animal lupus. Hence, therapeutic application of these novel INH-ODNs in human lupus, particularly class R INH-ODNs, may result in more selective and disease-specific immunosuppression...
  8. pmc Inhibitory oligodeoxynucleotides - therapeutic promise for systemic autoimmune diseases?
    P Lenert
    Division of Rheumatology, Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
    Clin Exp Immunol 140:1-10. 2005
    ....
  9. ncbi request reprint TLR-9 activation of marginal zone B cells in lupus mice regulates immunity through increased IL-10 production
    Petar Lenert
    Division of Rheumatology, Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
    J Clin Immunol 25:29-40. 2005
    ..Therefore, B cells may contribute to the lupus pathogenesis in many different ways: as antigen-presenting cells for self antigens, as effector cells for autoantibody production, and as IL-10 secreting regulatory cells...
  10. ncbi request reprint Inhibitory oligonucleotides block the induction of AP-1 transcription factor by stimulatory CpG oligonucleotides in B cells
    Petar Lenert
    Department of Internal Medicine, University of Iowa, College of Medicine, Iowa City, IA 52242, USA
    Antisense Nucleic Acid Drug Dev 13:143-50. 2003
    ..These data suggest that inhibitory ODNs block the CpG ODN-driven signaling pathway at a site proximal to AP-1 induction...
  11. ncbi request reprint Innate immune responses in lupus-prone Palmerston North mice: differential responses to LPS and bacterial DNA/CpG oligonucleotides
    Petar Lenert
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Clin Immunol 23:202-13. 2003
    ....
  12. ncbi request reprint CpG stimulation of primary mouse B cells is blocked by inhibitory oligodeoxyribonucleotides at a site proximal to NF-kappaB activation
    P Lenert
    Department of Internal Medicine, University of Iowa, College of Medicine, Iowa City 52242, USA
    Antisense Nucleic Acid Drug Dev 11:247-56. 2001
    ....
  13. pmc Aggregation and secondary loop structure of oligonucleotides do not determine their ability to inhibit TLR9
    Robert F Ashman
    Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, United States
    Int Immunopharmacol 11:1032-7. 2011
    ..These results support the conclusion that certain features of the primary linear sequence are critical for TLR9 inhibition, but changes in secondary structure or in ODN aggregation are irrelevant...
  14. ncbi request reprint Identification of methylated CpG motifs as inhibitors of the immune stimulatory CpG motifs
    Y Chen
    Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Gene Ther 8:1024-32. 2001
    ..Our results suggest that methylated DNA may be applied to alleviate the unwanted immune stimulation and inflammation in systemic inflammatory response syndrome and in gene therapy with plasmid DNA...

Research Grants4

  1. Mechanism of Action of Inhibitory CpG Oligonucleotides
    Petar Lenert; Fiscal Year: 2007
    ....
  2. Therapeutic use of inhibitory DNA sequences in animal models of lupus
    Petar Lenert; Fiscal Year: 2006
    ..Future extension of these studies to humans may lead to the design of novel therapeutic agents for human SLE. ..
  3. Mechanism of Action of Inhibitory CpG Oligonucleotides
    Petar Lenert; Fiscal Year: 2009
    ..abstract_text> ..