Research Topics
| JOSE A LEMOSSummaryAffiliation: University of Rochester Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Streptococcus mutans: a new Gram-positive paradigm?JOSE A LEMOS
Center for Oral Biology and Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
Microbiology 159:436-45. 2013..In this article, we provide an argument that places S. mutans, an organism that evolved in close association with the human host, as a novel Gram-positive model organism...
Global regulation by (p)ppGpp and CodY in Streptococcus mutansJOSE A LEMOS
Department of Microbiology and Immunology and Center for Oral Biology, University of Rochester Medical Center, Rochester, New York 14642, USA
J Bacteriol 190:5291-9. 2008..Notably, the identification of putative CodY-binding boxes upstream of genes that were downregulated in the codY mutant indicates that CodY may also function as a transcriptional activator in S. mutans...- A model of efficiency: stress tolerance by Streptococcus mutansJOSE A LEMOS
Center for Oral Biology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
Microbiology 154:3247-55. 2008..Here, we highlight advances in dissection of the stress regulon of S. mutans and its intimate interrelationship with pathogenesis... - Two Spx proteins modulate stress tolerance, survival, and virulence in Streptococcus mutansJessica K Kajfasz
Center for Oral Biology, University of Rochester Medical Center, Box 611, 601 Elmwood Ave, Rochester, NY 14642, USA
J Bacteriol 192:2546-56. 2010..Given the high degree of conservation between Spx proteins of low-GC gram-positive bacteria, these results are likely to have broad implications... - Role of Clp proteins in expression of virulence properties of Streptococcus mutansJessica K Kajfasz
Center for Oral Biology, University of Rochester Medical Center, NY 14642, USA
J Bacteriol 191:2060-8. 2009..mutans and indicates that the underlying mechanisms by which ClpXP affect virulence traits are associated with the accumulation of two Spx orthologues... - The Spx regulator modulates stress responses and virulence in Enterococcus faecalisJessica K Kajfasz
Center for Oral Biology, University of Rochester Medical Center, Rochester, New York, USA
Infect Immun 80:2265-75. 2012..Collectively, our results show that Spx is a major stress gene regulator and is implicated in the pathophysiology of E. faecalis. The relationship of Spx to other oxidative stress regulators is also discussed... - The collagen-binding protein Cnm is required for Streptococcus mutans adherence to and intracellular invasion of human coronary artery endothelial cellsJacqueline Abranches
Center for Oral Biology, University of Rochester Medical Center, Box 611, 601 Elmwood Ave, Rochester, NY 14642, USA
Infect Immun 79:2277-84. 2011..Thus, Cnm is required for S. mutans invasion of endothelial cells and possibly represents an important virulence factor of S. mutans that may contribute to cardiovascular infections and pathologies... - Global transcriptional analysis of the stringent response in Enterococcus faecalisAnthony O Gaca
Center for Oral Biology and Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
Microbiology 158:1994-2004. 2012..Thus, while ΔrelA and ΔrelAΔrelQ cannot use (p)ppGpp to sense and respond to stresses, fitness of ΔrelAΔrelQ may be further impaired due to an unbalanced metabolism... - Novel antibiofilm chemotherapy targets exopolysaccharide synthesis and stress tolerance in Streptococcus mutans to modulate virulence expression in vivoMegan L Falsetta
Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA
Antimicrob Agents Chemother 56:6201-11. 2012..These observations may have relevance for development of enhanced therapies against other biofilm-dependent infections... - Transcriptome analysis reveals that ClpXP proteolysis controls key virulence properties of Streptococcus mutansJessica K Kajfasz
Center for Oral Biology, University of Rochester Medical Center, Rochester, NY 14642, USA
Microbiology 157:2880-90. 2011..Collectively, our results reveal the broad scope of ClpXP regulation in S. mutans homeostasis and identify several virulence-related traits that are influenced by ClpXP proteolysis... - Dynamics of Streptococcus mutans transcriptome in response to starch and sucrose during biofilm developmentMarlise I Klein
Center for Oral Biology and Eastman Department of Dentistry, University of Rochester Medical Center, Rochester, New York, United States of America
PLoS ONE 5:e13478. 2010..Our data show complex remodeling of S. mutans-transcriptome in response to changing environmental conditions in situ, which could modulate the dynamics of biofilm development and pathogenicity... - Protocols to study the physiology of oral biofilmsJOSE A LEMOS
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA
Methods Mol Biol 666:87-102. 2010..In this chapter, we use oral streptococci as examples for studying the physiology of oral biofilms... - The molecular alarmone (p)ppGpp mediates stress responses, vancomycin tolerance, and virulence in Enterococcus faecalisJacqueline Abranches
Center for Oral Biology, University of Rochester Medical Center, NY 14642, USA
J Bacteriol 191:2248-56. 2009..Taken together, these results indicate that (p)ppGpp pools modulate environmental stress responses, vancomycin tolerance, and virulence in this important nosocomial pathogen...
Research Grants
- ADAPTIVE ACID TOLERANCE OF STREPTOCOCCUS SOBRINUSJOSE LEMOS; Fiscal Year: 2007..sobrinus, and (ii) analysis of the acid tolerance properties of a S. sobrinus strain lacking the glucose-specific enzyme II (EIIGIc) of the PTS. ..
- Role of the Spx Regulator in Streptococcus mutansJOSE A LEMOS; Fiscal Year: 2010..mutans to adhere to the tooth, produce acids, and survive acidic conditions in the oral cavity. Our studies will facilitate the discovery of new products that could be used to reduce or eliminate caries. ..