JOSE A LEMOS

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Basal levels of (p)ppGpp in Enterococcus faecalis: the magic beyond the stringent response
    Anthony O Gaca
    Center for Oral Biology and Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA
    MBio 4:e00646-13. 2013
  2. pmc The cell wall-targeting antibiotic stimulon of Enterococcus faecalis
    Jacqueline Abranches
    Center for Oral Biology, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 8:e64875. 2013
  3. doi request reprint Streptococcus mutans: a new Gram-positive paradigm?
    JOSE A LEMOS
    Center for Oral Biology and Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Microbiology 159:436-45. 2013
  4. pmc Global regulation by (p)ppGpp and CodY in Streptococcus mutans
    JOSE A LEMOS
    Department of Microbiology and Immunology and Center for Oral Biology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Bacteriol 190:5291-9. 2008
  5. pmc A model of efficiency: stress tolerance by Streptococcus mutans
    JOSE A LEMOS
    Center for Oral Biology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Microbiology 154:3247-55. 2008
  6. pmc Two Spx proteins modulate stress tolerance, survival, and virulence in Streptococcus mutans
    Jessica K Kajfasz
    Center for Oral Biology, University of Rochester Medical Center, Box 611, 601 Elmwood Ave, Rochester, NY 14642, USA
    J Bacteriol 192:2546-56. 2010
  7. pmc The Spx regulator modulates stress responses and virulence in Enterococcus faecalis
    Jessica K Kajfasz
    Center for Oral Biology, University of Rochester Medical Center, Rochester, New York, USA
    Infect Immun 80:2265-75. 2012
  8. pmc The collagen-binding protein Cnm is required for Streptococcus mutans adherence to and intracellular invasion of human coronary artery endothelial cells
    Jacqueline Abranches
    Center for Oral Biology, University of Rochester Medical Center, Box 611, 601 Elmwood Ave, Rochester, NY 14642, USA
    Infect Immun 79:2277-84. 2011
  9. pmc Role of Clp proteins in expression of virulence properties of Streptococcus mutans
    Jessica K Kajfasz
    Center for Oral Biology, University of Rochester Medical Center, NY 14642, USA
    J Bacteriol 191:2060-8. 2009
  10. doi request reprint Global transcriptional analysis of the stringent response in Enterococcus faecalis
    Anthony O Gaca
    Center for Oral Biology and Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Microbiology 158:1994-2004. 2012

Research Grants

Collaborators

Detail Information

Publications15

  1. pmc Basal levels of (p)ppGpp in Enterococcus faecalis: the magic beyond the stringent response
    Anthony O Gaca
    Center for Oral Biology and Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA
    MBio 4:e00646-13. 2013
    ..Collectively, this study highlights the critical but still underappreciated role of basal (p)ppGpp pools under balanced growth conditions...
  2. pmc The cell wall-targeting antibiotic stimulon of Enterococcus faecalis
    Jacqueline Abranches
    Center for Oral Biology, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 8:e64875. 2013
    ..The phenotypes obtained for two of these mutants, ΔEF1533 and ΔEF3245, support further characterization of these genes as potential candidates for the development of novel preventive or therapeutic approaches...
  3. doi request reprint Streptococcus mutans: a new Gram-positive paradigm?
    JOSE A LEMOS
    Center for Oral Biology and Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Microbiology 159:436-45. 2013
    ..In this article, we provide an argument that places S. mutans, an organism that evolved in close association with the human host, as a novel Gram-positive model organism...
  4. pmc Global regulation by (p)ppGpp and CodY in Streptococcus mutans
    JOSE A LEMOS
    Department of Microbiology and Immunology and Center for Oral Biology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Bacteriol 190:5291-9. 2008
    ..Notably, the identification of putative CodY-binding boxes upstream of genes that were downregulated in the codY mutant indicates that CodY may also function as a transcriptional activator in S. mutans...
  5. pmc A model of efficiency: stress tolerance by Streptococcus mutans
    JOSE A LEMOS
    Center for Oral Biology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Microbiology 154:3247-55. 2008
    ..Here, we highlight advances in dissection of the stress regulon of S. mutans and its intimate interrelationship with pathogenesis...
  6. pmc Two Spx proteins modulate stress tolerance, survival, and virulence in Streptococcus mutans
    Jessica K Kajfasz
    Center for Oral Biology, University of Rochester Medical Center, Box 611, 601 Elmwood Ave, Rochester, NY 14642, USA
    J Bacteriol 192:2546-56. 2010
    ..Given the high degree of conservation between Spx proteins of low-GC gram-positive bacteria, these results are likely to have broad implications...
  7. pmc The Spx regulator modulates stress responses and virulence in Enterococcus faecalis
    Jessica K Kajfasz
    Center for Oral Biology, University of Rochester Medical Center, Rochester, New York, USA
    Infect Immun 80:2265-75. 2012
    ..Collectively, our results show that Spx is a major stress gene regulator and is implicated in the pathophysiology of E. faecalis. The relationship of Spx to other oxidative stress regulators is also discussed...
  8. pmc The collagen-binding protein Cnm is required for Streptococcus mutans adherence to and intracellular invasion of human coronary artery endothelial cells
    Jacqueline Abranches
    Center for Oral Biology, University of Rochester Medical Center, Box 611, 601 Elmwood Ave, Rochester, NY 14642, USA
    Infect Immun 79:2277-84. 2011
    ..Thus, Cnm is required for S. mutans invasion of endothelial cells and possibly represents an important virulence factor of S. mutans that may contribute to cardiovascular infections and pathologies...
  9. pmc Role of Clp proteins in expression of virulence properties of Streptococcus mutans
    Jessica K Kajfasz
    Center for Oral Biology, University of Rochester Medical Center, NY 14642, USA
    J Bacteriol 191:2060-8. 2009
    ..mutans and indicates that the underlying mechanisms by which ClpXP affect virulence traits are associated with the accumulation of two Spx orthologues...
  10. doi request reprint Global transcriptional analysis of the stringent response in Enterococcus faecalis
    Anthony O Gaca
    Center for Oral Biology and Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Microbiology 158:1994-2004. 2012
    ..Thus, while ΔrelA and ΔrelAΔrelQ cannot use (p)ppGpp to sense and respond to stresses, fitness of ΔrelAΔrelQ may be further impaired due to an unbalanced metabolism...
  11. pmc Novel antibiofilm chemotherapy targets exopolysaccharide synthesis and stress tolerance in Streptococcus mutans to modulate virulence expression in vivo
    Megan L Falsetta
    Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA
    Antimicrob Agents Chemother 56:6201-11. 2012
    ..These observations may have relevance for development of enhanced therapies against other biofilm-dependent infections...
  12. pmc Transcriptome analysis reveals that ClpXP proteolysis controls key virulence properties of Streptococcus mutans
    Jessica K Kajfasz
    Center for Oral Biology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Microbiology 157:2880-90. 2011
    ..Collectively, our results reveal the broad scope of ClpXP regulation in S. mutans homeostasis and identify several virulence-related traits that are influenced by ClpXP proteolysis...
  13. pmc The molecular alarmone (p)ppGpp mediates stress responses, vancomycin tolerance, and virulence in Enterococcus faecalis
    Jacqueline Abranches
    Center for Oral Biology, University of Rochester Medical Center, NY 14642, USA
    J Bacteriol 191:2248-56. 2009
    ..Taken together, these results indicate that (p)ppGpp pools modulate environmental stress responses, vancomycin tolerance, and virulence in this important nosocomial pathogen...
  14. pmc Dynamics of Streptococcus mutans transcriptome in response to starch and sucrose during biofilm development
    Marlise I Klein
    Center for Oral Biology and Eastman Department of Dentistry, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 5:e13478. 2010
    ..Our data show complex remodeling of S. mutans-transcriptome in response to changing environmental conditions in situ, which could modulate the dynamics of biofilm development and pathogenicity...
  15. pmc Protocols to study the physiology of oral biofilms
    JOSE A LEMOS
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA
    Methods Mol Biol 666:87-102. 2010
    ..In this chapter, we use oral streptococci as examples for studying the physiology of oral biofilms...

Research Grants3

  1. ADAPTIVE ACID TOLERANCE OF STREPTOCOCCUS SOBRINUS
    JOSE LEMOS; Fiscal Year: 2007
    ..sobrinus, and (ii) analysis of the acid tolerance properties of a S. sobrinus strain lacking the glucose-specific enzyme II (EIIGIc) of the PTS. ..
  2. Role of the Spx Regulator in Streptococcus mutans
    JOSE A LEMOS; Fiscal Year: 2010
    ..mutans to adhere to the tooth, produce acids, and survive acidic conditions in the oral cavity. Our studies will facilitate the discovery of new products that could be used to reduce or eliminate caries. ..