Mark Lemmon

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Pleckstrin homology domains: two halves make a hole?
    Mark A Lemmon
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell 120:574-6. 2005
  2. pmc ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor
    Diego Alvarado
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, 809C Stellar Chance Laboratories, 422 Curie Boulevard, Philadelphia, Pennsylvania 19104 6059, USA
    Nature 461:287-91. 2009
  3. pmc Assessing the range of kinase autoinhibition mechanisms in the insulin receptor family
    Stephen C Artim
    Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, 809C Stellar Chance Laboratories, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    Biochem J 448:213-20. 2012
  4. pmc Erlotinib binds both inactive and active conformations of the EGFR tyrosine kinase domain
    Jin H Park
    Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Biochem J 448:417-23. 2012
  5. pmc Live cell imaging with protein domains capable of recognizing phosphatidylinositol 4,5-bisphosphate; a comparative study
    Zsofia Szentpetery
    Sections on molecular signal transduction, Program for Developmental Neuroscience, NICHD, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Cell Biol 10:67. 2009
  6. pmc Cell signaling by receptor tyrosine kinases
    Mark A Lemmon
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6059, USA
    Cell 141:1117-34. 2010
  7. pmc Signal-dependent membrane targeting by pleckstrin homology (PH) domains
    M A Lemmon
    The Johnson Research Foundation and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, 809C Stellar Chance Laboratories, Philadelphia, PA 19104 6059, USA
    Biochem J 350:1-18. 2000
  8. pmc Ligand-induced ErbB receptor dimerization
    Mark A Lemmon
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, 809C Stellar Chance Laboratories, 422 Curie Boulevard, Philadelphia, PA 19104 6059, USA
    Exp Cell Res 315:638-48. 2009
  9. ncbi request reprint Pleckstrin homology domains: not just for phosphoinositides
    M A Lemmon
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, 809C Stellar Chance Laboratories, 422 Curie Blvd, Philadelphia, PA 19104 6059, USA
    Biochem Soc Trans 32:707-11. 2004
  10. ncbi request reprint Signaling by the sea
    Mark A Lemmon
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nat Struct Mol Biol 11:682-5. 2004

Research Grants

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Pleckstrin homology domains: two halves make a hole?
    Mark A Lemmon
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell 120:574-6. 2005
    ....
  2. pmc ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor
    Diego Alvarado
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, 809C Stellar Chance Laboratories, 422 Curie Boulevard, Philadelphia, Pennsylvania 19104 6059, USA
    Nature 461:287-91. 2009
    ..Our findings have important implications for ErbB2 regulation in human cancer, and for developing therapeutic approaches that target novel aspects of this orphan receptor...
  3. pmc Assessing the range of kinase autoinhibition mechanisms in the insulin receptor family
    Stephen C Artim
    Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, 809C Stellar Chance Laboratories, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    Biochem J 448:213-20. 2012
    ..We also describe symmetrical dimers of the inactive TrkA TKD resembling those found in other RTKs, possibly reflecting an arrangement of kinase domains in a pre-formed TrkA dimer...
  4. pmc Erlotinib binds both inactive and active conformations of the EGFR tyrosine kinase domain
    Jin H Park
    Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Biochem J 448:417-23. 2012
    ..Through parallel computational and crystallographic studies, we show in the present study that erlotinib also binds the inactive EGFR-TKD conformation, which may have significant implications for its use in EGFR-mutated cancers...
  5. pmc Live cell imaging with protein domains capable of recognizing phosphatidylinositol 4,5-bisphosphate; a comparative study
    Zsofia Szentpetery
    Sections on molecular signal transduction, Program for Developmental Neuroscience, NICHD, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Cell Biol 10:67. 2009
    ..Here we report on a comparative analysis of several recently-described yeast PH domains as well as the mammalian Tubby domain to evaluate their usefulness as PtdIns(4,5)P2 imaging tools...
  6. pmc Cell signaling by receptor tyrosine kinases
    Mark A Lemmon
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6059, USA
    Cell 141:1117-34. 2010
    ..Much remains to be learned, however, about the complex signaling networks downstream from RTKs and how alterations in these networks are translated into cellular responses...
  7. pmc Signal-dependent membrane targeting by pleckstrin homology (PH) domains
    M A Lemmon
    The Johnson Research Foundation and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, 809C Stellar Chance Laboratories, Philadelphia, PA 19104 6059, USA
    Biochem J 350:1-18. 2000
    ..We discuss the possibility that membrane targeting by PH domains with low affinity for phosphoinositides could be driven by alteration of their oligomeric state and thus the avidity of their membrane binding...
  8. pmc Ligand-induced ErbB receptor dimerization
    Mark A Lemmon
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, 809C Stellar Chance Laboratories, 422 Curie Boulevard, Philadelphia, PA 19104 6059, USA
    Exp Cell Res 315:638-48. 2009
    ..These considerations underline the need to consider the intact ErbB receptors as intact allosterically regulated enzymes, and to combine cellular and structural studies into a complete picture...
  9. ncbi request reprint Pleckstrin homology domains: not just for phosphoinositides
    M A Lemmon
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, 809C Stellar Chance Laboratories, 422 Curie Blvd, Philadelphia, PA 19104 6059, USA
    Biochem Soc Trans 32:707-11. 2004
    ..These findings herald a change in our perspective of PH domain function, which will be significantly more diverse than previously supposed...
  10. ncbi request reprint Signaling by the sea
    Mark A Lemmon
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nat Struct Mol Biol 11:682-5. 2004
    ..Topics discussed ranged from precise structural details of signaling events to animal models for understanding signaling disorders...
  11. ncbi request reprint Phosphoinositide recognition domains
    Mark A Lemmon
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Traffic 4:201-13. 2003
    ..By contrast, certain other domains, notably the epsin ENTH domain, appear to promote bilayer curvature by inserting into the membrane upon binding...
  12. ncbi request reprint Molecular determinants in pleckstrin homology domains that allow specific recognition of phosphoinositides
    M A Lemmon
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6059, USA
    Biochem Soc Trans 29:377-84. 2001
    ..We discuss the architecture of the specific phosphoinositide-binding sites of PH domains, and how selectivity can be modulated by sequence changes...
  13. ncbi request reprint A new twist in the transmembrane signaling tool-kit
    Mark A Lemmon
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell 130:213-5. 2007
    ..The structures explain how SCF drives dimerization of the receptor. They also reveal important receptor-receptor contacts that may explain how several Kit mutations lead to cancer...
  14. doi request reprint Membrane recognition by phospholipid-binding domains
    Mark A Lemmon
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, 809C Stellar Chance Laboratories, 422 Curie Boulevard, Philadelphia, Pennsylvania 19104 6059, USA
    Nat Rev Mol Cell Biol 9:99-111. 2008
    ..A full appreciation of these processes is crucial for understanding how protein localization and membrane topography and trafficking are regulated in cells...
  15. pmc Structural basis for EGFR ligand sequestration by Argos
    Daryl E Klein
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, 809C Stellar Chance Laboratories, 422 Curie Boulevard, Philadelphia, Pennsylvania 19104 6059, USA
    Nature 453:1271-5. 2008
    ..In addition, the structures presented here define requirements for the design of artificial EGF-sequestering proteins that would be valuable anti-cancer therapeutics...
  16. ncbi request reprint Argos inhibits epidermal growth factor receptor signalling by ligand sequestration
    Daryl E Klein
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, 809C Stellar Chance Laboratories, 422 Curie Boulevard, Philadelphia, Pennsylvania 19104 6059, USA
    Nature 430:1040-4. 2004
    ..Our results provide an insight into the mechanism of Argos function, and suggest new strategies for EGFR inhibitor design...
  17. ncbi request reprint Ligand-induced structural transitions in ErbB receptor extracellular domains
    Jessica P Dawson
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    Structure 15:942-54. 2007
    ..These findings explain why tether mutants fail to activate EGF receptor and provide new insight into regulation of ErbB receptor conformation...
  18. ncbi request reprint The single transmembrane domains of ErbB receptors self-associate in cell membranes
    Jeannine M Mendrola
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6059, USA
    J Biol Chem 277:4704-12. 2002
    ..Our findings suggest a role for TM domain interactions in ErbB receptor function, possibly in stabilizing inactive ligand-independent receptor dimers that have been observed by several groups...
  19. pmc Structural basis for negative cooperativity in growth factor binding to an EGF receptor
    Diego Alvarado
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6059, USA
    Cell 142:568-79. 2010
    ..Our results explain the cell-surface binding characteristics of EGF receptors and suggest how individual EGFR ligands might stabilize distinct dimeric species with different signaling properties...
  20. pmc Epidermal growth factor receptor dimerization and activation require ligand-induced conformational changes in the dimer interface
    Jessica P Dawson
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, 19104 6059, USA
    Mol Cell Biol 25:7734-42. 2005
    ..Our data also suggest that similar conformational changes may determine the specificity of ErbB receptor homo- versus heterodimerization...
  21. ncbi request reprint ErbB3/HER3 does not homodimerize upon neuregulin binding at the cell surface
    Mitchell B Berger
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6059, USA
    FEBS Lett 569:332-6. 2004
    ..We, therefore, suggest that ErbB3 is an obligate heterodimerization partner because of its inability to homodimerize...
  22. pmc A possible effector role for the pleckstrin homology (PH) domain of dynamin
    Kelley A Bethoney
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6059, USA
    Proc Natl Acad Sci U S A 106:13359-64. 2009
    ..PtdIns(4,5)P(2) clustering could promote vesicle scission through direct effects on membrane properties, or might play a role in dynamin's ability to regulate actin polymerization...
  23. ncbi request reprint Genome-wide analysis of membrane targeting by S. cerevisiae pleckstrin homology domains
    Jong W Yu
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 USA
    Mol Cell 13:677-88. 2004
    ..These findings have significant implications for understanding the function of proteins that contain this common domain...
  24. pmc Inhibition of nuclear import and cell-cycle progression by mutated forms of the dynamin-like GTPase MxB
    Megan C King
    Department of Biochemistry and Biophysics and the Graduate Group in Biochemistry and Molecular Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 101:8957-62. 2004
    ..These studies indicate an unexpected role for a dynamin-like protein in nucleocytoplasmic trafficking and suggest that a related function might be usurped by its antiviral relatives...
  25. ncbi request reprint Argos mutants define an affinity threshold for spitz inhibition in vivo
    Diego Alvarado
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6059, USA
    J Biol Chem 281:28993-9001. 2006
    ..In agreement with previously reported computational studies, our results define an affinity threshold for optimal Argos inhibition of dEGFR signaling during development...
  26. ncbi request reprint EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization
    Kathryn M Ferguson
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mol Cell 11:507-17. 2003
    ..This contrasts starkly with other RTK activation mechanisms and suggests new approaches for designing ErbB receptor antagonists...
  27. pmc Determining selectivity of phosphoinositide-binding domains
    Kartik Narayan
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6059, USA
    Methods 39:122-33. 2006
    ..We also discuss briefly a few examples in which no clear consensus has yet been reached as to the specificity of a given domain or protein because of discrepancies between different commonly used approaches...
  28. ncbi request reprint Pleckstrin homology domains and the cytoskeleton
    Mark A Lemmon
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, 809C Stellar Chance Laboratories, 422 Curie Boulevard, Philadelphia, PA 19104 6059, USA
    FEBS Lett 513:71-6. 2002
    ....
  29. ncbi request reprint Protein kinase C regulation: C1 meets C-tail
    Marcelo G Kazanietz
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Structure 19:144-6. 2011
    ..2011) describe the structure of PKCĪ²II, an AGC kinase, revealing an unanticipated intramolecular autoinhibitory interaction between its C-terminal tail and the diacylglycerol and phorbol ester binding site of its C1b domain...
  30. pmc ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation
    Fumin Shi
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:7692-7. 2010
    ..These findings suggest that ErbB3 kinase activity within receptor dimers may be crucial for signaling and could represent an important therapeutic target...
  31. pmc Essential role for Rac in heregulin beta1 mitogenic signaling: a mechanism that involves epidermal growth factor receptor and is independent of ErbB4
    Chengfeng Yang
    Department of Pharmacology, University of Pennsylvania School of Medicine, 816 Biomedical Research Building II III, 421 Curie Blvd, Philadelphia, PA 19104 6160, USA
    Mol Cell Biol 26:831-42. 2006
    ....
  32. pmc N-terminal domains elicit formation of functional Pmel17 amyloid fibrils
    BRENDA WATT
    Departments of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 284:35543-55. 2009
    ..These data define the structural core of Pmel17 amyloid, imply that the RPT domain plays a regulatory role in timing amyloid conversion, and suggest that fibril formation might be physically linked with multivesicular body sorting...
  33. pmc The Dbs PH domain contributes independently to membrane targeting and regulation of guanine nucleotide-exchange activity
    Mark A Baumeister
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Biochem J 400:563-72. 2006
    ..Thus, we suggest that the PH domain plays dual roles, contributing independently to membrane localization of Dbs (as part of a multi-domain interaction) and allosteric regulation of the DH domain...
  34. ncbi request reprint Genome-wide analysis of signaling domain function
    Jong W Yu
    Graduate Group in Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Curr Opin Chem Biol 7:103-9. 2003
    ..These reports suggest, for some domains at least, that the prospect of generating 'wiring diagrams' with this simple approach is feasible...
  35. ncbi request reprint Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting
    Mark A Baumeister
    Department of Biochemistry and Biophysics and the Graduate Group in Immunology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 278:11457-64. 2003
    ..We suggest instead that ligand binding to the PH domain induces conformational and/or orientational changes at the membrane surface that are required for maximum exchange activity of its adjacent DH domain...
  36. pmc Dynamin GTPase regulation is altered by PH domain mutations found in centronuclear myopathy patients
    Jon A Kenniston
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    EMBO J 29:3054-67. 2010
    ..Our data suggest that changes in the PH domain may couple lipid binding to dynamin GTPase activation at sites of vesicle invagination...
  37. ncbi request reprint Normalization of nomenclature for peptide motifs as ligands of modular protein domains
    Rein Aasland
    Department of Molecular Biology, University of Bergen, 5020 Bergen, Norway
    FEBS Lett 513:141-4. 2002
    ..This proposal will be reviewed in the future and will therefore be open for the inclusion of new rules, modifications and changes...
  38. ncbi request reprint Phosphoinositide binding by the pleckstrin homology domains of Ipl and Tih1
    Anjana Saxena
    Institute for Cancer Genetics, Department of Pathology, Columbia University, 1150 St Nicholas Avenue, New York, NY 10032, USA
    J Biol Chem 277:49935-44. 2002
    ..Thus, Ipl and Tih1 are bona fide PH domain proteins, with broad specificity and moderate affinity for PIPs...
  39. ncbi request reprint An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors
    Antony W Burgess
    Cooperative Research Centre for Cellular Growth Factors, P O Box 2008, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Mol Cell 12:541-52. 2003
    ..We outline a mechanistic view of ErbB receptor homo- and heterodimerization, which suggests new approaches for interfering with these processes when they are implicated in human cancers...
  40. ncbi request reprint Specificity of the myotubularin family of phosphatidylinositol-3-phosphatase is determined by the PH/GRAM domain
    Papiya Choudhury
    Department of Medicine, The Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    J Biol Chem 281:31762-9. 2006
    ..Identifying the specific binding partners of the CC and PH/G domains on other MTMs will provide important clues to the specific functions regulated by other MTMs as well as the mechanism(s) whereby loss of some MTMs lead to disease...
  41. pmc The tethered configuration of the EGF receptor extracellular domain exerts only a limited control of receptor function
    Dawn Mattoon
    Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 101:923-8. 2004
    ..Furthermore, the autoinhibition conferred by the tethered configuration of the extracellular ligand-binding domain provides only a limited control of EGFR function...
  42. pmc A structure-based model for ligand binding and dimerization of EGF receptors
    Peter Klein
    Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 101:929-34. 2004
    ..However, these extended receptors do not correspond directly with the "high-affinity" EGF-binding sites seen in EGF-binding studies on intact cells...
  43. ncbi request reprint The p21-activated protein kinase-related kinase Cla4 is a coincidence detector of signaling by Cdc42 and phosphatidylinositol 4-phosphate
    Angela C Wild
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 279:17101-10. 2004
    ..In mammalian cells, the myotonic dystrophy-related Cdc42-binding kinase possesses p21-binding and PH domains, suggesting that this kinase may be a coincidence detector of signaling by Cdc42 and phosphoinositides...
  44. pmc Membrane activity of the phospholipase C-delta1 pleckstrin homology (PH) domain
    Frits M Flesch
    Department of Molecular Cell Biology, Faculty of Biology, Institute of Biomembranes, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Biochem J 389:435-41. 2005
    ..This is the first report of membrane activity in an isolated PH domain and has implications for understanding the membrane targeting by this common type of domain...
  45. ncbi request reprint Computational analysis of EGFR inhibition by Argos
    Gregory T Reeves
    Department of Chemical Engineering, Princeton University, Princeton, NJ 08544, USA Lewis Sigler Institute for Integrative Genomics, Princeton University, Carl Icahn Laboratory, Washington Road, Princeton, NJ 08544, USA
    Dev Biol 284:523-35. 2005
    ..Thus, the spatial range of Argos does not have to be tightly regulated or may act at different ranges in distinct developmental contexts...
  46. pmc Mechanism of activation and inhibition of the HER4/ErbB4 kinase
    Chen Qiu
    Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Structure 16:460-7. 2008
    ..These results demonstrate that key elements of kinase activation and inhibition are conserved among ErbB family members...
  47. ncbi request reprint Palmitoylation of the EGFR ligand Spitz by Rasp increases Spitz activity by restricting its diffusion
    Grant I Miura
    Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Dev Cell 10:167-76. 2006
    ..These data suggest a role for palmitoylation in restricting Spitz diffusion, allowing its local concentration to reach the threshold required for biological function...
  48. pmc On the nature of low- and high-affinity EGF receptors on living cells
    Ferruh Ozcan
    Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 103:5735-40. 2006
    ....
  49. ncbi request reprint Nuclear signaling by receptor tyrosine kinases: the first robin of spring
    Joseph Schlessinger
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 127:45-8. 2006
    ..The fragment forms a complex with the adaptor TAB2 and the corepressor N-CoR and transits to the nucleus, where it represses transcription of genes that promote the formation of astrocytes...
  50. pmc Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors
    Stephen K Dove
    School of Biosciences, University of Birmingham, Birmingham, UK
    EMBO J 23:1922-33. 2004
    ..Svp1p is not involved in the contributions of FAB1/PtdIns(3,5)P2 to MVB sorting or to vacuole acidification and so additional PtdIns(3,5)P2 effectors must exist...
  51. ncbi request reprint SH2 and PTB domains in tyrosine kinase signaling
    Joseph Schlessinger
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA
    Sci STKE 2003:RE12. 2003
    ....
  52. ncbi request reprint Phosphatidylinositol 3,5-bisphosphate: metabolism and cellular functions
    Robert H Michell
    School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
    Trends Biochem Sci 31:52-63. 2006
    ....

Research Grants35

  1. SPECIFICITY OF DOMAIN INTERACTIONS IN CELL SIGNALING
    Mark Lemmon; Fiscal Year: 2006
    ..abstract_text> ..
  2. ErbB receptor homo- and hetero-dimerization
    Mark A Lemmon; Fiscal Year: 2010
    ..We anticipate that the mechanistic insight provided by our proposed research will stimulate work towards a new generation of more sophisticated ErbB receptor-targeted therapeutics. ..
  3. SPECIFICITY OF DOMAIN INTERACTIONS IN CELL SIGNALING
    Mark Lemmon; Fiscal Year: 2009
    ..In parallel, we will map orthologous interactions in mammalian cells, establishing a new paradigm for PH domains that resembles the role of SH2, and SH3 domains. ..
  4. Mechanisms of dynamin family GTPases
    Mark Lemmon; Fiscal Year: 2007
    ..We will also investigate the structural basis for cardiolipin recognition. Together, these studies promise to provide valuable insight into the mechanisms of action of these important large GTPases. ..
  5. ERBB RECEPTOR HOMO- AND HETERO- DIMERIZATION
    Mark Lemmon; Fiscal Year: 2003
    ..By understanding this, we hope that approaches will be suggested for modulating erbB receptor signaling when it is disrupted in human cancers. ..
  6. SPECIFICITY OF DOMAIN INTERACTIONS IN CELL SIGNALING
    Mark Lemmon; Fiscal Year: 1999
    ..These studies will provide a fuller understanding of the way these small domains participate in recruitment of signaling molecules to the membrane surface following activation of cell-surface receptors. ..
  7. ErbB Receptor Homo-and Hetero-Dimerization
    Mark Lemmon; Fiscal Year: 2007
    ....
  8. Mechanisms of invertebrate EGF receptor inhibition
    Mark Lemmon; Fiscal Year: 2007
    ..2. A comparative mechanistic analysis of EGFR signaling inhibition by the secreted inhibitor Argos and the membrane protein Kekkon-1. ..
  9. ErbB receptor homo- and hetero-dimerization
    Mark Lemmon; Fiscal Year: 2009
    ..We anticipate that the mechanistic insight provided by our proposed research will stimulate work towards a new generation of more sophisticated ErbB receptor-targeted therapeutics. ..
  10. Mechanisms of invertebrate EGF receptor inhibition
    Mark Lemmon; Fiscal Year: 2009
    ..2. A comparative mechanistic analysis of EGFR signaling inhibition by the secreted inhibitor Argos and the membrane protein Kekkon-1. ..
  11. Mechanisms of dynamin family GTPases
    Mark A Lemmon; Fiscal Year: 2010
    ..We will also investigate the structural basis for cardiolipin recognition. Together, these studies promise to provide valuable insight into the mechanisms of action of these important large GTPases. ..
  12. ErbB receptor homo- and hetero-dimerization
    Mark Lemmon; Fiscal Year: 2009
    ..Inclusion of ErbB3-targeted agents with Herceptin and/or Tykerb should significantly improve the response rate to these drugs in a variety of different regimens. ..
  13. Mechanisms of invertebrate EGF receptor inhibition
    Mark A Lemmon; Fiscal Year: 2010
    ..2. A comparative mechanistic analysis of EGFR signaling inhibition by the secreted inhibitor Argos and the membrane protein Kekkon-1. ..
  14. Mechanisms of ErbB2/HER2/Neu Activation
    Mark Lemmon; Fiscal Year: 2006
    ..3. To determine which portions of erbB receptors are required for interactions that cause transmodulation. ..
  15. ErbB Receptor Homo-and Hetero-Dimerization
    Mark Lemmon; Fiscal Year: 2006
    ....
  16. SPECIFICITY OF DOMAIN INTERACTIONS IN CELL SIGNALING
    Mark Lemmon; Fiscal Year: 2005
    ..abstract_text> ..
  17. ERBB RECEPTOR HOMO- AND HETERO- DIMERIZATION
    Mark Lemmon; Fiscal Year: 2001
    ..By understanding this, we hope that approaches will be suggested for modulating erbB receptor signaling when it is disrupted in human cancers. ..
  18. Mechanisms of ErbB2/HER2/Neu Activation
    Mark Lemmon; Fiscal Year: 2002
    ..3. To determine which portions of erbB receptors are required for interactions that cause transmodulation. ..
  19. SPECIFICITY OF DOMAIN INTERACTIONS IN CELL SIGNALING
    Mark Lemmon; Fiscal Year: 2002
    ..These studies will provide a fuller understanding of the way these small domains participate in recruitment of signaling molecules to the membrane surface following activation of cell-surface receptors. ..
  20. ErbB Receptor Homo-and Hetero-Dimerization
    Mark Lemmon; Fiscal Year: 2004
    ....
  21. Mechanisms of ErbB2/HER2/Neu Activation
    Mark Lemmon; Fiscal Year: 2004
    ..3. To determine which portions of erbB receptors are required for interactions that cause transmodulation. ..
  22. Mechanisms of ErbB2/HER2/Neu Activation
    Mark Lemmon; Fiscal Year: 2005
    ..3. To determine which portions of erbB receptors are required for interactions that cause transmodulation. ..
  23. SPECIFICITY OF DOMAIN INTERACTIONS IN CELL SIGNALING
    Mark A Lemmon; Fiscal Year: 2010
    ..In parallel, we will map orthologous interactions in mammalian cells, establishing a new paradigm for PH domains that resembles the role of SH2, and SH3 domains. ..
  24. SPECIFICITY OF DOMAIN INTERACTIONS IN CELL SIGNALING
    Mark Lemmon; Fiscal Year: 2004
    ..abstract_text> ..
  25. SPECIFICITY OF DOMAIN INTERACTIONS IN CELL SIGNALING
    Mark Lemmon; Fiscal Year: 2001
    ..These studies will provide a fuller understanding of the way these small domains participate in recruitment of signaling molecules to the membrane surface following activation of cell-surface receptors. ..
  26. ErbB Receptor Homo-and Hetero-Dimerization
    Mark Lemmon; Fiscal Year: 2005
    ....
  27. Mechanisms of dynamin family GTPases
    Mark Lemmon; Fiscal Year: 2009
    ..We will also investigate the structural basis for cardiolipin recognition. Together, these studies promise to provide valuable insight into the mechanisms of action of these important large GTPases. ..
  28. Mechanisms of ErbB2/HER2/Neu Activation
    Mark Lemmon; Fiscal Year: 2003
    ..3. To determine which portions of erbB receptors are required for interactions that cause transmodulation. ..
  29. SPECIFICITY OF DOMAIN INTERACTIONS IN CELL SIGNALING
    Mark Lemmon; Fiscal Year: 2003
    ..abstract_text> ..
  30. SPECIFICITY OF DOMAIN INTERACTIONS IN CELL SIGNALING
    Mark Lemmon; Fiscal Year: 2000
    ..These studies will provide a fuller understanding of the way these small domains participate in recruitment of signaling molecules to the membrane surface following activation of cell-surface receptors. ..
  31. ERBB RECEPTOR HOMO- AND HETERO- DIMERIZATION
    Mark Lemmon; Fiscal Year: 2000
    ..By understanding this, we hope that approaches will be suggested for modulating erbB receptor signaling when it is disrupted in human cancers. ..
  32. ERBB RECEPTOR HOMO- AND HETERO- DIMERIZATION
    Mark Lemmon; Fiscal Year: 2002
    ..By understanding this, we hope that approaches will be suggested for modulating erbB receptor signaling when it is disrupted in human cancers. ..