Kevin V Lemley

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. doi request reprint Protecting podocytes: how good do we need to be?
    Kevin V Lemley
    Division of Nephrology, Children s Hospital Los Angeles, Los Angeles, California 90027, USA
    Kidney Int 81:9-11. 2012
  2. ncbi request reprint An introduction to biomarkers: applications to chronic kidney disease
    Kevin V Lemley
    Division of Nephrology MS 40, Childrens Hospital Los Angeles, 4650 Sunset Blvd, Los Angeles, CA 90027, USA
    Pediatr Nephrol 22:1849-59. 2007
  3. doi request reprint When to initiate ACEI/ARB therapy in patients with type 1 and 2 diabetes
    Kevin V Lemley
    Division of Nephrology, MS 40, Childrens Hospital Los Angeles, 4650 Sunset Boulevard, Los Angeles, CA 90027, USA
    Pediatr Nephrol 25:2021-34. 2010
  4. pmc Kidney disease in nail-patella syndrome
    Kevin V Lemley
    Division of Nephrology, MS 40, Childrens Hospital Los Angeles, 4650 Sunset Blvd, Los Angeles, CA 90027, USA
    Pediatr Nephrol 24:2345-54. 2009
  5. doi request reprint Diabetes and chronic kidney disease: lessons from the Pima Indians
    Kevin V Lemley
    Division of Nephrology, Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    Pediatr Nephrol 23:1933-40. 2008
  6. ncbi request reprint Prediction of early progression in recently diagnosed IgA nephropathy
    Kevin V Lemley
    Division of Nephrology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Nephrol Dial Transplant 23:213-22. 2008
  7. pmc Injection of amniotic fluid stem cells delays progression of renal fibrosis
    Sargis Sedrakyan
    GOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics, Children s Hospital Los Angeles, Division of Urology, Saban Research Institute, University of Southern California, Los Angeles, California 90027, USA
    J Am Soc Nephrol 23:661-73. 2012
  8. ncbi request reprint Modeling GFR trajectories in diabetic nephropathy
    Kevin V Lemley
    Division of Pediatric Nephrology, Stanford Univ School of Medicine, Stanford, CA 94305 5208, USA
    Am J Physiol Renal Physiol 289:F863-70. 2005
  9. ncbi request reprint Determinants of glomerular hypofiltration in aging humans
    Khoi Hoang
    Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
    Kidney Int 64:1417-24. 2003
  10. ncbi request reprint Podocytopenia and disease severity in IgA nephropathy
    Kevin V Lemley
    Division of Pediatric Nephrology, Stanford University School of Medicine, Stanford, California 94305 5208, USA
    Kidney Int 61:1475-85. 2002

Research Grants

Collaborators

Detail Information

Publications16

  1. doi request reprint Protecting podocytes: how good do we need to be?
    Kevin V Lemley
    Division of Nephrology, Children s Hospital Los Angeles, Los Angeles, California 90027, USA
    Kidney Int 81:9-11. 2012
    ..Quantitative monitoring of podocyte loss (e.g., to assess therapy) remains a challenge...
  2. ncbi request reprint An introduction to biomarkers: applications to chronic kidney disease
    Kevin V Lemley
    Division of Nephrology MS 40, Childrens Hospital Los Angeles, 4650 Sunset Blvd, Los Angeles, CA 90027, USA
    Pediatr Nephrol 22:1849-59. 2007
    ..It is likely that clinical practice will come to depend increasingly on multiplex (vector) biomarkers used in conjunction with risk markers in early diagnosis as well as to guide therapy...
  3. doi request reprint When to initiate ACEI/ARB therapy in patients with type 1 and 2 diabetes
    Kevin V Lemley
    Division of Nephrology, MS 40, Childrens Hospital Los Angeles, 4650 Sunset Boulevard, Los Angeles, CA 90027, USA
    Pediatr Nephrol 25:2021-34. 2010
    ..Recent studies suggest that very early initiation of ACEI/ARB therapy may not have demonstrable beneficial effects even over a period of years...
  4. pmc Kidney disease in nail-patella syndrome
    Kevin V Lemley
    Division of Nephrology, MS 40, Childrens Hospital Los Angeles, 4650 Sunset Blvd, Los Angeles, CA 90027, USA
    Pediatr Nephrol 24:2345-54. 2009
    ..g. NPHS2, CD2AP), the transription of which is regulated by LMX1B...
  5. doi request reprint Diabetes and chronic kidney disease: lessons from the Pima Indians
    Kevin V Lemley
    Division of Nephrology, Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    Pediatr Nephrol 23:1933-40. 2008
    ..At this point, most evidence in humans suggests detachment of intact podocytes from the glomerular basement membrane, rather than apoptosis, as the predominant mechanism of podocyte loss...
  6. ncbi request reprint Prediction of early progression in recently diagnosed IgA nephropathy
    Kevin V Lemley
    Division of Nephrology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Nephrol Dial Transplant 23:213-22. 2008
    ..Most studies of prognosis in IgA nephropathy (IgAN) have tried to predict dichotomous outcomes based on a small number of clinical or semi-quantitative histological variables in large numbers of patients...
  7. pmc Injection of amniotic fluid stem cells delays progression of renal fibrosis
    Sargis Sedrakyan
    GOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics, Children s Hospital Los Angeles, Division of Urology, Saban Research Institute, University of Southern California, Los Angeles, California 90027, USA
    J Am Soc Nephrol 23:661-73. 2012
    ..In conclusion, treatment with amniotic fluid stem cells may be beneficial in kidney diseases characterized by progressive renal fibrosis...
  8. ncbi request reprint Modeling GFR trajectories in diabetic nephropathy
    Kevin V Lemley
    Division of Pediatric Nephrology, Stanford Univ School of Medicine, Stanford, CA 94305 5208, USA
    Am J Physiol Renal Physiol 289:F863-70. 2005
    ....
  9. ncbi request reprint Determinants of glomerular hypofiltration in aging humans
    Khoi Hoang
    Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
    Kidney Int 64:1417-24. 2003
    ..The purpose of the present study was to confirm the extent to which glomerular filtration rate (GFR) is depressed in healthy, aging subjects and to elucidate the mechanism of such hypofiltration...
  10. ncbi request reprint Podocytopenia and disease severity in IgA nephropathy
    Kevin V Lemley
    Division of Pediatric Nephrology, Stanford University School of Medicine, Stanford, California 94305 5208, USA
    Kidney Int 61:1475-85. 2002
    ..The present study was designed to investigate functional and morphological covariates of disease severity in patients with IgA nephropathy...
  11. pmc Protective effect of human amniotic fluid stem cells in an immunodeficient mouse model of acute tubular necrosis
    Laura Perin
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Childrens Hospital Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e9357. 2010
    ..We therefore speculate that AFSC could represent a novel source of stem cells that may function to modulate the kidney immune milieu in renal failure caused by ATN...
  12. pmc Gene expression in the normal adult human kidney assessed by complementary DNA microarray
    John P T Higgins
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Mol Biol Cell 15:649-56. 2004
    ..The distinctive patterns of gene expression in discrete portions of the kidney may serve as a resource for further understanding of renal physiology and the molecular and cellular organization of the nephron...
  13. pmc Urinary excretion of viable podocytes in health and renal disease
    Stefanie U Vogelmann
    Division of Nephrology, Department of Medicine, Stanford University School of Medicine, CA 94305, USA
    Am J Physiol Renal Physiol 285:F40-8. 2003
    ....
  14. ncbi request reprint Neonatal nephrotic presentation of a child with heterozygous NPHS1 mutation
    Kevin V Lemley
    Division of Nephrology, S161, Stanford University Medical Center, Stanford, CA 94305 5114, USA
    Pediatr Nephrol 21:864-6. 2006
    ....
  15. ncbi request reprint National Kidney Foundation's Kidney Disease Outcomes Quality Initiative clinical practice guidelines for chronic kidney disease in children and adolescents: evaluation, classification, and stratification
    Ronald J Hogg
    North Texas Hospital for Children and the Department of Clinical Research at Medical City Dallas Hospital, Dallas, Texas 75230, USA
    Pediatrics 111:1416-21. 2003
    ....
  16. ncbi request reprint The effect of dopamine on glomerular filtration rate in normotensive, oliguric premature neonates
    Susan K Lynch
    Department of Pediatrics, West Virginia University School of Medicine, West Virginia, USA
    Pediatr Nephrol 18:649-52. 2003
    ..5 micro g/kg per min of dopamine. This probably reflects the effects of afferent vasodilatation and may be important clinically when enhancement of GFR is the major treatment objective...

Research Grants1

  1. Urinary Podocyte Excretion Using FACS Methodology
    Kevin Lemley; Fiscal Year: 2003
    ..e. is podocyturia an earlier biomarker of incipient nephropathy? and 2) do the responses of albuminuria and podocyturia to treatment with angiotensin-converting enzyme inhibitors differ? ..