R F Lemanske

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Distribution and seasonality of rhinovirus and other respiratory viruses in a cross-section of asthmatic children in Trinidad, West Indies
    Jason Matthew
    Department of Para Clinical Sciences, The University of the West Indies, St Augustine, Trinidad and Tobago
    Ital J Pediatr 35:16. 2009
  2. pmc Inhaled corticosteroid use is associated with increased circulating T regulatory cells in children with asthma
    Anne Marie Singh
    Departments of Pediatrics, University of Wisconsin, 1111 Highland Avenue, 4139 WIMR, Madison, WI 53705 2275, USA
    Clin Mol Allergy 11:1. 2013
  3. pmc A rat model of picornavirus-induced airway infection and inflammation
    Louis A Rosenthal
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI 53792, USA
    Virol J 6:122. 2009
  4. ncbi request reprint The childhood origins of asthma (COAST) study
    Robert F Lemanske
    University of Wisconsin Madison Medical School, Madison, WI, USA
    Pediatr Allergy Immunol 13:38-43. 2002
  5. ncbi request reprint Viruses and asthma: Inception, exacerbation, and possible prevention
    Robert F Lemanske
    Division of Pediatric Allergy, Immunology, and Rheumatology, Department of Pediatrics, University of Wisconsin Medical School, Madison 53792, USA
    J Pediatr 142:S3-7; discussion S7-8. 2003
  6. ncbi request reprint 6. Asthma: Factors underlying inception, exacerbation, and disease progression
    Robert F Lemanske
    Departments of Pediatrics and Medicine, University Hospital, University of Wisconsin Medical School, 600 Highland Avenue K4 916, Madison, WI 43792, USA
    J Allergy Clin Immunol 117:S456-61. 2006
  7. ncbi request reprint Gene by environment interactions in respiratory tract diseases
    Robert F Lemanske
    University of Wisconsin, School of Medicine and Public Health, Madison, WI, USA
    Paediatr Respir Rev 7:S88-9. 2006
  8. ncbi request reprint Omalizumab improves asthma-related quality of life in children with allergic asthma
    Robert F Lemanske
    University of Wisconsin, Madison, Wisconsin 53792, USA
    Pediatrics 110:e55. 2002
  9. ncbi request reprint Viral infections and asthma inception
    Robert F Lemanske
    Departments of Pediatrics and Medicine, Division of Pediatric Allergy, Immunology, and Rheumatology, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA
    J Allergy Clin Immunol 114:1023-6. 2004
  10. pmc Asthma therapies revisited: what have we learned?
    Robert F Lemanske
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    Proc Am Thorac Soc 6:312-5. 2009

Research Grants

  1. Treatment of Severe Persistent Asthma
    ROBERT LEMANSKE; Fiscal Year: 2007
  2. CARE Network - Madison Clinical Center
    ROBERT LEMANSKE; Fiscal Year: 2007
  3. ASTHMA CLINICAL RESEARCH NETWORK
    ROBERT LEMANSKE; Fiscal Year: 2002
  4. CYTOKINE DYSREGULATION, VIRUSES, AND CHILDHOOD ASTHMA
    ROBERT LEMANSKE; Fiscal Year: 2001
  5. Investigating Effects of Viral Infection on Lung Development
    Xin Sun; Fiscal Year: 2010

Detail Information

Publications91

  1. pmc Distribution and seasonality of rhinovirus and other respiratory viruses in a cross-section of asthmatic children in Trinidad, West Indies
    Jason Matthew
    Department of Para Clinical Sciences, The University of the West Indies, St Augustine, Trinidad and Tobago
    Ital J Pediatr 35:16. 2009
    ..We examined the distribution of respiratory viruses and their association with seasons in acute and stable asthmatic children in Trinidad...
  2. pmc Inhaled corticosteroid use is associated with increased circulating T regulatory cells in children with asthma
    Anne Marie Singh
    Departments of Pediatrics, University of Wisconsin, 1111 Highland Avenue, 4139 WIMR, Madison, WI 53705 2275, USA
    Clin Mol Allergy 11:1. 2013
    ..The secondary aim was to explore the association between Treg cell frequency with allergen sensitization, disease severity and medication use...
  3. pmc A rat model of picornavirus-induced airway infection and inflammation
    Louis A Rosenthal
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI 53792, USA
    Virol J 6:122. 2009
    ....
  4. ncbi request reprint The childhood origins of asthma (COAST) study
    Robert F Lemanske
    University of Wisconsin Madison Medical School, Madison, WI, USA
    Pediatr Allergy Immunol 13:38-43. 2002
    ..Efforts to determine and define the importance of these three factors to asthma pathogenesis are the focus and goal of the COAST (Childhood Origins of Asthma) project...
  5. ncbi request reprint Viruses and asthma: Inception, exacerbation, and possible prevention
    Robert F Lemanske
    Division of Pediatric Allergy, Immunology, and Rheumatology, Department of Pediatrics, University of Wisconsin Medical School, Madison 53792, USA
    J Pediatr 142:S3-7; discussion S7-8. 2003
    ..This review discusses these associations as they pertain to both the pathogenesis and treatment of childhood asthma...
  6. ncbi request reprint 6. Asthma: Factors underlying inception, exacerbation, and disease progression
    Robert F Lemanske
    Departments of Pediatrics and Medicine, University Hospital, University of Wisconsin Medical School, 600 Highland Avenue K4 916, Madison, WI 43792, USA
    J Allergy Clin Immunol 117:S456-61. 2006
    ..Unfortunately, despite the availability of effective therapies, suboptimal asthma control exists in many patients on a worldwide basis. The future development of novel therapies and treatment paradigms should address these disparities...
  7. ncbi request reprint Gene by environment interactions in respiratory tract diseases
    Robert F Lemanske
    University of Wisconsin, School of Medicine and Public Health, Madison, WI, USA
    Paediatr Respir Rev 7:S88-9. 2006
  8. ncbi request reprint Omalizumab improves asthma-related quality of life in children with allergic asthma
    Robert F Lemanske
    University of Wisconsin, Madison, Wisconsin 53792, USA
    Pediatrics 110:e55. 2002
    ..Here we report the effects of treatment with omalizumab on asthma-related quality of life (AQoL) in children with allergic asthma...
  9. ncbi request reprint Viral infections and asthma inception
    Robert F Lemanske
    Departments of Pediatrics and Medicine, Division of Pediatric Allergy, Immunology, and Rheumatology, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA
    J Allergy Clin Immunol 114:1023-6. 2004
    ..This review will highlight available data on respiratory syncytial virus infections and their relationship to asthma inception in childhood...
  10. pmc Asthma therapies revisited: what have we learned?
    Robert F Lemanske
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    Proc Am Thorac Soc 6:312-5. 2009
    ..These research approaches can be categorized into three questions. Who is the right patient to treat? When is the right time to begin treatment? And finally, what is the appropriate treatment to prescribe?..
  11. pmc Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroids
    Robert F Lemanske
    University of Wisconsin School of Medicine and Public Health, Madison, USA
    N Engl J Med 362:975-85. 2010
    ..For children who have uncontrolled asthma despite the use of low-dose inhaled corticosteroids (ICS), evidence to guide step-up therapy is lacking...
  12. ncbi request reprint Inflammation in childhood asthma and other wheezing disorders
    Robert F Lemanske
    Department of Pediatrics and Medicine, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    Pediatrics 109:368-72. 2002
    ..Although progress has been made in the differential diagnoses of asthma in young children, more research is needed to define unique markers for distinguishing asthma from other respiratory conditions that produce wheezing...
  13. ncbi request reprint Choosing therapy for childhood asthma
    R F Lemanske
    University of Wisconsin Children s Hospital, H4 432, 600 Highland Avenue, Madison, WI 53792, USA
    Paediatr Drugs 3:915-25. 2001
    ..The anti-immunoglobulin E antibody, omalizumab, is a novel therapy that attacks a fundamental immunopathological process of asthma and has shown promising results in several clinical trials...
  14. pmc Asthma: clinical expression and molecular mechanisms
    Robert F Lemanske
    Department of Pediatrics, University of Wisconsin Medical School, Madison, Wis, USA
    J Allergy Clin Immunol 125:S95-102. 2010
    ..This review will highlight some of the important clinical features of asthma and emphasize recent advances in both pathophysiology and treatment...
  15. ncbi request reprint Inhaled corticosteroid reduction and elimination in patients with persistent asthma receiving salmeterol: a randomized controlled trial
    R F Lemanske
    University of Wisconsin Children s Hospital, 600 Highland Ave, K4 916 9988, Madison, WI 53792, USA
    JAMA 285:2594-603. 2001
    ..Inhaled long-acting beta(2)-agonists improve asthma control when added to inhaled corticosteroid (ICS) therapy...
  16. ncbi request reprint Characterization of within-subject responses to fluticasone and montelukast in childhood asthma
    Stanley J Szefler
    Department of Pediatrics, National Jewish Medical and Research Medical Center and University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 115:233-42. 2005
    ..Responses to inhaled corticosteroids (ICSs) and leukotriene receptor antagonists (LTRAs) vary among asthmatic patients...
  17. pmc Episodic use of an inhaled corticosteroid or leukotriene receptor antagonist in preschool children with moderate-to-severe intermittent wheezing
    Leonard B Bacharier
    Department of Pediatrics, Washington University and St Louis Children s Hospital, St Louis, MO 63110, USA
    J Allergy Clin Immunol 122:1127-1135.e8. 2008
    ..Acute wheezing illnesses in preschoolers require better management strategies to reduce morbidity...
  18. pmc Signs and symptoms that precede wheezing in children with a pattern of moderate-to-severe intermittent wheezing
    Katherine Rivera-Spoljaric
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110 1077, USA
    J Pediatr 154:877-81.e4. 2009
    ..To examine parent-reported signs and symptoms as antecedents of wheezing in preschool children with previous moderate to severe wheezing episodes, and to determine the predictive capacity of these symptom patterns for wheezing events...
  19. pmc Specific patterns of allergic sensitization in early childhood and asthma & rhinitis risk
    D J Stoltz
    University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Clin Exp Allergy 43:233-41. 2013
    ..Specific patterns of allergic sensitization as well as quantification of the in vitro IgE response in early life may provide relevant clinical insight into future rhinitis and asthma risk...
  20. ncbi request reprint Response profiles to fluticasone and montelukast in mild-to-moderate persistent childhood asthma
    Robert S Zeiger
    Department of Pediatrics, University of California San Diego, San Diego, CA 92111, USA
    J Allergy Clin Immunol 117:45-52. 2006
    ..Outcome data are needed to base recommendations for controller asthma medication use in school-aged children...
  21. ncbi request reprint Sex-related differences in immune development and the expression of atopy in early childhood
    Sara J Uekert
    Department of Pediatrics, University of Wisconsin Madison, Madison, WI, USA
    J Allergy Clin Immunol 118:1375-81. 2006
    ..Sex and age are known to influence the clinical expression of asthma and allergic diseases...
  22. pmc Azithromycin or montelukast as inhaled corticosteroid-sparing agents in moderate-to-severe childhood asthma study
    Robert C Strunk
    Department of Pediatrics, Washington University and St Louis Children s Hospital, St Louis, MO 63110, USA
    J Allergy Clin Immunol 122:1138-1144.e4. 2008
    ..Clinical trials in children with moderate-to-severe persistent asthma are limited...
  23. doi request reprint Impulse oscillometry versus spirometry in a long-term study of controller therapy for pediatric asthma
    Gary L Larsen
    Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 123:861-7.e1. 2009
    ..Determination of the benefits and limitations of specific physiologic tests has not been well studied in long-term clinical pediatric trials...
  24. pmc Phenotypic predictors of long-term response to inhaled corticosteroid and leukotriene modifier therapies in pediatric asthma
    Jason E Knuffman
    Schools of Medicine and Pharmacy, University of Wisconsin, Madison, Wis, USA
    J Allergy Clin Immunol 123:411-6. 2009
    ..In children with mild-to-moderate persistent asthma, identification of phenotypic predictors to guide selection of a controller regimen is essential...
  25. ncbi request reprint Significant variability in response to inhaled corticosteroids for persistent asthma
    Stanley J Szefler
    National Jewish Medical and Research Center, Department of Pediatrics, Denver, CO 80206, USA
    J Allergy Clin Immunol 109:410-8. 2002
    ..A clinical model is needed to compare inhaled corticosteroids (ICSs) with respect to efficacy...
  26. pmc Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthma
    Nathan Rabinovitch
    Department of Pediatrics, National Jewish Health and the University of Colorado Denver School of Medicine, Denver, Colo 80206, USA
    J Allergy Clin Immunol 126:545-51.e1-4. 2010
    ..A subset of children with asthma respond better to leukotriene receptor antagonists than to inhaled corticosteroids. Information is needed to identify children with these preferential responses...
  27. ncbi request reprint Recruitment strategies in the Asthma Clinical Research Network
    C A Sorkness
    University of Wisconsin, Madison, WI 53792 3244, USA
    Control Clin Trials 22:222S-35S. 2001
    ..Particular attention is given to the strategies for the recruitment of women and minorities. Finally, the specific strategies of each of the six ACRN clinical centers are presented...
  28. doi request reprint Effects of dog ownership in early childhood on immune development and atopic diseases
    J D Bufford
    Department of Allergy, Marshfield Clinic, Marshfield, WI, USA
    Clin Exp Allergy 38:1635-43. 2008
    ..Exposure to pets in childhood has been associated with a reduced risk of wheezing and atopy...
  29. ncbi request reprint No growth suppression in children treated with the maximum recommended dose of fluticasone propionate aqueous nasal spray for one year
    David B Allen
    University of Wisconsin Children s Hospital, 600 Highland Ave, Madison, Wisconsin 53792, USA
    Allergy Asthma Proc 23:407-13. 2002
    ....
  30. ncbi request reprint Developmental cytokine response profiles and the clinical and immunologic expression of atopy during the first year of life
    William A Neaville
    Department of Pediatrics, University of Wisconsin Madison, USA
    J Allergy Clin Immunol 112:740-6. 2003
    ..Allergic diseases have been linked to abnormal patterns of immune development, and this has stimulated efforts to define the precise patterns of cytokine dysregulation that are associated with specific atopic phenotypes...
  31. ncbi request reprint Origins and treatment of airway inflammation in childhood asthma
    R F Lemanske
    Departments of Pediatrics and Medicine, University of Wisconsin Medical School, Madison, Wisconsin, USA
    Pediatr Pulmonol Suppl 21:17-25. 2001
    ..Therapeutic trials using LTRAs in children should prove beneficial...
  32. ncbi request reprint Chronic postbronchiolitis airway instability induced with anti-IFN-gamma antibody in F344 rats
    Ronald L Sorkness
    Division of Allergy and Immunology, Department of Medicine, University of Wisconsin, Madison, Wisconsin 53792, USA
    Pediatr Res 52:382-6. 2002
    ..The presence of premature airway closure that is independent of airway wall inflammation or changes in lung elastic recoil suggests peripheral airway instability as a mechanism for the airway obstruction...
  33. ncbi request reprint Viral infections, cytokine dysregulation and the origins of childhood asthma and allergic diseases
    Samuel L Friedlander
    Department of Medicine, Wisconsin State Laboratory of Hygiene, University of Wisconsin, Madison, WI, USA
    Pediatr Infect Dis J 24:S170-6, discussion S174-5. 2005
    ..The origins of asthma and allergic disease begin in early life for many individuals. It is vital to understand the factors and/or events leading to their development...
  34. ncbi request reprint Bidirectional interactions between viral respiratory illnesses and cytokine responses in the first year of life
    James E Gern
    Department of Pediatrics, University of Wisconsin Hospital, 600 Highland Avenue, Madison, WI 53792, USA
    J Allergy Clin Immunol 117:72-8. 2006
    ..Viral infections are the major cause of acute wheezing illnesses in childhood. Variations in immunologic responses at birth may be determinants of the risk of acquiring these illnesses...
  35. pmc Patient characteristics associated with improved outcomes with use of an inhaled corticosteroid in preschool children at risk for asthma
    Leonard B Bacharier
    Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, MO 63017, USA
    J Allergy Clin Immunol 123:1077-82, 1082.e1-5. 2009
    ..However, determination of baseline features associated with ICS responsiveness may identify children most likely to benefit from ICS treatment...
  36. ncbi request reprint Persistence of viral RNA in 2 rat strains differing in susceptibility to postbronchiolitis airway dysfunction
    Ronald L Sorkness
    Morris Institute for Respiratory Research, Department of Medicine, School of Pharmacy, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA
    J Allergy Clin Immunol 110:607-9. 2002
    ..The persistent increase in IL-13 suggests instead that the strain-related variability in virus-associated airway pathology might be determined by the host response to infection rather than by the intensity or duration of infection...
  37. ncbi request reprint Relationships among specific viral pathogens, virus-induced interleukin-8, and respiratory symptoms in infancy
    James E Gern
    Department of Pediatrics, University of Wisconsin Madison, USA
    Pediatr Allergy Immunol 13:386-93. 2002
    ..In contrast, for RSV and parainfluenza infections, factors in addition to IL-8 production appear to contribute to the generation of clinical symptoms...
  38. pmc Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children
    Daniel J Jackson
    Department of Pediatrics, University of Wisconsin Madison, Madison, WI, USA
    Am J Respir Crit Care Med 178:667-72. 2008
    ..Virus-induced wheezing episodes in infancy often precede the development of asthma. Whether infections with specific viral pathogens confer differential future asthma risk is incompletely understood...
  39. ncbi request reprint Infections and asthma in children
    Michelle M Montalbano
    Department of Allergy Immunology, University of Wisconsin Madison, 53792, USA
    Curr Opin Pediatr 14:334-7. 2002
    ..The following review will briefly highlight the relationships between various microbial infections and the pathophysiology of asthma...
  40. ncbi request reprint Bronchiolitis to asthma: a review and call for studies of gene-virus interactions in asthma causation
    Anne Marie Singh
    Department of Medicine, University of Wisconsin Madison, Madison, WI 53792, USA
    Am J Respir Crit Care Med 175:108-19. 2007
    ..Characterizing these relationships offers the potential of identifying at-risk hosts in whom preventing or delaying infection could alter the phenotypic expression of asthma...
  41. ncbi request reprint Long-term comparison of 3 controller regimens for mild-moderate persistent childhood asthma: the Pediatric Asthma Controller Trial
    Christine A Sorkness
    Clinical Science Center, University of Wisconsin, Madison, WI 53792, USA
    J Allergy Clin Immunol 119:64-72. 2007
    ..More evidence is needed on which to base recommendations for treatment of mild-moderate persistent asthma in school-aged children...
  42. ncbi request reprint Altered allergen-induced eosinophil trafficking and physiological dysfunction in airways with preexisting virus-induced injury
    Ronald L Sorkness
    School of Pharmacy, Department of Medicine, University of Wisconsin at Madison, 777 Highland Ave, Madison, WI 53705, USA
    Am J Physiol Lung Cell Mol Physiol 292:L85-91. 2007
    ....
  43. ncbi request reprint Infectious triggers of pediatric asthma
    James E Gern
    Department of Pediatrics, University of Wisconsin Medical School, Madison, WI 53792, USA
    Pediatr Clin North Am 50:555-75, vi. 2003
    ..In this article, the epidemiologic, mechanistic, and treatment implications of the association between respiratory infections and asthma are discussed...
  44. pmc A diverse group of previously unrecognized human rhinoviruses are common causes of respiratory illnesses in infants
    Wai Ming Lee
    Department of Pediatrics and Medicine, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS ONE 2:e966. 2007
    ..Defining the role of specific strains in various HRV illnesses has been difficult because traditional serology, which requires viral culture and neutralization tests using 101 serotype-specific antisera, is insensitive and laborious...
  45. pmc Early childhood weight status in relation to asthma development in high-risk children
    Zhumin Zhang
    Department of Nutritional Sciences, University of Wisconsin College of Agriculture and Life Sciences, Madison, WI 53706 1562, USA
    J Allergy Clin Immunol 126:1157-62. 2010
    ..Obesity has been proposed to be a risk factor for the development of childhood asthma...
  46. ncbi request reprint Cytokine response patterns, exposure to viruses, and respiratory infections in the first year of life
    Christopher C Copenhaver
    Department of Pediatrics, University of Wisconsin Hospital, Madison, WI 53792 9988, USA
    Am J Respir Crit Care Med 170:175-80. 2004
    ..Conversely, the frequency of viral infections in infancy can influence IFN-gamma responses...
  47. doi request reprint The Inhaled Steroid Treatment As Regular Therapy in Early Asthma (START) study 5-year follow-up: effectiveness of early intervention with budesonide in mild persistent asthma
    William W Busse
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, J5 219 CSC, Box 2454, 600 Highland Ave, Madison, WI 53792, USA
    J Allergy Clin Immunol 121:1167-74. 2008
    ....
  48. pmc The role of respiratory virus infections in childhood asthma inception
    Daniel J Jackson
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI 53792, USA
    Immunol Allergy Clin North Am 30:513-22, vi. 2010
    ..In this article, the authors review the impact of virus infections during early life, focusing primarily on RSV and HRV, and their potential roles in asthma inception...
  49. pmc Role of viral respiratory infections in asthma and asthma exacerbations
    William W Busse
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Lancet 376:826-34. 2010
    ....
  50. ncbi request reprint Attenuated innate mechanisms of interferon-gamma production in rats susceptible to postviral airway dysfunction
    Louis A Rosenthal
    Morris Institute for Respiratory Research, University of Wisconsin Medical School, Madison, WI 53792, USA
    Am J Respir Cell Mol Biol 30:702-9. 2004
    ..Attenuation of innate IFN-gamma-producing responses to SeV in BN weanlings may be a critical factor in their susceptibility to postbronchiolitis chronic airway dysfunction...
  51. pmc Weekly monitoring of children with asthma for infections and illness during common cold seasons
    Jaime P Olenec
    Department of Pediatrics, University of Wisconsin, Madison, WI 53792 4108, USA
    J Allergy Clin Immunol 125:1001-1006.e1. 2010
    ..Exacerbations of childhood asthma and rhinovirus infections both peak during the spring and fall, suggesting that viral infections are major contributors to seasonal asthma morbidity...
  52. ncbi request reprint Effects of viral respiratory infections on lung development and childhood asthma
    James E Gern
    Department of Pediatrics, University of Wisconsin Madison, 600 Highland Avenue, Madison, WI 53792 9988, USA
    J Allergy Clin Immunol 115:668-74; quiz 675. 2005
    ..Greater understanding of the effects of viral infections on lung development and growth in early childhood might lead to the discovery of additional strategies for the prevention of recurrent wheezing and chronic asthma...
  53. pmc Fractional exhaled nitric oxide measurements are most closely associated with allergic sensitization in school-age children
    Daniel J Jackson
    Department of Pediatrics, University of Wisconsin Madison, Madison, Wis, USA
    J Allergy Clin Immunol 124:949-53. 2009
    ..Factors affecting fractional exhaled nitric oxide (FeNO) in early childhood are incompletely understood...
  54. pmc Early life origins of asthma
    J E Gern
    Departments of Medicine and Pediatrics, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    J Clin Invest 104:837-43. 1999
  55. pmc Rhinovirus upper respiratory infection increases airway hyperreactivity and late asthmatic reactions
    R F Lemanske
    University of Wisconsin Medical School, Department of Medicine, Madison 53792
    J Clin Invest 83:1-10. 1989
    ....
  56. ncbi request reprint Effects of dog ownership and genotype on immune development and atopy in infancy
    James E Gern
    Department of Pediatrics, University of Wisconsin Madison, Madison, Wis, USA
    J Allergy Clin Immunol 113:307-14. 2004
    ..Exposure to furred pets might confer protection against the development of allergic sensitization through a mechanism that is incompletely understood...
  57. ncbi request reprint Reduced interferon-gamma secretion by natural killer cells from rats susceptible to postviral chronic airway dysfunction
    L D Mikus
    Division of Allergy, Departments of Medicine and Pediatrics, and School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53792, USA
    Am J Respir Cell Mol Biol 24:74-82. 2001
    ..05). Therefore, reduced IFN-gamma secretion by NK cells in BN weanlings may play a role in the development of postviral chronic airway dysfunction...
  58. ncbi request reprint Classifying asthma severity in children: mismatch between symptoms, medication use, and lung function
    Leonard B Bacharier
    Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, One Children s Place, St Louis, MO 63110, USA
    Am J Respir Crit Care Med 170:426-32. 2004
    ..FEV(1) is generally normal, even in severe persistent childhood asthma, whereas FEV(1)/FVC declines as asthma severity increases...
  59. ncbi request reprint 6. Asthma
    Robert F Lemanske
    Departments of Medicine and Pediatrics, University of Wisconsin Medical School, Madison, WI 53792, USA
    J Allergy Clin Immunol 111:S502-19. 2003
    ....
  60. ncbi request reprint The influence of processing factors and non-atopy-related maternal and neonate characteristics on yield and cytokine responses of cord blood mononuclear cells
    K T Sullivan Dillie
    Department of Pediatrics, University of Wisconsin, Madison, WI 53792 4108, USA
    Clin Exp Allergy 38:298-304. 2008
    ..Variations in blood processing factors and maternal and infant characteristics are typically not accounted for and may contribute to these inconsistencies...
  61. ncbi request reprint Issues in understanding pediatric asthma: epidemiology and genetics
    Robert F Lemanske
    Department of Pediatrics, The University of Wisconsin Medical School, Madison, USA
    J Allergy Clin Immunol 109:S521-4. 2002
    ..Identifying the pathogenic mechanisms should enable clinicians to identify children at high risk and thereby to treat childhood asthma more effectively...
  62. ncbi request reprint Rhinovirus illnesses during infancy predict subsequent childhood wheezing
    Robert F Lemanske
    Department of Pediatrics, University of Wisconsin, Madison, WI 53792 9988, USA edu
    J Allergy Clin Immunol 116:571-7. 2005
    ..The contribution of viral respiratory infections during infancy to the development of subsequent wheezing and/or allergic diseases in early childhood is not established...
  63. ncbi request reprint Is asthma an infectious disease?: Thomas A. Neff lecture
    Robert F Lemanske
    Departments of Pediatrics and Medicine, Division of Pediatric Allergy, Immunology, and Rheumatology, University of Wisconsin Medical School, Madison, WI 53762, USA
    Chest 123:385S-90S. 2003
    ..In an attempt to address the question posed in the title, this article will briefly review these various associations as they pertain to the pathogenesis of asthma in both children and adults...
  64. ncbi request reprint Newborn immunology: relevance to the clinician
    David B Lewis
    Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USA
    Curr Probl Pediatr Adolesc Health Care 36:189-204. 2006
  65. ncbi request reprint Association between CD4(+)CD25(high) T cells and atopy in children
    Tuomas Jartti
    Department of Pediatrics, University of Wisconsin, Madison, WI 53792 4108, USA
    J Allergy Clin Immunol 120:177-83. 2007
    ..There is evidence that CD4(+)CD25(high) T-regulatory cells are important for establishing tolerance to allergens, but information in children is limited...
  66. ncbi request reprint Integrin beta 3 genotype influences asthma and allergy phenotypes in the first 6 years of life
    Emma E Thompson
    Department of Human Genetics, University of Chicago, Chicago, Ill, USA
    J Allergy Clin Immunol 119:1423-9. 2007
    ..Previous work from our laboratory reported associations between single nucleotide polymorphisms (SNPs) in ITGB3 and asthma and allergic sensitization in 4 populations...
  67. ncbi request reprint Daily versus as-needed corticosteroids for mild persistent asthma
    Homer A Boushey
    University of California at San Francisco, San Francisco, USA
    N Engl J Med 352:1519-28. 2005
    ....
  68. pmc Variation in ITGB3 is associated with asthma and sensitization to mold allergen in four populations
    Lauren A Weiss
    Department of Human Genetics, University of Chicago, 920 East 58th Street, CSLC 507C, Chicago, IL 60637, USA
    Am J Respir Crit Care Med 172:67-73. 2005
    ..We therefore evaluated the integrin-beta3 gene (ITGB3), an integrin gene within an asthma linkage peak on chromosome 17, as a candidate for susceptibility to asthma- and atopy-related phenotypes...
  69. ncbi request reprint Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroids
    Aaron Deykin
    Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    J Allergy Clin Immunol 115:720-7. 2005
    ..Although inhaled corticosteroids (ICSs) are effective in preventing deterioration in asthma control, at least half of subjects with mild-to-moderate asthma will remain stable when these agents are discontinued...
  70. ncbi request reprint The Prevention of Early Asthma in Kids study: design, rationale and methods for the Childhood Asthma Research and Education network
    Theresa W Guilbert
    Division of Pediatric Pulmonary Medicine, Arizona Respiratory Center, University of Arizona, 1501 N Campbell Avenue, PO Box 245073, Tucson, AZ 85724, USA
    Control Clin Trials 25:286-310. 2004
    ..These measures were chosen to reflect the progression of the disease from intermittent wheezing to persistent asthma and measurement of the extent of airflow limitation and airway reactivity...
  71. pmc Gene-environment interaction effects on the development of immune responses in the 1st year of life
    Sabine Hoffjan
    Department of Human Genetics, The University of Chicago, Chicago, IL 60637, USA
    Am J Hum Genet 76:696-704. 2005
    ....
  72. ncbi request reprint Atopic characteristics of children with recurrent wheezing at high risk for the development of childhood asthma
    Theresa W Guilbert
    Arizona Respiratory Center, University of Arizona, Tucson, AZ 85724, USA
    J Allergy Clin Immunol 114:1282-7. 2004
    ....
  73. ncbi request reprint Airway tissue mast cells in persistent asthma: predictor of treatment failure when patients discontinue inhaled corticosteroids
    Monica Kraft
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    Chest 124:42-50. 2003
    ..To determine if persistent airway tissue mast cells are associated with treatment failure when patients discontinue inhaled corticosteroids (ICS)...
  74. ncbi request reprint Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial
    Elliot Israel
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Lancet 364:1505-12. 2004
    ..However, the existence of any genotype-dependent difference has not been tested in a prospective clinical trial...
  75. ncbi request reprint Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy
    Sabine Hoffjan
    Department of Human Genetics, University of Chicago, IL 60637, USA
    J Allergy Clin Immunol 113:511-8. 2004
    ..Although candidate gene studies have identified many potential asthma susceptibility genes in adult populations, few have studied associations with immune phenotypes in the first year that might be early clinical markers of asthma...
  76. ncbi request reprint Relationship of exhaled nitric oxide to clinical and inflammatory markers of persistent asthma in children
    Robert C Strunk
    Washington University School of Medicine, St Louis, MO, USA
    J Allergy Clin Immunol 112:883-92. 2003
    ..Insufficient information is available concerning correlations between eNO and biologic, physiologic, and clinical characteristics of asthma in children currently not taking controller medications...
  77. pmc beta-Adrenergic receptor polymorphisms and response to salmeterol
    Michael E Wechsler
    Brigham and Women s Hospital, 75 Francis Street, Boston, MA, 02115, USA
    Am J Respir Crit Care Med 173:519-26. 2006
    ..Several studies suggest that patients with asthma who are homozygous for arginine at the 16th position of the beta2-adrenergic receptor may not benefit from short-acting beta-agonists...
  78. ncbi request reprint Does respiratory syncytial viral-induced bronchiolitis result from helper T cell type 1/type 2 cytokine imbalance?
    Robert F Lemanske
    Am J Respir Crit Care Med 168:625-7. 2003
  79. doi request reprint Aeroallergen sensitization correlates with PC(20) and exhaled nitric oxide in subjects with mild-to-moderate asthma
    Timothy J Craig
    Division of Pulmonary Care, Pennsylvania State University College of Medicine, Hershey, PA 17033 0853, USA
    J Allergy Clin Immunol 121:671-7. 2008
    ..Aeroallergen sensitization in adult asthmatic patients from a wide geographic area has not been correlated with patients' characteristics, markers of airways inflammation, and lung function...
  80. pmc Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function
    Carole Ober
    University of Chicago, Chicago, IL 60637, USA
    N Engl J Med 358:1682-91. 2008
    ..We hypothesized that single-nucleotide polymorphisms (SNPs) that affect YKL-40 levels also influence asthma status and lung function...
  81. pmc The Predicting Response to Inhaled Corticosteroid Efficacy (PRICE) trial
    Richard J Martin
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 119:73-80. 2007
    ..Although guidelines recommend anti-inflammatory therapy for persistent asthma, recent studies suggest that 25% to 35% of patients with asthma may not improve lung function with inhaled corticosteroids...
  82. pmc Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma
    Stephen C Lazarus
    University of California, San Francisco, 505 Parnassus Avenue, M 1083, San Francisco, CA 94143 0111, USA
    Am J Respir Crit Care Med 175:783-90. 2007
    ..One-quarter to one-third of individuals with asthma smoke, which may affect response to therapy and contribute to poor asthma control...
  83. doi request reprint Early identification of atopy in the prediction of persistent asthma in children
    Peter D Sly
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, WA, Australia
    Lancet 372:1100-6. 2008
    ..Identification of an asthmatic child's atopic status in early life has practical clinical and prognostic implications, and sets the basis for future preventative strategies...
  84. pmc Guideline-defining asthma clinical trials of the National Heart, Lung, and Blood Institute's Asthma Clinical Research Network and Childhood Asthma Research and Education Network
    Loren C Denlinger
    Department of Medicine, College of Medicine, Pennsylvania State University, Hershey, PA, USA
    J Allergy Clin Immunol 119:3-11; quiz 12-3. 2007
    ....
  85. ncbi request reprint Systemic effect comparisons of six inhaled corticosteroid preparations
    Richard J Martin
    National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Respir Crit Care Med 165:1377-83. 2002
    ..This study represents the first step in evaluation of ICS efficacy based on equisystemic (cortisol suppression) effects of a given ICS, rather than doses judged arbitrarily to be comparable on a microgram basis...
  86. pmc Combination therapy with a long-acting beta-agonist and a leukotriene antagonist in moderate asthma
    Aaron Deykin
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 175:228-34. 2007
    ..The elements of asthma control achieved by LABAs (improved lung function) and leukotriene receptor antagonists (LTRAs; protection against exacerbations) may be complementary as well...
  87. ncbi request reprint Long-term inhaled corticosteroids in preschool children at high risk for asthma
    Theresa W Guilbert
    Division of Pediatric Pulmonary Medicine, Arizona Respiratory Center, University of Arizona, Tucson, AZ 85724, USA
    N Engl J Med 354:1985-97. 2006
    ..It is unknown whether inhaled corticosteroids can modify the subsequent development of asthma in preschool children at high risk for asthma...
  88. ncbi request reprint Asthma guidelines: a changing paradigm to improve asthma care
    William W Busse
    J Allergy Clin Immunol 110:703-5. 2002
  89. ncbi request reprint Expert Panel Report 3: Moving forward to improve asthma care
    William W Busse
    J Allergy Clin Immunol 120:1012-4. 2007
  90. pmc Allele-specific targeting of microRNAs to HLA-G and risk of asthma
    Zheng Tan
    Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Am J Hum Genet 81:829-34. 2007
    ....
  91. pmc Induction of asthma and the environment: what we know and need to know
    MaryJane K Selgrade
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Environ Health Perspect 114:615-9. 2006
    ..Research to address these questions could have a significant public health and economic impact that would be well worth the investment...

Research Grants13

  1. Treatment of Severe Persistent Asthma
    ROBERT LEMANSKE; Fiscal Year: 2007
    ..abstract_text> ..
  2. CARE Network - Madison Clinical Center
    ROBERT LEMANSKE; Fiscal Year: 2007
    ..abstract_text> ..
  3. ASTHMA CLINICAL RESEARCH NETWORK
    ROBERT LEMANSKE; Fiscal Year: 2002
    ....
  4. CYTOKINE DYSREGULATION, VIRUSES, AND CHILDHOOD ASTHMA
    ROBERT LEMANSKE; Fiscal Year: 2001
    ..The results of these studies will provide information that will be a major step forward in our understanding of the relative influence that genetic and environmental risk factors on the development of childhood asthma. ..
  5. Investigating Effects of Viral Infection on Lung Development
    Xin Sun; Fiscal Year: 2010
    ..End of Abstract) ..