Research Topics
Genomes and Genes | Norbert LeitingerSummaryAffiliation: University of Virginia Country: USA Publications
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Publications
Oxidized phospholipids reduce ventilator-induced vascular leak and inflammation in vivoStephanie Nonas
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Crit Care 12:R27. 2008....
Oxidized phospholipids as triggers of inflammation in atherosclerosisNorbert Leitinger
Department of Pharmacology and Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
Mol Nutr Food Res 49:1063-71. 2005..Better understanding of how OxPL contribute to vascular inflammation should lead to new strategies in the treatment of chronic inflammatory disorders...- Oxidized phospholipids induce type VIII collagen expression and vascular smooth muscle cell migrationOlga A Cherepanova
Department of Molecular Physiology and Biological Physics, University of Virginia, Robert M Berne Cardiovascular Research Center, Charlottesville, VA 22908, USA
Circ Res 104:609-18. 2009.... - Single bolus injection of bilirubin improves the clinical outcome in a mouse model of endotoxemiaAlexandra Kadl
Cardiovascular Research Center and Department of Pharmacology, University of Virginia, Charlottesville, Virginia, USA
Shock 28:582-8. 2007..These data show that single-dose administration of bilirubin attenuates tissue injury induced by endotoxin, and that bilirubin, in addition to its antioxidant effects, also exerts potent anti-inflammatory activity... - Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2Alexandra Kadl
Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA
Circ Res 107:737-46. 2010..In atherosclerosis, oxidative tissue damage accompanies chronic inflammation; however, macrophage phenotypic changes in response to oxidatively modified molecules are not known... - Oxidized phospholipid-induced inflammation is mediated by Toll-like receptor 2Alexandra Kadl
Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
Free Radic Biol Med 51:1903-9. 2011..Together, our findings demonstrate that TLR2 mediates cellular responses to oxidative tissue damage and they provide new insights into how oxidative stress is linked to acute and chronic inflammation... 
The role of phospholipid oxidation products in inflammatory and autoimmune diseases: evidence from animal models and in humansNorbert Leitinger
Department of Pharmacology and Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, USA
Subcell Biochem 49:325-50. 2008....- Induction of CCR2-dependent macrophage accumulation by oxidized phospholipids in the air-pouch model of inflammationAlexandra Kadl
Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
Arthritis Rheum 60:1362-71. 2009.... - NF-E2-related factor 2 regulates the stress response to UVA-1-oxidized phospholipids in skin cellsFlorian Gruber
Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
FASEB J 24:39-48. 2010..Our findings suggest a different view on UV-generated lipid mediators that were commonly regarded as detrimental.. - Plasminogen activator inhibitor-1 regulates myoendothelial junction formationKatherine R Heberlein
Robert M Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
Circ Res 106:1092-102. 2010..Plasminogen activator inhibitor-1 (PAI-1) is a biomarker for several vascular disease states; however, its target of action within the vessel wall is undefined... - Nrf2 deficiency in myeloid cells is not sufficient to protect mice from high-fat diet-induced adipose tissue inflammation and insulin resistanceAkshaya K Meher
Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA
Free Radic Biol Med 52:1708-15. 2012..Together, our data demonstrate a dominant role for nonmyeloid Nrf2 in controlling HFD-induced adipose tissue inflammation and the development of insulin resistance... - IL-2-controlled expression of multiple T cell trafficking genes and Th2 cytokines in the regulatory T cell-deficient scurfy mice: implication to multiorgan inflammation and control of skin and lung inflammationRahul Sharma
Department of Medicine, Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, VA 22908, USA
J Immunol 186:1268-78. 2011..Thus, IL-2 is potentially a master regulator for multiorgan inflammation and an underlying etiological factor for various diseases associated with skin and lung inflammation... - Characterization of Ath29, a major mouse atherosclerosis susceptibility locus, and identification of Rcn2 as a novel regulator of cytokine expressionAni Manichaikul
Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia 22908, USA
Am J Physiol Heart Circ Physiol 301:H1056-61. 2011..Ath29 is confirmed to be a major atherosclerosis susceptibility locus affecting both early and advanced lesion formation in mice, and Rcn2 is identified as a novel regulator of cytokine expression... - Expression of heme oxygenase-1 in human vascular cells is regulated by peroxisome proliferator-activated receptorsGerhard Kronke
Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, P O Box 801394, Charlottesville, VA, USA
Arterioscler Thromb Vasc Biol 27:1276-82. 2007..Here we investigate if the vasculoprotective and anti-inflammatory enzyme heme oxygenase-1 (HO-1) is regulated by PPAR ligands in vascular cells... - Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearanceMichael R Elliott
Beirne B Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908, USA
Nature 461:282-6. 2009.... - Oxidized phospholipids induce phenotypic switching of vascular smooth muscle cells in vivo and in vitroNataliya A Pidkovka
University of Virginia, Cardiovascular Research Center, Department of Molecular Physiology and Biophysics, 415 Lane Road, Charlottesville, VA 22908, USA
Circ Res 101:792-801. 2007..These results may have important novel implications for the mechanisms by which oxPLs contribute to the pathogenesis of atherosclerosis... - Phenotypic modulation of macrophages in response to plaque lipidsSamantha Adamson
Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
Curr Opin Lipidol 22:335-42. 2011..In this review, we summarize recent advances in our understanding of the effects of plaque lipids on macrophage phenotypic polarization... - Effects of native and modified low-density lipoproteins on monocyte recruitment in atherosclerosisChristian A Gleissner
Department of Biomedical Engineering, Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
Hypertension 50:276-83. 2007 - Oxidized phospholipids alter vascular connexin expression, phosphorylation, and heterocellular communicationBrant E Isakson
Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
Arterioscler Thromb Vasc Biol 26:2216-21. 2006..Lipoprotein-derived phospholipid oxidation products (OxPAPC) play a critical role in atherosclerosis, and we hypothesized that they may act as trigger molecules causing the changes in connexin expression... - The role of endothelial cells in the resolution of acute inflammationAlexandra Kadl
Cardiovascular Research Center and Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA
Antioxid Redox Signal 7:1744-54. 2005..This review will summarize recent advances in the field of endothelial biology, which point to an active participation of the endothelial barrier in the resolving process... - Specific monocyte adhesion to endothelial cells induced by oxidized phospholipids involves activation of cPLA2 and lipoxygenaseJoakim Huber
Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Austria
J Lipid Res 47:1054-62. 2006..Further analysis of signaling pathways induced by oxidized phospholipids that lead to specific monocyte adhesion should ultimately lead to the development of novel therapeutic approaches against chronic inflammatory diseases... - Oxidized phospholipids induce expression of human heme oxygenase-1 involving activation of cAMP-responsive element-binding proteinGerhard Kronke
Department of Vascular Biology and Thrombosis Research, University of Vienna, Vienna A 1090, Austria
J Biol Chem 278:51006-14. 2003..Induction of HO-1 expression by lipid oxidation products via CREB may represent a feedback mechanism to limit inflammation and associated tissue damage... - Oxidized phospholipids as modulators of inflammation in atherosclerosisNorbert Leitinger
Department of Vascular Biology and Thrombosis Research, University of Vienna, Vienna, Austria
Curr Opin Lipidol 14:421-30. 2003..This review will summarize recent evidence demonstrating that biologically active phospholipid oxidation products modulate inflammatory reactions... - Anti-inflammatory properties of lipid oxidation productsValery N Bochkov
Department of Vascular Biology and Thrombosis Research, University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
J Mol Med (Berl) 81:613-26. 2003..We discuss confirmed and suggested mechanisms as well as the (patho)physiological significance of these findings... - The isoprostane 8-iso-PGE2 stimulates endothelial cells to bind monocytes via cyclic AMP- and p38 MAP kinase-dependent signaling pathwaysJoakim Huber
Department of Vascular Biology and Thrombosis Research, University of Vienna, Schwarzspanierstrasse 17, A-1090 Vienna, Austria
Antioxid Redox Signal 5:163-9. 2003..Thus, formation of 8-iso-PGE(2) may play an important role in chronic inflammatory diseases such as atherosclerosis by increasing adhesion and extravasation of monocytes... - Glucose regulates monocyte adhesion through endothelial production of interleukin-8Suseela Srinivasan
Division of Cardiology, University of California Los Angeles, Los Angeles, Calif, USA
Circ Res 92:371-7. 2003..These data indicate that glucose regulates monocyte:endothelial interactions through stimulation of IL-8 and ROS production and activation of the alpha5beta1 integrin complex on HAECs... - Analysis of inflammatory gene induction by oxidized phospholipids in vivo by quantitative real-time RT-PCR in comparison with effects of LPSAlexandra Kadl
Department of Vascular Biology and Thrombosis Research, University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
Vascul Pharmacol 38:219-27. 2002..In addition, we demonstrate that the quantitative real-time RT-PCR technology is a proper tool to investigate differential inflammatory gene induction in vivo... - Protective role of phospholipid oxidation products in endotoxin-induced tissue damageValery N Bochkov
Department of Vascular Biology and Thrombosis Research, University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
Nature 419:77-81. 2002..Furthermore, identified chemical structures capable of inhibiting the effects of endotoxins such as LPS could be used for the development of new drugs for treatment of sepsis... - Regulation of platelet adhesion by oxidized lipoproteins and oxidized phospholipidsJadwiga Hartwich
Department of Clinical Biochemistry, , Poland
Platelets 13:141-51. 2002..The effect of okadaic acid on CD36 and CD41 argue for the participation of phosphorylation-dependent reorganization of cellular trafficking and microtubule organization by ox-PAPC... - Oxidized cholesteryl linoleates stimulate endothelial cells to bind monocytes via the extracellular signal-regulated kinase 1/2 pathwayJoakim Huber
Department of Vascular Biology and Thrombosis Research, University of Vienna, Vienna, Austria
Arterioscler Thromb Vasc Biol 22:581-6. 2002..Thus, oxidized cholesteryl esters may play an important role as novel mediators in the initiation and progression of atherosclerosis... - Oxidized membrane vesicles and blebs from apoptotic cells contain biologically active oxidized phospholipids that induce monocyte-endothelial interactionsJoakim Huber
Department of Vascular Biology and Thrombosis Research, University of Vienna, Austria
Arterioscler Thromb Vasc Biol 22:101-7. 2002..In addition to oxidized lipoproteins, oxidized MVs and apoptotic blebs may play an important role in chronic inflammatory diseases, such as atherosclerosis... - Oxidized phospholipids stimulate tissue factor expression in human endothelial cells via activation of ERK/EGR-1 and Ca(++)/NFATValery N Bochkov
Department of Vascular Biology and Thrombosis Research, University of Vienna, Austria
Blood 99:199-206. 2002..Thus, oxidized phospholipids may contribute to inflammation by activating pathways alternative to the classical NF-kappa B pathway... - Signal transduction pathways activated in human pulmonary endothelial cells by OxPAPC, a bioactive component of oxidized lipoproteinsKonstantin G Birukov
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Microvasc Res 67:18-28. 2004.... - Apoptotic cells as sources for biologically active oxidized phospholipidsAlexandra Kadl
Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria
Antioxid Redox Signal 6:311-20. 2004..In this review, we discuss the hypothesis that oxidized phospholipids generated in apoptotic cells (a) propagate chronic inflammation and (b) contribute to the resolution of acute inflammation... - A rancid culprit in vascular inflammation acts on the prostaglandin receptor EP2Norbert Leitinger
Circ Res 98:587-9. 2006 - Oxysterol-induced up-regulation of MCP-1 expression and synthesis in macrophage cellsGabriella Leonarduzzi
Department of Clinical and Biological Sciences, University of Turin, S Luigi Hospital, 10043 Orbassano Turin, Italy
Free Radic Biol Med 39:1152-61. 2005..The results indicate that cholesterol may contribute to the progression of atherosclerotic lesions by strongly up-regulating crucial proinflammatory factors like MCP-1, but only after having been oxidized to oxysterols... - Oxidized phospholipids stimulate angiogenesis via autocrine mechanisms, implicating a novel role for lipid oxidation in the evolution of atherosclerotic lesionsValery N Bochkov
Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
Circ Res 99:900-8. 2006..Our data suggest that accumulation of OxPLs may contribute to increased growth of blood capillaries in advanced lesions, thus leading to progression and destabilization of atherosclerotic plaques... - Oxidized phospholipids inhibit phagocytosis and impair outcome in gram-negative sepsis in vivoSylvia Knapp
Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Immunol 178:993-1001. 2007..These data suggest that oxidized phospholipids such as produced during inflammatory reactions may contribute to mortality during Gram-negative sepsis in vivo via impairment of the phagocytic properties of professional phagocytes... - Oxidized phospholipids negatively regulate dendritic cell maturation induced by TLRs and CD40Stefan Bluml
Institute of Immunology, Medical University of Vienna, Medical University of Vienna, Vienna, Austria
J Immunol 175:501-8. 2005..Thus, formation of ox-PLs during the course of an inflammatory response may represent a negative-feedback loop preventing excessive and sustained immune reactions through regulating DC maturation... - Oxidized phospholipids trigger atherogenic inflammation in murine arteriesAlexander Furnkranz
Department of Vascular Biology and Thrombosis Research, University of Vienna, Austria
Arterioscler Thromb Vasc Biol 25:633-8. 2005.... - Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and RacKonstantin G Birukov
Division of Pulmonary and Critical Care Medicine, Center for Translational Respiratory Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Circ Res 95:892-901. 2004..Thus, oxidative modification of phospholipids during inflammation leads to the formation of novel regulators that may be critically involved in restoration of vascular barrier function... - Cholesteryl ester oxidation products in atherosclerosisNorbert Leitinger
Department of Vascular Biology and Thrombosis Research, University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
Mol Aspects Med 24:239-50. 2003..Based on the current knowledge, cholesteryl ester oxidation leads to the formation of biologically active substances, which could actively contribute to the progression of atherosclerotic lesions and their resulting complications... - Photooxidation generates biologically active phospholipids that induce heme oxygenase-1 in skin cellsFlorian Gruber
Deparment of Dermatology, Medical University of Vienna, Vienna 1090, Austria
J Biol Chem 282:16934-41. 2007.... - The dietary soy flavonoid genistein abrogates tissue factor induction in endothelial cells induced by the atherogenic oxidized phospholipid oxPAPCGregor Holzer
Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
Thromb Res 120:71-9. 2007.... - Modification of LDL with oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (oxPAPC) results in a novel form of minimally modified LDL that modulates gene expression in macrophagesMathijs Groeneweg
Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
Biochim Biophys Acta 1781:336-43. 2008 - Oxidized phospholipids reduce vascular leak and inflammation in rat model of acute lung injuryStephanie Nonas
Division of Pulmonary and Critical Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am J Respir Crit Care Med 173:1130-8. 2006..CONCLUSIONS: These studies demonstrate in vivo and in vitro protective effects of oxidized phospholipids on LPS-induced lung dysfunction... - Oxidation as a crucial reaction for cholesterol to induce tissue degeneration: CD36 overexpression in human promonocytic cells treated with a biologically relevant oxysterol mixtureGabriella Leonarduzzi
Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
Aging Cell 7:375-82. 2008..These experimental findings point to cholesterol oxidation as an essential reaction for this sterol to exert cellular stress and tissue damage in age-related diseases in which inflammation represents a main driving force...
Research Grants
- Oxidized Phospholipid-Induced Inflammation in AtherosclerosisNorbert Leitinger; Fiscal Year: 2010..We will investigate the chemokine expression pattern as well as time course of expression in OxPL-induced compared to LPS-induced inflammation. Furthermore, we will investigate the role of 12-LO in OxPL-induced inflammation in vivo. ..
- Oxidized Phospholipid-Induced Inflammation in AtherosclerosisNorbert Leitinger; Fiscal Year: 2007..We will investigate the chemokine expression pattern as well as time course of expression in OxPL-induced compared to LPS-induced inflammation. Furthermore, we will investigate the role of 12-LO in OxPL-induced inflammation in vivo. ..