Norbert Leitinger

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Oxidized phospholipids as triggers of inflammation in atherosclerosis
    Norbert Leitinger
    Department of Pharmacology and Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    Mol Nutr Food Res 49:1063-71. 2005
  2. pmc Phenotypic polarization of macrophages in atherosclerosis
    Norbert Leitinger
    Department of Pharmacology, University of Virginia, Charlottesville, VA 22908 0735, USA
    Arterioscler Thromb Vasc Biol 33:1120-6. 2013
  3. pmc Oxidized phospholipids reduce ventilator-induced vascular leak and inflammation in vivo
    Stephanie Nonas
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Crit Care 12:R27. 2008
  4. pmc Oxidized phospholipids induce type VIII collagen expression and vascular smooth muscle cell migration
    Olga A Cherepanova
    Department of Molecular Physiology and Biological Physics, University of Virginia, Robert M Berne Cardiovascular Research Center, Charlottesville, VA 22908, USA
    Circ Res 104:609-18. 2009
  5. ncbi request reprint Single bolus injection of bilirubin improves the clinical outcome in a mouse model of endotoxemia
    Alexandra Kadl
    Cardiovascular Research Center and Department of Pharmacology, University of Virginia, Charlottesville, Virginia, USA
    Shock 28:582-8. 2007
  6. pmc Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2
    Alexandra Kadl
    Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA
    Circ Res 107:737-46. 2010
  7. pmc Oxidized phospholipid-induced inflammation is mediated by Toll-like receptor 2
    Alexandra Kadl
    Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    Free Radic Biol Med 51:1903-9. 2011
  8. pmc NF-E2-related factor 2 regulates the stress response to UVA-1-oxidized phospholipids in skin cells
    Florian Gruber
    Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    FASEB J 24:39-48. 2010
  9. doi request reprint The role of phospholipid oxidation products in inflammatory and autoimmune diseases: evidence from animal models and in humans
    Norbert Leitinger
    Department of Pharmacology and Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, USA
    Subcell Biochem 49:325-50. 2008
  10. pmc Induction of CCR2-dependent macrophage accumulation by oxidized phospholipids in the air-pouch model of inflammation
    Alexandra Kadl
    Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    Arthritis Rheum 60:1362-71. 2009

Collaborators

Detail Information

Publications50

  1. ncbi request reprint Oxidized phospholipids as triggers of inflammation in atherosclerosis
    Norbert Leitinger
    Department of Pharmacology and Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    Mol Nutr Food Res 49:1063-71. 2005
    ..Better understanding of how OxPL contribute to vascular inflammation should lead to new strategies in the treatment of chronic inflammatory disorders...
  2. pmc Phenotypic polarization of macrophages in atherosclerosis
    Norbert Leitinger
    Department of Pharmacology, University of Virginia, Charlottesville, VA 22908 0735, USA
    Arterioscler Thromb Vasc Biol 33:1120-6. 2013
    ..Most importantly, revealing the functional characteristics of individual macrophage phenotypes will lead to a better understanding of their contribution to lesion development and plaque stability...
  3. pmc Oxidized phospholipids reduce ventilator-induced vascular leak and inflammation in vivo
    Stephanie Nonas
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Crit Care 12:R27. 2008
    ....
  4. pmc Oxidized phospholipids induce type VIII collagen expression and vascular smooth muscle cell migration
    Olga A Cherepanova
    Department of Molecular Physiology and Biological Physics, University of Virginia, Robert M Berne Cardiovascular Research Center, Charlottesville, VA 22908, USA
    Circ Res 104:609-18. 2009
    ....
  5. ncbi request reprint Single bolus injection of bilirubin improves the clinical outcome in a mouse model of endotoxemia
    Alexandra Kadl
    Cardiovascular Research Center and Department of Pharmacology, University of Virginia, Charlottesville, Virginia, USA
    Shock 28:582-8. 2007
    ..These data show that single-dose administration of bilirubin attenuates tissue injury induced by endotoxin, and that bilirubin, in addition to its antioxidant effects, also exerts potent anti-inflammatory activity...
  6. pmc Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2
    Alexandra Kadl
    Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA
    Circ Res 107:737-46. 2010
    ..In atherosclerosis, oxidative tissue damage accompanies chronic inflammation; however, macrophage phenotypic changes in response to oxidatively modified molecules are not known...
  7. pmc Oxidized phospholipid-induced inflammation is mediated by Toll-like receptor 2
    Alexandra Kadl
    Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    Free Radic Biol Med 51:1903-9. 2011
    ..Together, our findings demonstrate that TLR2 mediates cellular responses to oxidative tissue damage and they provide new insights into how oxidative stress is linked to acute and chronic inflammation...
  8. pmc NF-E2-related factor 2 regulates the stress response to UVA-1-oxidized phospholipids in skin cells
    Florian Gruber
    Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    FASEB J 24:39-48. 2010
    ..Our findings suggest a different view on UV-generated lipid mediators that were commonly regarded as detrimental..
  9. doi request reprint The role of phospholipid oxidation products in inflammatory and autoimmune diseases: evidence from animal models and in humans
    Norbert Leitinger
    Department of Pharmacology and Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, USA
    Subcell Biochem 49:325-50. 2008
    ....
  10. pmc Induction of CCR2-dependent macrophage accumulation by oxidized phospholipids in the air-pouch model of inflammation
    Alexandra Kadl
    Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    Arthritis Rheum 60:1362-71. 2009
    ....
  11. pmc Plasminogen activator inhibitor-1 regulates myoendothelial junction formation
    Katherine R Heberlein
    Robert M Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Circ Res 106:1092-102. 2010
    ..Plasminogen activator inhibitor-1 (PAI-1) is a biomarker for several vascular disease states; however, its target of action within the vessel wall is undefined...
  12. pmc Nrf2 deficiency in myeloid cells is not sufficient to protect mice from high-fat diet-induced adipose tissue inflammation and insulin resistance
    Akshaya K Meher
    Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA
    Free Radic Biol Med 52:1708-15. 2012
    ..Together, our data demonstrate a dominant role for nonmyeloid Nrf2 in controlling HFD-induced adipose tissue inflammation and the development of insulin resistance...
  13. pmc IL-2-controlled expression of multiple T cell trafficking genes and Th2 cytokines in the regulatory T cell-deficient scurfy mice: implication to multiorgan inflammation and control of skin and lung inflammation
    Rahul Sharma
    Department of Medicine, Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 186:1268-78. 2011
    ..Thus, IL-2 is potentially a master regulator for multiorgan inflammation and an underlying etiological factor for various diseases associated with skin and lung inflammation...
  14. pmc Characterization of Ath29, a major mouse atherosclerosis susceptibility locus, and identification of Rcn2 as a novel regulator of cytokine expression
    Ani Manichaikul
    Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia 22908, USA
    Am J Physiol Heart Circ Physiol 301:H1056-61. 2011
    ..Ath29 is confirmed to be a major atherosclerosis susceptibility locus affecting both early and advanced lesion formation in mice, and Rcn2 is identified as a novel regulator of cytokine expression...
  15. ncbi request reprint Oxidized phospholipids induce phenotypic switching of vascular smooth muscle cells in vivo and in vitro
    Nataliya A Pidkovka
    University of Virginia, Cardiovascular Research Center, Department of Molecular Physiology and Biophysics, 415 Lane Road, Charlottesville, VA 22908, USA
    Circ Res 101:792-801. 2007
    ..These results may have important novel implications for the mechanisms by which oxPLs contribute to the pathogenesis of atherosclerosis...
  16. ncbi request reprint Expression of heme oxygenase-1 in human vascular cells is regulated by peroxisome proliferator-activated receptors
    Gerhard Kronke
    Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, P O Box 801394, Charlottesville, VA, USA
    Arterioscler Thromb Vasc Biol 27:1276-82. 2007
    ..Here we investigate if the vasculoprotective and anti-inflammatory enzyme heme oxygenase-1 (HO-1) is regulated by PPAR ligands in vascular cells...
  17. pmc The role of pannexin1 in the induction and resolution of inflammation
    Samantha E Adamson
    Department of Pharmacology, University of Virginia, United States
    FEBS Lett 588:1416-22. 2014
    ..Together, Panx1, ATP, purinergic receptors, and ectonucleotidases contribute to important feedback loops during the inflammatory response, and thus represent promising candidates for new therapies. ..
  18. ncbi request reprint Effects of native and modified low-density lipoproteins on monocyte recruitment in atherosclerosis
    Christian A Gleissner
    Department of Biomedical Engineering, Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    Hypertension 50:276-83. 2007
  19. pmc S-nitrosylation inhibits pannexin 1 channel function
    Alexander W Lohman
    Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 287:39602-12. 2012
    ..Taken together, these results indicate that S-nitrosylation of Panx1 at Cys-40 and Cys-346 inhibits Panx1 channel currents and ATP release...
  20. pmc Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
    Michael R Elliott
    Beirne B Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908, USA
    Nature 461:282-6. 2009
    ....
  21. pmc Phenotypic modulation of macrophages in response to plaque lipids
    Samantha Adamson
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    Curr Opin Lipidol 22:335-42. 2011
    ..In this review, we summarize recent advances in our understanding of the effects of plaque lipids on macrophage phenotypic polarization...
  22. ncbi request reprint The role of endothelial cells in the resolution of acute inflammation
    Alexandra Kadl
    Cardiovascular Research Center and Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA
    Antioxid Redox Signal 7:1744-54. 2005
    ..This review will summarize recent advances in the field of endothelial biology, which point to an active participation of the endothelial barrier in the resolving process...
  23. ncbi request reprint Oxidized phospholipids alter vascular connexin expression, phosphorylation, and heterocellular communication
    Brant E Isakson
    Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Arterioscler Thromb Vasc Biol 26:2216-21. 2006
    ..Lipoprotein-derived phospholipid oxidation products (OxPAPC) play a critical role in atherosclerosis, and we hypothesized that they may act as trigger molecules causing the changes in connexin expression...
  24. ncbi request reprint A rancid culprit in vascular inflammation acts on the prostaglandin receptor EP2
    Norbert Leitinger
    Circ Res 98:587-9. 2006
  25. ncbi request reprint Signal transduction pathways activated in human pulmonary endothelial cells by OxPAPC, a bioactive component of oxidized lipoproteins
    Konstantin G Birukov
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Microvasc Res 67:18-28. 2004
    ....
  26. ncbi request reprint Oxidized phospholipids induce expression of human heme oxygenase-1 involving activation of cAMP-responsive element-binding protein
    Gerhard Kronke
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Vienna A 1090, Austria
    J Biol Chem 278:51006-14. 2003
    ..Induction of HO-1 expression by lipid oxidation products via CREB may represent a feedback mechanism to limit inflammation and associated tissue damage...
  27. ncbi request reprint Oxidized phospholipids as modulators of inflammation in atherosclerosis
    Norbert Leitinger
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Vienna, Austria
    Curr Opin Lipidol 14:421-30. 2003
    ..This review will summarize recent evidence demonstrating that biologically active phospholipid oxidation products modulate inflammatory reactions...
  28. ncbi request reprint Anti-inflammatory properties of lipid oxidation products
    Valery N Bochkov
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
    J Mol Med (Berl) 81:613-26. 2003
    ..We discuss confirmed and suggested mechanisms as well as the (patho)physiological significance of these findings...
  29. ncbi request reprint The isoprostane 8-iso-PGE2 stimulates endothelial cells to bind monocytes via cyclic AMP- and p38 MAP kinase-dependent signaling pathways
    Joakim Huber
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Schwarzspanierstrasse 17, A 1090 Vienna, Austria
    Antioxid Redox Signal 5:163-9. 2003
    ..Thus, formation of 8-iso-PGE(2) may play an important role in chronic inflammatory diseases such as atherosclerosis by increasing adhesion and extravasation of monocytes...
  30. ncbi request reprint Glucose regulates monocyte adhesion through endothelial production of interleukin-8
    Suseela Srinivasan
    Division of Cardiology, University of California Los Angeles, Los Angeles, Calif, USA
    Circ Res 92:371-7. 2003
    ..These data indicate that glucose regulates monocyte:endothelial interactions through stimulation of IL-8 and ROS production and activation of the alpha5beta1 integrin complex on HAECs...
  31. ncbi request reprint Analysis of inflammatory gene induction by oxidized phospholipids in vivo by quantitative real-time RT-PCR in comparison with effects of LPS
    Alexandra Kadl
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
    Vascul Pharmacol 38:219-27. 2002
    ..In addition, we demonstrate that the quantitative real-time RT-PCR technology is a proper tool to investigate differential inflammatory gene induction in vivo...
  32. ncbi request reprint Protective role of phospholipid oxidation products in endotoxin-induced tissue damage
    Valery N Bochkov
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
    Nature 419:77-81. 2002
    ..Furthermore, identified chemical structures capable of inhibiting the effects of endotoxins such as LPS could be used for the development of new drugs for treatment of sepsis...
  33. ncbi request reprint Regulation of platelet adhesion by oxidized lipoproteins and oxidized phospholipids
    Jadwiga Hartwich
    Department of Clinical Biochemistry, Jagiellonian University Collegium Medicum Kraków, Poland
    Platelets 13:141-51. 2002
    ..The effect of okadaic acid on CD36 and CD41 argue for the participation of phosphorylation-dependent reorganization of cellular trafficking and microtubule organization by ox-PAPC...
  34. ncbi request reprint Oxidized cholesteryl linoleates stimulate endothelial cells to bind monocytes via the extracellular signal-regulated kinase 1/2 pathway
    Joakim Huber
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Vienna, Austria
    Arterioscler Thromb Vasc Biol 22:581-6. 2002
    ..Thus, oxidized cholesteryl esters may play an important role as novel mediators in the initiation and progression of atherosclerosis...
  35. ncbi request reprint Oxidized membrane vesicles and blebs from apoptotic cells contain biologically active oxidized phospholipids that induce monocyte-endothelial interactions
    Joakim Huber
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Austria
    Arterioscler Thromb Vasc Biol 22:101-7. 2002
    ..In addition to oxidized lipoproteins, oxidized MVs and apoptotic blebs may play an important role in chronic inflammatory diseases, such as atherosclerosis...
  36. ncbi request reprint Apoptotic cells as sources for biologically active oxidized phospholipids
    Alexandra Kadl
    Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria
    Antioxid Redox Signal 6:311-20. 2004
    ..In this review, we discuss the hypothesis that oxidized phospholipids generated in apoptotic cells (a) propagate chronic inflammation and (b) contribute to the resolution of acute inflammation...
  37. ncbi request reprint Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and Rac
    Konstantin G Birukov
    Division of Pulmonary and Critical Care Medicine, Center for Translational Respiratory Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circ Res 95:892-901. 2004
    ..Thus, oxidative modification of phospholipids during inflammation leads to the formation of novel regulators that may be critically involved in restoration of vascular barrier function...
  38. ncbi request reprint Oxidized phospholipids stimulate angiogenesis via autocrine mechanisms, implicating a novel role for lipid oxidation in the evolution of atherosclerotic lesions
    Valery N Bochkov
    Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
    Circ Res 99:900-8. 2006
    ..Our data suggest that accumulation of OxPLs may contribute to increased growth of blood capillaries in advanced lesions, thus leading to progression and destabilization of atherosclerotic plaques...
  39. ncbi request reprint Oxidized phospholipids inhibit phagocytosis and impair outcome in gram-negative sepsis in vivo
    Sylvia Knapp
    Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 178:993-1001. 2007
    ..These data suggest that oxidized phospholipids such as produced during inflammatory reactions may contribute to mortality during Gram-negative sepsis in vivo via impairment of the phagocytic properties of professional phagocytes...
  40. ncbi request reprint Specific monocyte adhesion to endothelial cells induced by oxidized phospholipids involves activation of cPLA2 and lipoxygenase
    Joakim Huber
    Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Austria
    J Lipid Res 47:1054-62. 2006
    ..Further analysis of signaling pathways induced by oxidized phospholipids that lead to specific monocyte adhesion should ultimately lead to the development of novel therapeutic approaches against chronic inflammatory diseases...
  41. ncbi request reprint Oxysterol-induced up-regulation of MCP-1 expression and synthesis in macrophage cells
    Gabriella Leonarduzzi
    Department of Clinical and Biological Sciences, University of Turin, S Luigi Hospital, 10043 Orbassano Turin, Italy
    Free Radic Biol Med 39:1152-61. 2005
    ..The results indicate that cholesterol may contribute to the progression of atherosclerotic lesions by strongly up-regulating crucial proinflammatory factors like MCP-1, but only after having been oxidized to oxysterols...
  42. ncbi request reprint Oxidized phospholipids negatively regulate dendritic cell maturation induced by TLRs and CD40
    Stefan Bluml
    Institute of Immunology, Medical University of Vienna, Medical University of Vienna, Vienna, Austria
    J Immunol 175:501-8. 2005
    ..Thus, formation of ox-PLs during the course of an inflammatory response may represent a negative-feedback loop preventing excessive and sustained immune reactions through regulating DC maturation...
  43. ncbi request reprint Oxidized phospholipids trigger atherogenic inflammation in murine arteries
    Alexander Furnkranz
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Austria
    Arterioscler Thromb Vasc Biol 25:633-8. 2005
    ..Therefore, the aim of this study was to investigate if structurally defined oxidized phospholipids induce expression of atherogenic chemokines and monocyte adhesion in intact murine arteries...
  44. ncbi request reprint Oxidized phospholipids stimulate tissue factor expression in human endothelial cells via activation of ERK/EGR-1 and Ca(++)/NFAT
    Valery N Bochkov
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Austria
    Blood 99:199-206. 2002
    ..Thus, oxidized phospholipids may contribute to inflammation by activating pathways alternative to the classical NF-kappa B pathway...
  45. ncbi request reprint Cholesteryl ester oxidation products in atherosclerosis
    Norbert Leitinger
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria
    Mol Aspects Med 24:239-50. 2003
    ..Based on the current knowledge, cholesteryl ester oxidation leads to the formation of biologically active substances, which could actively contribute to the progression of atherosclerotic lesions and their resulting complications...
  46. ncbi request reprint The dietary soy flavonoid genistein abrogates tissue factor induction in endothelial cells induced by the atherogenic oxidized phospholipid oxPAPC
    Gregor Holzer
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Thromb Res 120:71-9. 2007
    ....
  47. ncbi request reprint Photooxidation generates biologically active phospholipids that induce heme oxygenase-1 in skin cells
    Florian Gruber
    Deparment of Dermatology, Medical University of Vienna, Vienna 1090, Austria
    J Biol Chem 282:16934-41. 2007
    ....
  48. doi request reprint Oxidation as a crucial reaction for cholesterol to induce tissue degeneration: CD36 overexpression in human promonocytic cells treated with a biologically relevant oxysterol mixture
    Gabriella Leonarduzzi
    Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
    Aging Cell 7:375-82. 2008
    ..These experimental findings point to cholesterol oxidation as an essential reaction for this sterol to exert cellular stress and tissue damage in age-related diseases in which inflammation represents a main driving force...
  49. pmc Oxidized phospholipids reduce vascular leak and inflammation in rat model of acute lung injury
    Stephanie Nonas
    Division of Pulmonary and Critical Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Respir Crit Care Med 173:1130-8. 2006
    ....
  50. doi request reprint Modification of LDL with oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (oxPAPC) results in a novel form of minimally modified LDL that modulates gene expression in macrophages
    Mathijs Groeneweg
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Biochim Biophys Acta 1781:336-43. 2008

Research Grants5

  1. Oxidized Phospholipid-Induced Inflammation in Atherosclerosis
    Norbert Leitinger; Fiscal Year: 2010
    ..We will investigate the chemokine expression pattern as well as time course of expression in OxPL-induced compared to LPS-induced inflammation. Furthermore, we will investigate the role of 12-LO in OxPL-induced inflammation in vivo. ..
  2. Oxidized Phospholipid-Induced Inflammation in Atherosclerosis
    Norbert Leitinger; Fiscal Year: 2006
    ..We will investigate the chemokine expression pattern as well as time course of expression in OxPL-induced compared to LPS-induced inflammation. Furthermore, we will investigate the role of 12-LO in OxPL-induced inflammation in vivo. ..
  3. Oxidized Phospholipid-Induced Inflammation in Atherosclerosis
    Norbert Leitinger; Fiscal Year: 2007
    ..We will investigate the chemokine expression pattern as well as time course of expression in OxPL-induced compared to LPS-induced inflammation. Furthermore, we will investigate the role of 12-LO in OxPL-induced inflammation in vivo. ..
  4. Oxidized Phospholipid-Induced Inflammation in Atherosclerosis
    Norbert Leitinger; Fiscal Year: 2009
    ..We will investigate the chemokine expression pattern as well as time course of expression in OxPL-induced compared to LPS-induced inflammation. Furthermore, we will investigate the role of 12-LO in OxPL-induced inflammation in vivo. ..