LESLIE ANNE LEINWAND

Summary

Affiliation: University of Colorado
Country: USA

Publications

  1. pmc Erratum to: Identification of functional differences between recombinant human α and β cardiac myosin motors
    John C Deacon
    Department of Molecular, Cellular and Developmental Biology and Biofrontiers Institute, University of Colorado, MCDB, UCB 347, Boulder, CO 80309, USA
    Cell Mol Life Sci 69:4239-55. 2012
  2. doi request reprint Young at heart
    Leslie A Leinwand
    Department of Molecular, Cellular, and Developmental Biology and Biofrontiers Institute, University of Colorado at Boulder, Boulder, CO 80309, USA
    Cell 153:743-5. 2013
  3. pmc Estrogenic compounds are not always cardioprotective and can be lethal in males with genetic heart disease
    Christopher D Haines
    Department of Molecular, Cellular, and Developmental Biology and Biofrontiers Institute, University of Colorado, Boulder, Colorado 80309, USA
    Endocrinology 153:4470-9. 2012
  4. pmc Estrogens mediate cardiac hypertrophy in a stimulus-dependent manner
    Christopher D Haines
    Department of Molecular, Cellular, and Developmental Biology and Biofrontiers Institute, University of Colorado, 3415 Colorado Avenue, Boulder, CO 80309 0347, USA
    Endocrinology 153:4480-90. 2012
  5. pmc Identification of functional differences between recombinant human α and β cardiac myosin motors
    John C Deacon
    Department of Molecular, Cellular and Developmental Biology and Biofrontiers Institute, University of Colorado, MCDB, Boulder, CO 80309, USA
    Cell Mol Life Sci 69:2261-77. 2012
  6. pmc Sex is a potent modifier of the cardiovascular system
    Leslie A Leinwand
    Department of Molecular, Cellular, and Developmental Biology, 347 UCB, University of Colorado, Boulder, Colorado 80309, USA
    J Clin Invest 112:302-7. 2003
  7. ncbi request reprint The effects of biological sex and diet on the development of heart failure
    John P Konhilas
    Department of Molecular, Cellular, and Developmental Biology, CB347, University of Colorado, Boulder, CO 80309, USA
    Circulation 116:2747-59. 2007
  8. pmc IIb or not IIb? Regulation of myosin heavy chain gene expression in mice and men
    Brooke C Harrison
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, CO 80309, USA
    Skelet Muscle 1:5. 2011
  9. ncbi request reprint Genetic variability in forced and voluntary endurance exercise performance in seven inbred mouse strains
    Imanuel Lerman
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, 80309, USA
    J Appl Physiol 92:2245-55. 2002
  10. pmc Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats
    Annemarie Ledeboer
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO, USA
    Brain Behav Immun 21:686-98. 2007

Research Grants

  1. MECHANISMS OF CARDIOVASCULAR DISEASE AND GENE THERAPY
    Leslie Leinwand; Fiscal Year: 2005
  2. MYOSIN GENE DIVERSITY AND FUNCTION
    Leslie Leinwand; Fiscal Year: 2006
  3. Developmental Myosin Heavy Chain Regulation and Function
    Leslie Leinwand; Fiscal Year: 2006
  4. CARDIAC ADAPTATION: DISEASE, EXERCISE, SEX AND DIET
    Leslie Leinwand; Fiscal Year: 2006
  5. Mechanisms of myopathy caused by mutations in the myosin rod
    Leslie Leinwand; Fiscal Year: 2007
  6. MYOSIN GENE DIVERSITY AND FUNCTION
    Leslie Leinwand; Fiscal Year: 2007
  7. MYOSIN GENE DIVERSITY AND FUNCTION
    Leslie Leinwand; Fiscal Year: 2009
  8. Mechanisms of myopathy caused by mutations in the myosin rod
    LESLIE ANNE LEINWAND; Fiscal Year: 2010
  9. Mediators of Cardiac Adaptation
    LESLIE ANNE LEINWAND; Fiscal Year: 2010
  10. DENVER CARDIOVASCULAR HEALTH EDUCATION ALLIANCE, PHASE I
    Leslie Leinwand; Fiscal Year: 2004

Collaborators

Detail Information

Publications56

  1. pmc Erratum to: Identification of functional differences between recombinant human α and β cardiac myosin motors
    John C Deacon
    Department of Molecular, Cellular and Developmental Biology and Biofrontiers Institute, University of Colorado, MCDB, UCB 347, Boulder, CO 80309, USA
    Cell Mol Life Sci 69:4239-55. 2012
    ..Overall, the cycle times are ten-fold faster for α-S1 but the portion of time each myosin spends tightly bound to actin (the duty ratio) is similar. Sequence analysis points to regions that might underlie the basis for this finding...
  2. doi request reprint Young at heart
    Leslie A Leinwand
    Department of Molecular, Cellular, and Developmental Biology and Biofrontiers Institute, University of Colorado at Boulder, Boulder, CO 80309, USA
    Cell 153:743-5. 2013
    ..These data suggest that GDF11 therapy may be a useful tool in combating age-related cardiac hypertrophy...
  3. pmc Estrogenic compounds are not always cardioprotective and can be lethal in males with genetic heart disease
    Christopher D Haines
    Department of Molecular, Cellular, and Developmental Biology and Biofrontiers Institute, University of Colorado, Boulder, Colorado 80309, USA
    Endocrinology 153:4470-9. 2012
    ..These results implicate the phytoestrogen genistein in mediating cardiac pathology in males with HCM and, importantly, establish that estrogen is not protective in the setting of HCM...
  4. pmc Estrogens mediate cardiac hypertrophy in a stimulus-dependent manner
    Christopher D Haines
    Department of Molecular, Cellular, and Developmental Biology and Biofrontiers Institute, University of Colorado, 3415 Colorado Avenue, Boulder, CO 80309 0347, USA
    Endocrinology 153:4480-90. 2012
    ..These findings provide insight into the apparent loss of cardioprotection after menopause and suggest that caution is warranted in the long-term use of aromatase inhibitors in the setting of breast cancer prevention...
  5. pmc Identification of functional differences between recombinant human α and β cardiac myosin motors
    John C Deacon
    Department of Molecular, Cellular and Developmental Biology and Biofrontiers Institute, University of Colorado, MCDB, Boulder, CO 80309, USA
    Cell Mol Life Sci 69:2261-77. 2012
    ..Overall, the cycle times are ten-fold faster for α-S1 but the portion of time each myosin spends tightly bound to actin (the duty ratio) is similar. Sequence analysis points to regions that might underlie the basis for this finding...
  6. pmc Sex is a potent modifier of the cardiovascular system
    Leslie A Leinwand
    Department of Molecular, Cellular, and Developmental Biology, 347 UCB, University of Colorado, Boulder, Colorado 80309, USA
    J Clin Invest 112:302-7. 2003
  7. ncbi request reprint The effects of biological sex and diet on the development of heart failure
    John P Konhilas
    Department of Molecular, Cellular, and Developmental Biology, CB347, University of Colorado, Boulder, CO 80309, USA
    Circulation 116:2747-59. 2007
  8. pmc IIb or not IIb? Regulation of myosin heavy chain gene expression in mice and men
    Brooke C Harrison
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, CO 80309, USA
    Skelet Muscle 1:5. 2011
    ....
  9. ncbi request reprint Genetic variability in forced and voluntary endurance exercise performance in seven inbred mouse strains
    Imanuel Lerman
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, 80309, USA
    J Appl Physiol 92:2245-55. 2002
    ..Expression of molecular indicators of hypertrophy (atrial natriuretic factor and beta-myosin heavy chain) was significantly elevated in DBA/2J myocardium compared with all other analyzed strains...
  10. pmc Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats
    Annemarie Ledeboer
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO, USA
    Brain Behav Immun 21:686-98. 2007
    ..We propose that targeting the production of proinflammatory cytokines by intrathecal IL-10 gene therapy may be a promising therapeutic strategy for the relief of paclitaxel-induced neuropathic pain...
  11. ncbi request reprint Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo
    David L Allen
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309 0347, USA
    J Biol Chem 280:17126-34. 2005
    ..Together, these data demonstrate that the quantitative differences in MyHC expression in mouse skeletal muscle have evolved at least in part through the elimination of positive-acting transcription factor binding sites...
  12. ncbi request reprint Loaded wheel running and muscle adaptation in the mouse
    John P Konhilas
    Dept of Molecular, Cellular, and Developmental Biology, Univ of Colorado, Campus Box 347, Boulder, CO 80309 0347, USA
    Am J Physiol Heart Circ Physiol 289:H455-65. 2005
    ..In conclusion, unloaded and loaded cage wheel exercise have a differential impact on cage wheel performance and muscle (cardiac and skeletal) adaptation...
  13. pmc Sex modifies exercise and cardiac adaptation in mice
    John P Konhilas
    Dept of Molecular, Cellular, and Developmental Biology, Univ of Colorado, Campus Box 347, Boulder, CO 80309 0347, USA
    Am J Physiol Heart Circ Physiol 287:H2768-76. 2004
    ..We have also identified sex-specific differences in hypertrophic signaling within the cardiac myocyte that may contribute to sexual dimorphism in exercise and cardiac adaptation to exercise...
  14. ncbi request reprint Controlling pathological pain by adenovirally driven spinal production of the anti-inflammatory cytokine, interleukin-10
    Erin D Milligan
    Department of Psychology and the Center for Neuroscience, University of CO at Boulder, Boulder, CO 80309, USA
    Eur J Neurosci 21:2136-48. 2005
    ..These studies support that this gene therapy approach provides an alternative to neuronally focused drug and gene therapies for clinical pain control...
  15. ncbi request reprint Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain
    Erin D Milligan
    Department of Psychology and the Center for Neuroscience, University of CO at Boulder, Boulder, CO 80309, USA
    Pain 126:294-308. 2006
    ..Together, these data suggest that intrathecal IL-10 gene therapy may provide a novel approach for prolonged clinical pain control...
  16. ncbi request reprint Molecular events underlying pregnancy-induced cardiomyopathy
    Leslie A Leinwand
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    Cell 128:437-8. 2007
    ..Cathepsin D generates an antiangiogenic cleavage product of the hormone prolactin. The authors show that an inhibitor of prolactin secretion may be useful in treating this disease...
  17. pmc A randomized library approach to identifying functional lox site domains for the Cre recombinase
    Jamie Sheren
    University of Colorado, Department of Molecular, Cellular and Developmental Biology, 347 UCB, Boulder, CO 80309 0347, USA
    Nucleic Acids Res 35:5464-73. 2007
    ..Finally, we found that in vitro Cre recombination reactions are much more stringent for evaluating which sequences can support efficient recombination compared to the 294-CRE system...
  18. pmc Intrathecal polymer-based interleukin-10 gene delivery for neuropathic pain
    Erin D Milligan
    Department of Psychology, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Neuron Glia Biol 2:293-308. 2006
    ..In conclusion, synthetic polymers used as i.t. gene-delivery systems are well-tolerated and improve the long-duration efficacy of pDNA-IL-10 gene therapy...
  19. doi request reprint Sex-based cardiac physiology
    Elizabeth D Luczak
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
    Annu Rev Physiol 71:1-18. 2009
    ..Environmental estrogen-like molecules, such as phytoestrogens, can also affect cardiac physiology in both a positive and a negative manner...
  20. ncbi request reprint Morphological and functional alterations in ventricular myocytes from male transgenic mice with hypertrophic cardiomyopathy
    M Charlotte Olsson
    Department of Integrative Physiology, University of Colorado, Boulder, Colo 80309 0354, USA
    Circ Res 94:201-7. 2004
    ..Thus, myocytes from the alpha-MyHC TG mouse model display many morphological and functional abnormalities that may help explain the LV dysfunction seen in this TG mouse model of FHC...
  21. ncbi request reprint Rational promoter selection for gene transfer into cardiac cells
    Alexander Maass
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Campus Box 347, Boulder, CO 80309 0347, USA
    J Mol Cell Cardiol 35:823-31. 2003
    ..These results suggest the following use of the tested promoters: an inducible system (CMV), a myocyte-enriched system (RSV), or a stable control system (MEF2)...
  22. pmc Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10
    Erin D Milligan
    Department of Psychology and the Center for Neuroscience, University of CO at Boulder, Boulder, CO 80309 USA
    Mol Pain 1:9. 2005
    ..Taken together, these data provide initial support that intrathecal gene therapy to drive the production of IL-10 may prove to be an efficacious treatment for neuropathic pain...
  23. ncbi request reprint Intracellular calcium and myosin isoform transitions. Calcineurin and calcium-calmodulin kinase pathways regulate preferential activation of the IIa myosin heavy chain promoter
    David L Allen
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
    J Biol Chem 277:45323-30. 2002
    ..Downstream mediators of these effects are the activities of the MEF-2 and NFAT transcription factors, whose binding sites in the MyHC IIa promoter are required for calcium-induced activation of the MyHC IIa promoter...
  24. pmc Influence of sex hormones and phytoestrogens on heart disease in men and women
    Poornima Bhupathy
    Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309 80347, USA
    Womens Health (Lond Engl) 6:77-95. 2010
    ..In this review, the sex-based differences in cardiac (patho-) physiology are discussed with emphasis on the impact of sex hormones, hormone receptors and diet on heart disease...
  25. pmc Immunogenicity of intrathecal plasmid gene delivery: cytokine release and effects on transgene expression
    Travis S Hughes
    Department of Molecular, Cellular and Developmental Biology, University of CO, Boulder, CO, USA
    J Gene Med 11:782-90. 2009
    ....
  26. ncbi request reprint Suppressor tRNAs: protocols and applications for cardiac gene transfer
    Massimo Buvoli
    Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, USA
    Methods Mol Biol 219:115-27. 2003
  27. ncbi request reprint MyoD, Myf5, and the calcineurin pathway activate the developmental myosin heavy chain genes
    Doris Heidysch Beylkin
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309 0347, USA
    Dev Biol 294:541-53. 2006
    ..Some common features are shared between the promoters of these two genes; however, the mechanisms of their regulation appear distinct...
  28. ncbi request reprint Direct gene transfer into mouse heart
    Massimo Buvoli
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
    Methods Enzymol 346:134-42. 2002
  29. pmc Intrathecal injection of naked plasmid DNA provides long-term expression of secreted proteins
    Travis S Hughes
    Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309 0347, USA
    Mol Ther 17:88-94. 2009
    ..These data suggest that naked DNA has the potential to be used as a therapeutic tool for applications that require long-term release of transgenes into the CSF...
  30. pmc Uncoupling of expression of an intronic microRNA and its myosin host gene by exon skipping
    Matthew L Bell
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    Mol Cell Biol 30:1937-45. 2010
    ..Thus, concerted transcription and alternative splicing uncouple the level of expression of MYH7b and miR-499 when their coexpression is not required...
  31. ncbi request reprint Hypertrophy, fibrosis, and sudden cardiac death in response to pathological stimuli in mice with mutations in cardiac troponin T
    Alexander H Maass
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309 0347, USA
    Circulation 110:2102-9. 2004
    ..Little is known about how these phenotypes affect the responses to additional pathological stimuli...
  32. ncbi request reprint Yin Yang 1 represses alpha-myosin heavy chain gene expression in pathologic cardiac hypertrophy
    Peter D Mariner
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    Biochem Biophys Res Commun 326:79-86. 2005
    ....
  33. pmc Skeletal myosin heavy chain function in cultured lung myofibroblasts
    Nancy A Rice
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, CO 80309, USA
    J Cell Biol 163:119-29. 2003
    ..Interestingly, the regulation of skeletal myosin expression in myofibroblasts is distinct from that observed in muscle cells and suggests that cell context is important in its control...
  34. pmc Evidence that opioids may have toll-like receptor 4 and MD-2 effects
    Mark R Hutchinson
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Behav Immun 24:83-95. 2010
    ..These data provide evidence that select opioids may non-stereoselectively influence TLR4 signaling and have behavioral consequences resulting, in part, via TLR4 signaling...
  35. ncbi request reprint Loss of desmin leads to impaired voluntary wheel running and treadmill exercise performance
    Kurt W Haubold
    Dept of Molecular, Cellular, and Developmental Biology, Univ of Colorado, Campus Box 347, Boulder, CO 80309 0347, USA
    J Appl Physiol 95:1617-22. 2003
    ....
  36. ncbi request reprint Acute effects of desmin mutations on cytoskeletal and cellular integrity in cardiac myocytes
    Kurt Haubold
    Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309 0347, USA
    Cell Motil Cytoskeleton 54:105-21. 2003
    ..These results indicate that mutations in desmin have both direct and indirect effects on the cytoarchitecture of cardiac myocytes...
  37. ncbi request reprint Alterations in mitochondrial function in a mouse model of hypertrophic cardiomyopathy
    David T Lucas
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder 80309, USA
    Am J Physiol Heart Circ Physiol 284:H575-83. 2003
    ..Thus our results suggest that mitochondria may contribute to the hemodynamic dysfunction seen in some forms of HCM and offer a plausible mechanism responsible for some of the heterogeneity of the disease phenotypes...
  38. pmc Bioinformatics assessment of beta-myosin mutations reveals myosin's high sensitivity to mutations
    Massimo Buvoli
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    Trends Cardiovasc Med 18:141-9. 2008
    ..Increasing knowledge of the characteristics of MH7 mutations may provide a valuable resource for scientists and clinicians studying diagnosis, risk stratification, and treatment of disease associated with these mutations...
  39. ncbi request reprint Blocking cardiac growth in hypertrophic cardiomyopathy induces cardiac dysfunction and decreased survival only in males
    Stephen W Luckey
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Campus Box 347, Boulder, Colorado 80309 0347, USA
    Am J Physiol Heart Circ Physiol 292:H838-45. 2007
    ..Furthermore, these results show that blocking hypertrophy by active GSK-3beta in this HCM model is not therapeutic...
  40. ncbi request reprint Diversity in transcriptional start site selection and alternative splicing affects the 5'-UTR of mouse striated muscle myosin transcripts
    Briana K Dennehey
    Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder, CO 80309, USA
    J Muscle Res Cell Motil 27:559-75. 2006
    ..These findings indicate that alternative TSS usage and alternative splicing in the 5'-UTR are a general feature of murine Myh gene expression and that Myh gene regulation is more complex than previously appreciated...
  41. ncbi request reprint Molecular and genetic approaches to studying exercise performance and adaptation
    David L Allen
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder 80309, USA
    Exerc Sport Sci Rev 30:99-105. 2002
    ..We discuss three molecular approaches that can evaluate the role of individual genes in the exercise response, and could provide a foundation for more effective exercise regimens for humans...
  42. ncbi request reprint Exercise can prevent and reverse the severity of hypertrophic cardiomyopathy
    John P Konhilas
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309 0347, USA
    Circ Res 98:540-8. 2006
    ..Remarkably, there were no differences in mortality between exercised NTG and HCM mice. Thus, not only was exercise not harmful but also it was able to prevent and even reverse established cardiac disease phenotypes in this HCM model...
  43. pmc The role of MEKK1 in hypertrophic cardiomyopathy
    John P Konhilas
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309 0347, USA
    Int Heart J 51:277-84. 2010
    ..We conclude that the absence of MEKK1 induces a more pronounced cardiac hypertrophy to HCM through altered expression of proteases implicated in cardiac remodeling and increased apoptosis...
  44. doi request reprint Fighting fat with muscle: bulking up to slim down
    Brooke C Harrison
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, CO 80309, USA
    Cell Metab 7:97-8. 2008
    ..2008) reveal a striking link between Akt1 signaling, fast muscle fiber size, and whole-body metabolism. These results provide new insights into the ability of muscle to combat diet-induced obesity and metabolic dysfunction...
  45. pmc Functional diversity among a family of human skeletal muscle myosin motors
    Daniel I Resnicow
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, UCB347, Boulder, CO 80309, USA
    Proc Natl Acad Sci U S A 107:1053-8. 2010
    ....
  46. ncbi request reprint Serum deprivation improves seeding and repopulation of acellular matrices with valvular interstitial cells
    Melinda C Cushing
    Department of Chemical and Biological Engineering, ECCH 111, UCB 424, University of Colorado, Boulder, CO 80309 0424, USA
    J Biomed Mater Res A 75:232-41. 2005
    ....
  47. pmc Mutations in the beta-myosin rod cause myosin storage myopathy via multiple mechanisms
    Thomas Z Armel
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    Proc Natl Acad Sci U S A 106:6291-6. 2009
    ....
  48. pmc The role of Akt/GSK-3beta signaling in familial hypertrophic cardiomyopathy
    Stephen W Luckey
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Campus Box 347, Boulder, Colorado 80309 0347, USA
    J Mol Cell Cardiol 46:739-47. 2009
    ..Moreover, increased activity of these molecules implicated in beneficial cardiac phenotypes exacerbates the progression of disease in the R92Q TnT mutant...
  49. pmc Soy diet worsens heart disease in mice
    Brian L Stauffer
    Department of Medicine, Division of Cardiology, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Clin Invest 116:209-16. 2006
    ..Further, this diet prevents a number of pathologic indicators in males, including fibrosis, induction of beta-myosin heavy chain, inactivation of glycogen synthase kinase 3beta (GSK3beta), and caspase-3 activation...
  50. pmc Increased thermoregulation in cold-exposed transgenic mice overexpressing lipoprotein lipase in skeletal muscle: an avian phenotype?
    Dalan R Jensen
    Division of Endocrinology, Diabetes, and Metabolism, University of Colorado at Denver, Aurora, CO, USA
    J Lipid Res 49:870-9. 2008
    ....
  51. ncbi request reprint Expression of cardiac troponin T with COOH-terminal truncation accelerates cross-bridge interaction kinetics in mouse myocardium
    Julian E Stelzer
    Dept of Physiology, University of Wisconsin School of Medicine, 1300 University Avenue, Madison, WI 53706, USA
    Am J Physiol Heart Circ Physiol 287:H1756-61. 2004
    ..Although these mechanisms would not be expected to depress systolic function per se in cTnT(trunc) hearts, they would account for slowed rates of myocardial relaxation during early diastole...
  52. ncbi request reprint Task Force on Strategic Research Direction: Basic Science Subgroup key science topics report
    Joseph Loscalzo
    Circulation 106:e149-61. 2002
  53. ncbi request reprint Mechanisms of the pathogenesis of troponin T-based familial hypertrophic cardiomyopathy
    Alexander H Maass
    Department of Medicine, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany
    Trends Cardiovasc Med 13:232-7. 2003
    ..Such models ideally allow for testing of the role of individual phenotypes in the pathways leading to cardiomyopathy, as well as identification of factors such as exercise that can affect the disease...
  54. ncbi request reprint Cell type specific targeted intracellular delivery into muscle of a monoclonal antibody that binds myosin IIb
    Richard H Weisbart
    Department of Medicine, Division of Rheumatology, Veterans Affairs Greater Los Angeles Health Care System, Sepulveda, CA 91343, USA
    Mol Immunol 39:783-9. 2003
    ..Myosin IIb is implicated in the specific targeting of mAb 3E10 to skeletal muscle...
  55. pmc Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers
    Aron M Geurts
    Department of Genetics, Cell Biology, and Development, University of Minnesota Twin Cities, Minneapolis, Minnesota, United States of America
    PLoS Genet 2:e156. 2006
    ..Additionally, these mice may serve as a model for chromosome rearrangements caused by transposable elements during the evolution of vertebrate genomes...
  56. pmc Partnering up for cardiac hypertrophy
    John P Konhilas
    Circ Res 98:985-7. 2006

Research Grants38

  1. MECHANISMS OF CARDIOVASCULAR DISEASE AND GENE THERAPY
    Leslie Leinwand; Fiscal Year: 2005
    ..In addition, we have established a formal link with the MD-PhD) program in Denver that allows those students to do their thesis work in Boulder. This training grant can facilitate those ventures. ..
  2. MYOSIN GENE DIVERSITY AND FUNCTION
    Leslie Leinwand; Fiscal Year: 2006
    ....
  3. Developmental Myosin Heavy Chain Regulation and Function
    Leslie Leinwand; Fiscal Year: 2006
    ..Specifically, we will test the hypothesis that embryonic MyHC contractile function is necessary for muscle development. These studies will define the role of the developmental MyHC isoforms in skeletal muscle form and function. ..
  4. CARDIAC ADAPTATION: DISEASE, EXERCISE, SEX AND DIET
    Leslie Leinwand; Fiscal Year: 2006
    ..We feel that these approaches will be very useful to our understanding of the basic biology of adaptive and maladaptive cardiac hypertrophy and pathogenesis. ..
  5. Mechanisms of myopathy caused by mutations in the myosin rod
    Leslie Leinwand; Fiscal Year: 2007
    ..Relevance to public health: Genetic heart disease is an important health problem and this specific type of heart disease we study is the leading cause of sudden death in young people. ..
  6. MYOSIN GENE DIVERSITY AND FUNCTION
    Leslie Leinwand; Fiscal Year: 2007
    ..Many diseases affect muscle function and our work focuses on how normal muscle works and how mutant genes caused muscle disease. ..
  7. MYOSIN GENE DIVERSITY AND FUNCTION
    Leslie Leinwand; Fiscal Year: 2009
    ..Many diseases affect muscle function and our work focuses on how normal muscle works and how mutant genes caused muscle disease. ..
  8. Mechanisms of myopathy caused by mutations in the myosin rod
    LESLIE ANNE LEINWAND; Fiscal Year: 2010
    ..Relevance to public health: Genetic heart disease is an important health problem and this specific type of heart disease we study is the leading cause of sudden death in young people. ..
  9. Mediators of Cardiac Adaptation
    LESLIE ANNE LEINWAND; Fiscal Year: 2010
    ....
  10. DENVER CARDIOVASCULAR HEALTH EDUCATION ALLIANCE, PHASE I
    Leslie Leinwand; Fiscal Year: 2004
    ..abstract_text> ..
  11. Conference on Molecular Biology of the Heart
    Leslie Leinwand; Fiscal Year: 2002
    ..It will be a multidisciplinary meeting that should bring together people who are beginning to have regular dialogues but whose traditions have been somewhat separate. ..
  12. MYOSIN GENE DIVERSITY AND FUNCTION
    Leslie Leinwand; Fiscal Year: 2001
    ..Using cultured myofibroblast model systems, the role and organization of sarcomeric proteins in myofibroblast contractility will be determined. ..
  13. MYOSIN GENE DIVERSITY AND FUNCTION
    LESLIE ANNE LEINWAND; Fiscal Year: 2010
    ..Many diseases affect muscle function and our work focuses on how normal muscle works and how mutant genes caused muscle disease. ..