GEORGE DOUGLAS LEIKAUF

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Functional genomic assessment of phosgene-induced acute lung injury in mice
    George D Leikauf
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, PA 15219, USA
    Am J Respir Cell Mol Biol 49:368-83. 2013
  2. pmc Integrative assessment of chlorine-induced acute lung injury in mice
    George D Leikauf
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, PA 15219 3130, USA
    Am J Respir Cell Mol Biol 47:234-44. 2012
  3. pmc Functional genomics of chlorine-induced acute lung injury in mice
    George D Leikauf
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, 100 Technology Drive, Pittsburgh, PA 15219 3130, USA
    Proc Am Thorac Soc 7:294-6. 2010
  4. pmc Haplotype association mapping of acute lung injury in mice implicates activin a receptor, type 1
    George D Leikauf
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219 3130, USA
    Am J Respir Crit Care Med 183:1499-509. 2011
  5. doi Acrolein - a pulmonary hazard
    Kiflai Bein
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219 3130, USA
    Mol Nutr Food Res 55:1342-60. 2011
  6. pmc Endothelial dysfunction and claudin 5 regulation during acrolein-induced lung injury
    An Soo Jang
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219 3130, USA
    Am J Respir Cell Mol Biol 44:483-90. 2011

Research Grants

  1. Genetic Determinants of Nickel-induced Lung Injury
    GEORGE LEIKAUF; Fiscal Year: 2005
  2. Growth Factor Protection in Acute Lung Injury
    GEORGE LEIKAUF; Fiscal Year: 2007
  3. Functional Genomics of Chemical -Induced Acute Lung Injury
    GEORGE LEIKAUF; Fiscal Year: 2007
  4. Growth Factor Protection in Acute Lung Injury
    GEORGE LEIKAUF; Fiscal Year: 2009
  5. GENETIC DETERMINATION OF ACUTE LUNG INJURY
    GEORGE LEIKAUF; Fiscal Year: 2004
  6. MURINE MODELS OF OCCUPATIONAL COPD
    GEORGE LEIKAUF; Fiscal Year: 2001
  7. Role of Metalloproteinases in Mucin Overproduction in COPD
    GEORGE DOUGLAS LEIKAUF; Fiscal Year: 2010

Detail Information

Publications6

  1. pmc Functional genomic assessment of phosgene-induced acute lung injury in mice
    George D Leikauf
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, PA 15219, USA
    Am J Respir Cell Mol Biol 49:368-83. 2013
    ..In addition, a gene with a suggestive SNP association, Itga9, is linked to transforming growth factor β1 signaling, which previously has been associated with the susceptibility to ALI in mice. ..
  2. pmc Integrative assessment of chlorine-induced acute lung injury in mice
    George D Leikauf
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, PA 15219 3130, USA
    Am J Respir Cell Mol Biol 47:234-44. 2012
    ..The leading candidate genes associated with increased susceptibility to acute lung injury in mice included Klf4, Sema7a, Tns1, Aacs, and a gene that encodes an amino acid carrier, Slc38a4...
  3. pmc Functional genomics of chlorine-induced acute lung injury in mice
    George D Leikauf
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, 100 Technology Drive, Pittsburgh, PA 15219 3130, USA
    Proc Am Thorac Soc 7:294-6. 2010
    ..Gene-targeted mice then could be used to test the functional significance of susceptibility candidate genes, which could be valuable in revealing novel insights into the biology of acute lung injury...
  4. pmc Haplotype association mapping of acute lung injury in mice implicates activin a receptor, type 1
    George D Leikauf
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219 3130, USA
    Am J Respir Crit Care Med 183:1499-509. 2011
    ..Because acute lung injury is a sporadic disease produced by heterogeneous precipitating factors, previous genetic analyses are mainly limited to candidate gene case-control studies...
  5. doi Acrolein - a pulmonary hazard
    Kiflai Bein
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219 3130, USA
    Mol Nutr Food Res 55:1342-60. 2011
    ..Consequent to its pathophysiological impact, acrolein contributes to the morbidly and mortality associated with acute lung injury and COPD, and possibly asthma and lung cancer...
  6. pmc Endothelial dysfunction and claudin 5 regulation during acrolein-induced lung injury
    An Soo Jang
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219 3130, USA
    Am J Respir Cell Mol Biol 44:483-90. 2011
    ..The phosphorylation status of these transcription factors was consistent with the observed CLDN5 alteration. Preservation of endothelial CLDN5 may be a novel clinical approach for ALI therapy...

Research Grants22

  1. Genetic Determinants of Nickel-induced Lung Injury
    GEORGE LEIKAUF; Fiscal Year: 2005
    ..Determination of the relative roles of the genetic loci linked to nickel sulfate exposure is likely to improve our understanding of the mechanisms involved in acute lung injury. ..
  2. Growth Factor Protection in Acute Lung Injury
    GEORGE LEIKAUF; Fiscal Year: 2007
    ..The anticipated impact of these studies would be an evidence-based scientific verification or refutation of the likelihood that therapeutics directed at TGFalpha/EGFR signaling could be considered for the treatment of acute lung injury. ..
  3. Functional Genomics of Chemical -Induced Acute Lung Injury
    GEORGE LEIKAUF; Fiscal Year: 2007
    ..abstract_text> ..
  4. Growth Factor Protection in Acute Lung Injury
    GEORGE LEIKAUF; Fiscal Year: 2009
    ..The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page. RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
  5. GENETIC DETERMINATION OF ACUTE LUNG INJURY
    GEORGE LEIKAUF; Fiscal Year: 2004
    ..Significance: This investigation seeks to uncover novel genes not previously associated with survival during acute lung injury. Such findings could provide new biological information and insights into this severe clinical condition. ..
  6. MURINE MODELS OF OCCUPATIONAL COPD
    GEORGE LEIKAUF; Fiscal Year: 2001
    ..The well-characterized mouse model generated by this proposal will be useful in the further understanding of the relationship between occupational exposures, genetic markers, inflammatory responses, and COPD. ..
  7. Role of Metalloproteinases in Mucin Overproduction in COPD
    GEORGE DOUGLAS LEIKAUF; Fiscal Year: 2010
    ....