Iliya Lefterov

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Expression profiling in APP23 mouse brain: inhibition of Abeta amyloidosis and inflammation in response to LXR agonist treatment
    Iliya Lefterov
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Mol Neurodegener 2:20. 2007
  2. pmc Apolipoprotein A-I deficiency increases cerebral amyloid angiopathy and cognitive deficits in APP/PS1DeltaE9 mice
    Iliya Lefterov
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    J Biol Chem 285:36945-57. 2010
  3. pmc Abca1 deficiency affects Alzheimer's disease-like phenotype in human ApoE4 but not in ApoE3-targeted replacement mice
    Nicholas F Fitz
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    J Neurosci 32:13125-36. 2012
  4. pmc Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice
    Nicholas F Fitz
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    J Neurosci 30:6862-72. 2010
  5. pmc Proton pump inhibitor lansoprazole is a nuclear liver X receptor agonist
    Andrea A Cronican
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Biochem Pharmacol 79:1310-6. 2010
  6. pmc The role of ATP-binding cassette transporter A1 in Alzheimer's disease and neurodegeneration
    Radosveta Koldamova
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Biochim Biophys Acta 1801:824-30. 2010
  7. pmc Genome-wide alteration of histone H3K9 acetylation pattern in mouse offspring prenatally exposed to arsenic
    Andrea A Cronican
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA
    PLoS ONE 8:e53478. 2013
  8. pmc Genome-wide approaches reveal EGR1-controlled regulatory networks associated with neurodegeneration
    Radosveta Koldamova
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA Electronic address
    Neurobiol Dis 63:107-14. 2014
  9. pmc Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models"
    Nicholas F Fitz
    Department of Environmental and Occupational Health, University of Pittsburgh, 100 Technology Drive, Pittsburgh, PA 15219, USA
    Science 340:924-c. 2013
  10. ncbi request reprint Role of LXR and ABCA1 in the pathogenesis of Alzheimer's disease - implications for a new therapeutic approach
    Radosveta Koldamova
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Curr Alzheimer Res 4:171-8. 2007

Collaborators

Detail Information

Publications18

  1. pmc Expression profiling in APP23 mouse brain: inhibition of Abeta amyloidosis and inflammation in response to LXR agonist treatment
    Iliya Lefterov
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Mol Neurodegener 2:20. 2007
    ..We also performed a series of experiments with primary brain cells derived from wild type and LXR knockout mice subjected to various LXR agonist treatments and inflammatory stimuli...
  2. pmc Apolipoprotein A-I deficiency increases cerebral amyloid angiopathy and cognitive deficits in APP/PS1DeltaE9 mice
    Iliya Lefterov
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    J Biol Chem 285:36945-57. 2010
    ..We conclude that lack of apoA-I aggravates the memory deficits in APP/PS1ΔE9 mice in parallel to significantly increased cerebral amyloid angiopathy...
  3. pmc Abca1 deficiency affects Alzheimer's disease-like phenotype in human ApoE4 but not in ApoE3-targeted replacement mice
    Nicholas F Fitz
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    J Neurosci 32:13125-36. 2012
    ..Overall, our results prove that the presence of functional Abca1 significantly influences the phenotype of APP mice expressing human ApoE4 and further substantiate therapeutic approaches in AD based on ABCA1-APOE regulatory axis...
  4. pmc Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice
    Nicholas F Fitz
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    J Neurosci 30:6862-72. 2010
    ..The data presented conclusively shows that LXR activation in the context of a metabolic challenge has critical effects on AD phenotype progression by attenuating Abeta deposition and facilitating its clearance...
  5. pmc Proton pump inhibitor lansoprazole is a nuclear liver X receptor agonist
    Andrea A Cronican
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Biochem Pharmacol 79:1310-6. 2010
    ..The identification of a widely used drug with LXR agonist-like activity opens the possibility for systematic preclinical testing in at least two diseases--Alzheimer's disease and atherosclerosis...
  6. pmc The role of ATP-binding cassette transporter A1 in Alzheimer's disease and neurodegeneration
    Radosveta Koldamova
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Biochim Biophys Acta 1801:824-30. 2010
    ..This review will summarize the results of research on ABCA1, particularly related to AD and neurodegeneration...
  7. pmc Genome-wide alteration of histone H3K9 acetylation pattern in mouse offspring prenatally exposed to arsenic
    Andrea A Cronican
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA
    PLoS ONE 8:e53478. 2013
    ....
  8. pmc Genome-wide approaches reveal EGR1-controlled regulatory networks associated with neurodegeneration
    Radosveta Koldamova
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA Electronic address
    Neurobiol Dis 63:107-14. 2014
    ..The results of this study suggest that EGR1 regulates the expression of genes involved in CME, vesicular transport and synaptic transmission that may be critical for AD pathogenesis. ..
  9. pmc Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models"
    Nicholas F Fitz
    Department of Environmental and Occupational Health, University of Pittsburgh, 100 Technology Drive, Pittsburgh, PA 15219, USA
    Science 340:924-c. 2013
    ....
  10. ncbi request reprint Role of LXR and ABCA1 in the pathogenesis of Alzheimer's disease - implications for a new therapeutic approach
    Radosveta Koldamova
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Curr Alzheimer Res 4:171-8. 2007
    ....
  11. ncbi request reprint Improvement of Memory Deficits and Amyloid-β Clearance in Aged APP23 Mice Treated with a Combination of Anti-Amyloid-β Antibody and LXR Agonist
    Nicholas F Fitz
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    J Alzheimers Dis 41:535-49. 2014
    ....
  12. ncbi request reprint 22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion
    Radosveta P Koldamova
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 278:13244-56. 2003
    ..These effects of 22R-hydroxycholesterol may provide a novel strategy to decrease amyloid beta secretion and consequently reduce the amyloid burden in the brain...
  13. ncbi request reprint The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease
    Radosveta P Koldamova
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 280:4079-88. 2005
    ..Our experiments demonstrate that T0901317 decreases amyloidogenic processing of APP in vitro and in vivo, thus supporting the search for potent and specific LXR ligands with properties allowing therapeutic application...
  14. ncbi request reprint Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice
    Radosveta Koldamova
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 280:43224-35. 2005
    ..These results suggest that ABCA1 plays a role in the pathogenesis of parenchymal and cerebrovascular amyloid pathology and thus may be considered a therapeutic target in AD...
  15. ncbi request reprint Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer's disease brain but not in transgenic mouse brain
    William E Klunk
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 25:10598-606. 2005
    ....
  16. pmc Functional and genetic characterization of the promoter region of apolipoprotein H (beta2-glycoprotein I)
    Sangita Suresh
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    FEBS J 277:951-63. 2010
    ..In conclusion, we have characterized the functional promoter of APOH and identified functional variants that affect the transcriptional activity of the APOH promoter...
  17. ncbi request reprint Binding and inhibition of Cdc25 phosphatases by vitamin K analogues
    Siddhartha Kar
    Department of Surgery, Liver Cancer Center, Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Biochemistry 42:10490-7. 2003
    ..The results demonstrate a direct interaction and binding between this growth-inhibiting K vitamin derivative with both purified as well as with cellular Cdc25A, Cdc25B, and Cdc25C...

Research Grants3

  1. Therapeutic potential-LXR ligands in Alzheimer's Disease
    Iliya Lefterov; Fiscal Year: 2005
    ..abstract_text> ..
  2. ABCA1 knock-in mouse model to study molecular pathology of Alzheimer's Disease
    Iliya Lefterov; Fiscal Year: 2007
    ..The effect of the mutated ABCA1N93ss on brain lipoproteins and endogenous APR processing and ABeta generation in vivo will be determined as a preliminary step to substantiate future detailed biochemical studies. ..