Iliya Lefterov

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi Apolipoprotein A-I deficiency increases cerebral amyloid angiopathy and cognitive deficits in APP/PS1DeltaE9 mice
    Iliya Lefterov
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    J Biol Chem 285:36945-57. 2010
  2. ncbi Expression profiling in APP23 mouse brain: inhibition of Abeta amyloidosis and inflammation in response to LXR agonist treatment
    Iliya Lefterov
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Mol Neurodegener 2:20. 2007
  3. ncbi Abca1 deficiency affects Alzheimer's disease-like phenotype in human ApoE4 but not in ApoE3-targeted replacement mice
    Nicholas F Fitz
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    J Neurosci 32:13125-36. 2012
  4. ncbi Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice
    Nicholas F Fitz
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    J Neurosci 30:6862-72. 2010
  5. ncbi Proton pump inhibitor lansoprazole is a nuclear liver X receptor agonist
    Andrea A Cronican
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Biochem Pharmacol 79:1310-6. 2010
  6. ncbi The role of ATP-binding cassette transporter A1 in Alzheimer's disease and neurodegeneration
    Radosveta Koldamova
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Biochim Biophys Acta 1801:824-30. 2010
  7. ncbi Role of LXR and ABCA1 in the pathogenesis of Alzheimer's disease - implications for a new therapeutic approach
    Radosveta Koldamova
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Curr Alzheimer Res 4:171-8. 2007
  8. ncbi Genome-wide alteration of histone H3K9 acetylation pattern in mouse offspring prenatally exposed to arsenic
    Andrea A Cronican
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA
    PLoS ONE 8:e53478. 2013
  9. ncbi The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease
    Radosveta P Koldamova
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 280:4079-88. 2005
  10. ncbi 22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion
    Radosveta P Koldamova
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 278:13244-56. 2003

Research Grants

  1. Therapeutic potential-LXR ligands in Alzheimer's Disease
    Iliya Lefterov; Fiscal Year: 2005
  2. ABCA1 knock-in mouse model to study molecular pathology of Alzheimer's Disease
    Iliya Lefterov; Fiscal Year: 2007

Collaborators

Detail Information

Publications14

  1. ncbi Apolipoprotein A-I deficiency increases cerebral amyloid angiopathy and cognitive deficits in APP/PS1DeltaE9 mice
    Iliya Lefterov
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    J Biol Chem 285:36945-57. 2010
    ..We conclude that lack of apoA-I aggravates the memory deficits in APP/PS1ΔE9 mice in parallel to significantly increased cerebral amyloid angiopathy...
  2. ncbi Expression profiling in APP23 mouse brain: inhibition of Abeta amyloidosis and inflammation in response to LXR agonist treatment
    Iliya Lefterov
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Mol Neurodegener 2:20. 2007
    ..We also performed a series of experiments with primary brain cells derived from wild type and LXR knockout mice subjected to various LXR agonist treatments and inflammatory stimuli...
  3. ncbi Abca1 deficiency affects Alzheimer's disease-like phenotype in human ApoE4 but not in ApoE3-targeted replacement mice
    Nicholas F Fitz
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    J Neurosci 32:13125-36. 2012
    ..Overall, our results prove that the presence of functional Abca1 significantly influences the phenotype of APP mice expressing human ApoE4 and further substantiate therapeutic approaches in AD based on ABCA1-APOE regulatory axis...
  4. ncbi Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice
    Nicholas F Fitz
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    J Neurosci 30:6862-72. 2010
    ..The data presented conclusively shows that LXR activation in the context of a metabolic challenge has critical effects on AD phenotype progression by attenuating Abeta deposition and facilitating its clearance...
  5. ncbi Proton pump inhibitor lansoprazole is a nuclear liver X receptor agonist
    Andrea A Cronican
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Biochem Pharmacol 79:1310-6. 2010
    ..The identification of a widely used drug with LXR agonist-like activity opens the possibility for systematic preclinical testing in at least two diseases--Alzheimer's disease and atherosclerosis...
  6. ncbi The role of ATP-binding cassette transporter A1 in Alzheimer's disease and neurodegeneration
    Radosveta Koldamova
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Biochim Biophys Acta 1801:824-30. 2010
    ..This review will summarize the results of research on ABCA1, particularly related to AD and neurodegeneration...
  7. ncbi Role of LXR and ABCA1 in the pathogenesis of Alzheimer's disease - implications for a new therapeutic approach
    Radosveta Koldamova
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Curr Alzheimer Res 4:171-8. 2007
    ....
  8. ncbi Genome-wide alteration of histone H3K9 acetylation pattern in mouse offspring prenatally exposed to arsenic
    Andrea A Cronican
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA
    PLoS ONE 8:e53478. 2013
    ....
  9. ncbi The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease
    Radosveta P Koldamova
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 280:4079-88. 2005
    ..Our experiments demonstrate that T0901317 decreases amyloidogenic processing of APP in vitro and in vivo, thus supporting the search for potent and specific LXR ligands with properties allowing therapeutic application...
  10. ncbi 22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion
    Radosveta P Koldamova
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 278:13244-56. 2003
    ..These effects of 22R-hydroxycholesterol may provide a novel strategy to decrease amyloid beta secretion and consequently reduce the amyloid burden in the brain...
  11. ncbi Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer's disease brain but not in transgenic mouse brain
    William E Klunk
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 25:10598-606. 2005
    ....
  12. ncbi Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice
    Radosveta Koldamova
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 280:43224-35. 2005
    ..These results suggest that ABCA1 plays a role in the pathogenesis of parenchymal and cerebrovascular amyloid pathology and thus may be considered a therapeutic target in AD...
  13. ncbi Functional and genetic characterization of the promoter region of apolipoprotein H (beta2-glycoprotein I)
    Sangita Suresh
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    FEBS J 277:951-63. 2010
    ..In conclusion, we have characterized the functional promoter of APOH and identified functional variants that affect the transcriptional activity of the APOH promoter...
  14. ncbi Binding and inhibition of Cdc25 phosphatases by vitamin K analogues
    Siddhartha Kar
    Department of Surgery, Liver Cancer Center, Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Biochemistry 42:10490-7. 2003
    ..The results demonstrate a direct interaction and binding between this growth-inhibiting K vitamin derivative with both purified as well as with cellular Cdc25A, Cdc25B, and Cdc25C...

Research Grants3

  1. Therapeutic potential-LXR ligands in Alzheimer's Disease
    Iliya Lefterov; Fiscal Year: 2005
    ..abstract_text> ..
  2. ABCA1 knock-in mouse model to study molecular pathology of Alzheimer's Disease
    Iliya Lefterov; Fiscal Year: 2007
    ..The effect of the mutated ABCA1N93ss on brain lipoproteins and endogenous APR processing and ABeta generation in vivo will be determined as a preliminary step to substantiate future detailed biochemical studies. ..