C Leeuwenburgh

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. ncbi request reprint Oxidative stress and antioxidants in exercise
    C Leeuwenburgh
    Center for Exercise Science, Aging Biochemistry Laboratory, College of Health and Human Performance, University of Florida, Gainesville, FL 32611, USA
    Curr Med Chem 8:829-38. 2001
  2. pmc Iron accumulation with age, oxidative stress and functional decline
    Jinze Xu
    Department of Aging and Geriatrics, Division of Biology of Aging, Genomics and Biomarkers Core of the Institute on Aging, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 3:e2865. 2008
  3. pmc Increased iron content and RNA oxidative damage in skeletal muscle with aging and disuse atrophy
    Tim Hofer
    Department of Aging and Geriatrics, Division of Biology of Aging, Genomics and Biomarkers Core of the Institute on Aging, University of Florida, Gainesville, USA
    Exp Gerontol 43:563-70. 2008
  4. ncbi request reprint Mitochondrial iron accumulation with age and functional consequences
    Arnold Y Seo
    Department of Aging and Geriatrics, Division of Biology of Aging, Genomics and Biomarkers Core of the Institute on Aging, University of Florida, Gainesville, FL 32611, USA
    Aging Cell 7:706-16. 2008
  5. ncbi request reprint Age-associated increases in oxidative stress and antioxidant enzyme activities in cardiac interfibrillar mitochondria: implications for the mitochondrial theory of aging
    Sharon Judge
    University of Florida, Biochemistry of Aging Laboratory, Gainesville, FL 32611, USA
    FASEB J 19:419-21. 2005
  6. ncbi request reprint Muscle fiber specific apoptosis and TNF-alpha signaling in sarcopenia are attenuated by life-long calorie restriction
    Tracey Phillips
    University of Florida, Department of Aging and Geriatric Research, College of Medicine, Biochemistry of Aging Laboratory, Gainesville, Florida 32611, USA
    FASEB J 19:668-70. 2005
  7. ncbi request reprint Cytochrome c release from mitochondria in the aging heart: a possible mechanism for apoptosis with age
    Sharon Phaneuf
    Biochemistry of Aging Laboratory, College of Health and Human Performance, Center for Exercise Science, College of Medicine, University of Florida, Gainesville, Florida 32611, USA
    Am J Physiol Regul Integr Comp Physiol 282:R423-30. 2002
  8. pmc The emerging role of iron dyshomeostasis in the mitochondrial decay of aging
    Jinze Xu
    Department of Aging and Geriatrics Research, Division of Biology of Aging, Genomics, Metabolism and Biomarkers Core of the Institute on Aging, University of Florida, Gainesville, FL 32611, USA
    Mech Ageing Dev 131:487-93. 2010
  9. ncbi request reprint Exercise by lifelong voluntary wheel running reduces subsarcolemmal and interfibrillar mitochondrial hydrogen peroxide production in the heart
    Sharon Judge
    Univ of Florida, College of Medicine, Dept of Aging and Geriatric Research, Genomics and Biomarkers Core Institute on Aging, Biochemistry of Aging Laboratory, Gainesville, FL 32608, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1564-72. 2005
  10. ncbi request reprint Aging and lifelong calorie restriction result in adaptations of skeletal muscle apoptosis repressor, apoptosis-inducing factor, X-linked inhibitor of apoptosis, caspase-3, and caspase-12
    Amie J Dirks
    Biochemistry of Aging Laboratory, University of Florida, Gainesville, FL 32611, USA
    Free Radic Biol Med 36:27-39. 2004

Detail Information

Publications93

  1. ncbi request reprint Oxidative stress and antioxidants in exercise
    C Leeuwenburgh
    Center for Exercise Science, Aging Biochemistry Laboratory, College of Health and Human Performance, University of Florida, Gainesville, FL 32611, USA
    Curr Med Chem 8:829-38. 2001
    ..These include increased antioxidant defenses, reduced basal production of oxidants, and reduction of radical leak during oxidative phosphorylation...
  2. pmc Iron accumulation with age, oxidative stress and functional decline
    Jinze Xu
    Department of Aging and Geriatrics, Division of Biology of Aging, Genomics and Biomarkers Core of the Institute on Aging, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 3:e2865. 2008
    ..These findings strongly suggest that the age-related iron accumulation in muscle contributes to increased oxidative damage and sarcopenia, and that CR effectively attenuates these negative effects...
  3. pmc Increased iron content and RNA oxidative damage in skeletal muscle with aging and disuse atrophy
    Tim Hofer
    Department of Aging and Geriatrics, Division of Biology of Aging, Genomics and Biomarkers Core of the Institute on Aging, University of Florida, Gainesville, USA
    Exp Gerontol 43:563-70. 2008
    ..These results suggest that RNA oxidation, possibly mediated by increased non-heme iron, might contribute to muscle atrophy due to disuse particularly in aged muscle...
  4. ncbi request reprint Mitochondrial iron accumulation with age and functional consequences
    Arnold Y Seo
    Department of Aging and Geriatrics, Division of Biology of Aging, Genomics and Biomarkers Core of the Institute on Aging, University of Florida, Gainesville, FL 32611, USA
    Aging Cell 7:706-16. 2008
    ..Overall, our data suggest that age-dependent accumulation of mitochondrial iron may increase mitochondrial dysfunction and oxidative damage,thereby enhancing the susceptibility to apoptosis...
  5. ncbi request reprint Age-associated increases in oxidative stress and antioxidant enzyme activities in cardiac interfibrillar mitochondria: implications for the mitochondrial theory of aging
    Sharon Judge
    University of Florida, Biochemistry of Aging Laboratory, Gainesville, FL 32611, USA
    FASEB J 19:419-21. 2005
    ..Our results emphasize the importance of studying both mitochondrial populations when attempting to elucidate the contribution of mitochondrial dysfunction to myocardial aging...
  6. ncbi request reprint Muscle fiber specific apoptosis and TNF-alpha signaling in sarcopenia are attenuated by life-long calorie restriction
    Tracey Phillips
    University of Florida, Department of Aging and Geriatric Research, College of Medicine, Biochemistry of Aging Laboratory, Gainesville, Florida 32611, USA
    FASEB J 19:668-70. 2005
    ..Such a specific potential may constitute a major proponent in the pathogenesis of sarcopenia...
  7. ncbi request reprint Cytochrome c release from mitochondria in the aging heart: a possible mechanism for apoptosis with age
    Sharon Phaneuf
    Biochemistry of Aging Laboratory, College of Health and Human Performance, Center for Exercise Science, College of Medicine, University of Florida, Gainesville, Florida 32611, USA
    Am J Physiol Regul Integr Comp Physiol 282:R423-30. 2002
    ..This is the first study to report cytochrome c release from the mitochondria and alterations in Bcl-2 with age in vivo, providing a potential mechanism for the increase in apoptosis seen in the aging heart...
  8. pmc The emerging role of iron dyshomeostasis in the mitochondrial decay of aging
    Jinze Xu
    Department of Aging and Geriatrics Research, Division of Biology of Aging, Genomics, Metabolism and Biomarkers Core of the Institute on Aging, University of Florida, Gainesville, FL 32611, USA
    Mech Ageing Dev 131:487-93. 2010
    ..A substantial research effort now focuses on developing and testing safe pharmacologic interventions to combat iron dyshomeostasis in aging, acute injuries and in iron overload disorders...
  9. ncbi request reprint Exercise by lifelong voluntary wheel running reduces subsarcolemmal and interfibrillar mitochondrial hydrogen peroxide production in the heart
    Sharon Judge
    Univ of Florida, College of Medicine, Dept of Aging and Geriatric Research, Genomics and Biomarkers Core Institute on Aging, Biochemistry of Aging Laboratory, Gainesville, FL 32608, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1564-72. 2005
    ..The health benefits of chronic exercise may be, at least partially, due to a reduction in mitochondrial oxidant production; however, we could not detect a significant reduction in several selected parameters of oxidative stress...
  10. ncbi request reprint Aging and lifelong calorie restriction result in adaptations of skeletal muscle apoptosis repressor, apoptosis-inducing factor, X-linked inhibitor of apoptosis, caspase-3, and caspase-12
    Amie J Dirks
    Biochemistry of Aging Laboratory, University of Florida, Gainesville, FL 32611, USA
    Free Radic Biol Med 36:27-39. 2004
    ..Calorie restriction is able to lower the apoptotic potential in aged skeletal muscle by altering several key apoptotic proteins toward cellular survival, thereby reducing the potential for sarcopenia...
  11. pmc Bioenergetics and permeability transition pore opening in heart subsarcolemmal and interfibrillar mitochondria: effects of aging and lifelong calorie restriction
    Tim Hofer
    Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, Division of Biology of Aging, University of Florida, Gainesville, FL 32610, USA
    Mech Ageing Dev 130:297-307. 2009
    ..In summary, the age-related reduction of Ca(2+) retention capacity in IFM may explain the increased susceptibility to stress-induced cell death in the aged myocardium...
  12. ncbi request reprint Short-term caloric restriction and regulatory proteins of apoptosis in heart, skeletal muscle and kidney of Fischer 344 rats
    Colin Selman
    University of Florida, Biochemistry of Aging Laboratory, College of Health and Human Performance, Box 118206, Gainesville, FL 32611, USA
    Biogerontology 4:141-7. 2003
    ....
  13. doi request reprint Modulation of GH/IGF-1 axis: potential strategies to counteract sarcopenia in older adults
    Silvia Giovannini
    Department of Aging and Geriatric Research, University of Florida, Gainesville, USA
    Mech Ageing Dev 129:593-601. 2008
    ....
  14. ncbi request reprint Doxorubicin treatment in vivo causes cytochrome C release and cardiomyocyte apoptosis, as well as increased mitochondrial efficiency, superoxide dismutase activity, and Bcl-2:Bax ratio
    April C Childs
    University of Florida, Biochemistry of Aging Laboratory, College of Health and Human Performance, Gainesville, Florida 32611, USA
    Cancer Res 62:4592-8. 2002
    ..These findings demonstrate that doxorubicin induces oxidative stress and mitochondrial-mediated apoptosis, as well as adaptive responses by the mitochondria to protect cardiac myocytes in vivo...
  15. ncbi request reprint Effects of caloric restriction and exercise on age-related, chronic inflammation assessed by C-reactive protein and interleukin-6
    Rizwan Kalani
    Department of Aging and Geriatric Research, University of Florida, Gainesville, FL 32608, USA
    J Gerontol A Biol Sci Med Sci 61:211-7. 2006
    ..These studies highlight the anti-inflammatory effects of CR and exercise...
  16. ncbi request reprint Exercise training-induced alterations in skeletal muscle antioxidant capacity: a brief review
    S K Powers
    Department of Exercise and Sport Sciences, Center for Exercise Science, University of Florida, Gainesville 32611, USA
    Med Sci Sports Exerc 31:987-97. 1999
    ..It seems plausible that increased cellular concentrations of these antioxidants will reduce the risk of cellular injury, improve performance, and delay muscle fatigue...
  17. ncbi request reprint Age-related differences in apoptosis with disuse atrophy in soleus muscle
    Christiaan Leeuwenburgh
    Biochemistry of Aging Laboratory and Department of Aging and Geriatric Research, University of Florida, Gainesville, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1288-96. 2005
    ..Apoptosis in skeletal muscle is partly mediated by the subsarcolemmal mitochondria through EndoG translocation to the nucleus in response to HS...
  18. pmc Long-term effects of caloric restriction or exercise on DNA and RNA oxidation levels in white blood cells and urine in humans
    Tim Hofer
    Department of Aging and Geriatrics, Division of Clinical Research, and Genomics and Biomarkers Core of The Institute on Aging, University of Florida, 210 East Mowry Road, Gainesville, FL 32611, USA
    Rejuvenation Res 11:793-9. 2008
    ....
  19. ncbi request reprint Short-term CR decreases cardiac mitochondrial oxidant production but increases carbonyl content
    Sharon Judge
    Univ of Florida, Biochemistry of Aging Laboratory, P O Box 118206, Gainesville, FL 32611, USA
    Am J Physiol Regul Integr Comp Physiol 286:R254-9. 2004
    ....
  20. ncbi request reprint Apoptosis in skeletal muscle with aging
    Amie Dirks
    University of Florida, Biochemistry of Aging Laboratory, College of Health and Human Performance, Center for Exercise Science, College of Medicine, Gainesville, Florida 32611, USA
    Am J Physiol Regul Integr Comp Physiol 282:R519-27. 2002
    ..This is the first study to explore the role of apoptosis in sarcopenia and suggests that subtle changes in apoptosis are involved...
  21. pmc Lifelong calorie restriction alleviates age-related oxidative damage in peripheral nerves
    Katherine Opalach
    Department of Neuroscience, McKnight Brain Institute, and The Institute on Aging, University of Florida, Gainesville, Florida 2610 0244, USA
    Rejuvenation Res 13:65-74. 2010
    ..Together these results show that dietary restriction is an efficient means of defying age-related oxidative damage and maintaining a younger state in peripheral nerves...
  22. ncbi request reprint Hepatic oxidative stress during aging: effects of 8% long-term calorie restriction and lifelong exercise
    Arnold Y Seo
    Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, Biochemistry of Aging Laboratory, University of Florida, Gainesville, Florida 36210 0107, USA
    Antioxid Redox Signal 8:529-38. 2006
    ..The age-associated increase in oxidative stress and upregulation of pro-inflammatory proteins was attenuated in the livers from both the CR and the exercise + CR groups...
  23. ncbi request reprint The role of apoptosis in the normal aging brain, skeletal muscle, and heart
    Michael Pollack
    Biochemistry of Aging Laboratory, Box 118206, College of Health and Human Performance, College of Medicine, Center for Exercise Science, University of Florida, Gainesville, Florida 32611, USA
    Ann N Y Acad Sci 959:93-107. 2002
    ..Our results demonstrate that a tissue-specific adaptation of the Bcl-2/Bax ratio occurs with age and may directly influence the release of cytochrome c...
  24. ncbi request reprint Effects of age and caloric restriction on brain neuronal cell death/survival
    Asimina Hiona
    University of Florida, Biochemistry of Aging Laboratory, Gainesville, FL 32611, USA
    Ann N Y Acad Sci 1019:96-105. 2004
    ..Our findings suggest that caloric restriction may provide neuroprotection to the aging brain by preserving DNA repair enzymes in their intact form, and/or upregulating specific antiapoptotic proteins involved in neuronal cell death...
  25. doi request reprint Modulation of age-induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle
    Emanuele Marzetti
    Department of Aging and Geriatric Research, University of Florida Institute on Aging, College of Medicine, Gainesville, FL 32610, USA
    Free Radic Biol Med 44:160-8. 2008
    ..The most recent evidence on the relevance of skeletal muscle apoptosis to sarcopenia, as well as its modulation by calorie restriction and exercise, is reviewed...
  26. ncbi request reprint Doxorubicin treatment in vivo activates caspase-12 mediated cardiac apoptosis in both male and female rats
    Young Mok Jang
    Biochemistry of Aging Laboratory, University of Florida, P O Box 118206, Gainesville, FL 32611, USA
    FEBS Lett 577:483-90. 2004
    ..Moreover, no major sex differences exist in apoptosis signaling transduction cascade due to doxorubicin treatment...
  27. ncbi request reprint Moderate caloric restriction increases diaphragmatic antioxidant enzyme mRNA, but not when combined with lifelong exercise
    Keith C DeRuisseau
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida 32611, USA
    Antioxid Redox Signal 8:539-47. 2006
    ..085). In summary, although CR elevated the mRNA of key antioxidant enzymes in the diaphragm, lifelong CR alone or in combination with voluntary exercise did not alter diaphragm CS activity, antioxidant protein quantity, or GSH levels...
  28. ncbi request reprint A dietary supplement attenuates IL-6 and CRP after eccentric exercise in untrained males
    Tracey Phillips
    University of Florida, Biochemistry of Aging Laboratory, College of Health and Human Performance, Center for Exercise Science, College of Medicine, Gainesville 32611, USA
    Med Sci Sports Exerc 35:2032-7. 2003
    ..This study investigated the effects of a dietary supplement on exercise-induced markers of cell damage and the inflammatory mediators C-reactive protein (CRP) and interleukin-6 (IL-6)...
  29. ncbi request reprint Life-long calorie restriction in Fischer 344 rats attenuates age-related loss in skeletal muscle-specific force and reduces extracellular space
    Anthony M Payne
    Muscle Physiology Laboratory, University of Florida, Center for Exercise Science, Gainesville, FL 32611, USA
    J Appl Physiol 95:2554-62. 2003
    ..05) but not in the soleus muscle (r = -0.38; P > 0.05). Hence, this study shows a loss of muscle function with age and suggests that long-term calorie restriction is an effective intervention against the loss of muscle function with age...
  30. ncbi request reprint Effects of short-term GH supplementation and treadmill exercise training on physical performance and skeletal muscle apoptosis in old rats
    Emanuele Marzetti
    Department of Aging and Geriatrics, Institute on Aging, Division of Biology of Aging, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610, USA
    Am J Physiol Regul Integr Comp Physiol 294:R558-67. 2008
    ..In contrast, short-term administration of GH late in life does not provide any protection against functional decline or muscle aging and may even accelerate apoptosis in slow-twitch muscles, such as the soleus...
  31. pmc The role of mitochondrial DNA mutations in aging and sarcopenia: implications for the mitochondrial vicious cycle theory of aging
    Asimina Hiona
    Department of Aging and Geriatrics, Division of Biology of Aging, Biochemistry of Aging Laboratory, Genomics and Biomarkers Core of the Institute on Aging, College of Medicine, University of Florida, Gainesville, FL 32611, USA
    Exp Gerontol 43:24-33. 2008
    ..Potential mechanism(s) by which mtDNA mutations may mediate their pathological consequences in skeletal muscle are also discussed...
  32. pmc Comparison of lifelong and late life exercise on oxidative stress in the cerebellum
    Li Cui
    Department of Neuroscience, Evelyn F and William L McKnight Brain Institute, University of Florida College of Medicine, PO Box 100244, Gainesville, FL 32610 0244, USA
    Neurobiol Aging 30:903-9. 2009
    ..In addition, modest exercise initiated late in life can have a beneficial effect on lipid oxidation and motor function...
  33. pmc Beneficial effects of a Q-ter based nutritional mixture on functional performance, mitochondrial function, and oxidative stress in rats
    Jinze Xu
    Division of Biology of Aging, Genomics and Biomarkers Core of the Institute on Aging, Department of Aging and Geriatric Research, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 5:e10572. 2010
    ..Selected antioxidants and specific combinations of nutritional compounds could target many biochemical pathways that affect both oxidative stress and mitochondrial function and, thereby, preserve or enhance physical performance...
  34. ncbi request reprint Impact of inflammation on the relationship among alcohol consumption, mortality, and cardiac events: the health, aging, and body composition study
    Cinzia Maraldi
    Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, 1329 SW 16th St, Gainesville, FL 32608, USA
    Arch Intern Med 166:1490-7. 2006
    ..We investigated the relationship of alcohol intake with all-cause mortality and cardiac events and evaluated whether this relationship is mediated or modified by inflammatory markers...
  35. ncbi request reprint Autophagy in the heart and liver during normal aging and calorie restriction
    Stephanie E Wohlgemuth
    Biochemistry of Aging Laboratory, Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, Florida 32610 0107, USA
    Rejuvenation Res 10:281-92. 2007
    ..Thus, calorie restriction may mediate some of its beneficial effects by stimulating autophagy in the heart, indicating the potential for cardioprotective therapies...
  36. ncbi request reprint Skeletal muscle apoptosis, sarcopenia and frailty at old age
    Emanuele Marzetti
    Department of Aging and Geriatrics, College of Medicine, University of Florida, Division of Biology of Aging, Institute on Aging, Biochemistry of Aging Laboratory, Gainesville, FL 32611, USA
    Exp Gerontol 41:1234-8. 2006
    ..Here, we will review the most recent evidence regarding various pathways of muscle apoptosis and their modulation by several interventions (caloric restriction, physical exercise, muscle unloading)...
  37. ncbi request reprint Anabolic effects of testosterone are preserved during inhibition of 5alpha-reductase
    Stephen E Borst
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center, Gainesville, Florida 32608 1197, USA
    Am J Physiol Endocrinol Metab 293:E507-14. 2007
    ..Our study demonstrates that the effects of testosterone on muscle and bone can be separated from the prostate effects and provides a testable strategy for combating sarcopenia and osteopenia in older hypogonadal men...
  38. pmc Effects of life-long caloric restriction and voluntary exercise on age-related changes in levels of catecholamine biosynthetic enzymes and angiotensin II receptors in the rat adrenal medulla and hypothalamus
    Benedek Erdos
    Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Gainesville, FL 32608, USA
    Exp Gerontol 42:745-52. 2007
    ..05). These data indicate that a small decrease in daily food intake can avert age-related changes in catecholamine biosynthetic enzyme levels in the adrenal medulla and hypothalamus, possibly through affecting angiotensin II signaling...
  39. pmc Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy
    Thomas W Buford
    Institute on Aging, University of Florida, Gainesville, FL 32611, United States
    Ageing Res Rev 9:369-83. 2010
    ..Elucidating biochemical pathways related to accelerated muscle atrophy may allow for improved discovery of therapeutic treatments related to sarcopenia...
  40. pmc Changes in IL-15 expression and death-receptor apoptotic signaling in rat gastrocnemius muscle with aging and life-long calorie restriction
    Emanuele Marzetti
    Department of Aging and Geriatric Research, Institute on Aging, Division of Biology of Aging, University of Florida, Gainesville, FL 32610 0143, USA
    Mech Ageing Dev 130:272-80. 2009
    ..Preservation of IL-15 signaling by CR may therefore represent a further mechanism contributing to the anti-aging effect of this dietary intervention in skeletal muscle...
  41. doi request reprint Sarcopenia of aging: underlying cellular mechanisms and protection by calorie restriction
    Emanuele Marzetti
    Department of Aging and Geriatric Research, Institute on Aging, Division of Biology of Aging, University of Florida, Gainesville, FL 32610, USA
    Biofactors 35:28-35. 2009
    ..Further research is warranted to investigate whether CR may represent a safe and efficient strategy to delay the onset and mitigate the progression of sarcopenia in older adults...
  42. pmc Skeletal muscle autophagy and apoptosis during aging: effects of calorie restriction and life-long exercise
    Stephanie Eva Wohlgemuth
    Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, Division of Biology of Aging, University of Florida, Gainesville, FL 32610, USA
    Exp Gerontol 45:138-48. 2010
    ..We conclude that mild CR attenuates the age-related impairment of autophagy in rodent skeletal muscle, which might be one of the mechanisms by which CR attenuates age-related cellular damage and cell death in skeletal muscle in vivo...
  43. doi request reprint Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases
    Mitchell D Knutson
    Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida, USA
    Nutr Rev 66:591-6. 2008
    ..Substantial research effort now focuses on identifying and testing more bioavailable and potent activators of SIRT1 for use as pharmacologic interventions in aging and age-related disorders...
  44. pmc Cellular mechanisms of cardioprotection by calorie restriction: state of the science and future perspectives
    Emanuele Marzetti
    Department of Aging and Geriatric Research, Institute on Aging, Division of Biology of Aging, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610 0143, USA
    Clin Geriatr Med 25:715-32, ix. 2009
    ..Results from ongoing clinical trials will reveal whether the intriguing alternative of CR mimetics represents a safe and effective strategy to promote cardiovascular health and delay cardiac aging in humans...
  45. doi request reprint Myeloperoxidase levels and mortality in frail community-living elderly individuals
    Silvia Giovannini
    Department of Gerontology and Geriatrics, Catholic University of Sacred Heart, Rome, Italy
    J Gerontol A Biol Sci Med Sci 65:369-76. 2010
    ....
  46. doi request reprint Multiple pathways to the same end: mechanisms of myonuclear apoptosis in sarcopenia of aging
    Emanuele Marzetti
    Department of Aging and Geriatric Research, Institute on Aging, Division of Biology of Aging, University of Florida, Gainesville, USA
    ScientificWorldJournal 10:340-9. 2010
    ....
  47. pmc Age-related activation of mitochondrial caspase-independent apoptotic signaling in rat gastrocnemius muscle
    Emanuele Marzetti
    Department of Aging and Geriatric Research, Institute on Aging, Division of Biology of Aging, University of Florida, Gainesville, FL 32610 0143, USA
    Mech Ageing Dev 129:542-9. 2008
    ..Our findings indicate that the mitochondrial caspase-independent apoptotic pathway may play a more prominent role in skeletal muscle loss than caspase-mediated apoptosis...
  48. pmc Influence of calorie restriction on measures of age-related cognitive decline: role of increased physical activity
    Christy S Carter
    Department of Aging and Geriatric Research, College of Medicine, University of Florida, 210 East Mowry Road, Gainesville, FL 32610, USA
    J Gerontol A Biol Sci Med Sci 64:850-9. 2009
    ..Finally, CR resulted in an overall increase in physical activity, one of several behavioral confounders to consider in the interpretation of cognitive outcomes in both tasks...
  49. pmc Frailty syndrome and skeletal muscle: results from the Invecchiare in Chianti study
    Matteo Cesari
    Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, FL 32608, USA
    Am J Clin Nutr 83:1142-8. 2006
    ..Frailty is a common condition in elders and identifies a state of vulnerability for adverse health outcomes...
  50. ncbi request reprint Oxidative damage and platelet activation as new predictors of mobility disability and mortality in elders
    Matteo Cesari
    Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, Florida 36208, USA
    Antioxid Redox Signal 8:609-19. 2006
    ..g., physical activity, dietary restriction, smoking cessation) play an important role in the reduction of oxidative damage levels and are associated with improved physical performance and muscle strength...
  51. pmc Mitochondrial death effectors: relevance to sarcopenia and disuse muscle atrophy
    Emanuele Marzetti
    Department of Aging and Geriatrics, Institute on Aging, Division of Biology of Aging, University of Florida, Gainesville, FL 32610 0143, USA
    Biochim Biophys Acta 1800:235-44. 2010
    ..Furthermore, a translational effort is required to determine the role played by apoptosis in the pathogenesis of sarcopenia and disuse-induced muscle loss in human subjects...
  52. ncbi request reprint Role of apoptosis in sarcopenia
    Christiaan Leeuwenburgh
    Biochemistry of Aging Laboratory, University of Florida, Gainesville 32611, USA
    J Gerontol A Biol Sci Med Sci 58:999-1001. 2003
    ....
  53. ncbi request reprint A method to determine RNA and DNA oxidation simultaneously by HPLC-ECD: greater RNA than DNA oxidation in rat liver after doxorubicin administration
    Tim Hofer
    Department of Aging and Geriatric Research, College of Medicine, University of Florida, Genomics and Biomarkers Core of the Institute on Aging, Biochemistry of Aging Laboratory, 1329 SW 16th Street, Gainesville, FL 32608, USA
    Biol Chem 387:103-11. 2006
    ..This new method could be useful to assess oxidatively damaged RNA and DNA simultaneously, and our data show that RNA is more susceptible to oxidative stress than DNA in vivo and in vitro...
  54. doi request reprint Hydrogen sulfide induces oxidative damage to RNA and DNA in a sulfide-tolerant marine invertebrate
    Joanna Joyner-Matos
    Department of Zoology, University of Florida, Gainesville, Florida 32611, USA
    Physiol Biochem Zool 83:356-65. 2010
    ..This suggests that sulfide can be an environmental mutagen in sulfide-tolerant invertebrates...
  55. ncbi request reprint Increased hepatic apoptosis during short-term caloric restriction is not associated with an enhancement in caspase levels
    Colin Selman
    Biochemistry of Aging Laboratory, College of Health and Human Performance, University of Florida, P O Box 118206, Gainesville, FL 32611 8206, USA
    Exp Gerontol 38:897-903. 2003
    ....
  56. ncbi request reprint Method for measuring ATP production in isolated mitochondria: ATP production in brain and liver mitochondria of Fischer-344 rats with age and caloric restriction
    Barry Drew
    Univ of Florida, Biochemistry of Aging Laboratory, P O Box 118206, Gainesville, FL 32611, USA
    Am J Physiol Regul Integr Comp Physiol 285:R1259-67. 2003
    ..This study introduces a highly sensitive, reproducible, and quick methodology for measuring ATP in isolated mitochondria...
  57. pmc Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice
    Asimina Hiona
    Division of Biology of Aging, Department of Aging and Geriatric Research, Institute on Aging, College of Medicine, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 5:e11468. 2010
    ..Mitochondrial DNA (mtDNA) mutations accumulate with aging in skeletal muscle and correlate with muscle loss, although no causal relationship has been established...
  58. ncbi request reprint Life long calorie restriction increases heat shock proteins and proteasome activity in soleus muscles of Fisher 344 rats
    Joshua T Selsby
    Muscle Physiology Laboratory, Department of Applied Physiology and Kinesiology, University of Florida, P O Box 118205, Gainesville, FL 32611, USA
    Exp Gerontol 40:37-42. 2005
    ..The large increase in HSP 90 is intriguing and further studies are required to elucidate its role in maintaining 20S proteasome function...
  59. ncbi request reprint Supplementation with vitamin C and N-acetyl-cysteine increases oxidative stress in humans after an acute muscle injury induced by eccentric exercise
    A Childs
    Biochemistry of Aging Laboratory, Center for Exercice Science, College of Human Performance, University of Florida, Gainesville, FL 32611, USA
    Free Radic Biol Med 31:745-53. 2001
    ..This acute human inflammatory model strongly suggests that vitamin C and NAC supplementation immediately post-injury, transiently increases tissue damage and oxidative stress...
  60. ncbi request reprint Apoptosis and exercise
    S Phaneuf
    Biochemistry of Aging Laboratory, Center for Exercise Science, College of Health and Human Performance, University of Florida, Gainesville, FL 32611, USA
    Med Sci Sports Exerc 33:393-6. 2001
    ..We speculate that exercise-induced apoptosis is a normal regulatory process that serves to remove certain damaged cells without a pronounced inflammatory response, thus ensuring optimal body function...
  61. ncbi request reprint Lifelong caloric restriction increases expression of apoptosis repressor with a caspase recruitment domain (ARC) in the brain
    Rajani R J Shelke
    University of Florida, Biochemistry of Aging Laboratory, College of Health and Human Performance, Gainesville 32611, USA
    FASEB J 17:494-6. 2003
    ..Furthermore, our data suggest that calorie restriction provides neuroprotection through ARC by suppressing cytochrome c release and caspase-2 activity...
  62. pmc Molecular architecture of myelinated peripheral nerves is supported by calorie restriction with aging
    Sunitha Rangaraju
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610 0244, USA
    Aging Cell 8:178-91. 2009
    ..Together, the in vitro and in vivo results suggest that there might be an age-limit by which dietary intervention needs to be initiated to elicit a beneficial response on peripheral nerve health...
  63. ncbi request reprint Cardiac mitochondrial bioenergetics, oxidative stress, and aging
    Sharon Judge
    Dept of Medicine, University of Florida, College of Medicine, Gainesville, FL 32611, USA
    Am J Physiol Cell Physiol 292:C1983-92. 2007
    ..The role that mitochondrial dysfunction and oxidative stress play in contributing to cardiac aging will be discussed along with the use of lifelong exercise and calorie restriction as countermeasures to aging...
  64. doi request reprint Urinary CTX-II concentrations are elevated and associated with knee pain and function in subjects with ACL reconstruction
    T L Chmielewski
    Department of Physical Therapy, University of Florida, Gainesville, FL 32610 0154, USA
    Osteoarthritis Cartilage 20:1294-301. 2012
    ..This study examined the magnitude and change over time in urinary CTX-II (uCTX-II) concentrations shortly after ACL reconstruction, and, secondarily, the associations with knee pain and function...
  65. ncbi request reprint Effects of ACE-inhibition on IGF-1 and IGFBP-3 concentrations in older adults with high cardiovascular risk profile
    S Giovannini
    Dept of Aging and Geriatric Research, Division of Biology of Aging, University of Florida, Institute on Aging, 1600 SW Archer Road, PO Box 100143, Gainesville, FL 32610, USA
    J Nutr Health Aging 14:457-60. 2010
    ..The present study evaluates the effects of a 6-month treatment with an ACE-inhibitor (ie, fosinopril) on serum concentrations of total IGF-1 and IGF binding protein (IGFBP)-3 in older adults at high risk for cardiovascular disease...
  66. ncbi request reprint Reactive carbonyl formation by oxidative and non-oxidative pathways
    S Adams
    Biochemistry of Aging Laboratory, University of Florida, Box 118206, Gainesville, FL 32611, USA
    Front Biosci 6:A17-24. 2001
    ..These studies show that carbonyl content could be due to oxidative as well as non-oxidative mechanisms and that heme-containing compounds may effect carbonyl quantification...
  67. ncbi request reprint Apoptosis and aging: role of the mitochondria
    M Pollack
    Biochemistry of Aging Laboratory, College of Health and Human Performance, University of Florida, Gainesville, 32611, USA
    J Gerontol A Biol Sci Med Sci 56:B475-82. 2001
    ..Mitochondrial oxidative stress and a decline in mitochondrial energy production in vitro often leads to activation of apoptotic pathways, but whether this occurs in vivo is unclear...
  68. ncbi request reprint Energy expenditure of calorically restricted rats is higher than predicted from their altered body composition
    Colin Selman
    University of Florida, Department of Aging and Geriatric Research, College of Medicine, Gainesville, 32608, USA
    Mech Ageing Dev 126:783-93. 2005
    ....
  69. ncbi request reprint Mitochondrial dysfunction is an early indicator of doxorubicin-induced apoptosis
    Pattie S Green
    University of Florida, Biochemistry of Aging Laboratory, P O Box 118206, Gainesville, FL 32611, USA
    Biochim Biophys Acta 1588:94-101. 2002
    ..In addition, caspase-3 activity was increased with doxorubicin administration in the H9C2 myocyte cell line. An oxidant-mediated threshold of mitochondrial death may be required for doxorubicin-induced apoptosis...
  70. ncbi request reprint Urinary analysis of 8-oxoguanine, 8-oxoguanosine, fapy-guanine and 8-oxo-2'-deoxyguanosine by high-performance liquid chromatography-electrospray tandem mass spectrometry as a measure of oxidative stress
    Bhaskar Malayappan
    Department of Aging and Geriatrics, College of Medicine, Institute on Aging, Division of Biology of Aging, University of Florida, Gainesville, FL 32611, USA
    J Chromatogr A 1167:54-62. 2007
    ..These findings suggest that a highly specific and sensitive analytical method such as isotope dilution HPLC-MS/MS may represent a valuable tool for the measurement of oxidative stress in human subjects...
  71. ncbi request reprint Effects of aging and caloric restriction on mitochondrial energy production in gastrocnemius muscle and heart
    B Drew
    University of Florida, Biochemistry of Aging Laboratory, College of Health and Human Performance, Center for Exercise Science, Gainesville, Florida 32611, USA
    Am J Physiol Regul Integr Comp Physiol 284:R474-80. 2003
    ....
  72. ncbi request reprint Ageing and subcellular distribution of mitochondria: role of mitochondrial DNA deletions and energy production
    B Drew
    Biochemistry of Aging Laboratory, University of Florida, Gainesville, FL 32611, USA
    Acta Physiol Scand 182:333-41. 2004
    ..Hence, while future research attempts to explain the mechanisms responsible for ageing in the mitochondrion, it should also take into account the independent pathways of these two distinctly different populations...
  73. ncbi request reprint The role of apoptosis in age-related skeletal muscle atrophy
    Amie J Dirks
    School of Pharmacy, Wingate University, Wingate, North Carolina, USA
    Sports Med 35:473-83. 2005
    ..Exercise training and caloric restriction are two interventions known to enhance skeletal muscle function. The effects of these interventions on apoptosis are discussed...
  74. ncbi request reprint Mitochondrial DNA mutations, energy metabolism and apoptosis in aging muscle
    Amie J Dirks
    Wingate University, School of Pharmacy, 316 N Main Street, Wingate, NC 28174, USA
    Ageing Res Rev 5:179-95. 2006
    ..Evidence concerning these series of events leading to energy depletion and apoptosis are discussed...
  75. ncbi request reprint The role of Id2 and apoptosis during skeletal muscle remodeling
    Colin Selman
    Am J Physiol Regul Integr Comp Physiol 284:R538-9. 2003
  76. pmc Evaluation of sex differences on mitochondrial bioenergetics and apoptosis in mice
    Alberto Sanz
    Department of Animal Physiology II, Faculty of Biology, Complutense University, Madrid 28040, Spain
    Exp Gerontol 42:173-82. 2007
    ..These results support the Mitochondrial Free Radical Theory of Aging, and indicate that oxidative stress generation independent of estrogen levels determines aging rate...
  77. ncbi request reprint Genetics, redox signaling, oxidative stress, and apoptosis in mammalian aging
    Christiaan Leeuwenburgh
    Antioxid Redox Signal 8:503-5. 2006
  78. ncbi request reprint Sarcopenia: the role of apoptosis and modulation by caloric restriction
    Amie J Dirks Naylor
    School of Pharmacy, Wingate University, Wingate, NC 28174, USA
    Exerc Sport Sci Rev 36:19-24. 2008
    ..The signaling pathways responsible for the execution of apoptosis in aging muscle and the modulation of these pathways by caloric restriction are discussed...
  79. ncbi request reprint Tumor necrosis factor alpha signaling in skeletal muscle: effects of age and caloric restriction
    Amie J Dirks
    Wingate University, School of Pharmacy, Wingate, NC 28174, USA
    J Nutr Biochem 17:501-8. 2006
    ..The potential role of TNF-alpha in the progression of sarcopenia will be discussed, as well as the effects of life-long caloric restriction on TNF-alpha signaling...
  80. pmc A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice
    Jamie L Barger
    LifeGen Technologies, LLC, Madison, Wisconsin, United States of America
    PLoS ONE 3:e2264. 2008
    ..Resveratrol, at doses that can be readily achieved in humans, fulfills the definition of a dietary compound that mimics some aspects of CR...
  81. ncbi request reprint Vulnerability of the mid aged rat myocardium to the age-induced oxidative stress: influence of exercise training on antioxidant defense system
    Pushpalatha Kakarla
    Division of Exercise Physiology, Department of Zoology, SV University, Tirupati, India
    Free Radic Res 39:1211-7. 2005
    ....
  82. ncbi request reprint Effects of acute exercise on lung antioxidant enzymes in young and old rats
    Hidekazu Hatao
    Fifth Department of Internal Medicine, Tokyo Medical University, 3 20 1 Chuou, Ami, Inashiki, Ibaraki 300 0395, Japan
    Mech Ageing Dev 127:384-90. 2006
    ..In summary, antioxidant enzymes responsible for the removal of hydrogen peroxide were unable to increase their enzyme activities in the old animals with exercise...
  83. ncbi request reprint Short-term caloric restriction and sites of oxygen radical generation in kidney and skeletal muscle mitochondria
    Ricardo Gredilla
    Department of Animal Biology II Animal Physiology, Faculty of Biology, Complutense University, 28040 Madrid, Spain
    Ann N Y Acad Sci 1019:333-42. 2004
    ....
  84. ncbi request reprint Effects of dietary calcium restriction and acute exercise on the antioxidant enzyme system and oxidative stress in rat diaphragm
    Masayuki Itoh
    Fifth Dept of Internal Medicine, Tokyo Medical Univ, 3 20 1, Chuou, Ami, Inashiki, Ibaraki 300 0395, Japan
    Am J Physiol Regul Integr Comp Physiol 287:R33-8. 2004
    ....
  85. pmc Lifelong exercise and mild (8%) caloric restriction attenuate age-induced alterations in plantaris muscle morphology, oxidative stress and IGF-1 in the Fischer-344 rat
    Jong Hee Kim
    Redox Biology and Cell Signaling Laboratory, Department of Health and Kinesiology, Texas A and M University, College Station, TX 77843, USA
    Exp Gerontol 43:317-29. 2008
    ..Total hydroperoxides were higher in OAL than YAL, but were not elevated in OExCR, with out a change in MnSOD. IGF-1 levels were lower in OAL (-57%) than YAL, but partially protected in the OExCR group (+51%)...
  86. ncbi request reprint Mitochondrial DNA mutations and apoptosis in mammalian aging
    Gregory C Kujoth
    Department of Genetics and Medical Genetics, University of Wisconsin, 425 G Henry Mall, Madison, WI 53706, USA
    Cancer Res 66:7386-9. 2006
    ..Further studies in this model may provide deeper insights into the relationship between mitochondria, aging, and susceptibility to age-associated diseases, such as cancer...
  87. ncbi request reprint Caloric restriction in humans: potential pitfalls and health concerns
    Amie J Dirks
    Wingate University, School of Pharmacy, 316 N Main Street, Wingate, NC 28174, USA
    Mech Ageing Dev 127:1-7. 2006
    ..These potential pitfalls and "side effects" are not clearly addressed in the literature and will be a focus of this review...
  88. doi request reprint Molecular mechanism of PPAR in the regulation of age-related inflammation
    Jae Heun Chung
    Department of Pharmacy, College of Pharmacy, Pusan National University, San 30, Jang Jun dong, Geomjung ku, Busan, South Korea
    Ageing Res Rev 7:126-36. 2008
    ....
  89. ncbi request reprint An Aging Interventions Testing Program: study design and interim report
    Richard A Miller
    Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor VA Medical Center, Ann Arbor, MI 48109 2200, USA
    Aging Cell 6:565-75. 2007
    ..More data will be needed to determine if any of these compounds can extend maximal lifespan, but the current data show that NDGA reduces early life mortality risks in genetically heterogeneous mice at multiple test sites...
  90. ncbi request reprint Lifelong aspirin supplementation as a means to extending life span
    Tracey Phillips
    Biochemistry of Aging Laboratory, University of Florida, Gainesville, FL 32611, USA
    Rejuvenation Res 7:243-51. 2004
    ....
  91. pmc C-reactive protein genotype affects exercise training-induced changes in insulin sensitivity
    Thomas O Obisesan
    Department of Kinesiology, University of Maryland, College Park, MD 20742, USA
    Metabolism 55:453-60. 2006
    ....
  92. pmc C-reactive protein genotypes affect baseline, but not exercise training-induced changes, in C-reactive protein levels
    Thomas O Obisesan
    Department of Kinesiology, University of Maryland, College Park, MD 20742 2611, USA
    Arterioscler Thromb Vasc Biol 24:1874-9. 2004
    ..The goal of this study is to determine whether C-reactive protein (CRP) gene variants affect baseline and training-induced changes in plasma CRP levels...
  93. ncbi request reprint Linkage between insulin and the free radical theory of aging
    David Julian
    Am J Physiol Regul Integr Comp Physiol 286:R20-1. 2004