M A Leehey

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi Progression of tremor and ataxia in male carriers of the FMR1 premutation
    Maureen A Leehey
    Department of Neurology, University of Colorado at Denver and Health Sciences Center, Denver, Colorado 80262, USA
    Mov Disord 22:203-6. 2007
  2. ncbi The fragile X premutation presenting as essential tremor
    Maureen A Leehey
    Department of Neurology, University of Colorado Health Science Center, Denver, CO 80262, USA
    Arch Neurol 60:117-21. 2003
  3. pmc FMR1 CGG repeat length predicts motor dysfunction in premutation carriers
    M A Leehey
    Department of Neurology, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    Neurology 70:1397-402. 2008
  4. ncbi Initial diagnoses given to persons with the fragile X associated tremor/ataxia syndrome (FXTAS)
    D A Hall
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Neurology 65:299-301. 2005
  5. ncbi Prevalence of FMR1 repeat expansions in movement disorders. A systematic review
    D A Hall
    Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Neuroepidemiology 26:151-5. 2006
  6. ncbi Bell's palsy in an older patient with uncontrolled hypertension due to medication nonadherence
    S L Ellis
    School of Pharmacy, Department of Pharmacy Practice, University of Colorado Health Sciences Center, Denver 80262, USA
    Ann Pharmacother 33:1269-73. 1999
  7. ncbi Impairment of executive cognitive functioning in males with fragile X-associated tremor/ataxia syndrome
    Jim Grigsby
    Department of Medicine, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045 5701, USA
    Mov Disord 22:645-50. 2007
  8. ncbi Cognitive impairment in a 65-year-old male with the fragile X-associated tremor-ataxia syndrome (FXTAS)
    Jim Grigsby
    Department of Medicine, University of Colorado Health Sciences Center, Aurora, CO 80045 5701, USA
    Cogn Behav Neurol 19:165-71. 2006
  9. ncbi Impairment in the cognitive functioning of men with fragile X-associated tremor/ataxia syndrome (FXTAS)
    Jim Grigsby
    Department of Medicine, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    J Neurol Sci 248:227-33. 2006
  10. doi Cognitive profile of fragile X premutation carriers with and without fragile X-associated tremor/ataxia syndrome
    Jim Grigsby
    Department of Medicine, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045 5701, USA
    Neuropsychology 22:48-60. 2008

Research Grants

Detail Information

Publications26

  1. ncbi Progression of tremor and ataxia in male carriers of the FMR1 premutation
    Maureen A Leehey
    Department of Neurology, University of Colorado at Denver and Health Sciences Center, Denver, Colorado 80262, USA
    Mov Disord 22:203-6. 2007
    ..Preliminary data on life expectancy are variable, with a range from 5 to 25 years...
  2. ncbi The fragile X premutation presenting as essential tremor
    Maureen A Leehey
    Department of Neurology, University of Colorado Health Science Center, Denver, CO 80262, USA
    Arch Neurol 60:117-21. 2003
    ..Essential tremor is a frequent cause of tremor in elderly patients and in some cases is associated with impaired tandem gait and cognitive deficits...
  3. pmc FMR1 CGG repeat length predicts motor dysfunction in premutation carriers
    M A Leehey
    Department of Neurology, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    Neurology 70:1397-402. 2008
    ..This study determines whether CGG repeat length correlates with severity and type of motor dysfunction in premutation carriers...
  4. ncbi Initial diagnoses given to persons with the fragile X associated tremor/ataxia syndrome (FXTAS)
    D A Hall
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Neurology 65:299-301. 2005
    ..Data from this study and others were used to develop guidelines for FMR1 diagnostic testing for FXTAS...
  5. ncbi Prevalence of FMR1 repeat expansions in movement disorders. A systematic review
    D A Hall
    Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Neuroepidemiology 26:151-5. 2006
    ..The heterogeneous design of the studies, inclusion criteria and mean age of subjects may have led to underestimation of FMR1 repeat expansion prevalence rates...
  6. ncbi Bell's palsy in an older patient with uncontrolled hypertension due to medication nonadherence
    S L Ellis
    School of Pharmacy, Department of Pharmacy Practice, University of Colorado Health Sciences Center, Denver 80262, USA
    Ann Pharmacother 33:1269-73. 1999
    ..To describe and inform pharmacists of a rarely reported occurrence of facial palsy in an elderly patient with uncontrolled hypertension resulting from nonadherence to blood pressure medications...
  7. ncbi Impairment of executive cognitive functioning in males with fragile X-associated tremor/ataxia syndrome
    Jim Grigsby
    Department of Medicine, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045 5701, USA
    Mov Disord 22:645-50. 2007
    ....
  8. ncbi Cognitive impairment in a 65-year-old male with the fragile X-associated tremor-ataxia syndrome (FXTAS)
    Jim Grigsby
    Department of Medicine, University of Colorado Health Sciences Center, Aurora, CO 80045 5701, USA
    Cogn Behav Neurol 19:165-71. 2006
    ..This is the first case report of a comprehensive neuropsychologic examination of an older man with the fragile X-associated tremor-ataxia syndrome (FXTAS)...
  9. ncbi Impairment in the cognitive functioning of men with fragile X-associated tremor/ataxia syndrome (FXTAS)
    Jim Grigsby
    Department of Medicine, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    J Neurol Sci 248:227-33. 2006
    ..The results provide evidence that FXTAS involves marked impairment of executive cognitive abilities...
  10. doi Cognitive profile of fragile X premutation carriers with and without fragile X-associated tremor/ataxia syndrome
    Jim Grigsby
    Department of Medicine, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045 5701, USA
    Neuropsychology 22:48-60. 2008
    ..Longitudinal research currently underway will provide insight into the progression of the disorder...
  11. ncbi Symptomatic treatment in the fragile X-associated tremor/ataxia syndrome
    Deborah A Hall
    Department of Neurology, University of Colorado Health Sciences Center at Denver, Denver, Colorado 80262, USA
    Mov Disord 21:1741-4. 2006
    ..This study suggests that patients with FXTAS can derive improvement from medication treatment for some of their symptoms...
  12. pmc Parkinsonism in FMR1 premutation carriers may be indistinguishable from Parkinson disease
    Deborah A Hall
    Department of Neurology, University of Colorado at Denver and Health Sciences Center, Denver, CO, USA
    Parkinsonism Relat Disord 15:156-9. 2009
    ..Although screening all PD patients is likely to be low yield, genetic testing of FMR1 in individuals with PD and a family history of fragile X syndrome, autism or developmental delay, or other related FMR1 phenotypes is warranted...
  13. ncbi Do patients with Parkinson's disease benefit from embryonic dopamine cell transplantation?
    Curt R Freed
    Departments of Medicine, Neurology, Psychiatry, and Neurosurgery Box, University of Colorado School of Medicine, 4200 East Ninth Avenue, C237, Denver, CO 80220, USA
    J Neurol 250:III44-6. 2003
    ..Neurotransplantation should be tried earlier in the clinical course of Parkinson's to see if earlier intervention can prevent progression of the disease, particularly the dyskinetic responses seen after longterm L-dopa treatment...
  14. ncbi PRNP H187R mutation associated with neuropsychiatric disorders in childhood and dementia
    D A Hall
    Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Neurology 64:1304-6. 2005
    ..Mutations in PRNP may cause neuropsychiatric disorders that predate dementia by many years...
  15. ncbi MS vs. HD: can white matter and subcortical gray matter pathology be distinguished neuropsychologically?
    Jose M Lafosse
    Regis University, Department of Psychology and Neuroscience Program, Denver, CO 80221 1099, USA
    J Clin Exp Neuropsychol 29:142-54. 2007
    ..These results suggest that involvement of white and subcortical gray matter may produce different neuropsychological effects...
  16. ncbi Fragile X premutation carriers: characteristic MR imaging findings of adult male patients with progressive cerebellar and cognitive dysfunction
    James A Brunberg
    Department of Radiology, University of California, Davis, School of Medicine, Sacramento, CA 95817, USA
    AJNR Am J Neuroradiol 23:1757-66. 2002
    ..Our purpose was to characterize the findings of MR imaging of the brain of adult male fragile X premutation carriers with a recently identified disorder characterized by ataxia, tremor, rigidity, and cognitive dysfunction...
  17. ncbi Neuropathy as a presenting feature in fragile X-associated tremor/ataxia syndrome
    Randi J Hagerman
    Department of Pediatrics, University of California at Davis Medical Center, Sacramento, California 95817, USA
    Am J Med Genet A 143:2256-60. 2007
    ....
  18. ncbi Fragile X-associated tremor/ataxia syndrome: clinical features, genetics, and testing guidelines
    Elizabeth Berry-Kravis
    Department of Pediatrics, Rush University Medical Center, Chicago, Illinois 60612, USA
    Mov Disord 22:2018-30, quiz 2140. 2007
    ..We also provide guidelines for the practitioner to assist with identifying appropriate patients for DNA testing for FXTAS, as well as recommendations for genetic counseling once a diagnosis of FXTAS is made...
  19. ncbi CGG repeat length correlates with age of onset of motor signs of the fragile X-associated tremor/ataxia syndrome (FXTAS)
    Flora Tassone
    Department of Biochemistry and Molecular Medicine, University of California, School of Medicine, Davis, California 95616, USA
    Am J Med Genet B Neuropsychiatr Genet 144:566-9. 2007
    ..001) and ataxia (P = 0.002), as well as overall onset (P < 0.0001). Our findings indicate that the CGG repeat number is a potential predictor of the age of onset of core motor features of FXTAS...
  20. ncbi Fragile X syndrome vs fragile X-associated tremor/ataxia syndrome
    Maureen A Leehey
    Arch Neurol 64:289; author reply 289-90. 2007
  21. ncbi Penetrance of the fragile X-associated tremor/ataxia syndrome in a premutation carrier population
    Sebastien Jacquemont
    MIND Institute, University of California Davis Medical Center, Sacramento, USA
    JAMA 291:460-9. 2004
    ..Additional documented symptoms include short-term memory loss, executive functional deficits, cognitive decline, parkinsonism, peripheral neuropathy, lower-limb proximal muscle weakness, and autonomic dysfunction...
  22. ncbi Fragile-X syndrome and fragile X-associated tremor/ataxia syndrome: two faces of FMR1
    Sebastien Jacquemont
    Service de Genetique, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Lancet Neurol 6:45-55. 2007
    ..A similar mechanism is probably involved in premature ovarian failure, which affects up to 20% of female carriers of an altered FMR1 gene...
  23. ncbi Neuropathic features in fragile X premutation carriers
    Elizabeth Berry-Kravis
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA
    Am J Med Genet A 143:19-26. 2007
    ..These data suggest that neuropathic signs are associated with the fragile X premutation, presumably occurring through the same mechanism proposed for CNS disease, namely, toxicity from expanded-CGG-repeat FMR1 mRNA...
  24. ncbi Abnormal elevation of FMR1 mRNA is associated with psychological symptoms in individuals with the fragile X premutation
    David Hessl
    Medical Investigation of Neurodevelopmental Disorders Institute, University of California Davis Medical Center, Sacramento, CA 95817, USA
    Am J Med Genet B Neuropsychiatr Genet 139:115-21. 2005
    ....
  25. ncbi Psychiatric phenotype of the fragile X-associated tremor/ataxia syndrome (FXTAS) in males: newly described fronto-subcortical dementia
    Susan Bacalman
    M I N D Institute, and Departments of Psychiatry and Behavioral Sciences, UCDavis Medical Center, University of California Davis, 2230 Stockton Boulevard, Sacramento, CA 95817, USA
    J Clin Psychiatry 67:87-94. 2006
    ..The authors describe and quantify the neuropsychiatric symptoms present in a cohort of males with the fragile X mental retardation 1 (FMR1) premutation allele who have developed fragile X-associated tremor/ataxia syndrome (FXTAS)...
  26. pmc Size bias of fragile X premutation alleles in late-onset movement disorders
    Sebastien Jacquemont
    Service de Genetique, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Med Genet 43:804-9. 2006
    ..However, the prevalence of FXTAS within other diagnostic categories is not well defined...

Research Grants4

  1. U Colorado Parkinson's Disease Clinical Research
    Maureen Leehey; Fiscal Year: 2002
    ..In summary, the PD clinical research team and clinical study program at the UCMDP is able to contribute significantly to the development and execution of the proposed NIH/NINDS PD Neuroprotection Trial. ..
  2. U Colorado Parkinson's Disease Clinical Research
    Maureen Leehey; Fiscal Year: 2004
    ..In summary, the PD clinical research team and clinical study program at the UCMDP is able to contribute significantly to the development and execution of the proposed NIH/NINDS PD Neuroprotection Trial. ..
  3. University of Colorado Parkinson's Disease Clinical Research Program
    Maureen Leehey; Fiscal Year: 2007
    ..In summary, the PD clinical research team and clinical study program at the UCMDP is able to contribute significantly to the development and execution of the proposed NIH/NINDS PD Neuroprotection Trial. ..