Younghee Lee

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. pmc Variants affecting exon skipping contribute to complex traits
    Younghee Lee
    Department of Medicine, The University of Chicago, Chicago, IL, USA
    PLoS Genet 8:e1002998. 2012
  2. pmc Network models of genome-wide association studies uncover the topological centrality of protein interactions in complex diseases
    Younghee Lee
    Center for Biomedical Informatics, The University of Chicago, Chicago, Illinois, USA
    J Am Med Inform Assoc 20:619-29. 2013
  3. pmc Complex-disease networks of trait-associated single-nucleotide polymorphisms (SNPs) unveiled by information theory
    Haiquan Li
    Center for Biomedical Informatics, Department of Medicine, University of Chicago, Illinois, USA
    J Am Med Inform Assoc 19:295-305. 2012
  4. pmc Curation-free biomodules mechanisms in prostate cancer predict recurrent disease
    James L Chen
    Center for Biomed Informatics and Department of Medicine, The University of Chicago, Chicago, IL, USA
    BMC Med Genomics 6:S4. 2013
  5. pmc Translating Mendelian and complex inheritance of Alzheimer's disease genes for predicting unique personal genome variants
    Kelly Regan
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60637, USA
    J Am Med Inform Assoc 19:306-16. 2012
  6. pmc Protein interaction network underpins concordant prognosis among heterogeneous breast cancer signatures
    James Chen
    Sections of Hematology Oncology, the University of Chicago Cancer Research Center, The Ludwig Center for Metastasis Research, The University of Chicago, Chicago, IL, USA
    J Biomed Inform 43:385-96. 2010
  7. pmc Stromal microenvironment processes unveiled by biological component analysis of gene expression in xenograft tumor models
    Xinan Yang
    Section of Genetic Medicine, Dept, of Medicine, University of Chicago, IL, USA
    BMC Bioinformatics 11:S11. 2010
  8. pmc GO-Module: functional synthesis and improved interpretation of Gene Ontology patterns
    Xinan Yang
    Department of Medicine, Section of Genetic Medicine and Center for Biomedical Informatics, The University of Chicago, Chicago, IL, USA
    Bioinformatics 27:1444-6. 2011
  9. doi request reprint Hidden dangers: a cryptic exon disrupts BRCA2 mRNA
    James D Fackenthal
    Center for Clinical Cancer Genetics and Global Health, The University of Chicago Medical Center, Chicago, IL 60637, USA
    Clin Cancer Res 18:4865-7. 2012
  10. pmc Network modeling identifies molecular functions targeted by miR-204 to suppress head and neck tumor metastasis
    Younghee Lee
    Section of Genetic Medicine and Center for Biomedical Informatics, Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America
    PLoS Comput Biol 6:e1000730. 2010

Detail Information

Publications10

  1. pmc Variants affecting exon skipping contribute to complex traits
    Younghee Lee
    Department of Medicine, The University of Chicago, Chicago, IL, USA
    PLoS Genet 8:e1002998. 2012
    ..We find that SNPs we would predict to affect exon skipping are enriched among the set of SNPs reported to be associated with complex human traits...
  2. pmc Network models of genome-wide association studies uncover the topological centrality of protein interactions in complex diseases
    Younghee Lee
    Center for Biomedical Informatics, The University of Chicago, Chicago, Illinois, USA
    J Am Med Inform Assoc 20:619-29. 2013
    ..Physical protein interactions have been utilized to increase our understanding of human Mendelian disease loci but have yet to be fully exploited for complex traits...
  3. pmc Complex-disease networks of trait-associated single-nucleotide polymorphisms (SNPs) unveiled by information theory
    Haiquan Li
    Center for Biomedical Informatics, Department of Medicine, University of Chicago, Illinois, USA
    J Am Med Inform Assoc 19:295-305. 2012
    ..The authors hypothesize that biological annotations of host genes of trait-associated SNPs may reveal the biomolecular modularity across complex-disease traits and offer insights for drug repositioning...
  4. pmc Curation-free biomodules mechanisms in prostate cancer predict recurrent disease
    James L Chen
    Center for Biomed Informatics and Department of Medicine, The University of Chicago, Chicago, IL, USA
    BMC Med Genomics 6:S4. 2013
    ....
  5. pmc Translating Mendelian and complex inheritance of Alzheimer's disease genes for predicting unique personal genome variants
    Kelly Regan
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60637, USA
    J Am Med Inform Assoc 19:306-16. 2012
    ....
  6. pmc Protein interaction network underpins concordant prognosis among heterogeneous breast cancer signatures
    James Chen
    Sections of Hematology Oncology, the University of Chicago Cancer Research Center, The Ludwig Center for Metastasis Research, The University of Chicago, Chicago, IL, USA
    J Biomed Inform 43:385-96. 2010
    ..http://www.lussierlab.org/publication/networksignature/...
  7. pmc Stromal microenvironment processes unveiled by biological component analysis of gene expression in xenograft tumor models
    Xinan Yang
    Section of Genetic Medicine, Dept, of Medicine, University of Chicago, IL, USA
    BMC Bioinformatics 11:S11. 2010
    ..Our purpose is to elucidate stromal microenvironment signals from probes on human arrays unintentionally cross-hybridizing with mouse homologous genes in xenograft tumor models...
  8. pmc GO-Module: functional synthesis and improved interpretation of Gene Ontology patterns
    Xinan Yang
    Department of Medicine, Section of Genetic Medicine and Center for Biomedical Informatics, The University of Chicago, Chicago, IL, USA
    Bioinformatics 27:1444-6. 2011
    ..Altogether, the features (biomodules) of GO-Module outputs are better organized and on average four times smaller than the input GO terms list (P = 0.0005, n = 16)...
  9. doi request reprint Hidden dangers: a cryptic exon disrupts BRCA2 mRNA
    James D Fackenthal
    Center for Clinical Cancer Genetics and Global Health, The University of Chicago Medical Center, Chicago, IL 60637, USA
    Clin Cancer Res 18:4865-7. 2012
    ..The mutation lies deep within an intron and would not have been detected by conventional screening methods. In the future, more mutations may be discovered by direct mRNA analysis...
  10. pmc Network modeling identifies molecular functions targeted by miR-204 to suppress head and neck tumor metastasis
    Younghee Lee
    Section of Genetic Medicine and Center for Biomedical Informatics, Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America
    PLoS Comput Biol 6:e1000730. 2010
    ....