Yong Woo Lee

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. ncbi request reprint Estrogen-mediated protection against HIV Tat protein-induced inflammatory pathways in human vascular endothelial cells
    Yong Woo Lee
    Department of Surgery Division of Neurosurgery, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Cardiovasc Res 63:139-48. 2004
  2. pmc Gene expression profile in interleukin-4-stimulated human vascular endothelial cells
    Yong Woo Lee
    Department of Surgery Division of Neurosurgery, University of Kentucky College of Medicine, 800 Rose Street, Lexington, Kentucky 40536, USA
    Mol Med 10:19-27. 2004
  3. ncbi request reprint Methamphetamine potentiates HIV-1 Tat protein-mediated activation of redox-sensitive pathways in discrete regions of the brain
    Govinder Flora
    Department of Surgery, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536, USA
    Exp Neurol 179:60-70. 2003
  4. ncbi request reprint HIV-1 Tat protein upregulates inflammatory mediators and induces monocyte invasion into the brain
    Hong Pu
    Department of Surgery Neurosurgery, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536, USA
    Mol Cell Neurosci 24:224-37. 2003
  5. ncbi request reprint Interplay between epidermal growth factor receptor and Janus kinase 3 regulates polychlorinated biphenyl-induced matrix metalloproteinase-3 expression and transendothelial migration of tumor cells
    Sung Yong Eum
    Molecular Neuroscience and Vascular Biology Laboratory, Department of Surgery, University of Kentucky, Lexington, USA
    Mol Cancer Res 4:361-70. 2006
  6. ncbi request reprint PCB 104-induced proinflammatory reactions in human vascular endothelial cells: relationship to cancer metastasis and atherogenesis
    Wangsun Choi
    Department of Surgery, University of Kentucky, Lexington, Kentucky 40536, USA
    Toxicol Sci 75:47-56. 2003
  7. ncbi request reprint HIV-Tat protein induces P-glycoprotein expression in brain microvascular endothelial cells
    Kentaro Hayashi
    Molecular Neuroscience and Vascular Biology Laboratory, Department of Surgery, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    J Neurochem 93:1231-41. 2005
  8. ncbi request reprint HIV-Tat protein induces oxidative and inflammatory pathways in brain endothelium
    Michal Toborek
    Department of Surgery, Animal Sciences and Neurology, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    J Neurochem 84:169-79. 2003
  9. ncbi request reprint Proinflammatory synergism of ethanol and HIV-1 Tat protein in brain tissue
    Govinder Flora
    Department of Surgery, University of Kentucky, Lexington, KY 40536, USA
    Exp Neurol 191:2-12. 2005
  10. ncbi request reprint Mechanisms of the blood-brain barrier disruption in HIV-1 infection
    Michal Toborek
    Department of Surgery, University of Kentucky, Lexington, Kentucky 40536, USA
    Cell Mol Neurobiol 25:181-99. 2005

Collaborators

  • Bernhard Hennig
  • Sung Yong Eum
  • William Maragos
  • Avi Nath
  • AARON SANFORD GOLDSTEIN
  • Michal Toborek
  • Govinder Flora
  • Hong Pu
  • Michelle R Kreke
  • Kentaro Hayashi
  • Ibolya E Andras
  • Jing Tian
  • Kwang Yong Cho
  • Wangsun Choi
  • Rosario Garrido
  • Simone Kaiser
  • Lindsay A Sharp
  • Edward Wylegala
  • R Ravikumar
  • Jae Yu Moon
  • Andrzej Malecki
  • Joo Hong Yeo
  • Ki Ho Kim
  • Hae Yong Kweon
  • Chong Su Cho
  • Larry W Robertson
  • Hans Christian Bauer
  • Kwang Gill Lee

Detail Information

Publications20

  1. ncbi request reprint Estrogen-mediated protection against HIV Tat protein-induced inflammatory pathways in human vascular endothelial cells
    Yong Woo Lee
    Department of Surgery Division of Neurosurgery, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Cardiovasc Res 63:139-48. 2004
    ..In the present study, we assessed the hypothesis that estrogen may attenuate the HIV Tat protein-induced inflammatory pathways in human vascular endothelium...
  2. pmc Gene expression profile in interleukin-4-stimulated human vascular endothelial cells
    Yong Woo Lee
    Department of Surgery Division of Neurosurgery, University of Kentucky College of Medicine, 800 Rose Street, Lexington, Kentucky 40536, USA
    Mol Med 10:19-27. 2004
    ..In addition, a better understanding of IL-4-induced vascular injury at the level of gene expression could lead to the identification of new therapeutic strategies for atherosclerosis...
  3. ncbi request reprint Methamphetamine potentiates HIV-1 Tat protein-mediated activation of redox-sensitive pathways in discrete regions of the brain
    Govinder Flora
    Department of Surgery, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536, USA
    Exp Neurol 179:60-70. 2003
    ..Such synergistic proinflammatory stimulation may have significant implications in HIV-infected patients who abuse drugs...
  4. ncbi request reprint HIV-1 Tat protein upregulates inflammatory mediators and induces monocyte invasion into the brain
    Hong Pu
    Department of Surgery Neurosurgery, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536, USA
    Mol Cell Neurosci 24:224-37. 2003
    ..These data demonstrate that intracerebral administration of Tat can induce profound proinflammatory effects in the brain, leading to monocyte infiltration...
  5. ncbi request reprint Interplay between epidermal growth factor receptor and Janus kinase 3 regulates polychlorinated biphenyl-induced matrix metalloproteinase-3 expression and transendothelial migration of tumor cells
    Sung Yong Eum
    Molecular Neuroscience and Vascular Biology Laboratory, Department of Surgery, University of Kentucky, Lexington, USA
    Mol Cancer Res 4:361-70. 2006
    ....
  6. ncbi request reprint PCB 104-induced proinflammatory reactions in human vascular endothelial cells: relationship to cancer metastasis and atherogenesis
    Wangsun Choi
    Department of Surgery, University of Kentucky, Lexington, Kentucky 40536, USA
    Toxicol Sci 75:47-56. 2003
    ..We hypothesize that these proinflammatory processes may contribute to the development of cancer metastasis and/or atherogenesis in patients exposed to PCBs...
  7. ncbi request reprint HIV-Tat protein induces P-glycoprotein expression in brain microvascular endothelial cells
    Kentaro Hayashi
    Molecular Neuroscience and Vascular Biology Laboratory, Department of Surgery, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    J Neurochem 93:1231-41. 2005
    ..These results suggest that Tat-induced overexpression of P-gp in brain microvessels may have significant implications for the development of resistance to HAART and may be a contributing factor for low efficacy of HAART in the CNS...
  8. ncbi request reprint HIV-Tat protein induces oxidative and inflammatory pathways in brain endothelium
    Michal Toborek
    Department of Surgery, Animal Sciences and Neurology, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    J Neurochem 84:169-79. 2003
    ..These changes can directly lead to disruption of the BBB. Thus, Tat can play an important role in the development of detrimental vascular changes in the brains of HIV-infected patients...
  9. ncbi request reprint Proinflammatory synergism of ethanol and HIV-1 Tat protein in brain tissue
    Govinder Flora
    Department of Surgery, University of Kentucky, Lexington, KY 40536, USA
    Exp Neurol 191:2-12. 2005
    ..Such potentiation of proinflammatory stimulation may further contribute to CNS pathology in HIV-infected patients who are alcohol abusers...
  10. ncbi request reprint Mechanisms of the blood-brain barrier disruption in HIV-1 infection
    Michal Toborek
    Department of Surgery, University of Kentucky, Lexington, Kentucky 40536, USA
    Cell Mol Neurobiol 25:181-99. 2005
    ..In addition, this review describes the mechanisms of the BBB disruption due to HIV-1 or Tat protein interaction with selected risk factors for HIV infection, such as substance abuse and aging...
  11. ncbi request reprint VEGF regulates PCB 104-mediated stimulation of permeability and transmigration of breast cancer cells in human microvascular endothelial cells
    Sung Yong Eum
    Department of Surgery, University of Kentucky, Lexington, KY 40536, USA
    Exp Cell Res 296:231-44. 2004
    ..These results indicate that PCB 104 may contribute to tumor metastasis by inducing VEGF overexpression that stimulates endothelial hyperpermeability and transendothelial migration of cancer cells...
  12. ncbi request reprint Methamphetamine activates DNA binding of specific redox-responsive transcription factors in mouse brain
    Yong Woo Lee
    Division of Neurosurgery, Department of Surgery, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    J Neurosci Res 70:82-9. 2002
    ..These results suggest that METH-induced oxidative stress may trigger the molecular signaling pathways via specific and selective activation of AP-1 and CREB...
  13. ncbi request reprint 2,2',4,6,6'-pentachlorobiphenyl (PCB 104) induces apoptosis of human microvascular endothelial cells through the caspase-dependent activation of CREB
    Yong Woo Lee
    Department of Surgery, University of Kentucky, Lexington, KY 40536, USA
    Toxicol Appl Pharmacol 189:1-10. 2003
    ..These results suggest that PCB-induced death of human microvascular endothelial cells is mediated, at least in part, via the caspase-dependent apoptotic pathways and that the selective activation of CREB is involved in this process...
  14. ncbi request reprint Unsaturated fatty acids selectively induce an inflammatory environment in human endothelial cells
    Michal Toborek
    Department of Surgery, University of Kentucky Medical Center, Lexington 40536, USA
    Am J Clin Nutr 75:119-25. 2002
    ..However, the specific effects of fatty acids on inflammatory responses in endothelial cells are not fully understood...
  15. ncbi request reprint Measurement of inflammatory properties of fatty acids in human endothelial cells
    Michal Toborek
    Department of Surgery, Division of Neurosurgery, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    Methods Enzymol 352:198-219. 2002
  16. ncbi request reprint Redox-regulated mechanisms of IL-4-induced MCP-1 expression in human vascular endothelial cells
    Yong Woo Lee
    Department of Surgery, University of Kentucky Medical Center, Lexington 40536, USA
    Am J Physiol Heart Circ Physiol 284:H185-92. 2003
    ..These results demonstrate that IL-4-dependent MCP-1 induction in HUVEC is mediated by redox-regulated STAT1 activation...
  17. ncbi request reprint Methamphetamine-induced TNF-alpha gene expression and activation of AP-1 in discrete regions of mouse brain: potential role of reactive oxygen intermediates and lipid peroxidation
    Govinder Flora
    Departments of Surgery, University of Kentucky, Lexington 40536, USA
    Neuromolecular Med 2:71-85. 2002
    ..Furthermore, these data provide evidence for the role of oxidative stress in the neurotoxic effects of METH...
  18. ncbi request reprint Role of interleukin-4 in atherosclerosis
    Yong Woo Lee
    Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Arch Pharm Res 29:1-15. 2006
    ....
  19. ncbi request reprint Preparation of self-assembled silk sericin nanoparticles
    Kwang Yong Cho
    School of Biological Resources and Materials Engineering, Seoul National University, Suwon 441 744, South Korea
    Int J Biol Macromol 32:36-42. 2003
    ..The results suggest that sericin-PEG conjugates are self-associated to form spherical nanoparticles through hydrophobic interaction...
  20. doi request reprint Effect of intermittent shear stress on mechanotransductive signaling and osteoblastic differentiation of bone marrow stromal cells
    Michelle R Kreke
    Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 0211, USA
    Tissue Eng Part A 14:529-37. 2008
    ..This study demonstrates that the variation of perfusion regimen modulates mechanotransductive signaling...