W M Lee

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Hepatitis B virus infection: current status
    Ponsiano Ocama
    Mulago Hospital, Kampala, Uganda
    Am J Med 118:1413. 2005
  2. doi request reprint Acute liver failure
    William M Lee
    Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8887, USA
    Semin Respir Crit Care Med 33:36-45. 2012
  3. pmc Drug-induced acute liver failure
    William M Lee
    Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center at Dallas, 5959 Harry Hines Boulevard, Suite 420, Dallas, TX 75390 8887, USA Electronic address
    Clin Liver Dis 17:575-86, viii. 2013
  4. pmc Recent developments in acute liver failure
    William M Lee
    Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, TX 75390 8887, USA
    Best Pract Res Clin Gastroenterol 26:3-16. 2012
  5. pmc Comparison of amplification enzymes for Hepatitis C Virus quasispecies analysis
    Stephen J Polyak
    Virology Division, Department of Laboratory Medicine, University of Washington, Seattle, WA, USA
    Virol J 2:41. 2005
  6. doi request reprint Etiologies of acute liver failure
    William M Lee
    Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, TX 75390 8887, USA
    Semin Liver Dis 28:142-52. 2008
  7. doi request reprint Etiologies of acute liver failure
    William M Lee
    University of Texas Southwestern Medical Center at Dallas, Texas 75390 8887, USA
    Curr Opin Crit Care 14:198-201. 2008
  8. ncbi request reprint Acetaminophen and the U.S. Acute Liver Failure Study Group: lowering the risks of hepatic failure
    William M Lee
    Division of Digestive and Liver Diseases, University of Texas, Southwestern Medical Center, Dallas, 75390 9151, USA
    Hepatology 40:6-9. 2004
  9. ncbi request reprint Hepatic findings in long-term clinical trials of ximelagatran
    William M Lee
    University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9151, USA
    Drug Saf 28:351-70. 2005
  10. ncbi request reprint Brief report: no evidence for parvovirus B19 or hepatitis E virus as a cause of acute liver failure
    W M Lee
    Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8887, USA
    Dig Dis Sci 51:1712-5. 2006

Research Grants

Detail Information

Publications83

  1. ncbi request reprint Hepatitis B virus infection: current status
    Ponsiano Ocama
    Mulago Hospital, Kampala, Uganda
    Am J Med 118:1413. 2005
    ..A decline in the prevalence of hepatitis B infection worldwide will require changes in high-risk behavior and the wider use of vaccination...
  2. doi request reprint Acute liver failure
    William M Lee
    Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8887, USA
    Semin Respir Crit Care Med 33:36-45. 2012
    ..Particular attention will be paid to practical matters for clinicians to consider in approaching the ALF patient...
  3. pmc Drug-induced acute liver failure
    William M Lee
    Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center at Dallas, 5959 Harry Hines Boulevard, Suite 420, Dallas, TX 75390 8887, USA Electronic address
    Clin Liver Dis 17:575-86, viii. 2013
    ..Efforts in the future to improve outcomes should focus on more effective treatments and better methods to identify those that might experience poor outcomes. ..
  4. pmc Recent developments in acute liver failure
    William M Lee
    Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, TX 75390 8887, USA
    Best Pract Res Clin Gastroenterol 26:3-16. 2012
    ..Experience is helpful but experienced clinician managers are even rarer than the disease: few hepatologists or intensivists have in-depth experience with ALF patients...
  5. pmc Comparison of amplification enzymes for Hepatitis C Virus quasispecies analysis
    Stephen J Polyak
    Virology Division, Department of Laboratory Medicine, University of Washington, Seattle, WA, USA
    Virol J 2:41. 2005
    ..QS diversity and complexity were quantified using heteroduplex mobility assays (HMA)...
  6. doi request reprint Etiologies of acute liver failure
    William M Lee
    Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, TX 75390 8887, USA
    Semin Liver Dis 28:142-52. 2008
    ..Determining etiology is important for two reasons: specific antidotes or therapies may be indicated once the diagnosis is known, and knowing the cause provides a reasonably valid guide to predicting outcome...
  7. doi request reprint Etiologies of acute liver failure
    William M Lee
    University of Texas Southwestern Medical Center at Dallas, Texas 75390 8887, USA
    Curr Opin Crit Care 14:198-201. 2008
    ..This review highlights developments in the delineation of etiologies of this relatively rare condition...
  8. ncbi request reprint Acetaminophen and the U.S. Acute Liver Failure Study Group: lowering the risks of hepatic failure
    William M Lee
    Division of Digestive and Liver Diseases, University of Texas, Southwestern Medical Center, Dallas, 75390 9151, USA
    Hepatology 40:6-9. 2004
    ..It still must be asked: Is this amount of injury and death really acceptable for an over-the-counter pain reliever?..
  9. ncbi request reprint Hepatic findings in long-term clinical trials of ximelagatran
    William M Lee
    University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9151, USA
    Drug Saf 28:351-70. 2005
    ..In these studies, raised aminotransferase levels were observed during long-term use (>35 days). The aim of this analysis is to review the data regarding these hepatic findings in the long-term trials of ximelagatran...
  10. ncbi request reprint Brief report: no evidence for parvovirus B19 or hepatitis E virus as a cause of acute liver failure
    W M Lee
    Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8887, USA
    Dig Dis Sci 51:1712-5. 2006
    ....
  11. ncbi request reprint Acetaminophen toxicity: changing perceptions on a social/medical issue
    William M Lee
    University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Hepatology 46:966-70. 2007
  12. ncbi request reprint Reemergence of hepatitis C virus after 8.5 years in a patient with hypogammaglobulinemia: evidence for an occult viral reservoir
    William M Lee
    Department of Internal Medicine, Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas 75390 9151, USA
    J Infect Dis 192:1088-92. 2005
    ..5 years, had become monoclonal. The prolonged period of negativity for HCV RNA followed by relapse suggests that HCV may persist in apparent sustained viral responders...
  13. ncbi request reprint Acute liver failure in the United States
    William M Lee
    Division of Digestive Liver Diseases, University of Texas Southwestern Medical Center Dallas, Texas, USA
    Semin Liver Dis 23:217-26. 2003
    ..Future research in ALF in the United States should focus on limiting the number of cases related to drugs, searching for causes of the indeterminate cases, and developing more effective temporary liver support...
  14. pmc Intravenous N-acetylcysteine improves transplant-free survival in early stage non-acetaminophen acute liver failure
    William M Lee
    Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8887, USA
    Gastroenterology 137:856-64, 864.e1. 2009
    ..N-acetylcysteine (NAC), an antidote for acetaminophen poisoning, might benefit patients with non-acetaminophen-related acute liver failure...
  15. ncbi request reprint Drug-induced hepatotoxicity
    William M Lee
    Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 9151, USA
    N Engl J Med 349:474-85. 2003
  16. pmc Acute liver failure: Summary of a workshop
    William M Lee
    Division of Digestive and Liver Diseases, University of Texas Southwestern Medical School, Dallas, TX 75390 8887, USA
    Hepatology 47:1401-15. 2008
    ..Advances in stem cell research may allow provision of cells for bioartificial liver support. ALF presents many challenging opportunities in both clinical and basic research...
  17. pmc Outcome of acute liver failure in the elderly
    Frank V Schiødt
    Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Liver Transpl 15:1481-7. 2009
    ..However, overall survival was better for younger non-acetaminophen patients. Fewer older patients were listed for transplantation...
  18. pmc Evolution of hepatitis C virus NS5A region in breakthrough patients during pegylated interferon and ribavirin therapy*
    H J Yuan
    Divisions of Digestive and Liver Diseases and Infectious Diseases, UT Southwestern Medical Center at Dallas, Dallas, TX, USA
    J Viral Hepat 17:208-16. 2010
    ..Our results provide evidence that amino acid substitutions within the NS5A coding region may reflect a host response that drives selective pressure for viral adaptation...
  19. pmc Prolonged therapy of advanced chronic hepatitis C with low-dose peginterferon
    Adrian M Di Bisceglie
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, 3635 Vista Ave, St Louis, MO 63110, USA
    N Engl J Med 359:2429-41. 2008
    ..Whether long-term antiviral therapy can prevent progressive liver disease in such patients remains uncertain...
  20. ncbi request reprint Clinical responders to antiviral therapy of chronic HCV infection show elevated antiviral CD4+ and CD8+ T-cell responses
    Vinodh Pillai
    Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, TX, USA
    J Viral Hepat 14:318-29. 2007
    ....
  21. ncbi request reprint Chronic graft-versus-host disease after hematopoietic cell transplantation presenting as an acute hepatitis
    A H Malik
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75390-9151, USA
    Am J Gastroenterol 96:588-90. 2001
    ..High-dose steroids resulted in marked improvement of his liver enzyme levels. We report this patient as representing the acute hepatitic presentation of chronic GVHD of the liver...
  22. ncbi request reprint Influence of acute and chronic alcohol intake on the clinical course and outcome in acetaminophen overdose
    F V Schiødt
    Department of Hepatology, Rigshospitalet, Copenhagen, Denmark
    Aliment Pharmacol Ther 16:707-15. 2002
    ..Animal studies on acetaminophen toxicity suggest that chronic alcohol intake affects the outcome adversely, whereas acute alcohol intake seems protective. Few clinical data are available...
  23. pmc Acetaminophen dose does not predict outcome in acetaminophen-induced acute liver failure
    Blake Gregory
    University of Texas Southwestern Medical Center at Dallas, TX, USA
    J Investig Med 58:707-10. 2010
    ..We sought to assess the value of acetaminophen dosing information in patients with acute liver failure (ALF) due to acetaminophen toxicity to determine the role of dose as a prognostic indicator...
  24. ncbi request reprint Nonresponse to treatment for hepatitis C: current management strategies
    He Jun Yuan
    Division of Digestive and Liver Diseases, University of Texas Southwestern Medical School, Dallas, Texas 75390 8887, USA
    Drugs 68:27-42. 2008
    ..New small molecules are under development to treat chronic hepatitis C and may be important particularly in the treatment of prior nonresponders to current standard therapy...
  25. ncbi request reprint AASLD position paper: the management of acute liver failure
    Julie Polson
    Division of Digestive and Liver Diseases, University of Texas Southwestern Medical School Department, Dallas, Texas 75390 9151, USA
    Hepatology 41:1179-97. 2005
  26. ncbi request reprint Aminotransferase elevation in HIV/hepatitis B virus co-infected patients treated with two active hepatitis B virus drugs
    Mamta K Jain
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9113, USA
    AIDS Patient Care STDS 20:817-22. 2006
    ..Distinguishing clearly between drug-related hepatotoxicity and hepatitis reactivation may be difficult but is important as their clinical management differs...
  27. ncbi request reprint Do HIV care providers appropriately manage hepatitis B in coinfected patients treated with antiretroviral therapy?
    Mamta K Jain
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 9113, USA
    Clin Infect Dis 44:996-1000. 2007
    ..The common occurrence of hepatitis B virus (HBV) infection in patients who carry the human immunodeficiency virus (HIV) demands that both viruses be recognized, evaluated, and treated when appropriate...
  28. pmc Pegylated interferon and ribavirin promote early evolution of nonstructural 5A protein in individuals with hepatitis C who demonstrate a response to treatment
    Mamta K Jain
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 4323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Infect Dis 200:866-76. 2009
    ..We evaluated the influence of HCV therapy on changes in the nonstructural 5A (NS5A) protein...
  29. ncbi request reprint Serum alpha-fetoprotein levels in patients with advanced hepatitis C: results from the HALT-C Trial
    Adrian M Di Bisceglie
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, 3635 Vista Avenue, St Louis, MO 63110, USA
    J Hepatol 43:434-41. 2005
    ..We assessed serum AFP among patients with chronic hepatitis C and advanced fibrosis to establish predictors of AFP elevations and changes with antiviral therapy...
  30. ncbi request reprint Hepatitis C is associated with type 2 diabetes mellitus in HIV-infected persons without traditional risk factors
    M K Jain
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 9113, USA
    HIV Med 8:491-7. 2007
    ..We evaluated the effect of HCV on risk of DM in relation to traditional risk factors such as age, body mass index (BMI) and family history of DM in an HIV-infected population...
  31. doi request reprint What factors determine the severity of hepatitis A-related acute liver failure?
    V Ajmera
    Digestive and Liver Diseases Division, UT Southwestern Medical Center, Dallas, TX 75390 8887, USA
    J Viral Hepat 18:e167-74. 2011
    ..Recurrent cases of the rare sub-genotype IB over several years at a single centre imply a community reservoir of infection and possible increased pathogenicity of certain infrequent viral genotypes...
  32. pmc Susceptibility to acetaminophen (APAP) toxicity unexpectedly is decreased during acute viral hepatitis in mice
    Yonas Getachew
    Division of Liver and Digestive Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9151, USA
    Biochem Pharmacol 79:1363-71. 2010
    ..Rather than potentiating APAP-induced liver injury, acute viral hepatitis in this model resulted in selective down-regulation of APAP metabolizing P450s in liver and decreased the risk of APAP hepatotoxicity...
  33. ncbi request reprint Molecular mechanisms of resistance to antiviral therapy in patients with chronic hepatitis B
    He Jun Yuan
    Division of Digestive and Liver Diseases, L5 210, University of Texas Southwestern Medical School, 5323 Harry Hines Blvd, Dallas, TX 75390 8887, USA
    Curr Mol Med 7:185-97. 2007
    ..Newer promising nucleotide analog drugs with more potent antiviral efficacy are also under development...
  34. pmc False positive acetaminophen concentrations in patients with liver injury
    Julie Polson
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5959 Harry Hines Boulevard, Dallas, TX 75390, USA
    Clin Chim Acta 391:24-30. 2008
    ..However, recent case reports have suggested that acetaminophen concentrations may be falsely increased in the presence of hyperbilirubinemia...
  35. ncbi request reprint Fulminant liver disease
    Frank Vinholt Schiødt
    Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Clin Liver Dis 7:331-49, vi. 2003
    ..Many cases develop within a few days, dramatically transforming an otherwise healthy individual to a patient with a high risk for developing multi-organ failure and death...
  36. ncbi request reprint Acute liver failure due to amoxicillin and amoxicillin/clavulanate
    Robert J Fontana
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0362, USA
    Dig Dis Sci 50:1785-90. 2005
    ..Early transfer of patients with severe drug-induced hepatotoxicity (i.e., encephalopathy or coagulopathy) to a transplant center is recommended due to their poor likelihood of recovery...
  37. ncbi request reprint Treatment of hepatitis B with lamivudine and tenofovir in HIV/HBV-coinfected patients: factors associated with response
    M K Jain
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
    J Viral Hepat 14:176-82. 2007
    ..More patients infected with HBV genotype A responded than the non-A patients, regardless of therapeutic regimen, compliance or prior HIV therapy...
  38. ncbi request reprint Cholestatic presentation of chronic hepatitis C: a clinical and histological study with a review of the literature
    K S Kumar
    Department of Internal Medicine, University of Texas Southwestern Medical Center Dallas 75390, USA
    Dig Dis Sci 46:2066-73. 2001
    ..A subset of patients with chronic hepatitis C may present with prominent cholestatic features. The majority of these patients present with pruritus and have histological evidence of bile duct injury, which may be progressive...
  39. ncbi request reprint A randomized trial of high-dose interferon alpha-2b, with or without ribavirin, in chronic hepatitis C patients who have not responded to standard dose interferon
    A H Malik
    Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, TX 75390 9151, USA
    Aliment Pharmacol Ther 16:381-8. 2002
    ..The use of high-dose induction regimens may improve the initial clearance of virus, while the addition of ribavirin appears to improve the rates of sustained response once clearance is achieved...
  40. ncbi request reprint Predictive value of actin-free Gc-globulin in acute liver failure
    Frank V Schiødt
    Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Liver Transpl 13:1324-9. 2007
    ..A new enzyme-linked immunosorbent assay for actin-free Gc-globulin provides the same (but not optimal) prognostic information as KCH criteria in a single measurement at admission...
  41. ncbi request reprint Cancer chemotherapy II: atypical hepatic injuries
    Edmundo A Rodriguez-Frias
    Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Clin Liver Dis 11:663-76, viii. 2007
    ..This article discusses unique aspects of liver damage associated with cancer chemotherapy. These unique reactions merit special attention and a special vigilance from clinicians...
  42. ncbi request reprint Gc-globulin and prognosis in acute liver failure
    Frank V Schiødt
    Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, TX 75390 9151, USA
    Liver Transpl 11:1223-7. 2005
    ..Further refinements of the assay would be necessary to make it more accurate and of practical utility...
  43. pmc Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection
    Yueh Ming Loo
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 103:6001-6. 2006
    ..HCV protease inhibitors effectively prevent IPS-1 proteolysis, suggesting they may be capable of restoring this innate host response in clinical practice...
  44. ncbi request reprint Thrombopoietin in acute liver failure
    Frank V Schiødt
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 9151, USA
    Hepatology 37:558-61. 2003
    ..Despite severe hepatic dysfunction, serum TPO levels were initially normal and increased during hospitalization in acetaminophen-induced ALF, but did not prevent the development of thrombocytopenia...
  45. ncbi request reprint Elevated troponin I levels in acute liver failure: is myocardial injury an integral part of acute liver failure?
    Nimisha K Parekh
    Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Hepatology 45:1489-95. 2007
    ..Measurement of troponin I levels may be helpful in patients with acute liver failure, to detect unrecognized myocardial damage and as a marker of unfavorable outcome...
  46. ncbi request reprint Analyzing liver transplantation for fulminant hepatic failure at UCLA: a retrospective look at 18 years' experience
    William M Lee
    Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
    Liver Transpl 10:953-5. 2004
  47. pmc Fulminant hepatitis A virus infection in the United States: Incidence, prognosis, and outcomes
    Ryan M Taylor
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 0362, USA
    Hepatology 44:1589-97. 2006
    ....
  48. pmc Factors that determine the development and progression of gastroesophageal varices in patients with chronic hepatitis C
    Robert J Fontana
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0362, USA
    Gastroenterology 138:2321-31, 2331.e1-2. 2010
    ..We aimed to identify the incidence and predictors of de novo gastroesophageal variceal formation and progression in a large cohort of patients with chronic hepatitis C and advanced fibrosis...
  49. ncbi request reprint Alpha-fetoprotein and prognosis in acute liver failure
    Frank V Schiødt
    Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Liver Transpl 12:1776-81. 2006
    ..In this large prospective study, higher absolute values of AFP did not predict a favorable outcome, but a rising level of AFP over the first 3 hospital days frequently indicated survival...
  50. ncbi request reprint Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study
    Anne M Larson
    Department of Internal Medicine, Division of Gastroenterology, University of Washington Medical Center, Seattle, 98195, USA
    Hepatology 42:1364-72. 2005
    ..Susceptible patients have concomitant depression, chronic pain, alcohol or narcotic use, and/or take several preparations simultaneously. Education of patients, physicians, and pharmacies to limit high-risk use settings is recommended...
  51. ncbi request reprint Recombinant plasma gelsolin infusion attenuates burn-induced pulmonary microvascular dysfunction
    Patricia A Rothenbach
    Department of Surgery, University of Texas Sourthwestern Medical School and the Vererans Affairs North Texas Health Care System, Dallas, TX 75216, USA
    J Appl Physiol (1985) 96:25-31. 2004
    ..Our findings are consistent with the hypothesis that plasma gelsolin depletion contributes to the pathophysiology of pulmonary microvascular dysfunction during inflammation...
  52. ncbi request reprint Recognizing drug-induced liver injury: current problems, possible solutions
    William M Lee
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9151, USA
    Toxicol Pathol 33:155-64. 2005
    ....
  53. ncbi request reprint Adefovir dipivoxil added to ongoing lamivudine in chronic hepatitis B with YMDD mutant hepatitis B virus
    Robert Perrillo
    Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Gastroenterology 126:81-90. 2004
    ..We evaluated the efficacy and safety of adding adefovir dipivoxil to lamivudine in 135 patients with chronic hepatitis B (CHB) and YMDD mutant HBV...
  54. doi request reprint Screening for Wilson disease in acute liver failure: a comparison of currently available diagnostic tests
    Jessica D Korman
    Montefiore Medical Center, Bronx, NY, USA
    Hepatology 48:1167-74. 2008
    ..In addition, an AST:ALT ratio >2.2 yielded a sensitivity of 94%, a specificity of 86%, and a likelihood ratio of 7 for diagnosing fulminant WD. Combining the tests provided a diagnostic sensitivity and specificity of 100%...
  55. pmc Interpretation of positive transcription-mediated amplification test results from polymerase chain reaction-negative samples obtained after treatment of chronic hepatitis C
    Chihiro Morishima
    Department of Laboratory Medicine, Virology Division, University of Washington, Seattle, WA, USA
    Hepatology 48:1412-9. 2008
    ..With continued treatment, patients with inconsistently positive TMA results were more likely to become TMA-negative than TMA-positive (P < 0.0001)...
  56. ncbi request reprint Adherence to combination therapy enhances sustained response in genotype-1-infected patients with chronic hepatitis C
    John G McHutchison
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27715, USA
    Gastroenterology 123:1061-9. 2002
    ..We evaluated the impact of adherence to combination therapy with interferon or peginterferon plus ribavirin in chronic hepatitis C patients...
  57. ncbi request reprint Infection and the progression of hepatic encephalopathy in acute liver failure
    Javier Vaquero
    Department of Medicine, Freidburg Medical Schoolm Northwestern University, Chicago, Illinois, USA
    Gastroenterology 125:755-64. 2003
    ..Our aim was to identify predictive factors of worsening HE, including the relation of encephalopathy with the systemic inflammatory response (SIRS) and infection...
  58. ncbi request reprint Impact of disease severity on outcome of antiviral therapy for chronic hepatitis C: Lessons from the HALT-C trial
    Gregory T Everson
    Section of Hepatology, Division of Gastroenterology and Hepatology, University of Colorado School of Medicine, Denver, CO, USA
    Hepatology 44:1675-84. 2006
    ..In conclusion, disease severity is a major independent determinant of rate of SVR in patients with advanced chronic hepatitis C. New strategies are needed to optimize antiviral therapy in these "difficult-to-cure" patients...
  59. ncbi request reprint Liver transplantation for acute liver failure--better safe than sorry
    Frank Vinholt Schiødt
    Liver Transpl 8:1063-4. 2002
  60. ncbi request reprint Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States
    George Ostapowicz
    Department of Medicine, Gold Coast Hospital, 108 Nerang Street, Southport, QLD 4215, Australia
    Ann Intern Med 137:947-54. 2002
    ..Because acute liver failure is rare, related data have been sparse. Studies have suggested that viral hepatitis is the most common underlying cause of this condition...
  61. ncbi request reprint Viral hepatitis-related acute liver failure
    Frank Vinholt Schiødt
    Department of Gastroenterology, Rigshospitalet, Copenhagen, Denmark
    Am J Gastroenterol 98:448-53. 2003
    ..We aimed to determine the incidence of viral hepatitis-related ALF and to compare the outcome and clinical and biochemical variables in patients with hepatitis A and B...
  62. ncbi request reprint Entecavir
    Christopher K Opio
    Nat Rev Drug Discov 4:535-6. 2005
  63. ncbi request reprint Complications and use of intracranial pressure monitoring in patients with acute liver failure and severe encephalopathy
    Javier Vaquero
    Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Liver Transpl 11:1581-9. 2005
    ..In view of the high 30-day survival rate after LT, future studies of the impact of intracranial hypertension should also focus on long-term neurological recovery from ALF...
  64. ncbi request reprint Hepatic steatosis in hepatitis C: comparison of diabetic and nondiabetic patients in the hepatitis C antiviral long-term treatment against cirrhosis trial
    Anna S F Lok
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0362, USA
    Clin Gastroenterol Hepatol 5:245-54. 2007
    ....
  65. ncbi request reprint Impact of reducing peginterferon alfa-2a and ribavirin dose during retreatment in patients with chronic hepatitis C
    Mitchell L Shiffman
    Hepatology Section, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
    Gastroenterology 132:103-12. 2007
    ..However, prior studies did not assess the impact of reducing the dose of peginterferon independent of ribavirin or differentiate between dose reduction or interrupting or prematurely discontinuing treatment...
  66. ncbi request reprint Etiologies of acute liver failure: location, location, location!
    Julie Polson
    Liver Transpl 13:1362-3. 2007
  67. ncbi request reprint Predicting cirrhosis in patients with hepatitis C based on standard laboratory tests: results of the HALT-C cohort
    Anna S F Lok
    Division of Gastroenterology, University of Michigan Medical Center, 3912 Taubman Center, Ann Arbor, MI 48210, USA
    Hepatology 42:282-92. 2005
    ..In conclusion, a model based on standard laboratory test results can be used to predict histological cirrhosis with a high degree of accuracy in 50% of patients with CHC...
  68. ncbi request reprint Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial
    Leonard B Seeff
    Division of Digestive Diseases and Nutrition, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Hepatology 47:605-12. 2008
    ..Because its use among these HALT-C participants was self-motivated and uncontrolled, however, only a well-designed prospective study can determine whether silymarin provides benefit to persons with chronic hepatitis C...
  69. doi request reprint Blunted cytopenias and weight loss: new correlates of virologic null response to re-treatment of chronic hepatitis C
    Karen L Lindsay
    Division of Gastrointestinal and Liver Diseases, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Clin Gastroenterol Hepatol 6:234-41. 2008
    ..Although viral kinetic profiles in treatment responders shed light on the mechanism of action of interferon and ribavirin, minimal information is available to explain why some patients experience little or no virologic suppression...
  70. ncbi request reprint Detection of acetaminophen protein adducts in children with acute liver failure of indeterminate cause
    Laura P James
    Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children s Hospital Research Institute, Little Rock, Arkansas, USA
    Pediatrics 118:e676-81. 2006
    ..The objective of this study was to use a new assay for the detection of acetaminophen cysteine protein adducts in children with acute liver failure to determine the role of acetaminophen toxicity in acute liver failure of unknown cause...
  71. ncbi request reprint HCV RNA detection by TMA during the hepatitis C antiviral long-term treatment against cirrhosis (Halt-C) trial
    Chihiro Morishima
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98104, USA
    Hepatology 44:360-7. 2006
    ..In patients with negative PCR results during treatment, a single positive TMA test did not exclude SVR, although persistently positive tests did...
  72. pmc Soluble CD163 from activated macrophages predicts mortality in acute liver failure
    Holger Jon Møller
    Department of Clinical Biochemistry AS, Aarhus University Hospital, Aarhus, Denmark
    J Hepatol 47:671-6. 2007
    ..Soluble CD163 (sCD163) is a scavenger receptor shed in serum during inflammatory activation of macrophages. We investigated if sCD163 was increased and predicted outcome in acute liver failure (ALF)...
  73. ncbi request reprint Influence of high body mass index on outcome in acute liver failure
    Anna Rutherford
    GI Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Clin Gastroenterol Hepatol 4:1544-9. 2006
    ....
  74. ncbi request reprint Measurement of serum acetaminophen-protein adducts in patients with acute liver failure
    Timothy J Davern
    University of California at San Francisco, San Francisco, California, USA corrected
    Gastroenterology 130:687-94. 2006
    ..Measurement of serum adducts might improve diagnostic accuracy in acute liver failure (ALF) patients...
  75. ncbi request reprint Serum protein S-100b in acute liver failure: Results of the US Acute Liver Failure Study group
    Javier Vaquero
    Liver Transpl 9:887-8. 2003
  76. ncbi request reprint Evolution of the HALT-C Trial: pegylated interferon as maintenance therapy for chronic hepatitis C in previous interferon nonresponders
    William M Lee
    Control Clin Trials 25:472-92. 2004
    ..The protocol changes enhanced enrollment while upholding the original goals of the study and its integrity...
  77. ncbi request reprint Intensive care of patients with acute liver failure: recommendations of the U.S. Acute Liver Failure Study Group
    R Todd Stravitz
    Section of Hepatology, Virginia Commonwealth University, Richmond, USA
    Crit Care Med 35:2498-508. 2007
    ..To provide a uniform platform from which to study acute liver failure, the U.S. Acute Liver Failure Study Group has sought to standardize the management of patients with acute liver failure within participating centers...
  78. doi request reprint Liver failure and liver support
    William M Lee
    Semin Liver Dis 28:135-6. 2008
  79. doi request reprint Fulminant hepatic failure: when the hepatologist meets the neurointensivist
    William M Lee
    Neurocrit Care 9:1-2. 2008
  80. doi request reprint Therapeutic hypothermia for acute liver failure: toward a randomized, controlled trial in patients with advanced hepatic encephalopathy
    R Todd Stravitz
    Section of Hepatology, Hume Lee Transplant Center, Virginia Commonwealth University, Richmond, VA 23298 0341, USA
    Neurocrit Care 9:90-6. 2008
    ..Herein, we consider the many difficulties which will be encountered in the design of such a trial in patients with ALF at high risk of developing cerebral edema...
  81. ncbi request reprint Peginterferon alfa-2a and ribavirin in patients with chronic hepatitis C who have failed prior treatment
    Mitchell L Shiffman
    Hepatology Section, Virginia Commonwealth University, Richmond, 23298, USA
    Gastroenterology 126:1015-23; discussion 947. 2004
    ..This study evaluated the effectiveness of this treatment in patients who were nonresponders to previous interferon-based therapy...
  82. ncbi request reprint Investigation of SEN virus infection in patients with cryptogenic acute liver failure, hepatitis-associated aplastic anemia, or acute and chronic non-A-E hepatitis
    Takeji Umemura
    Department of Transfusion Medicine, Warren Grant Magnuson Clinical Center, National Heart, Lung, Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1184, USA
    J Infect Dis 188:1545-52. 2003
    ..The severity of acute or chronic hepatitis A, B, or C was not influenced by coexisting SENV infection. No etiological role for SENV in the cause of cryptogenic hepatitis could be demonstrated...

Research Grants11

  1. A Multi-Center Study of Acute Liver Failure in Adults
    William Lee; Fiscal Year: 2007
    ....
  2. A MULTI-CENTER THERAPY TRIAL FOR ACUTE LIVER FAILURE
    William Lee; Fiscal Year: 2004
    ..The overall goal is to apply modern clinical, epidemiological and virological techniques to the study of this rare but devastating illness. ..
  3. A MULTI-CENTER THERAPY TRIAL FOR ACUTE LIVER FAILURE
    William Lee; Fiscal Year: 2003
    ....