Genomes and Genes
Affiliation: University of Texas Southwestern Medical Center
- Sterol-dependent nuclear import of ORP1S promotes LXR regulated trans-activation of apoESungsoo Lee
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9039, United States
Exp Cell Res 318:2128-42. 2012..1 and ME.2 enhancer elements of the apoE gene. We propose that ORP1S is a cytoplasmic sterol sensor, which transports sterols to the nucleus and promotes LXR-dependent gene transcription through select enhancer elements...
- The N terminus controls sterol binding while the C terminus regulates the scaffolding function of OSBPPing Yuan Wang
Department of Cell Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9039, USA
J Biol Chem 283:8034-45. 2008..On the basis of this information we propose a new model for how OSBP is able to sense both membrane cholesterol and oxidized sterols and link this information to the ERK1/2 signaling pathway...