Seong Ho Lee

Summary

Affiliation: University of Tennessee
Country: USA

Publications

  1. pmc Capsaicin represses transcriptional activity of β-catenin in human colorectal cancer cells
    Seong Ho Lee
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996 4542, USA
    J Nutr Biochem 23:646-55. 2012
  2. pmc Resveratrol-induced apoptosis is mediated by early growth response-1, Krüppel-like factor 4, and activating transcription factor 3
    Nichelle C Whitlock
    Laboratory of Environmental Carcinogenesis, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennesse 37996, USA
    Cancer Prev Res (Phila) 4:116-27. 2011
  3. ncbi request reprint Indole-3-carbinol and 3,3'-diindolylmethane induce expression of NAG-1 in a p53-independent manner
    Seong Ho Lee
    Laboratory of Environmental Carcinogenesis, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Biochem Biophys Res Commun 328:63-9. 2005
  4. ncbi request reprint Conjugated linoleic acid stimulates an anti-tumorigenic protein NAG-1 in an isomer specific manner
    Seong Ho Lee
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Carcinogenesis 27:972-81. 2006
  5. ncbi request reprint A novel peroxisome proliferator-activated receptor gamma ligand, MCC-555, induces apoptosis via posttranscriptional regulation of NAG-1 in colorectal cancer cells
    Kiyoshi Yamaguchi
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Mol Cancer Ther 5:1352-61. 2006
  6. pmc Growth inhibition and apoptosis by (-)-epicatechin gallate are mediated by cyclin D1 suppression in head and neck squamous carcinoma cells
    Young Chang Lim
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996 4542, United States
    Eur J Cancer 42:3260-6. 2006
  7. ncbi request reprint Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells
    Seung Joon Baek
    Laboratory of Environmental Carcinogenesis, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Carcinogenesis 25:2425-32. 2004
  8. pmc MCC-555-induced NAG-1 expression is mediated in part by KLF4
    Maria Cekanova
    Department of Pathobiology, College of Veterinary Medicine, The University of Tennessee, Knoxville, Tennessee 37996, USA
    Eur J Pharmacol 637:30-7. 2010
  9. pmc The involvement of endoplasmic reticulum stress in the suppression of colorectal tumorigenesis by tolfenamic acid
    Xiaobo Zhang
    College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996 4542 Phone 865 974 8216 Fax 865 974 5616 Qingwang Li, College of Animal Science and Technology, Northwest A and F University, 22 Xinong Road, Yangling, Shaanxi 712100, People s Republic of China
    Cancer Prev Res (Phila) 6:1337-47. 2013
  10. ncbi request reprint Activating transcription factor 3 and early growth response 1 are the novel targets of LY294002 in a phosphatidylinositol 3-kinase-independent pathway
    Kiyoshi Yamaguchi
    Department of Pathobiology, University of Tennessee, Knoxville, Tennessee 37996, USA
    Cancer Res 66:2376-84. 2006

Collaborators

Detail Information

Publications23

  1. pmc Capsaicin represses transcriptional activity of β-catenin in human colorectal cancer cells
    Seong Ho Lee
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996 4542, USA
    J Nutr Biochem 23:646-55. 2012
    ..This study identifies a role for the β-catenin/TCF-dependent pathway that potentially contributes to the anticancer activity of capsaicin in human colorectal cancer cells...
  2. pmc Resveratrol-induced apoptosis is mediated by early growth response-1, Krüppel-like factor 4, and activating transcription factor 3
    Nichelle C Whitlock
    Laboratory of Environmental Carcinogenesis, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennesse 37996, USA
    Cancer Prev Res (Phila) 4:116-27. 2011
    ..Taken together, these results provide a novel mechanism by which resveratrol induces ATF3 expression and represent an additional explanation of how resveratrol exerts its antitumorigenic effects in human colorectal cancer cells...
  3. ncbi request reprint Indole-3-carbinol and 3,3'-diindolylmethane induce expression of NAG-1 in a p53-independent manner
    Seong Ho Lee
    Laboratory of Environmental Carcinogenesis, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Biochem Biophys Res Commun 328:63-9. 2005
    ..Furthermore, the mixture of I3C with resveratrol enhances NAG-1 expression, suggesting the synergistic effect of these two unrelated compounds on NAG-1 expression...
  4. ncbi request reprint Conjugated linoleic acid stimulates an anti-tumorigenic protein NAG-1 in an isomer specific manner
    Seong Ho Lee
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Carcinogenesis 27:972-81. 2006
    ..The current study demonstrates that t10,c12-CLA stimulates ATF3/NAG-1 expression and subsequently induces apoptosis in an isomer specific manner. These effects may be through inhibition of AKT/GSK-3beta pathway in human CRC cells...
  5. ncbi request reprint A novel peroxisome proliferator-activated receptor gamma ligand, MCC-555, induces apoptosis via posttranscriptional regulation of NAG-1 in colorectal cancer cells
    Kiyoshi Yamaguchi
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Mol Cancer Ther 5:1352-61. 2006
    ....
  6. pmc Growth inhibition and apoptosis by (-)-epicatechin gallate are mediated by cyclin D1 suppression in head and neck squamous carcinoma cells
    Young Chang Lim
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996 4542, United States
    Eur J Cancer 42:3260-6. 2006
    ..These results suggest that ECG has a potential usage as a chemopreventive agent in HNSCC...
  7. ncbi request reprint Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells
    Seung Joon Baek
    Laboratory of Environmental Carcinogenesis, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Carcinogenesis 25:2425-32. 2004
    ..The data generated by this study will help elucidate mechanisms of action for components in green tea and this information may lead to the design of more effective anticancer agents and informed clinical trials...
  8. pmc MCC-555-induced NAG-1 expression is mediated in part by KLF4
    Maria Cekanova
    Department of Pathobiology, College of Veterinary Medicine, The University of Tennessee, Knoxville, Tennessee 37996, USA
    Eur J Pharmacol 637:30-7. 2010
    ..This study shows that PPARgamma agonists up-regulate KLF4 expression in receptor-dependent manner, and KLF4 was identified as a novel transcription factor that controls NAG-1 promoter activity in human and mouse colorectal cancers...
  9. pmc The involvement of endoplasmic reticulum stress in the suppression of colorectal tumorigenesis by tolfenamic acid
    Xiaobo Zhang
    College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996 4542 Phone 865 974 8216 Fax 865 974 5616 Qingwang Li, College of Animal Science and Technology, Northwest A and F University, 22 Xinong Road, Yangling, Shaanxi 712100, People s Republic of China
    Cancer Prev Res (Phila) 6:1337-47. 2013
    ..Taken together, these results suggest ER stress is involved in tolfenamic acid-induced inhibition of colorectal cancer cell growth, which could contribute to antitumorigenesis in a mouse model...
  10. ncbi request reprint Activating transcription factor 3 and early growth response 1 are the novel targets of LY294002 in a phosphatidylinositol 3-kinase-independent pathway
    Kiyoshi Yamaguchi
    Department of Pathobiology, University of Tennessee, Knoxville, Tennessee 37996, USA
    Cancer Res 66:2376-84. 2006
    ..ATF3 and EGR-1 may provide a novel explanation for the antitumorigenic properties of LY294002 in human colorectal cancer cells...
  11. pmc Multiple mechanisms are involved in 6-gingerol-induced cell growth arrest and apoptosis in human colorectal cancer cells
    Seong Ho Lee
    The Laboratory of Environmental Carcinogenesis, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee 37996 4542, USA
    Mol Carcinog 47:197-208. 2008
    ..Multiple mechanisms appear to be involved in 6-gingerol action, including protein degradation as well as beta-catenin, PKCepsilon, and GSK-3beta pathways...
  12. ncbi request reprint Identification of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) as a novel downstream target of phosphatidylinositol 3-kinase/AKT/GSK-3beta pathway
    Kiyoshi Yamaguchi
    Laboratory of Environmental Carcinogenesis, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee 37996, USA
    J Biol Chem 279:49617-23. 2004
    ..These data suggest that expression of NAG-1 is regulated by PI3K/AKT/GSK-3beta pathway in HCT-116 cells and may provide a further understanding of the important role of PI3K/AKT/GSK-3beta pathway in tumorigenesis...
  13. ncbi request reprint Evaluation of polycyclic aromatic hydrocarbons in the activation of early growth response-1 and peroxisome proliferator activated receptors
    Jeong Ho Kim
    Department of Pathobiology, University of Tennessee, Knoxville, Tennessee 37996, USA
    Toxicol Sci 85:585-93. 2005
    ..In conclusion, PAHs activate PPAR alpha and PPAR beta/delta, and up-regulate EGR-1 expression in vitro as well as in vivo. These data may provide a diversity of PAH activity in several biological pathways...
  14. doi request reprint Induction of cell growth arrest by atmospheric non-thermal plasma in colorectal cancer cells
    Chul Ho Kim
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    J Biotechnol 150:530-8. 2010
    ..Therefore, non-thermal atmospheric plasma constitutes a new biologic tool with the potential for therapeutic applications that modulate cell signaling and function...
  15. pmc Molecular targets of apigenin in colorectal cancer cells: involvement of p21, NAG-1 and p53
    Yi Zhong
    Department of Pathobiology, The University of Tennessee, Knoxville, TN 37996, United States
    Eur J Cancer 46:3365-74. 2010
    ..Apigenin is able to reduce polyp numbers, accompanied by increasing p53 activation through phosphorylation in animal models. Our data suggest apparent beneficial effects of apigenin on colon cancer...
  16. pmc Damnacanthal, a noni component, exhibits antitumorigenic activity in human colorectal cancer cells
    Thararat Nualsanit
    Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996 4542, USA
    J Nutr Biochem 23:915-23. 2012
    ..Taken together, these results indicate that damnacanthal increases antitumorigenic activity in human colorectal cancer cells and that C/EBPβ plays a role in damnacanthal-induced NAG-1 expression...
  17. pmc NSAID-activated gene-1 as a molecular target for capsaicin-induced apoptosis through a novel molecular mechanism involving GSK3beta, C/EBPbeta and ATF3
    Seong Ho Lee
    Laboratory of Environmental Carcinogenesis, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Carcinogenesis 31:719-28. 2010
    ..These data indicate that C/EBPbeta phosphorylation through GSK3beta may mediate capsaicin-induced expression of NAG-1 and apoptosis through cooperation with ATF3 in human colorectal cancer cells...
  18. pmc Green tea catechin (-)-epicatechin gallate induces tumour suppressor protein ATF3 via EGR-1 activation
    Kyou Nam Cho
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Eur J Cancer 43:2404-12. 2007
    ..We also found that pro-oxidant activity of ECG contributed to ECG-induced ATF3 expression...
  19. ncbi request reprint Nonsteroidal anti-inflammatory drug-activated gene-1 over expression in transgenic mice suppresses intestinal neoplasia
    Seung Joon Baek
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA
    Gastroenterology 131:1553-60. 2006
    ..However, its antitumorigenic activity has not been elucidated in vivo...
  20. pmc A green tea component suppresses posttranslational expression of basic fibroblast growth factor in colorectal cancer
    Mugdha Sukhthankar
    Laboratory of Environmental Carcinogenesis, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee 37996, USA
    Gastroenterology 134:1972-80. 2008
    ..However, the exact molecular mechanism by which EGCG suppresses bFGF expression is not known. Our objective was to elucidate the molecular mechanisms by which EGCG inhibits bFGF expression in colorectal cancer...
  21. pmc 3,3'-diindolylmethane induces activating transcription factor 3 (ATF3) via ATF4 in human colorectal cancer cells
    Seong Ho Lee
    Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996 4542, USA
    J Nutr Biochem 24:664-71. 2013
    ..The current study demonstrates that DIM stimulates ATF3 expression through ATF4-mediated pathway and subsequently induces apoptosis in human CRC cells...
  22. pmc Antidiabetic Activities of Abutilon indicum (L.) Sweet Are Mediated by Enhancement of Adipocyte Differentiation and Activation of the GLUT1 Promoter
    Chutwadee Krisanapun
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Evid Based Complement Alternat Med 2011:167684. 2011
    ..indicum L. may be beneficial for reducing insulin resistance through its potency in regulating adipocyte differentiation through PPARγ agonist activity, and increasing glucose utilization via GLUT1...
  23. pmc ESE-1/EGR-1 pathway plays a role in tolfenamic acid-induced apoptosis in colorectal cancer cells
    Seong Ho Lee
    Laboratory of Environmental Carcinogenesis, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996 4542, USA
    Mol Cancer Ther 7:3739-50. 2008
    ..These results show that activation of ESE-1 via enhanced nuclear translocation mediates tolfenamic acid-induced EGR-1 expression, which plays a critical role in the activation of apoptosis...