Royce J Lee

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi Cerebrospinal fluid oxytocin, life history of aggression, and personality disorder
    Royce Lee
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, The Pritzker School of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Psychoneuroendocrinology 34:1567-73. 2009
  2. ncbi Childhood trauma and personality disorder: toward a biological model
    Royce Lee
    The University of Chicago, Department of Psychiatry, 5841 S Maryland Avenue, Chicago, IL 60613, USA
    Curr Psychiatry Rep 8:43-52. 2006
  3. ncbi Indices of orbitofrontal and prefrontal function in Cluster B and Cluster C personality disorders
    Anthony C Ruocco
    Department of Psychiatry, University of Chicago Medical Center, Chicago, IL, USA
    Psychiatry Res 170:282-5. 2009
  4. ncbi Plasma homovanillic acid correlates inversely with history of childhood trauma in personality disordered and healthy control adults
    Royce Lee
    Clinical Neuroscience Research Unit, Department of Psychiatry, University of Chicago, Chicago, USA
    J Neural Transm 117:1327-34. 2010
  5. ncbi Modulation of central serotonin affects emotional information processing in impulsive aggressive personality disorder
    Royce J Lee
    Clinical Neuroscience Research Unit, Department of Psychiatry, University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA
    J Clin Psychopharmacol 32:329-35. 2012
  6. ncbi Growth hormone responses to GABAB receptor challenge with baclofen and impulsivity in healthy control and personality disorder subjects
    Royce Lee
    Department of Psychiatry, The University of Chicago, Chicago, IL, USA
    Psychopharmacology (Berl) 215:41-8. 2011
  7. ncbi Plasma oxytocin in response to pharmaco-challenge to D-fenfluramine and placebo in healthy men
    Royce Lee
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry MC 3077, Pritzker School of Medicine, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Psychiatry Res 118:129-36. 2003
  8. ncbi Cerebrospinal fluid GABA concentration: relationship with impulsivity and history of suicidal behavior, but not aggression, in human subjects
    Royce Lee
    Department of Psychiatry, The University of Chicago School of Medicine, Chicago, IL 60637, USA
    J Psychiatr Res 43:353-9. 2009
  9. ncbi CSF corticotropin-releasing factor in personality disorder: relationship with self-reported parental care
    Royce J Lee
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, The University of Chicago, Chicago, IL 60637, USA
    Neuropsychopharmacology 31:2289-95. 2006
  10. ncbi Childhood trauma and personality disorder: positive correlation with adult CSF corticotropin-releasing factor concentrations
    Royce Lee
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, The University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Am J Psychiatry 162:995-7. 2005

Research Grants

  1. CRF and Personality Disorder: Behavioral Correlates
    Royce Lee; Fiscal Year: 2003

Detail Information

Publications21

  1. ncbi Cerebrospinal fluid oxytocin, life history of aggression, and personality disorder
    Royce Lee
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, The Pritzker School of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Psychoneuroendocrinology 34:1567-73. 2009
    ..We hypothesized that CSF Oxytocin levels would be inversely related to dimensional measures of lifetime aggression...
  2. ncbi Childhood trauma and personality disorder: toward a biological model
    Royce Lee
    The University of Chicago, Department of Psychiatry, 5841 S Maryland Avenue, Chicago, IL 60613, USA
    Curr Psychiatry Rep 8:43-52. 2006
    ..Identification of the biological mechanism by which childhood trauma exerts an effect on personality disorder may require modification of the conceptualization of personality disorder, either as a set of categories or dimensions...
  3. ncbi Indices of orbitofrontal and prefrontal function in Cluster B and Cluster C personality disorders
    Anthony C Ruocco
    Department of Psychiatry, University of Chicago Medical Center, Chicago, IL, USA
    Psychiatry Res 170:282-5. 2009
    ..The present study is among the first to report neurocognitive findings for the full range of Cluster B personality disorders and any Cluster C personality disorder...
  4. ncbi Plasma homovanillic acid correlates inversely with history of childhood trauma in personality disordered and healthy control adults
    Royce Lee
    Clinical Neuroscience Research Unit, Department of Psychiatry, University of Chicago, Chicago, USA
    J Neural Transm 117:1327-34. 2010
    ....
  5. ncbi Modulation of central serotonin affects emotional information processing in impulsive aggressive personality disorder
    Royce J Lee
    Clinical Neuroscience Research Unit, Department of Psychiatry, University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA
    J Clin Psychopharmacol 32:329-35. 2012
    ..The purpose of this study was to test the hypothesis that depletion of serotonin reserves by tryptophan depletion affects emotional information processing in susceptible individuals...
  6. ncbi Growth hormone responses to GABAB receptor challenge with baclofen and impulsivity in healthy control and personality disorder subjects
    Royce Lee
    Department of Psychiatry, The University of Chicago, Chicago, IL, USA
    Psychopharmacology (Berl) 215:41-8. 2011
    ..The purpose of this investigation is to test the hypothesis that dimensional measures of impulsivity and impulsive aggression are negatively correlated with growth hormone response...
  7. ncbi Plasma oxytocin in response to pharmaco-challenge to D-fenfluramine and placebo in healthy men
    Royce Lee
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry MC 3077, Pritzker School of Medicine, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Psychiatry Res 118:129-36. 2003
    ..g. aggression) than that of less central outcome parameters of 5-HT responsiveness (e.g. prolactin)...
  8. ncbi Cerebrospinal fluid GABA concentration: relationship with impulsivity and history of suicidal behavior, but not aggression, in human subjects
    Royce Lee
    Department of Psychiatry, The University of Chicago School of Medicine, Chicago, IL 60637, USA
    J Psychiatr Res 43:353-9. 2009
    ..Further work assessing this and other aspects of the central GABA system in personality disordered subjects are warranted...
  9. ncbi CSF corticotropin-releasing factor in personality disorder: relationship with self-reported parental care
    Royce J Lee
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, The University of Chicago, Chicago, IL 60637, USA
    Neuropsychopharmacology 31:2289-95. 2006
    ..The cross-sectional design of the study, however, limits causal inferences...
  10. ncbi Childhood trauma and personality disorder: positive correlation with adult CSF corticotropin-releasing factor concentrations
    Royce Lee
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, The University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Am J Psychiatry 162:995-7. 2005
    ....
  11. ncbi The relationship between impulsive verbal aggression and intermittent explosive disorder
    Michael S McCloskey
    Department of Psychiatry, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Aggress Behav 34:51-60. 2008
    ..These results support the clinical importance of frequent VA for future iterations of the IED criteria set...
  12. ncbi Norepinephrine function in personality disorder: plasma free MHPG correlates inversely with life history of aggression
    Emil F Coccaro
    Department of Psychiatry, University of Chicago, Illinois 60637, USA
    CNS Spectr 8:731-6. 2003
    ..In this study, the relationship between plasma free NE metabolite, plasma free 3-methoxy-4-hydroxyphenylglycol (pMHPG), and impulsive aggression was explored in subjects with personality disorder...
  13. ncbi Cerebrospinal fluid 5-hydroxyindolacetic acid and homovanillic acid: reciprocal relationships with impulsive aggression in human subjects
    Emil F Coccaro
    Department of Psychiatry and Behavioral Neuroscience, Pritzker School of Medicine, The University of Chicago, 5841, South Maryland Avenue, Chicago, IL 60637, USA
    J Neural Transm 117:241-8. 2010
    ....
  14. ncbi Aggression, suicidality, and intermittent explosive disorder: serotonergic correlates in personality disorder and healthy control subjects
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
    Neuropsychopharmacology 35:435-44. 2010
    ..These data have particular relevance to the notion of impulsive aggression and the biological validity of IED...
  15. ncbi Inverse relationship between numbers of 5-HT transporter binding sites and life history of aggression and intermittent explosive disorder
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL 60637, United States
    J Psychiatr Res 44:137-42. 2010
    ..Results from the examination of IED as a categorical aggression variable suggest that Research, rather than DSM-IV, criteria better identify individuals with reduced numbers of platelet 5-HTT sites...
  16. ncbi Developmental psychopathology and neurobiology of aggression
    Jackie K Gollan
    University of Chicago, Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, IL 60637, USA
    Dev Psychopathol 17:1151-71. 2005
    ..Finally, we comment on the data of the relative stability of aggression in BPD, adolescence as a developmental stage of potential vulnerability, and the course of aggressive behavior during the life span...
  17. ncbi Placebo-controlled, randomized trial of fluoxetine in the treatment of aggression in male intimate partner abusers
    Royce Lee
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, The University of Chicago, Chicago, Illinois
    Int Clin Psychopharmacol 23:337-41. 2008
    ..Despite the small sample, these results do not support the hypothesis that treatment with an SSRI is associated with a reduction in aggressive behavior among men with a history of intimate partner abuse...
  18. ncbi Prevalence of suicidal and self-injurious behavior among subjects with intermittent explosive disorder
    Michael S McCloskey
    Department of Psychiatry, University of Chicago, 5841 South Maryland Avenue, MC 3077, Chicago, IL 60637, USA
    Psychiatry Res 158:248-50. 2008
    ..Results showed 16% of IED subjects reported self-aggression, with 12.5% reporting suicide attempts and 7.4% reporting non-lethal self-injurious behaviors. Additional risk factors were identified...
  19. ncbi Acute tryptophan depletion and self-injurious behavior in aggressive patients and healthy volunteers
    Michael S McCloskey
    Department of Psychiatry, University of Chicago, 5841 South Maryland Avenue, MC 3077, Chicago, IL, 60637, USA
    Psychopharmacology (Berl) 203:53-61. 2009
    ..Studies to date, however, have relied on nonexperimental designs to examine this relationship, limiting the causal inferences that can be drawn about the role of 5-HT in self-aggressive behavior...
  20. ncbi The neuroendocrinology of childhood trauma in personality disorder
    Royce J Lee
    The University of Chicago Medical Center, 5841 S Maryland Ave, Chicago, IL 60637, United States
    Psychoneuroendocrinology 37:78-86. 2012
    ....
  21. ncbi A double-blind, randomized, placebo-controlled trial of fluoxetine in patients with intermittent explosive disorder
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, University of Chicago, Chicago, IL 60637, USA
    J Clin Psychiatry 70:653-62. 2009
    ..Since central serotonergic (5-HT) system dysfunction is related to impulsive aggressive behavior, pharmacologic enhancement of 5-HT activity should reduce impulsive aggressive behavior in individuals with IED...

Research Grants1

  1. CRF and Personality Disorder: Behavioral Correlates
    Royce Lee; Fiscal Year: 2003
    ..abstract_text> ..