Research Topics
| Randall J LeeSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
The relative importance of left atrial function versus dimension in predicting atrial fibrillation after coronary artery bypass graft surgeryToshiko Nakai
Department of Medicine, Section of Cardiac Electrophysiology, and Cardiovascular Research Institute, University of California, San Francisco 94143, USA
Am Heart J 143:181-6. 2002..The purpose of this study was to determine whether pre-existing left atrial dysfunction is a predictor of postoperative AF compared with other clinical predictors...- Antibody targeting of stem cells to infarcted myocardiumRandall J Lee
Department of Medicine and Cardiovascular Research Institute, University of California San Francisco, 500 Parnassus Avenue, San Francisco, CA 94143 1354, USA
Stem Cells 25:712-7. 2007..01). Bispecific antibody targeting offers a unique means to improve the delivery of stem cells to facilitate organ repair and a tool to study stem cell biology... 
Polymer-based restoration of left ventricular mechanicsRandall J Lee
Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA
Cell Transplant 22:529-33. 2013..A review of the rationale for an in situ tissue engineering approach for this treatment of heart failure and early clinical results of the Algisyl-LVR™ program are presented...- Stem cells for myocardial repair and regeneration: where are we today?Randall J Lee
Department of Medicine, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA
Methods Mol Biol 660:1-6. 2010..The overview provides the rationale for use of stem cells in myocardial repair. Potential stem cell types and technological challenges are highlighted... - Catheter-based left atrial appendage (LAA) ligation for the prevention of embolic events arising from the LAA: initial experience in a canine modelRandall J Lee
Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
Circ Cardiovasc Interv 3:224-9. 2010..A novel catheter-based approach for LAA ligation was evaluated for safety and effectiveness in a canine model... - The use of human mesenchymal stem cells encapsulated in RGD modified alginate microspheres in the repair of myocardial infarction in the ratJiashing Yu
University of California Berkeley and University of California San Francisco Joint Bioengineering Graduate Group, Berkeley San Francisco, 513 Parnassus Ave, San Francisco, CA 94143, USA
Biomaterials 31:7012-20. 2010.... 
Intracardiac and extracardiac markers of inflammation during atrial fibrillationGregory M Marcus
Division of Cardiology, University of California, San Francisco, CA, USA
Heart Rhythm 7:149-54. 2010....- Alcohol intake is significantly associated with atrial flutter in patients under 60 years of age and a shorter right atrial effective refractory periodGregory M Marcus
Division of Cardiology, Electrophysiology Section, University of California, San Francisco, San Francisco, California, USA
Pacing Clin Electrophysiol 31:266-72. 2008..Although evidence suggests that alcohol is associated with atrial fibrillation (AF), the association between alcohol and atrial flutter (AFL) has not been examined. The mechanism connecting alcohol and atrial arrhythmias is unknown... - Comparative effects of aspirin with ACE inhibitor or angiotensin receptor blocker on myocardial infarction and vascular functionBo Qing Zhu
Department of Medicine, Cardiology Research, VA Medical Center, University of California, San Francisco, 94143 0124, USA
J Renin Angiotensin Aldosterone Syst 4:31-7. 2003..The present study was undertaken to see if aspirin (ASA) antagonised the beneficial effects of captopril or losartan... - Regional left atrial voltage in patients with atrial fibrillationGregory M Marcus
Division of Cardiology, Electrophysiology Section, University of California, San Francisco, San Francisco, California 94143 1354, USA
Heart Rhythm 4:138-44. 2007..Regional differences in fibrosis, particularly related to the posterior wall and septum, may be important in atrial fibrillation (AF). Using electroanatomic mapping, voltage can be used as a measure of fibrosis... - Extracellular matrix-derived peptides and myocardial repairShirley S Mihardja
Cardiovascular Research Institute, University of California San Francisco, CA, USA
Cell Adh Migr 5:111-3. 2011..Our results indicate a potentially new strategy for repairing damaged tissue... - Protracted CRP elevation after atrial fibrillation ablationJames M McCabe
Division of Cardiology, Electrophysiology Section, University of California, San Francisco, California, USA
Pacing Clin Electrophysiol 31:1146-51. 2008..We hypothesized that this early recurrence is due to an inflammatory response to the ablation itself. We therefore sought to evaluate levels of CRP after AF ablation... - The effect of polypyrrole on arteriogenesis in an acute rat infarct modelShirley S Mihardja
Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
Biomaterials 29:4205-10. 2008..The results of this study highlight the potential clinical benefit of using this alginate-polypyrrole polymer blend as an injectable scaffold to repair ischemic myocardium after myocardial infarction... - Restoration of left ventricular geometry and improvement of left ventricular function in a rodent model of chronic ischemic cardiomyopathyJiashing Yu
University of California Berkeley and University of California San Francisco Joint Bioengineering Graduate Group, Berkeley San Francisco, CA, USA
J Thorac Cardiovasc Surg 137:180-7. 2009..Various approaches to myocardial reconstruction have been developed for the treatment of congestive heart failure resulting from ischemic cardiomyopathy... - Alcohol and vagal tone as triggers for paroxysmal atrial fibrillationMala C Mandyam
Division of Cardiology, Electrophysiology Section, University of California, San Francisco, San Francisco, CA, USA
Am J Cardiol 110:364-8. 2012..Alcohol and vagal triggers often were found in the same patients with PAF, raising the possibility that alcohol may precipitate AF by vagal mechanisms... - Impact of remote magnetic catheter navigation on ablation fluoroscopy and procedure timeAlbert M Kim
University of California, San Francisco, California, USA
Pacing Clin Electrophysiol 31:1399-404. 2008..Remote magnetic catheter navigation (RCN) is gaining acceptance in clinical cardiac electrophysiology, but details regarding how RCN affects procedure execution are not well characterized... - Injectable fibrin scaffold improves cell transplant survival, reduces infarct expansion, and induces neovasculature formation in ischemic myocardiumKaren L Christman
University of California Berkeley and San Francisco Joint Bioengineering Graduate Group, San Francisco, California, USA
J Am Coll Cardiol 44:654-60. 2004..Therefore, fibrin glue may have potential as a biomaterial scaffold to improve cellular cardiomyoplasty treat and MIs... - Prospective observations in the clinical and electrophysiological characteristics of intra-isthmus reentryYanfei Yang
University of California San Francisco, San Francisco, California 94143 1354, USA
J Cardiovasc Electrophysiol 21:1099-106. 2010..Intra-isthmus reentry (IIR) is a circuit within the cavotricuspid isthmus (CTI). The purpose of this study is to prospectively define the electrogram and surface ECG characteristics of IIR, and its clinical implications... - A first-degree family history in lone atrial fibrillation patientsGregory M Marcus
Division of Cardiology, Electrophysiology Section, University of California, San Francisco, California, USA
Heart Rhythm 5:826-30. 2008..A family history of AF in lone AF patients has not previously been compared with a family history of patients with AF and established risk factors (non-lone AF)... - Using extracellular matrix-derived peptides to alter the microenvironment for myocardial repairShirley S Mihardja
University of California San Francisco, Francisco, CA 94143, USA
Curr Vasc Pharmacol 10:342-6. 2012..This therapy opens up a potentially new non-invasive strategy for repairing damaged cardiac tissue... - Predictors of unusual ECG characteristics in cavotricuspid isthmus-dependent atrial flutter ablationKurt S Hoffmayer
San Francisco, California San Diego, CA 94143 1354, USA
Pacing Clin Electrophysiol 34:1251-7. 2011..Objective: Using baseline patient characteristics and echocardiography, we sought to study predictors of unusual electrocardiogram (ECG) characteristics in patients with CTI-dependent atrial flutter... - MR guidance of targeted injections into border and core of scarred myocardium in pigsMaythem Saeed
Department of Radiology, University of California San Francisco, 513 Parnassus Ave, Room HSW 207 B, San Francisco, CA 94143 0628, USA
Radiology 240:419-26. 2006.... - Pleiotrophin induces nitric oxide dependent migration of endothelial progenitor cellsChristian Heiss
Department of Medicine, Division of Cardiology, University of California, San Francisco, San Francisco, California 94143 0124, USA
J Cell Physiol 215:366-73. 2008..These data suggest that PTN may mediate its pro-angiogenic effects by increasing the local number of not only endothelial cells but also early EPCs at angiogenic sites... - Differences in accessory pathway location by sex and raceJonathan C Hsu
University of California, San Francisco, CA, USA
Heart Rhythm 7:52-6. 2010..The etiology of accessory pathway (AP) formation is generally unknown... - High-resolution optical mapping of ventricular tachycardia in rats with chronic myocardial infarctionChunhua Ding
Cardiac Electrophysiology and Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
Pacing Clin Electrophysiol 33:687-95. 2010..We report a reproducible VT model in rats with chronic MI induced by ischemia-reperfusion and describe its electrophysiological characteristics using high-resolution optical mapping... - Electrophysiologic properties of para-Hisian atrial tachycardiaSei Iwai
Department of Medicine, Division of Cardiology, Cornell University Medical Center, New York, New York, USA
Heart Rhythm 8:1245-53. 2011..Para-Hisian AT arising from the apex of the triangle of Koch has been considered to be a distinct entity, characterized by unique electrophysiological properties... - Predictors of axillary vein location for vascular access during pacemaker and defibrillator lead implantationJonathan C Hsu
Division of Cardiology, Electrophysiology Section, University of California, San Francisco, California, USA
Pacing Clin Electrophysiol 34:1585-92. 2011..We sought to describe variation in axillary vein location and identify predictors of a more cranial or caudal radiographic location to facilitate blind venous cannulation... - Markers of inflammation before and after curative ablation of atrial flutterGregory M Marcus
Division of Cardiology, Electrophysiology Section, University of California, San Francisco, San Francisco, California 94143 1354, USA
Heart Rhythm 5:215-21. 2008..Atrial arrhythmias are associated with inflammation. The cause and effect of the association are unknown... - Bone marrow-derived mesenchymal stem cells in fibrin augment angiogenesis in the chronically infarcted myocardiumNgan F Huang
University of California San Francisco, Cardiac Electrophysiology, MU East Tower, Box 1354, 500 Parnassus Avenue, San Francisco, CA 94143 1354, USA
Regen Med 4:527-38. 2009.... - Repeat transseptal catheterization after ablation for atrial fibrillationGregory M Marcus
Division of Cardiology, Electrophysiology Section, University of California, San Francisco, California 94143 1354, USA
J Cardiovasc Electrophysiol 18:55-9. 2007..The aim of this study was to determine the difficulty and/or success rates of repeat transseptal catheterization after left atrial ablation for AF... - Remote navigation guided ablation of incessant atrial tachycardia in a patient with restricted venous accessAlbert M Kim
UCSF Cardiac Electrophysiology, San Francisco, California 94143, USA
J Cardiovasc Electrophysiol 20:1061-4. 2009..This case demonstrates that remote navigation can facilitate the therapy of complex arrhythmias in challenging clinical situations... - Comparison of gene-transfer efficiency in human embryonic stem cellsFeng Cao
Department of Medicine, Division of Cardiology, Stanford University School of Medicine, Edwards Building R354, Stanford, CA 94305 5344, USA
Mol Imaging Biol 12:15-24. 2010..The double-fusion construct provides an attractive approach for generating stable hES cell lines and monitoring engraftment and proliferation in vitro and in vivo... - Targeted in vivo extracellular matrix formation promotes neovascularization in a rodent model of myocardial infarctionShirley S Mihardja
Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 5:e10384. 2010..We investigated whether extracellular matrix protein fragments could be targeted with antibodies to ischemically injured myocardium to promote angiogenesis and myocardial repair... - Atrial tachycardia arising from the coronary sinus musculature: electrophysiological characteristics and long-term outcomes of radiofrequency ablationNitish Badhwar
University of California, San Francisco, San Francisco, California 94143, USA
J Am Coll Cardiol 46:1921-30. 2005..Long-term success without complications can be accomplished by ablating within the CS in close proximity to the CS (P)... - Enhanced neovasculature formation in ischemic myocardium following delivery of pleiotrophin plasmid in a biopolymerKaren L Christman
University of California Berkeley and San Francisco Joint Bioengineering Graduate Group, San Francisco, CA 94143, USA
Biomaterials 26:1139-44. 2005..In this study, we demonstrate that delivery of PTN plasmid in fibrin glue increases neovasculature formation compared to injection of the naked plasmid in saline... - Pinhole single-photon emission computed tomography for myocardial perfusion imaging of miceMax C Wu
Department of Radiology, University of California, San Francisco, California, USA
J Am Coll Cardiol 42:576-82. 2003..83 (p < 0.001) between the measured and actual values of the defect size. CONCLUSIONS: These results demonstrate that myocardial perfusion can be characterized qualitatively and quantitatively in mice using pinhole SPECT... - Virtual reality of stem cell transplantation to repair injured myocardiumLawrence G Lum
Immunotherapy and Blood and Marrow Stem Cell Transplantation Programs, Adele R Decof Cancer Center, Department of Medicine, Brown University School of Medicine, USA
J Cell Biochem 95:869-74. 2005.... - Myocardial infarct size measurement in the mouse chronic infarction model: comparison of area- and length-based approachesJunya Takagawa
Department of Medicine, Division of Cardiology, University of California, San Francisco, 513 Parnassus Ave, Rm S1136, Box 0124, San Francisco, CA 94143 0124, USA
J Appl Physiol 102:2104-11. 2007.... - Increases in P-wave dispersion predict postoperative atrial fibrillation after coronary artery bypass graft surgeryJoby Chandy
Department of Anesthesia and Perioperative Care, University of California, San Francisco, USA
Anesth Analg 98:303-10, table of contents. 2004.... - Percutaneous left atrial appendage occlusion (PLAATO) for preventing cardioembolism: first experience in canine modelToshiko Nakai
Section of Cardiac Electrophysiology, Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco 94143, USA
Circulation 105:2217-22. 2002..This new strategy may provide an alternative treatment for patients with nonvalvular atrial fibrillation who are less than optimal candidates for warfarin... - The aging heart and post-infarction left ventricular remodelingHenry Shih
Department of Medicine, Division of Cardiology, University of California San Francisco, San Francisco, California 94143, USA
J Am Coll Cardiol 57:9-17. 2011..We review the cellular and molecular aspects of post-infarction remodeling in the aged heart, and relate them to the clinical problem of post-infarction remodeling in elderly patients... - An engineered cardiac reporter cell line identifies human embryonic stem cell-derived myocardial precursorsCarissa Ritner
Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 6:e16004. 2011..The identification of hMPs using this αMHC-GFP reporter line will provide important insight into the pathways regulating human myocardial development, and may provide a novel therapeutic reagent for the treatment of cardiac disease... - Fibrin glue alone and skeletal myoblasts in a fibrin scaffold preserve cardiac function after myocardial infarctionKaren L Christman
University of California Berkeley and San Francisco Joint Bioengineering Graduate Group, San Francisco, California, USA
Tissue Eng 10:403-9. 2004..40, 0.44, 0.43, respectively). Fibrin glue is capable of preserving infarct wall thickness and cardiac function after a myocardial infarction in rats and may be useful as a biomaterial scaffold for myocardial cell transplantation... - Protected circumferential conduction in the posterior atrioventricular vestibule of the left atrium: electrophysiologic and anatomic correlatesJie Cheng
Cardiac Electrophysiology, University of California, San Francisco, CA 94143-1354, USA
Pacing Clin Electrophysiol 28:692-701. 2005..The circumferential inferoposterior myocardial bundle may serve as the underlying anatomic substrate... - Scarred myocardium imposes additional burden on remote viable myocardium despite a reduction in the extent of area with late contrast MR enhancementMaythem Saeed
Department of Radiology, University of California, San Francisco, 94143 0628, USA
Eur Radiol 16:827-36. 2006..The integration of late enhancement and cine MRI incorporates anatomical and functional evaluation of remodeled hearts... - Pleiotrophin gene therapy for peripheral ischemia: evaluation of full-length and truncated gene variantsQizhi Fang
Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 8:e61413. 2013.... - Usefulness of a ventricular extrastimulus from the summit of the ventricular septum in diagnosis of septal accessory pathway in patients with supraventricular tachycardiaTakehiko Matsushita
Section of Cardiac Electrophysiology, University of California-San Francisco, San Francisco, California 94143, USA
Am J Cardiol 93:643-6. 2004..05). A VES during His bundle refractoriness from the RV summit increases the diagnostic yield for both the presence of an AP and its participation in the tachycardia circuit with respect to RV apical VES... - The renin-angiotensin system does not contribute to the endothelial dysfunction and increased infarct size in rats exposed to second hand smokeBo-qing Zhu
Department of Medicine, University of California, San Francisco 94143-0124, USA
J Renin Angiotensin Aldosterone Syst 3:54-60. 2002..SHS exposure impaired endothelial function and increased infarct size. The effects of losartan and SHS were consistently independent of each other. These results suggest that the RAS does not contribute to the adverse effects of SHS... - Postresuscitation stunning: postfibrillatory myocardial dysfunction caused by reduced myofilament Ca2+ responsiveness after ventricular fibrillation-induced myocyte Ca2+ overloadChristian E Zaugg
Department of Research, University Hospital Basel, Switzerland
J Cardiovasc Electrophysiol 13:1017-24. 2002..We tested whether this dysfunction can be caused by reduced myofilament Ca2+ responsiveness after VF-induced myocyte Ca2+ overload. We also tested whether electrical defibrillation shocks contribute to this dysfunction... - Surface electrocardiographic characteristics of right and left atrial flutterAndres Bochoeyer
Cardiovascular Research Institute and Section of Cardiac Electrophysiology, University of California, San Francisco 94143-1354, USA
Circulation 108:60-6. 2003..In contrast, a typical CW-CTI surface pattern was always seen in patients with upper-loop reentry, which was non-CTI dependent. LA AFL circuits had either flat or low-amplitude forces in the inferior leads... - Targeting of Lin-Sca+ hematopoietic stem cells with bispecific antibodies to injured myocardiumLawrence G Lum
Immunotherapy Program, Adele R Decof Cancer Center, Providence, RI 02908, USA
Blood Cells Mol Dis 32:82-7. 2004..These results suggest that stem cells retargeted with BiAb can be directly injected and retained by injured myocardium or targeted to injured myocardial tissues for tissue regeneration... - Targeting human CD34+ hematopoietic stem cells with anti-CD45 x anti-myosin light-chain bispecific antibody preserves cardiac function in myocardial infarctionTing C Zhao
Dept of Pediatrics, Women and Infants Hospital, Providence, RI 02905, USA
J Appl Physiol 104:1793-800. 2008..These results suggest that peripheral administration of armed CD34(+) HSC results in localization of CD34(+) HSC to injured myocardium and restores myocardial function... - Histologic assessment of right atrial appendage myocardium in patients with atrial fibrillation after coronary artery bypass graft surgeryToshiko Nakai
Division of Cardiovascular Medicine, Nihon University School of Medicine, Tokyo, Japan
Cardiology 108:90-6. 2007..85). These results suggest that the age-related atrial fibrosis rather than cellular hypertrophy may be important in the pathogenesis of AF after CABG surgery and should be further investigated... - The new face of bispecific antibodies: targeting cancer and much moreLawrence G Lum
Immunotherapy Program, Adele R Decof Cancer Center, Roger Williams Medical Center, Providence, RI 02908, USA
Exp Hematol 34:1-6. 2006.... - Chemical and physical regulation of stem cells and progenitor cells: potential for cardiovascular tissue engineeringNgan F Huang
Joint Graduate Group in Bioengineering, University of California San Francisco and University of California Berkeley, Berkeley, California, USA
Tissue Eng 13:1809-23. 2007.... - A rodent model of myocardial infarction for testing the efficacy of cells and polymers for myocardial reconstructionNgan F Huang
University of California San Francisco and University of California Berkeley Joint Bioengineering Graduate Group, Berkeley, California, 94720-1762 USA
Nat Protoc 1:1596-609. 2006..The model can be created in 7 days or less, depending on the timing of therapeutic intervention... - Pleiotrophin induces formation of functional neovasculature in vivoKaren L Christman
University of California Berkeley and San Francisco Joint Bioengineering Graduate Group, USA
Biochem Biophys Res Commun 332:1146-52. 2005..The data suggest that PTN signals the more "complete" new blood vessel formation through its ability to stimulate different functions in different cell types not limited to the endothelial cell... - Biomaterials for the treatment of myocardial infarctionKaren L Christman
University of California-Berkeley, Berkeley, California, USA
J Am Coll Cardiol 48:907-13. 2006..This review gives an overview of the current progress in the growing field of biomaterials for the treatment of MI... - Tissue engineering and stem cell therapy for myocardial repairYiping Gu
University of California Berkeley and San Francisco Joint Bioengineering Graduate Group, USA
Front Biosci 12:5157-65. 2007..Here, we review the current progress in cardiac tissue repair and engineering; and discuss the new emerging technologies... - Injectable biopolymers enhance angiogenesis after myocardial infarctionNgan F Huang
UCSF/UCB Joint Bioengineering Graduate Group, University of California Berkeley, Berkeley, California, USA
Tissue Eng 11:1860-6. 2005..The results of this study highlight the potential clinical benefit of these biopolymers as injectable scaffolds or cell delivery vehicles to the infarct zone after infarction...
Research Grants
- The influence of ischemic microenvironment and stem cell differentiationRandall Lee; Fiscal Year: 2007..Specific aim 2: To test the hypothesis that the microenvironment influences SC differentiation, angiogenesis and LV remodeling. ..