Pui Y Lee

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. pmc TLR7-dependent and FcgammaR-independent production of type I interferon in experimental mouse lupus
    Pui Y Lee
    Division of Rheumatology and Clinical Immunology and Center for Autoimmune Disease, University of Florida, Gainesville, FL 32610, USA
    J Exp Med 205:2995-3006. 2008
  2. pmc Type I interferon modulates monocyte recruitment and maturation in chronic inflammation
    Pui Y Lee
    Center for Autoimmune Disease, University of Florida, Gainesville, 32610 0221, USA
    Am J Pathol 175:2023-33. 2009
  3. pmc B cell proliferation, somatic hypermutation, class switch recombination, and autoantibody production in ectopic lymphoid tissue in murine lupus
    Dina C Nacionales
    Center for Autoimmune Disease, University of Florida, Gainesville, 32610, USA
    J Immunol 182:4226-36. 2009
  4. pmc Pleiotropic IFN-dependent and -independent effects of IRF5 on the pathogenesis of experimental lupus
    Yuan Xu
    Division of Rheumatology and Clinical Immunology, University of Florida, Gainesville, FL 32610 0221, USA
    J Immunol 188:4113-21. 2012
  5. pmc Monocyte surface expression of Fcgamma receptor RI (CD64), a biomarker reflecting type-I interferon levels in systemic lupus erythematosus
    Yi Li
    Division of Rheumatology and Clinical Immunology, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610 0221, USA
    Arthritis Res Ther 12:R90. 2010
  6. pmc Type I interferon production by tertiary lymphoid tissue developing in response to 2,6,10,14-tetramethyl-pentadecane (pristane)
    Dina C Nacionales
    Division of Rheumatology and Clinical Immunology, University of Florida, PO Box 100221, Gainesville, FL 32610 0221, USA
    Am J Pathol 168:1227-40. 2006
  7. pmc A novel type I IFN-producing cell subset in murine lupus
    Pui Y Lee
    Division of Rheumatology and Clinical Immunology and Center for Autoimmune Disease, University of Florida, Gainesville, FL 32610 0221, USA
    J Immunol 180:5101-8. 2008
  8. pmc Pathogenic role of B cells in the development of diffuse alveolar hemorrhage induced by pristane
    Tolga T Barker
    Division of Rheumatology and Clinical Immunology and Center for Autoimmune Disease, Department of Medicine, University of Florida, Gainesville, FL 32610 0221, USA
    Lab Invest 91:1540-50. 2011
  9. pmc Maintenance of anti-Sm/RNP autoantibody production by plasma cells residing in ectopic lymphoid tissue and bone marrow memory B cells
    Jason S Weinstein
    Division of Rheumatology and Clinical Immunology, University of Florida, Gainesville, FL 32610 0221, USA
    J Immunol 190:3916-27. 2013
  10. pmc IL-1α modulates neutrophil recruitment in chronic inflammation induced by hydrocarbon oil
    Pui Y Lee
    Division of Rheumatology and Clinical Immunology, University of Florida, Gainesville, FL 32610, USA
    J Immunol 186:1747-54. 2011

Collaborators

Detail Information

Publications20

  1. pmc TLR7-dependent and FcgammaR-independent production of type I interferon in experimental mouse lupus
    Pui Y Lee
    Division of Rheumatology and Clinical Immunology and Center for Autoimmune Disease, University of Florida, Gainesville, FL 32610, USA
    J Exp Med 205:2995-3006. 2008
    ..Collectively, the data demonstrate that TMPD-stimulated IFN-I production requires TLR7/MyD88 signaling and is independent of autoantibody-mediated uptake of ribonucleoproteins by FcgammaRs...
  2. pmc Type I interferon modulates monocyte recruitment and maturation in chronic inflammation
    Pui Y Lee
    Center for Autoimmune Disease, University of Florida, Gainesville, 32610 0221, USA
    Am J Pathol 175:2023-33. 2009
    ..Continuous monocyte recruitment and the lack of terminal differentiation induced by IFN-I may help sustain the chronic inflammatory response...
  3. pmc B cell proliferation, somatic hypermutation, class switch recombination, and autoantibody production in ectopic lymphoid tissue in murine lupus
    Dina C Nacionales
    Center for Autoimmune Disease, University of Florida, Gainesville, 32610, USA
    J Immunol 182:4226-36. 2009
    ....
  4. pmc Pleiotropic IFN-dependent and -independent effects of IRF5 on the pathogenesis of experimental lupus
    Yuan Xu
    Division of Rheumatology and Clinical Immunology, University of Florida, Gainesville, FL 32610 0221, USA
    J Immunol 188:4113-21. 2012
    ..Additionally, we uncovered a new, IFN-I-independent role of IRF5 in regulating chemokines involved in the homing of pDCs and certain lymphocyte subsets...
  5. pmc Monocyte surface expression of Fcgamma receptor RI (CD64), a biomarker reflecting type-I interferon levels in systemic lupus erythematosus
    Yi Li
    Division of Rheumatology and Clinical Immunology, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610 0221, USA
    Arthritis Res Ther 12:R90. 2010
    ..The aim of this study was to identify a surrogate marker for IFN-I activity in clinical samples for monitoring disease activity and response to therapy...
  6. pmc Type I interferon production by tertiary lymphoid tissue developing in response to 2,6,10,14-tetramethyl-pentadecane (pristane)
    Dina C Nacionales
    Division of Rheumatology and Clinical Immunology, University of Florida, PO Box 100221, Gainesville, FL 32610 0221, USA
    Am J Pathol 168:1227-40. 2006
    ..In view of the increased IFN-I production in systemic lupus erythematosus, these studies suggest that IFN-I from ectopic lymphoid tissue could play a role in the pathogenesis of experimental lupus in mice...
  7. pmc A novel type I IFN-producing cell subset in murine lupus
    Pui Y Lee
    Division of Rheumatology and Clinical Immunology and Center for Autoimmune Disease, University of Florida, Gainesville, FL 32610 0221, USA
    J Immunol 180:5101-8. 2008
    ..Therefore, immature monocytes rather than DCs appear to be the primary source of IFN-I in this model of IFN-I-dependent lupus...
  8. pmc Pathogenic role of B cells in the development of diffuse alveolar hemorrhage induced by pristane
    Tolga T Barker
    Division of Rheumatology and Clinical Immunology and Center for Autoimmune Disease, Department of Medicine, University of Florida, Gainesville, FL 32610 0221, USA
    Lab Invest 91:1540-50. 2011
    ..028). Pristane-induced alveolar hemorrhage is a useful model to study the pathogenesis and develop new therapy for this underappreciated and often life-threatening complication of SLE...
  9. pmc Maintenance of anti-Sm/RNP autoantibody production by plasma cells residing in ectopic lymphoid tissue and bone marrow memory B cells
    Jason S Weinstein
    Division of Rheumatology and Clinical Immunology, University of Florida, Gainesville, FL 32610 0221, USA
    J Immunol 190:3916-27. 2013
    ..However, peritoneal inflammation appears necessary to generate autoreactive B cells de novo...
  10. pmc IL-1α modulates neutrophil recruitment in chronic inflammation induced by hydrocarbon oil
    Pui Y Lee
    Division of Rheumatology and Clinical Immunology, University of Florida, Gainesville, FL 32610, USA
    J Immunol 186:1747-54. 2011
    ..Taken together, our findings uncover an IL-1α-dependent mechanism of neutrophil recruitment in hydrocarbon-induced peritonitis and illustrate the interactions of innate immune pathways in chronic inflammation...
  11. pmc Increased expression of FcgammaRI/CD64 on circulating monocytes parallels ongoing inflammation and nephritis in lupus
    Yi Li
    Division of Rheumatology and Clinical Immunology, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610 0221, USA
    Arthritis Res Ther 11:R6. 2009
    ..The goal of this study was to determine whether expression of Fc receptor (FcgammaR) I on circulating monocytes is associated with systemic inflammation and renal disease in SLE patients...
  12. pmc Deficiency of the type I interferon receptor protects mice from experimental lupus
    Dina C Nacionales
    University of Florida College of Medicine, Gainesville, Florida, USA
    Arthritis Rheum 56:3770-83. 2007
    ..The objective of this study was to examine the role of IFN-I signaling in the pathogenesis of murine lupus induced by 2,6,10,14-tetramethylpentadecane (TMPD)...
  13. pmc Endogenous type-I interferon activity is not associated with depression or fatigue in systemic lupus erythematosus
    Erinn S Kellner
    Division of Rheumatology and Clinical Immunology, University of Florida, Gainesville, FL 32610 0221, USA
    J Neuroimmunol 223:13-9. 2010
    ..Elevation of endogenous serum IFN-I levels is unlikely to account for the depression and fatigue associated with SLE...
  14. ncbi request reprint Type I interferon as a novel risk factor for endothelial progenitor cell depletion and endothelial dysfunction in systemic lupus erythematosus
    Pui Y Lee
    University of Florida College of Medicine, Gainesville, Florida, USA
    Arthritis Rheum 56:3759-69. 2007
    ....
  15. pmc B cells enhance early innate immune responses during bacterial sepsis
    Kindra M Kelly-Scumpia
    Department of Surgery, University of Florida College of Medicine, Gainesville, FL 32610, USA
    J Exp Med 208:1673-82. 2011
    ..This study identifies a novel role for IFN-I-activated B cells in protective early innate immune responses during bacterial sepsis...
  16. pmc Induction of autoimmunity by pristane and other naturally occurring hydrocarbons
    Westley H Reeves
    Division of Rheumatology and Clinical Immunology, and Laboratory Medicine, University of Florida, PO Box 100221, Gainesville, FL 32610 0221, United States
    Trends Immunol 30:455-64. 2009
    ..This model is well suited for examining links between dysregulated IFN-I production and the pathogenesis of human SLE, which like TMPD-lupus, is associated with high levels of IFN-I...
  17. pmc Colocalization of antigen-specific B and T cells within ectopic lymphoid tissue following immunization with exogenous antigen
    Jason S Weinstein
    Division of Rheumatology and Clinical Immunology and Center for Autoimmune Disease, University of Florida, Gainesville, FL 32610, USA
    J Immunol 181:3259-67. 2008
    ..This has implications for understanding the strong association of humoral autoimmunity with lymphoid neogenesis, which may be associated with deficient censoring of autoreactive cells...
  18. pmc Monocyte and macrophage abnormalities in systemic lupus erythematosus
    Yi Li
    Division of Rheumatology and Clinical Immunology and Center for Autoimmune Disease, University of Florida, PO Box 100221, Gainesville, FL 32610 0221, USA
    Arch Immunol Ther Exp (Warsz) 58:355-64. 2010
    ..In this review we summarize the current knowledge of monocyte/macrophage abnormalities in human SLE and discuss their implications for understanding the pathogenesis of lupus...
  19. ncbi request reprint Association of anti-nucleoprotein autoantibodies with upregulation of Type I interferon-inducible gene transcripts and dendritic cell maturation in systemic lupus erythematosus
    Haoyang Zhuang
    Division of Rheumatology and Clinical Immunology, University of Florida, Gainesville, FL 32610, USA
    Clin Immunol 117:238-50. 2005
    ....
  20. ncbi request reprint Short-term atorvastatin treatment enhances specific antibody production following tetanus toxoid vaccination in healthy volunteers
    Pui Y Lee
    General Clinical Research Center, University of Florida, Gainesville, FL 32610, USA
    Vaccine 24:4035-40. 2006
    ..This study illustrates a novel immunomodulatory effect of atorvastatin raising the possibility of using HMG-CoA reductase inhibitors to enhance humoral responses to vaccination...