Luke P Lee

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint An integrated optofluidic platform for Raman-activated cell sorting
    Adrian Y Lau
    Applied Physics and Biophysics Division, Lawrence Livermore National Laboratory, P O Box 808, L 211, Livermore, CA 94550, USA
    Lab Chip 8:1116-20. 2008
  2. ncbi request reprint Hemolysis-free blood plasma separation
    Jun Ho Son
    Department of Bioengineering, Department of Electrical Engineering and Computer Sciences, Biophysics Program, Berkeley Sensor and Actuator Center, University of California, Berkeley, CA 94720, USA
    Lab Chip 14:2287-92. 2014
  3. pmc A real-time PCR antibiogram for drug-resistant sepsis
    John R Waldeisen
    Department of Bioengineering, University of California, Berkeley, California, United States of America
    PLoS ONE 6:e28528. 2011
  4. pmc A handheld point-of-care genomic diagnostic system
    Frank B Myers
    Department of Bioengineering, University of California, Berkeley, California, USA
    PLoS ONE 8:e70266. 2013
  5. ncbi request reprint Robust pluripotent stem cell expansion and cardiomyocyte differentiation via geometric patterning
    Frank B Myers
    Department of Bioengineering, University of California, Berkeley, CA 94720, USA
    Integr Biol (Camb) 5:1495-506. 2013
  6. ncbi request reprint Inspirations from biological optics for advanced photonic systems
    Luke P Lee
    Berkeley Sensor and Actuator Center, Department of Bioengineering, University of California, Berkeley, CA 94720 1762, USA
    Science 310:1148-50. 2005
  7. doi request reprint Satellite nanoscope and cellular BioASICs for quantitative biomedicine
    Luke P Lee
    Department of Bioengineering, University of California, Berkeley, CA 94720, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:4582-5. 2009
  8. ncbi request reprint Single-cell electroporation arrays with real-time monitoring and feedback control
    Michelle Khine
    School of Engineering, University of California, Merced, CA, USA
    Lab Chip 7:457-62. 2007
  9. ncbi request reprint Open-access microfluidic patch-clamp array with raised lateral cell trapping sites
    Adrian Y Lau
    Biomolecular Nanotechnology Center, Berkeley Sensor and Actuator Center, Department of Bioengineering, University of California Berkeley, Berkeley, CA 94720, USA
    Lab Chip 6:1510-5. 2006
  10. ncbi request reprint Time-resolved optical sensing of oligonucleotide hybridization via Au colloidal nanoparticles
    Gang L Liu
    Biomolecular Nanotechnology Center, Berkeley Sensor and Actuator Center, Department of Bioengineering, University of California at Berkeley, Berkeley, CA 94720, USA
    J Nanosci Nanotechnol 5:1933-7. 2005

Collaborators

Detail Information

Publications76

  1. doi request reprint An integrated optofluidic platform for Raman-activated cell sorting
    Adrian Y Lau
    Applied Physics and Biophysics Division, Lawrence Livermore National Laboratory, P O Box 808, L 211, Livermore, CA 94550, USA
    Lab Chip 8:1116-20. 2008
    ..This functional prototype lays the foundation for the development of a label-free cell sorting platform based on intrinsic Raman markers for automated sampling and sorting of a large number of individual cells in solution...
  2. ncbi request reprint Hemolysis-free blood plasma separation
    Jun Ho Son
    Department of Bioengineering, Department of Electrical Engineering and Computer Sciences, Biophysics Program, Berkeley Sensor and Actuator Center, University of California, Berkeley, CA 94720, USA
    Lab Chip 14:2287-92. 2014
    ..This simple and robust on-chip blood plasma separation device integrates with downstream detection modules to ultimately create sample-to-answer microfluidic POC diagnostics devices. ..
  3. pmc A real-time PCR antibiogram for drug-resistant sepsis
    John R Waldeisen
    Department of Bioengineering, University of California, Berkeley, California, United States of America
    PLoS ONE 6:e28528. 2011
    ..The real-time PCR antibiogram achieves detection, susceptibility testing, minimum inhibitory concentration determination, and identification in less than 24 hours...
  4. pmc A handheld point-of-care genomic diagnostic system
    Frank B Myers
    Department of Bioengineering, University of California, Berkeley, California, USA
    PLoS ONE 8:e70266. 2013
    ....
  5. ncbi request reprint Robust pluripotent stem cell expansion and cardiomyocyte differentiation via geometric patterning
    Frank B Myers
    Department of Bioengineering, University of California, Berkeley, CA 94720, USA
    Integr Biol (Camb) 5:1495-506. 2013
    ..Furthermore, the ability to control where cardiomyocytes arise across a culture well during differentiation could greatly aid the design of electrophysiological assays for drug-screening. ..
  6. ncbi request reprint Inspirations from biological optics for advanced photonic systems
    Luke P Lee
    Berkeley Sensor and Actuator Center, Department of Bioengineering, University of California, Berkeley, CA 94720 1762, USA
    Science 310:1148-50. 2005
    ..This is in part due to the availability of polymers with customizable optical properties and the ability to rapidly fabricate complex designs using soft lithography and three-dimensional microscale processing techniques...
  7. doi request reprint Satellite nanoscope and cellular BioASICs for quantitative biomedicine
    Luke P Lee
    Department of Bioengineering, University of California, Berkeley, CA 94720, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:4582-5. 2009
    ....
  8. ncbi request reprint Single-cell electroporation arrays with real-time monitoring and feedback control
    Michelle Khine
    School of Engineering, University of California, Merced, CA, USA
    Lab Chip 7:457-62. 2007
    ....
  9. ncbi request reprint Open-access microfluidic patch-clamp array with raised lateral cell trapping sites
    Adrian Y Lau
    Biomolecular Nanotechnology Center, Berkeley Sensor and Actuator Center, Department of Bioengineering, University of California Berkeley, Berkeley, CA 94720, USA
    Lab Chip 6:1510-5. 2006
    ..The results demonstrate that the system is capable of performing whole cell measurements and drug profiling in a more efficient manner than the traditional patch-clamp set-up...
  10. ncbi request reprint Time-resolved optical sensing of oligonucleotide hybridization via Au colloidal nanoparticles
    Gang L Liu
    Biomolecular Nanotechnology Center, Berkeley Sensor and Actuator Center, Department of Bioengineering, University of California at Berkeley, Berkeley, CA 94720, USA
    J Nanosci Nanotechnol 5:1933-7. 2005
    ..The approach presented in this paper extends the application of Au nanoparticles as the optical probe in oligonucleotide recognitions without prior sample labeling...
  11. ncbi request reprint Biologically inspired artificial compound eyes
    Ki Hun Jeong
    Biomolecular Nanotechnology Center, Berkeley Sensor and Actuator Center, Department of Bioengineering, 485 Evans Hall No 1762, University of California, Berkeley, CA 94720, USA
    Science 312:557-61. 2006
    ..The angular acceptance is directly measured by three-dimensional optical sectioning with a confocal microscope, and the detailed optical characteristics are studied in comparison with a natural compound eye...
  12. ncbi request reprint An artificial liver sinusoid with a microfluidic endothelial-like barrier for primary hepatocyte culture
    Philip J Lee
    Department of Bioengineering, Biomolecular Nanotechnology Center, Berkeley Sensor and Actuator Center, University of California Berkeley, Berkeley, CA 94720 1762, USA
    Biotechnol Bioeng 97:1340-6. 2007
    ..Experiments with the metabolism mediated liver toxicant diclofenac showed no hepatotoxicity after 4 h and an IC(50) of 334 +/- 41 microM after 24 h...
  13. ncbi request reprint A novel high aspect ratio microfluidic design to provide a stable and uniform microenvironment for cell growth in a high throughput mammalian cell culture array
    Paul J Hung
    Berkeley Sensor and Actuator Center, Department of Bioengineering, University of California, Berkeley, California, USA
    Lab Chip 5:44-8. 2005
    ....
  14. ncbi request reprint Creating high density nanoantenna arrays via plasmon enhanced particle-cavity (PEP-C) architectures
    Benjamin M Ross
    Biomolecular Nanotechnology Center, Department of Bioengineering, University of California Berkeley, Berkeley, CA 94720, USA
    Opt Express 17:6860-6. 2009
    ..These properties make the PEP-C antenna an excellent candidate for plasmonic-based biomolecular sensors...
  15. ncbi request reprint Comparison of near- and far-field measures for plasmon resonance of metallic nanoparticles
    Benjamin M Ross
    Department of Bioengineering, Applied Science and Technology Graduate Group, Biomolecular Nanotechnology Center, University of Calfornia Berkeley, Berkeley, CA 94720, USA
    Opt Lett 34:896-8. 2009
    ..We expect that taking into account these differences can provide improvement in understanding and optimizing surface-enhanced spectroscopies...
  16. doi request reprint Hydrodynamic resettability for a microfluidic particulate-based arraying system
    Ryan D Sochol
    Department of Mechanical Engineering, University of California, Berkeley, USA
    Lab Chip 12:5051-6. 2012
    ..g., for subsequent analyses and/or use in additional experiments), and (ii) microarray reusability...
  17. ncbi request reprint Microfluidic alignment of collagen fibers for in vitro cell culture
    Philip Lee
    Biomolecular Nanotechnology Center, Berkeley Sensor and Actuator Center, Department of Bioengineering, University of California, Berkeley, CA, USA
    Biomed Microdevices 8:35-41. 2006
    ..The use of artificially aligned collagen gels could be applied to the study of cell movement, signaling, growth, and differentiation...
  18. ncbi request reprint Nanoliter scale microbioreactor array for quantitative cell biology
    Philip J Lee
    Department of Bioengineering, Biomolecular Nanotechnology Center, Berkeley Sensor and Actuator Center, University of California, Berkeley, 485 Evans Hall, 94720 1762, USA
    Biotechnol Bioeng 94:5-14. 2006
    ....
  19. pmc Label-free electrophysiological cytometry for stem cell-derived cardiomyocyte clusters
    Frank B Myers
    Department of Bioengineering, University of California, Berkeley, CA 94720, USA
    Lab Chip 13:220-8. 2013
    ..This is an entirely new approach to cell cytometry, in which a cell's functionality is assessed rather than its expression profile or physical characteristics...
  20. doi request reprint Single-cell level co-culture platform for intercellular communication
    Soongweon Hong
    Berkeley Sensor and Actuator Center, Department of Bioengineering, University of California at Berkeley, Berkeley, California 94720, USA
    Integr Biol (Camb) 4:374-80. 2012
    ..This study demonstrates the platform utility in providing a detailed and quantitative understanding of the complexity of cellular communication and its effects on cell behaviour in a variety of biological systems...
  21. pmc Disassembly of a core-satellite nanoassembled substrate for colorimetric biomolecular detection
    John R Waldeisen
    UC Berkeley UCSF Graduate Program in Bioengineering and Department of Bioengineering, Biomolecular Nanotechnology Center, Berkeley Sensor and Actuator Center, University of California, Berkeley, California 94720, USA
    ACS Nano 5:5383-9. 2011
    ..This colorimetric substrate may prove to be a favorable alternative to liquid-based colloidal sensors and a useful visual readout mechanism for point-of-care microfluidic diagnostic assays...
  22. pmc Photonic gene circuits by optically addressable siRNA-Au nanoantennas
    Somin Eunice Lee
    UCSF UCB Joint Graduate Group in Bioengineering, Berkeley Sensor and Actuator Center, Department of Bioengineering, University of California Berkeley, Berkeley, California, United States
    ACS Nano 6:7770-80. 2012
    ..Photonic gene circuits open new avenues for engineering functional gene circuits useful for fundamental bioscience, bioengineering, and medical applications...
  23. doi request reprint Self-assembled three-dimensional nanocrown array
    Soongweon Hong
    Biomolecular Nanotechnology Center, Berkeley Sensor and Actuator Center, Department of Bioengineering, University of California at Berkeley, Berkeley, California 94720, United States
    ACS Nano 6:5803-8. 2012
    ..Because of its tunable size (i.e., 50 nm core and 20 nm satellite GNPs), arrangement, and periodicity, the nanocrown array shows multiple optical resonance frequencies at visible wavelengths as well as angle-dependent optical properties...
  24. doi request reprint Omnidirectional 3D nanoplasmonic optical antenna array via soft-matter transformation
    Benjamin M Ross
    Applied Science and Technology Graduate Group, Biomolecular Nanotechnology Center, University of California Berkeley, Berkeley, California 94720, United States
    Nano Lett 11:2590-5. 2011
    ..In addition, the macroscale morphology can be independently manipulated into arbitrary three-dimensional geometries, demonstrated with the fabrication of an omnidirectional nanoplasmonic optical antenna array...
  25. ncbi request reprint Microfluidic self-assembly of tumor spheroids for anticancer drug discovery
    Liz Y Wu
    Biomolecular Nanotechnology Center, Berkeley Sensor and Actuator Center, Department of Bioengineering, University of California, Berkeley, CA 94720, USA
    Biomed Microdevices 10:197-202. 2008
    ..A large amount of tumor spheroids (7,500 spheroids per square centimeter) with a narrow size distribution (10 +/- 1 cells per spheroid) can be formed in the device to provide a good platform for anticancer drug assays...
  26. doi request reprint Shrinky-Dink microfluidics: 3D polystyrene chips
    Chi Shuo Chen
    School of Engineering, University of California, Merced, USA
    Lab Chip 8:622-4. 2008
    ..Design conception to fully functional chips can thus be completed within minutes...
  27. doi request reprint Biologically functional cationic phospholipid-gold nanoplasmonic carriers of RNA
    Somin Eunice Lee
    Biomolecular Nanotechnology Center, Department of Bioengineering, University of California Berkeley, UCSF UCB Joint Graduate Group in Bioengineering, Berkeley, California 94720 1762, USA
    J Am Chem Soc 131:14066-74. 2009
    ....
  28. doi request reprint Additional amplifications of SERS via an optofluidic CD-based platform
    Dukhyun Choi
    Biomolecular Nanotechnology Center, Berkeley Sensor and Actuator Center, Department of Bioengineering, University of California at Berkeley, Berkeley, California 94720, USA
    Lab Chip 9:239-43. 2009
    ..The uniform SERS signals from different positions in spots of 3 mm2 on the different CDs gives us confidence in the reliability and stability of our SERS substrates...
  29. ncbi request reprint Peptide-nanoparticle hybrid SERS probe for dynamic detection of active cancer biomarker enzymes
    Gang L Liu
    Department of Bioengineering, University of California at Berkeley, CA 94720, USA
    Conf Proc IEEE Eng Med Biol Soc 1:795-8. 2006
    ..Peptide-conjugated nanocrescents should also be applicable for measuring the intercellular and intracellular activity of other cancer-related proteases and protease activity profiling-enabled cancer cell identification...
  30. ncbi request reprint Dynamic single cell culture array
    Dino Di Carlo
    Berkeley Sensor and Actuator Center, Biomolecular Nanotechnology Center, Department of Bioengineering, University of California, Berkeley, CA 94720, USA
    Lab Chip 6:1445-9. 2006
    ..We anticipate uses in single cell analysis of drug toxicity with physiologically relevant perfused dosages as well as investigation of cell signaling pathways and systems biology...
  31. ncbi request reprint Peptide-nanoparticle hybrid SERS probes for optical detection of protease activity
    Gang L Liu
    Department of Bioengineering, Biomolecular Nanotechnology Center, Berkeley Sensor and Actuator Center, University of California, Berkeley, CA 94720, USA
    J Nanosci Nanotechnol 7:2323-30. 2007
    ....
  32. ncbi request reprint Optofluidic control using photothermal nanoparticles
    Gang L Liu
    Biomolecular Nanotechnology Center, Department of Bioengineering, University of California at Berkeley, Berkeley, California 94720, USA
    Nat Mater 5:27-32. 2006
    ..Instead, our optofluidic control method will allow the fabrication of all-optical large-scale integrated microfluidic circuits for biomolecular and cellular processing without any physical valve or mechanical pumping device...
  33. ncbi request reprint Nanophotonic crescent moon structures with sharp edge for ultrasensitive biomolecular detection by local electromagnetic field enhancement effect
    Yu Lu
    Berkeley Sensor and Actuator Center, Department of Bioengineering, University of California Berkeley, Berkeley, California 94720, USA
    Nano Lett 5:119-24. 2005
    ....
  34. ncbi request reprint On-chip cell lysis by local hydroxide generation
    Dino Di Carlo
    Department of Bioengineering, University of California at Berkeley, Berkeley, CA, USA
    Lab Chip 5:171-8. 2005
    ..The flow rate dependence of hydroxide concentration at the lysis filter is modeled and lysis efficiency is experimentally determined to be proportional to the hydroxide concentration for flow rates from 15 to 30 microl min(-1)...
  35. ncbi request reprint Microfluidic environment for high density hepatocyte culture
    Mimi Y Zhang
    UCSF UC Berkeley Joint Graduate Group in Bioengineering, Berkeley, CA, USA
    Biomed Microdevices 10:117-21. 2008
    ..Human hepatoma cells (HepG2/C3A) remained viable and functional as demonstrated by fluorescent viability assays and secretion of albumin for the one-week culture period...
  36. doi request reprint Non-invasive microfluidic gap junction assay
    Sisi Chen
    Biomolecular Nanotechnology Center, Berkeley Sensor and Actuator Center, Department of Bioengineering, University of California Berkeley, 408C Stanley Hall, CA 94720 1762, USA
    Integr Biol (Camb) 2:130-8. 2010
    ..This integrated microfluidic platform enables the in situ monitoring of gap junction communication, yielding dynamic information about intercellular molecular transfer and pharmacological inhibition and recovery...
  37. pmc Plasmon resonance energy transfer (PRET)-based molecular imaging of cytochrome c in living cells
    Yeonho Choi
    Biomolecular Nanotechnology Center, Berkeley Sensor and Actuator Center, Department of Bioengineering, University of California at Berkeley, Berkeley, California 94720, USA
    Nano Lett 9:85-90. 2009
    ..As a first demonstration of in vivo PRET imaging, we performed a visualization of the dynamics of intracellular cytochrome c in HepG2 cells under ethanol-induced apoptosis...
  38. ncbi request reprint Shrinky-Dink microfluidics: rapid generation of deep and rounded patterns
    Anthony Grimes
    School of Engineering, University of California, Merced, USA
    Lab Chip 8:170-2. 2008
    ..Finally, we demonstrate the utility of this simple microfabrication approach by fabricating a functional gradient generator. The whole process--from device design conception to working device--can be completed within minutes...
  39. ncbi request reprint Artificial ommatidia by self-aligned microlenses and waveguides
    Jaeyoun Kim
    Berkeley Sensor and Actuator Center, Department of Bioengineering, University of California, Berkeley, Berkeley, California 94720, USA
    Opt Lett 30:5-7. 2005
    ..75 degrees acceptance angle that is comparable to those found in nature. Using geometric and physical optics, we also investigate the relationship between angular sensitivity and the geometry of artificial ommatidia...
  40. ncbi request reprint Alkaline hemolysis fragility is dependent on cell shape: results from a morphology tracker
    Cristian Ionescu-Zanetti
    Bioengineering Department, University of California at Berkeley, Berkeley, California 94720, USA
    Cytometry A 65:116-23. 2005
    ..However, no quantitative data are available for changes in the morphology of individual cells during membrane poration-driven hemolysis or for the relation between cell shape and fragility...
  41. pmc Mammalian electrophysiology on a microfluidic platform
    Cristian Ionescu-Zanetti
    Department of Bioengineering, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 102:9112-7. 2005
    ..1 in mammalian cells compare well with traditional pipette recordings. The results make possible the integration of whole-cell electrophysiology with easily manufactured microfluidic lab-on-a-chip devices...
  42. ncbi request reprint Continuous perfusion microfluidic cell culture array for high-throughput cell-based assays
    Paul J Hung
    Berkeley Sensor and Actuator Center, Department of Bioengineering, University of California, 485 Evans Hall, Berkeley, CA 94720, USA
    Biotechnol Bioeng 89:1-8. 2005
    ..The cell culture array could offer a platform for a wide range of assays with applications in drug screening, bioinformatics, and quantitative cell biology...
  43. doi request reprint A point-of-care instrument for rapid multiplexed pathogen genotyping
    Frank B Myers
    Department of Bioengineering, University of California, Berkeley, CA, USA
    Conf Proc IEEE Eng Med Biol Soc 2011:3668-71. 2011
    ..The platform can be tailored for different economic situations--from a quantitative electronic readout to a simple binary readout with the naked eye...
  44. doi request reprint Engineered approaches to the stem cell microenvironment for cardiac tissue regeneration
    Ebrahim Ghafar-Zadeh
    Department of Bioengineering, University of California, Berkeley, USA
    Lab Chip 11:3031-48. 2011
    ....
  45. doi request reprint Stimulation and artifact-free extracellular electrophysiological recording of cells in suspension
    Frank B Myers
    Department of Bioengineering, University of California, Berkeley, CA, USA
    Conf Proc IEEE Eng Med Biol Soc 2011:4030-3. 2011
    ..Finally, we explain the relationship between extracellular field potentials and the more familiar transmembrane action potential signal, noting the physiologically important features of these signals...
  46. pmc Single-step nanoplasmonic VEGF165 aptasensor for early cancer diagnosis
    Hansang Cho
    Berkeley Sensor and Actuator Center, Department of Bioengineering, Department of Electrical Engineering and Computer Science, University of California, Berkeley, California 94720, United States
    ACS Nano 6:7607-14. 2012
    ..We envision that our developed aptasensor holds utilities for point-of-care cancer prognostics by incorporating simplicity in detection, low-cost for test, and required small sample volumes...
  47. ncbi request reprint Integrated microfluidic cell culture and lysis on a chip
    J Tanner Nevill
    Biomolecular Nanotechnology Center, Berkeley Sensor and Actuator Center, Department of Bioengineering, University of California, UCSF UCB Joint Graduate Group in Bioengineering, Berkeley, CA, USA
    Lab Chip 7:1689-95. 2007
    ..Sample proteins exposed to the electrochemical lysis conditions were immunodetectable (p53) and their enzymatic activity (HRP) was investigated...
  48. doi request reprint Generation of monodisperse silk microspheres prepared with microfluidics
    David N Breslauer
    UCSF UC Berkeley Bioengineering Graduate Group, Department of Bioengineering, University of California, Berkeley, Berkeley, California 94720, USA
    Biomacromolecules 11:643-7. 2010
    ..Because silk is well established as biocompatible and biodegradable, we anticipate that these silk microspheres could have particular utility in drug delivery and controlled release...
  49. ncbi request reprint Microfluidic bead-based diodes with targeted circular microchannels for low Reynolds number applications
    Ryan D Sochol
    Department of Mechanical Engineering, 668 Sutardja Dai Hall, Berkeley, CA 94720, USA
    Lab Chip 14:1585-94. 2014
    ..72 ± 0.41 to 10.21 ± 1.53 corresponding to Re varying from 0.1 to 0.6. ..
  50. doi request reprint Dual-mode hydrodynamic railing and arraying of microparticles for multi-stage signal detection in continuous flow biochemical microprocessors
    Ryan D Sochol
    Department of Mechanical Engineering, University of California, Berkeley, USA
    Lab Chip 14:1405-9. 2014
    ..g., for optical detection). We employ this methodology to detect the inflammatory cytokine, interferon-gamma (IFN-γ), via a six-stage aptamer-based sandwich assay. ..
  51. ncbi request reprint Quantized plasmon quenching dips nanospectroscopy via plasmon resonance energy transfer
    Gang Logan Liu
    Biomolecular Nanotechnology Center, Berkeley Sensor and Actuator Center, Department of Bioengineering, University of California Berkeley, 442 Stanley Hall, Berkeley, California 94720, USA
    Nat Methods 4:1015-7. 2007
    ..This label-free biomolecular absorption nanospectroscopic method has ultrahigh molecular sensitivity...
  52. ncbi request reprint Continuous flow multi-stage microfluidic reactors via hydrodynamic microparticle railing
    Ryan D Sochol
    Department of Mechanical Engineering, University of California, Berkeley, USA
    Lab Chip 12:4168-77. 2012
    ....
  53. ncbi request reprint A single cell electroporation chip
    Michelle Khine
    Berkeley Sensor and Actuator Center, Department of Bioengineering, University of California, Berkeley, CA 94720, USA
    Lab Chip 5:38-43. 2005
    ....
  54. ncbi request reprint Single-cell enzyme concentrations, kinetics, and inhibition analysis using high-density hydrodynamic cell isolation arrays
    Dino Di Carlo
    Biomolecular Nanotechnology Center, Berkeley Sensor and Actuator Center, Department of Bioengineering, University of California, Berkeley, California 94720, USA
    Anal Chem 78:4925-30. 2006
    ..For HeLa cells, 20 nM of the 50 nM total carboxylesterases was unaffected by NDGA. This type of analysis could be directly applied to quantify a variety of intracellular enzymes with available fluorogenic substrates...
  55. ncbi request reprint Dynamic single-cell analysis for quantitative biology
    Dino Di Carlo
    Department of Bioengineering, University of California Berkeley, Berkeley, CA 94720, USA
    Anal Chem 78:7918-25. 2006
  56. pmc Remote optical switch for localized and selective control of gene interference
    Somin Eunice Lee
    Department of Bioengineering, University of California Berkeley, CA, USA
    Nano Lett 9:562-70. 2009
    ..We demonstrate a novel gene-interfering technique offering spatial and temporal control, which is otherwise impossible using conventional gene-interfering techniques...
  57. pmc Biomolecular plasmonics for quantitative biology and nanomedicine
    Somin Eunice Lee
    Department of Bioengineering, University of California Berkeley, UCSF UCB Joint Graduate Group in Bioengineering, Berkeley Sensor and Actuator Center, Berkeley, CA, USA
    Curr Opin Biotechnol 21:489-97. 2010
    ..Nanoplasmonic molecular rulers and integrated photoacoustic-photothermal contrast agents are also described...
  58. doi request reprint Label-free and highly sensitive biomolecular detection using SERS and electrokinetic preconcentration
    Hansang Cho
    Biomolecular Nanotechnology Center, Department of Bioengineering, University of California, Berkeley, California 94720, USA
    Lab Chip 9:3360-3. 2009
    ..6 V cm(-1) after 25 min. The effectiveness of this method allows the creation of label-free, target-specific, and highly sensitive monitoring applications...
  59. ncbi request reprint Reagentless mechanical cell lysis by nanoscale barbs in microchannels for sample preparation
    Dino Di Carlo
    Berkeley Sensor and Actuator Center, Department of Bioengineering, University of California, Berkeley, CA 94720, USA
    Lab Chip 3:287-91. 2003
    ..At a flow rate of 300 microL min(-1) within the filter region total protein and hemoglobin accessibilities of 4.8% and 7.5% are observed respectively as compared to 1.9% and 3.2% for a filter without nanostructured barbs...
  60. doi request reprint Rapid detection of Aβ aggregation and inhibition by dual functions of gold nanoplasmic particles: catalytic activator and optical reporter
    Inhee Choi
    Berkeley Sensor and Actuator Center, Department of Bioengineering, Department of Electrical Engineering and Computer Science, University of California at Berkeley, Berkeley, California 94720, USA
    ACS Nano 7:6268-77. 2013
    ....
  61. doi request reprint Innovations in optical microfluidic technologies for point-of-care diagnostics
    Frank B Myers
    Biomolecular Nanotechnology Center, Berkeley Sensor and Actuator Center, Department of Bioengineering, University of California, Berkeley, CA 94720, USA
    Lab Chip 8:2015-31. 2008
    ..We also examine several emerging detection paradigms involving nanoengineered materials which do not suffer from the same miniaturization disadvantages as conventional measurements...
  62. doi request reprint Nanowire-based single-cell endoscopy
    Ruoxue Yan
    Department of Chemistry, University of California, and Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Nat Nanotechnol 7:191-6. 2012
    ..Moreover, insertion of the endoscope into cells and illumination of the guided laser did not induce any significant toxicity in the cells...
  63. ncbi request reprint High-density silver nanoparticle film with temperature-controllable interparticle spacing for a tunable surface enhanced Raman scattering substrate
    Yu Lu
    Berkeley Sensor and Actuator Center, Department of Bioengineering, University of California Berkeley, Berkeley, California 94720, USA
    Nano Lett 5:5-9. 2005
    ..The SERS spectra of Rhodamine 6G on a high-density silver particle film at various temperatures is characterized to demonstrate the tunable plasmon coupling between high-density nanoparticles...
  64. ncbi request reprint Theoretical and experimental study towards a nanogap dielectric biosensor
    Mingqiang Yi
    Berkeley Sensor and Actuator Center, Department of Bioengineering, University of California at Berkeley, Berkeley, CA 94720 1762, USA
    Biosens Bioelectron 20:1320-6. 2005
    ..A capacitance change of a 20 nm x (10)1.5 microm x 4mm gap from 3.5 to 4.1 nF at 200 Hz was recorded between deionized water (DI) and 100 nM ssDNA solution (about 70,000 molecules inside the gap for equilibrium state)...
  65. ncbi request reprint Microfluidics-based systems biology
    David N Breslauer
    UCSF UC Berkeley Bioengineering Graduate Group, Department of Bioengineering, University of California Berkeley, Berkeley, CA, USA
    Mol Biosyst 2:97-112. 2006
    ....
  66. pmc Optical properties of the crescent-shaped nanohole antenna
    Liz Y Wu
    Applied Science and Technology Graduate Group, Biomolecular Nanotechnology Center, Berkeley Sensor and Actuator Center, and Department of Bioengineering, University of CaliforniaBerkeley, Berkeley, California 94720
    Nano Lett 9:1956-61. 2009
    ....
  67. doi request reprint Simulation of flow in the silk gland
    David N Breslauer
    UCSF UC Berkeley Bioengineering Graduate Group, Bionanotechnology Center, and Department of Chemical Engineering, University of California, Berkeley, Berkeley, California, USA
    Biomacromolecules 10:49-57. 2009
    ..These results provide new insight into silk spinning processes and will guide the future development of novel fiber spinning technologies...
  68. doi request reprint Micropatterned hot-embossed polymeric surfaces influence cell proliferation and alignment
    Lorenzo Moroni
    Department of Bioengineering, University of California Berkeley, 459 Evans Hall No 1762, UC Berkeley, Berkeley, California 94720 1762, USA
    J Biomed Mater Res A 88:644-53. 2009
    ..These findings could be useful in tissue engineering applications where higher proliferation rates and eventual random or unidimensional alignments of cells are desirable...
  69. pmc Nanoplasmonic gene regulation
    Somin Eunice Lee
    Department of Bioengineering, University of California Berkeley, UCSF UCB Joint Graduate Group in Bioengineering, Berkeley Sensor and Actuator Center, Berkeley, CA, USA
    Curr Opin Chem Biol 14:623-33. 2010
    ....
  70. pmc Aptamer-based SERRS sensor for thrombin detection
    Hansang Cho
    Biomolecular Nanotechnology Center, Berkeley Sensor and Actuator Center, Department of Bioengineering, University of California, Berkeley, California 94720, USA
    Nano Lett 8:4386-90. 2008
    ..Furthermore, the proposed sensor may be implemented for multiplexed detection using different aptamer-Raman probe complexes...
  71. ncbi request reprint Biomimetic technique for adhesion-based collection and separation of cells in a microfluidic channel
    Wesley C Chang
    Berkeley Sensor and Actuator Center, University of California, Berkeley, 94720, USA
    Lab Chip 5:64-73. 2005
    ..Additionally, among collected cells, the difference in flow-driven, adhesion-mediated cell transit in the Square design suggested that the two cell types could at least be partially fractionated...
  72. ncbi request reprint Micromachined transmissive scanning confocal microscope
    Sunghoon Kwon
    Berkeley Sensor and Actuator Center, Department of Bioengineering, University of California, Berkeley, California 94720, USA
    Opt Lett 29:706-8. 2004
    ..We have demonstrated reflection confocal imaging with 3-microm transverse resolution over a 100-microm field of view and a 0.38-mm working distance at lambda = 633 nm...
  73. ncbi request reprint Total internal reflection-based biochip utilizing a polymer-filled cavity with a micromirror sidewall
    Nikolas Chronis
    Berkeley Sensor and Actuator Center, Department of Bioengineering, University of California, Berkeley, USA
    Lab Chip 4:125-30. 2004
    ..The proposed TIR-based chip simplifies current TIR optical configurations and could potentially be used as an optical-microfluidic platform for an integrated lab-on-a-chip microsystem...
  74. ncbi request reprint Plasmon tuning and local field enhancement maximization of the nanocrescent
    Benjamin M Ross
    Applied Science and Technology Graduate Group, Biomolecular Nanotechnology Center, Berkeley Sensor and Actuator Center, Department of Bioengineering, University of California Berkeley, Berkeley, CA 94720, USA
    Nanotechnology 19:275201. 2008
    ....
  75. doi request reprint A nanoplasmonic molecular ruler for measuring nuclease activity and DNA footprinting
    Gang L Liu
    Nat Nanotechnol 1:47-52. 2006
  76. doi request reprint Sample concentration and impedance detection on a microfluidic polymer chip
    Poorya Sabounchi
    Energy Systems Department, Sandia National Laboratories, Livermore, CA, USA
    Biomed Microdevices 10:661-70. 2008
    ....