Kyung N Lee

Summary

Affiliation: University of Oklahoma Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Characterization of wild-type and mutant alpha2-antiplasmins: fibrinolysis enhancement by reactive site mutant
    K N Lee
    William K Warren Medical Research Institute and the Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    Blood 94:164-71. 1999
  2. doi request reprint Enhancement of fibrinolysis by inhibiting enzymatic cleavage of precursor α2-antiplasmin
    K N Lee
    William K Warren Medical Research Center and Department of Medicine, University of Oklahoma College of Medicine, Oklahoma City, OK 73126, USA
    J Thromb Haemost 9:987-96. 2011
  3. doi request reprint Using substrate specificity of antiplasmin-cleaving enzyme for fibroblast activation protein inhibitor design
    Kyung N Lee
    William K Warren Research Center and Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73126, USA
    Biochemistry 48:5149-58. 2009
  4. ncbi request reprint Why alpha-antiplasmin must be converted to a derivative form for optimal function
    K N Lee
    William K Warren Medical Research Center and Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    J Thromb Haemost 5:2095-104. 2007
  5. ncbi request reprint Antiplasmin-cleaving enzyme is a soluble form of fibroblast activation protein
    Kyung N Lee
    W K Warren Medical Research Center, PO Box 26901, BSEB 306, Oklahoma City, OK 73190, USA
    Blood 107:1397-404. 2006
  6. ncbi request reprint Alpha2-antiplasmin: potential therapeutic roles in fibrin survival and removal
    Kyung N Lee
    William K Warren Medical Research Center and Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA
    Curr Med Chem Cardiovasc Hematol Agents 2:303-10. 2004
  7. ncbi request reprint Effect of a synthetic carboxy-terminal peptide of alpha(2)-antiplasmin on urokinase-induced fibrinolysis
    Kyung N Lee
    William K Warren Medical Research Institute and Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA
    Thromb Res 105:263-70. 2002
  8. ncbi request reprint Cross-linking of wild-type and mutant alpha 2-antiplasmins to fibrin by activated factor XIII and by a tissue transglutaminase
    K N Lee
    William K Warren Medical Research Institute and the Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA
    J Biol Chem 275:37382-9. 2000
  9. ncbi request reprint A novel plasma proteinase potentiates alpha2-antiplasmin inhibition of fibrin digestion
    Kyung N Lee
    Department of Medicine, University of Oklahoma Sciences Center, Oklahoma City, OK 73190, USA
    Blood 103:3783-8. 2004
  10. pmc Effect of fibroblast activation protein and alpha2-antiplasmin cleaving enzyme on collagen types I, III, and IV
    Victoria J Christiansen
    William K Warren Medical Research Center and Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    Arch Biochem Biophys 457:177-86. 2007

Detail Information

Publications13

  1. ncbi request reprint Characterization of wild-type and mutant alpha2-antiplasmins: fibrinolysis enhancement by reactive site mutant
    K N Lee
    William K Warren Medical Research Institute and the Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    Blood 94:164-71. 1999
    ....
  2. doi request reprint Enhancement of fibrinolysis by inhibiting enzymatic cleavage of precursor α2-antiplasmin
    K N Lee
    William K Warren Medical Research Center and Department of Medicine, University of Oklahoma College of Medicine, Oklahoma City, OK 73126, USA
    J Thromb Haemost 9:987-96. 2011
    ..We reasoned that an APCE inhibitor might decrease conversion of Met-α(2)AP to Asn-α(2)AP and thereby enhance endogenous fibrinolysis...
  3. doi request reprint Using substrate specificity of antiplasmin-cleaving enzyme for fibroblast activation protein inhibitor design
    Kyung N Lee
    William K Warren Research Center and Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73126, USA
    Biochemistry 48:5149-58. 2009
    ..Results indicate that Arg at P5, P6, or P7 distances from P1 enhances affinity and efficiency of substrates or inhibitors toward APCE or FAP...
  4. ncbi request reprint Why alpha-antiplasmin must be converted to a derivative form for optimal function
    K N Lee
    William K Warren Medical Research Center and Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    J Thromb Haemost 5:2095-104. 2007
    ..An R6W polymorphism has been suggested to affect fibrinolytic rate. Within circulating blood, antiplasmin-cleaving enzyme (APCE) cleaves Met-alpha(2)AP(R6) faster than Met-alpha(2)AP(W6) at the Pro12-Asn13 bond to yield Asn-alpha(2)AP...
  5. ncbi request reprint Antiplasmin-cleaving enzyme is a soluble form of fibroblast activation protein
    Kyung N Lee
    W K Warren Medical Research Center, PO Box 26901, BSEB 306, Oklahoma City, OK 73190, USA
    Blood 107:1397-404. 2006
    ....
  6. ncbi request reprint Alpha2-antiplasmin: potential therapeutic roles in fibrin survival and removal
    Kyung N Lee
    William K Warren Medical Research Center and Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA
    Curr Med Chem Cardiovasc Hematol Agents 2:303-10. 2004
    ..This review summarizes recent studies that may hold promise for modulating alpha2AP activity and its interactions with certain proteins as new therapeutic strategies for preventing and treating thrombotic disorders...
  7. ncbi request reprint Effect of a synthetic carboxy-terminal peptide of alpha(2)-antiplasmin on urokinase-induced fibrinolysis
    Kyung N Lee
    William K Warren Medical Research Institute and Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA
    Thromb Res 105:263-70. 2002
    ..Whether AP26 alone, or as part of another molecule, could have potential for enhancing thrombolysis will require further study...
  8. ncbi request reprint Cross-linking of wild-type and mutant alpha 2-antiplasmins to fibrin by activated factor XIII and by a tissue transglutaminase
    K N Lee
    William K Warren Medical Research Institute and the Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA
    J Biol Chem 275:37382-9. 2000
    ..These results show that alpha(2)AP is a better substrate for FXIIIa than for this particular tTG, but that either enzyme involves the same Gln substrate sites in alpha(2)AP and yields the same order of reactivities...
  9. ncbi request reprint A novel plasma proteinase potentiates alpha2-antiplasmin inhibition of fibrin digestion
    Kyung N Lee
    Department of Medicine, University of Oklahoma Sciences Center, Oklahoma City, OK 73190, USA
    Blood 103:3783-8. 2004
    ..APCE may represent a new target for pharmacologic inhibition, since less generation and incorporation of Asn-alpha2AP could result in a more rapid removal of fibrin by plasmin during atherogenesis, thrombosis, and inflammatory states...
  10. pmc Effect of fibroblast activation protein and alpha2-antiplasmin cleaving enzyme on collagen types I, III, and IV
    Victoria J Christiansen
    William K Warren Medical Research Center and Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    Arch Biochem Biophys 457:177-86. 2007
    ..We conclude that FAP works in synchrony with other proteinases to cleave partially degraded or denatured collagen I and III as ECM is excavated, and that derivative peptides might function to regulate malignant cell growth and motility...
  11. pmc The effect of a single nucleotide polymorphism on human alpha 2-antiplasmin activity
    Victoria J Christiansen
    William K Warren Medical Research Center and Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    Blood 109:5286-92. 2007
    ..Therefore, the Arg6Trp polymorphism may play a significant role in governing the long-term deposition/removal of intravascular fibrin...
  12. pmc Targeting inhibition of fibroblast activation protein-α and prolyl oligopeptidase activities on cells common to metastatic tumor microenvironments
    Victoria J Christiansen
    William K Warren Medical Research Center and Department of Medicine, University of Oklahoma College of Medicine, Oklahoma City, OK 73126, USA
    Neoplasia 15:348-58. 2013
    ....
  13. ncbi request reprint Crosslinking of alpha 2-antiplasmin to fibrin
    K N Lee
    William K. Warren Medical Research Institute, Oklahoma City, Oklahoma, USA
    Ann N Y Acad Sci 936:335-9. 2001
    ....