Kyung N Lee

Summary

Affiliation: University of Oklahoma Health Sciences Center
Country: USA

Publications

  1. request reprint
    Lee K, Tae W, Jackson K, Kwon S, McKee P. Characterization of wild-type and mutant alpha2-antiplasmins: fibrinolysis enhancement by reactive site mutant. Blood. 1999;94:164-71 pubmed
    ....
  2. request reprint
    Lee K, Jackson K, Christiansen V, Lee C, Chun J, McKee P. Why alpha-antiplasmin must be converted to a derivative form for optimal function. J Thromb Haemost. 2007;5:2095-104 pubmed
    ..The R6 W polymorphism in Met-alpha(2)AP does not affect its crosslinking to fibrin, but it does slow cleavage by APCE and reduces the amount of Asn-alpha(2)AP available for rapid crosslinking to fibrin. ..
  3. request reprint
    Lee K, Lee C, Tae W, Jackson K, Christiansen V, McKee P. Cross-linking of wild-type and mutant alpha 2-antiplasmins to fibrin by activated factor XIII and by a tissue transglutaminase. J Biol Chem. 2000;275:37382-9 pubmed
    ..These results show that alpha(2)AP is a better substrate for FXIIIa than for this particular tTG, but that either enzyme involves the same Gln substrate sites in alpha(2)AP and yields the same order of reactivities. ..
  4. request reprint
    Lee K, Jackson K, Christiansen V, Lee C, Chun J, McKee P. Antiplasmin-cleaving enzyme is a soluble form of fibroblast activation protein. Blood. 2006;107:1397-404 pubmed
    ....
  5. Lee K, Jackson K, Christiansen V, Dolence E, McKee P. Enhancement of fibrinolysis by inhibiting enzymatic cleavage of precursor ?2-antiplasmin. J Thromb Haemost. 2011;9:987-96 pubmed publisher
    ..These data establish that inhibition of APCE might represent a therapeutic approach for enhancing thrombolytic activity. ..

Locale

Detail Information

Publications5

  1. request reprint
    Lee K, Tae W, Jackson K, Kwon S, McKee P. Characterization of wild-type and mutant alpha2-antiplasmins: fibrinolysis enhancement by reactive site mutant. Blood. 1999;94:164-71 pubmed
    ....
  2. request reprint
    Lee K, Jackson K, Christiansen V, Lee C, Chun J, McKee P. Why alpha-antiplasmin must be converted to a derivative form for optimal function. J Thromb Haemost. 2007;5:2095-104 pubmed
    ..The R6 W polymorphism in Met-alpha(2)AP does not affect its crosslinking to fibrin, but it does slow cleavage by APCE and reduces the amount of Asn-alpha(2)AP available for rapid crosslinking to fibrin. ..
  3. request reprint
    Lee K, Lee C, Tae W, Jackson K, Christiansen V, McKee P. Cross-linking of wild-type and mutant alpha 2-antiplasmins to fibrin by activated factor XIII and by a tissue transglutaminase. J Biol Chem. 2000;275:37382-9 pubmed
    ..These results show that alpha(2)AP is a better substrate for FXIIIa than for this particular tTG, but that either enzyme involves the same Gln substrate sites in alpha(2)AP and yields the same order of reactivities. ..
  4. request reprint
    Lee K, Jackson K, Christiansen V, Lee C, Chun J, McKee P. Antiplasmin-cleaving enzyme is a soluble form of fibroblast activation protein. Blood. 2006;107:1397-404 pubmed
    ....
  5. Lee K, Jackson K, Christiansen V, Dolence E, McKee P. Enhancement of fibrinolysis by inhibiting enzymatic cleavage of precursor ?2-antiplasmin. J Thromb Haemost. 2011;9:987-96 pubmed publisher
    ..These data establish that inhibition of APCE might represent a therapeutic approach for enhancing thrombolytic activity. ..