Kristine E Lee

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Detecting disease-causing genes by LASSO-Patternsearch algorithm
    Weiliang Shi
    Department of Statistics, University of Wisconsin Madison, 1300 University Avenue, Madison, Wisconsin 53706, USA
    BMC Proc 1:S60. 2007
  2. ncbi request reprint Changes in refraction over 10 years in an adult population: the Beaver Dam Eye study
    Kristine E Lee
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53726, USA
    Invest Ophthalmol Vis Sci 43:2566-71. 2002
  3. pmc Association of age, stature, and education with ocular dimensions in an older white population
    Kristine E Lee
    Department of Ophthalmology and Visual Sciences, University of Wisconsin and Public Health, Madison, WI 53726 2336, USA
    Arch Ophthalmol 127:88-93. 2009
  4. ncbi request reprint Familial aggregation of retinal vessel caliber in the beaver dam eye study
    Kristine E Lee
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53726 2336, USA
    Invest Ophthalmol Vis Sci 45:3929-33. 2004
  5. ncbi request reprint Association of retinal vessel caliber to optic disc and cup diameters
    Kristine E Lee
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53726, USA
    Invest Ophthalmol Vis Sci 48:63-7. 2007
  6. pmc Familial aggregation of components of the multiple metabolic syndrome in the Framingham Heart and Offspring Cohorts: Genetic Analysis Workshop Problem 1
    Kristine E Lee
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin, USA
    BMC Genet 4:S94. 2003
  7. ncbi request reprint Supplements and age-related eye conditions the beaver dam eye study
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726, USA
    Ophthalmology 115:1203-8. 2008
  8. pmc Determinants of retinal venular diameter: the Beaver Dam Eye Study
    Chelsea E Myers
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726, USA
    Ophthalmology 119:2563-71. 2012
  9. pmc Retrodots in the lens in the Beaver Dam Eye Study cohort
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726 2336, USA
    Ophthalmology 117:1889-93. 2010
  10. pmc Risk alleles in CFH and ARMS2 and the long-term natural history of age-related macular degeneration: the Beaver Dam Eye Study
    Ronald Klein
    Departments of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, USA
    JAMA Ophthalmol 131:383-92. 2013

Detail Information

Publications80

  1. pmc Detecting disease-causing genes by LASSO-Patternsearch algorithm
    Weiliang Shi
    Department of Statistics, University of Wisconsin Madison, 1300 University Avenue, Madison, Wisconsin 53706, USA
    BMC Proc 1:S60. 2007
    ..In our analysis of Genetic Analysis Workshop 15 Problem 3 data we have identified most of the associated SNPs and relevant covariates. Upon using the model as a classifier, very competitive error rates were obtained...
  2. ncbi request reprint Changes in refraction over 10 years in an adult population: the Beaver Dam Eye study
    Kristine E Lee
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53726, USA
    Invest Ophthalmol Vis Sci 43:2566-71. 2002
    ..To quantify the 10-year change in refraction in persons more than 40 years of age...
  3. pmc Association of age, stature, and education with ocular dimensions in an older white population
    Kristine E Lee
    Department of Ophthalmology and Visual Sciences, University of Wisconsin and Public Health, Madison, WI 53726 2336, USA
    Arch Ophthalmol 127:88-93. 2009
    ..To describe ocular biometry relationships in older white adults...
  4. ncbi request reprint Familial aggregation of retinal vessel caliber in the beaver dam eye study
    Kristine E Lee
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53726 2336, USA
    Invest Ophthalmol Vis Sci 45:3929-33. 2004
    ..To describe familial correlations of retinal vessel measurements...
  5. ncbi request reprint Association of retinal vessel caliber to optic disc and cup diameters
    Kristine E Lee
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53726, USA
    Invest Ophthalmol Vis Sci 48:63-7. 2007
    ..To investigate whether optic disc size is related to retinal venule and arteriole diameters...
  6. pmc Familial aggregation of components of the multiple metabolic syndrome in the Framingham Heart and Offspring Cohorts: Genetic Analysis Workshop Problem 1
    Kristine E Lee
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin, USA
    BMC Genet 4:S94. 2003
    ..Measures of plasma cholesterol (total and HDL), body mass index (BMI), and systolic blood pressure were used from selected calendar years of exams. Familial correlations were calculated using FCOR in S.A.G.E...
  7. ncbi request reprint Supplements and age-related eye conditions the beaver dam eye study
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726, USA
    Ophthalmology 115:1203-8. 2008
    ..To investigate the association of use of vitamin, mineral, and nonvitamin nonmineral supplements with common age-related eye diseases...
  8. pmc Determinants of retinal venular diameter: the Beaver Dam Eye Study
    Chelsea E Myers
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726, USA
    Ophthalmology 119:2563-71. 2012
    ..To describe how retinal venular diameter changes over time for an individual and to examine differences in these changes among people with different risk profiles...
  9. pmc Retrodots in the lens in the Beaver Dam Eye Study cohort
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726 2336, USA
    Ophthalmology 117:1889-93. 2010
    ..To determine the prevalence of retrodots in the lens and the association of these lesions to age-related cataract, and to assess their association with visual impairment and contrast sensitivity...
  10. pmc Risk alleles in CFH and ARMS2 and the long-term natural history of age-related macular degeneration: the Beaver Dam Eye Study
    Ronald Klein
    Departments of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, USA
    JAMA Ophthalmol 131:383-92. 2013
    ....
  11. pmc Inflammatory and endothelial dysfunction markers and proteinuria in persons with type 1 diabetes mellitus
    Karine Sahakyan
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Fourth Floor WARF, Madison, Wisconsin 53726, USA
    Eur J Endocrinol 162:1101-5. 2010
    ..We examined the relationship of inflammatory and endothelial dysfunction markers with the prevalence and incidence of gross proteinuria (GP) in persons with type 1 diabetes mellitus...
  12. pmc The Wisconsin Epidemiologic Study of Diabetic Retinopathy XXIII: the twenty-five-year incidence of macular edema in persons with type 1 diabetes
    Ronald Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726 2336, USA
    Ophthalmology 116:497-503. 2009
    ..To examine the 25-year cumulative incidence of macular edema (ME) and its relation to various risk factors...
  13. pmc Changes in visual impairment prevalence by period of diagnosis of diabetes: the Wisconsin Epidemiologic Study of Diabetic Retinopathy
    Ronald Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726 2336, USA
    Ophthalmology 116:1937-42. 2009
    ..To examine relationships of period of diagnosis of type 1 diabetes mellitus (T1DM) to the prevalence of visual impairment (VI)...
  14. ncbi request reprint Misclassification can explain most apparent regression of age-related macular degeneration: results from multistate models with misclassification
    Ronald E Gangnon
    Department of Biostatistics and Medical Informatics and Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
    Invest Ophthalmol Vis Sci 55:1780-6. 2014
    ....
  15. pmc Effect of the Y402H variant in the complement factor H gene on the incidence and progression of age-related macular degeneration: results from multistate models applied to the Beaver Dam Eye Study
    Ronald E Gangnon
    Department of Biostatistics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, USA
    Arch Ophthalmol 130:1169-76. 2012
    ....
  16. pmc The 25-year incidence of visual impairment in type 1 diabetes mellitus the wisconsin epidemiologic study of diabetic retinopathy
    Ronald Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726 2336, USA
    Ophthalmology 117:63-70. 2010
    ..To examine the 25-year cumulative incidence of visual impairment (VI) and its relation to various risk factors...
  17. pmc Parents' attained age and biomarkers of aging in their children
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, 610 North Walnut Street, 4th Floor WARF, Madison, WI 53726 2336, USA
    Arch Gerontol Geriatr 49:284-8. 2009
    ....
  18. pmc Relationship of blood pressure and other factors to serial retinal arteriolar diameter measurements over time: the beaver dam eye study
    Ronald Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, 610 N Walnut St, 417 WARF, Madison, WI 53726, USA
    Arch Ophthalmol 130:1019-27. 2012
    ..To describe the relationship of blood pressure (BP), antihypertensive medication use, and other factors to serial measurements of retinal arteriolar diameters over time in the Beaver Dam Eye Study...
  19. pmc Changes in retinal vessel diameter and incidence and progression of diabetic retinopathy
    Ronald Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726 2336, USA
    Arch Ophthalmol 130:749-55. 2012
    ....
  20. pmc A longitudinal study of nonvitamin, nonmineral supplement use: prevalence, associations, and survival in an aging population
    Michael D Knudtson
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, School of Medicine and Public Health, Madison, WI 53726 2336, USA
    Ann Epidemiol 17:933-9. 2007
    ..We sought to describe population and survival characteristics in nonvitamin, nonmineral (NVNM) supplement users in a population-based cohort study...
  21. doi request reprint Incidence of age-related cataract over a 15-year interval the Beaver Dam Eye Study
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726, USA
    Ophthalmology 115:477-82. 2008
    ..To describe the long-term incidence of nuclear cataract, cortical cataract, and posterior subcapsular cataract (PSC) and to evaluate age and cohort effects on these rates...
  22. pmc Changing Incidence of Lens Extraction over 20 Years: The Beaver Dam Eye Study
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin Electronic address
    Ophthalmology 121:5-9. 2014
    ..To investigate trends in the incidence of lens extraction over the past 20 years...
  23. pmc Incidence of visual impairment over a 20-year period: the Beaver Dam Eye Study
    Ronald Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726 2336, USA
    Ophthalmology 120:1210-9. 2013
    ..To describe visual impairment (VI) over a 20-year period and its associations with age-related eye diseases and socioeconomic factors in the Beaver Dam Eye Study...
  24. pmc The relationship of cataract and cataract extraction to age-related macular degeneration: the Beaver Dam Eye Study
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    Ophthalmology 119:1628-33. 2012
    ..To examine the associations of cataract and cataract surgery with early and late age-related macular degeneration (AMD) over a 20-year interval...
  25. pmc Age-period-cohort effect on the incidence of age-related macular degeneration: the Beaver Dam Eye Study
    Ronald Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726 2336, USA
    Ophthalmology 115:1460-7. 2008
    ..To examine relationships of age, period, and birth cohort with the 5-year incidence of age-related macular degeneration (AMD)...
  26. pmc Cystatin C, other markers of kidney disease, and incidence of age-related cataract
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Madison, Wisconsin Alumni Research Foundation, Madison, WI 53726, USA
    Arch Ophthalmol 126:1724-30. 2008
    ..To investigate the 15-year incidence of 3 specific types of age-related cataract as related to cystatin C and other measures of kidney function...
  27. ncbi request reprint Revised formulas for summarizing retinal vessel diameters
    Michael D Knudtson
    Department of Ophthalmology, University of Wisconsin, Madison, WI 53726, USA
    Curr Eye Res 27:143-9. 2003
    ....
  28. pmc The Wisconsin Epidemiologic Study of Diabetic Retinopathy: XXII the twenty-five-year progression of retinopathy in persons with type 1 diabetes
    Ronald Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    Ophthalmology 115:1859-68. 2008
    ..To examine the 25-year cumulative progression and regression of diabetic retinopathy (DR) and its relation to various risk factors...
  29. ncbi request reprint Measures of body shape and adiposity as related to incidence of age-related eye diseases: observations from the Beaver Dam Eye Study
    Kerri P Howard
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States
    Invest Ophthalmol Vis Sci 55:2592-8. 2014
    ..To examine the effect of obesity on the incidence of age-related eye disease...
  30. ncbi request reprint Changes in visual acuity in a population over a 15-year period: the Beaver Dam Eye Study
    Ronald Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726 2336, USA
    Am J Ophthalmol 142:539-49. 2006
    ..To describe the change in visual acuity in a 15-year period...
  31. pmc Serum cystatin C and the incidence of hypertension in type 1 diabetes mellitus
    Karine Sahakyan
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, USA
    Am J Hypertens 24:59-63. 2011
    ..We examined the association of serum cystatin C with the incidence of hypertension over a 15-year period in people with type 1 diabetes mellitus...
  32. pmc Complete blood cell count and retinal vessel diameters
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin Madison, 610 N Walnut Street, Madison, WI 53726 2336, USA
    Arch Ophthalmol 129:490-7. 2011
    ..To examine the cross-sectional associations of components of the complete blood cell count with retinal vessel diameters...
  33. pmc Serum cystatin C level, kidney disease markers, and incidence of age-related macular degeneration: the Beaver Dam Eye Study
    Ronald Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, 610 N Walnut St, Room 417 WARF, Madison, WI 53726 2336, USA
    Arch Ophthalmol 127:193-9. 2009
    ..To examine the associations of the serum cystatin C level and chronic kidney disease with the incidence of age-related macular degeneration (AMD) over 15 years...
  34. ncbi request reprint Age-related eye disease, quality of life, and functional activity
    Michael D Knudtson
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, USA
    Arch Ophthalmol 123:807-14. 2005
    ....
  35. pmc 15-year cumulative incidence and associated risk factors for retinopathy in nondiabetic persons
    Ronald Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, 53726, USA
    Arch Ophthalmol 128:1568-75. 2010
    ..To investigate the relationship of systemic factors to the 15-year cumulative incidence of retinopathy in nondiabetic persons in the Beaver Dam Eye Study...
  36. ncbi request reprint Frailty, morbidity and survival
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, 405 WARF, Madison, WI 53726 2336, USA
    Arch Gerontol Geriatr 41:141-9. 2005
    ..Greater frailty was associated with greater likelihood of concurrent medical conditions and with decreased survival...
  37. ncbi request reprint Refractive errors, intraocular pressure, and glaucoma in a white population
    Tien Yin Wong
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA
    Ophthalmology 110:211-7. 2003
    ..To examine the relation of refractive errors to glaucoma and intraocular pressure (IOP) in a defined white population...
  38. ncbi request reprint Nitrate-nitrogen levels in rural drinking water: Is there an association with age-related macular degeneration?
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726 2336, USA
    J Environ Sci Health A Tox Hazard Subst Environ Eng 48:1757-63. 2013
    ..3% for low and 5.1% for the medium or high nitrate-nitrogen level, for the right eye). The OR for medium or high nitrate-nitrogen groups was 2.80 (95% CI: 1.07-7.31) compared to the low nitrate-nitrogen group. ..
  39. pmc Long-term use of aspirin and age-related macular degeneration
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison 53726 2336, USA
    JAMA 308:2469-78. 2012
    ..Aspirin is widely used for relief of pain and for cardioprotective effects. Its use is of concern to ophthalmologists when ocular surgery is being considered and also in the presence of age-related macular degeneration (AMD)...
  40. ncbi request reprint Detecting progression of nuclear sclerosis by using human grading versus semiautomated computer grading
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA
    Invest Ophthalmol Vis Sci 46:1155-62. 2005
    ..To assess indices of nuclear sclerosis derived from digitized images made from color (slide) photographs...
  41. pmc Selected sun-sensitizing medications and incident cataract
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, 53726 2336, USA
    Arch Ophthalmol 128:959-63. 2010
    ..To examine the relationship between the use of sun-sensitizing medications and cumulative incidence of age-related cataract...
  42. ncbi request reprint Markers of inflammation, vascular endothelial dysfunction, and age-related cataract
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, 610 N Walnut Street, 460 WARF, Madison, WI 53726, USA
    Am J Ophthalmol 141:116-22. 2006
    ..To examine the associations of systemic markers of inflammatory disease and vascular endothelial dysfunction with three types of age-related cataract...
  43. pmc Stability of 35-mm scanners as used in ophthalmologic research
    Karl Jensen
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726 2336, USA
    Ophthalmic Surg Lasers Imaging 41:60-6. 2010
    ..To assess the consistency of digitization of 35-mm slides as practiced in ophthalmologic research and estimate the impact of variation on semi-automated retinal vessel width measurements...
  44. ncbi request reprint Socioeconomic and lifestyle factors and the 10-year incidence of age-related cataracts
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53726 2397, USA
    Am J Ophthalmol 136:506-12. 2003
    ..To investigate the association of socioeconomic and lifestyle factors with incidence of age-related cataracts...
  45. pmc Cross-sectional associations of blood elements, clotting factors, nephropathy, and retinal outcomes in long duration type 1 diabetes
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726 2336, USA
    Ophthalmic Epidemiol 19:120-6. 2012
    ..To determine the association of blood elements, selected clotting factors, and nephropathy with proliferative diabetic retinopathy (PDR) and macular edema (ME) in those with long duration type 1 diabetes...
  46. ncbi request reprint Incidence of age-related cataract over a 10-year interval: the Beaver Dam Eye Study
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53705 2397, USA
    Ophthalmology 109:2052-7. 2002
    ..OBJECTIVE OR PURPOSE: To describe the cumulative incidence of age-related cataracts and cataract surgery over a 10-year interval...
  47. ncbi request reprint Components of the metabolic syndrome and risk of cardiovascular disease and diabetes in Beaver Dam
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53726, USA
    Diabetes Care 25:1790-4. 2002
    ..To determine whether components of the metabolic syndrome precede the 5-year incidence of cardiovascular disease and diabetes...
  48. ncbi request reprint Location of lesions associated with age-related maculopathy over a 10-year period: the Beaver Dam Eye Study
    Michael D Knudtson
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, 53726 2336, USA
    Invest Ophthalmol Vis Sci 45:2135-42. 2004
    ..To describe cumulative incidence and changes in retinal lesions associated with age-related maculopathy (ARM) by location over a 10-year period and to examine the relation of location of those lesions to progression of ARM...
  49. pmc Self- and registry-reported cancer in a population-based longitudinal study
    Barbara E K Klein
    University of Wisconsin Madison, School of Medicine and Public Health, Department of Ophthalmology and Visual Sciences, 610 N Walnut St, 4th Fl WARF, Madison, WI 53726 2336, USA
    WMJ 109:261-6. 2010
    ..To evaluate the concordance of cancer diagnosis from self- and registry reports...
  50. pmc Does the intraocular pressure effect on optic disc cupping differ by age?
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Madison, Madison, Wisconsin, USA
    Trans Am Ophthalmol Soc 104:143-8. 2006
    ..To investigate whether age influences optic disc cupping in addition to the effects of intraocular pressure (IOP)...
  51. ncbi request reprint Comparability of cup and disk diameters measured from nonstereoscopic digital and stereoscopic film images
    Andrew Ewen
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, 53726, USA
    Am J Ophthalmol 141:1126-1128. 2006
    ..To compare gradings of optic disk and cup diameters from stereoscopic film and nonstereoscopic digital images...
  52. pmc Using distance correlation and SS-ANOVA to assess associations of familial relationships, lifestyle factors, diseases, and mortality
    Jing Kong
    Department of Statistics, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 109:20352-7. 2012
    ....
  53. ncbi request reprint Signal quality assessment of retinal optical coherence tomography images
    Yijun Huang
    Fundus Photograph Reading Center, and Ocular Epidemiology Reading Center, Department of Ophthalmology, University of Wisconsin Madison, Madison, Wisconsin 53717, USA
    Invest Ophthalmol Vis Sci 53:2133-41. 2012
    ..The purpose of this article was to assess signal quality of retinal optical coherence tomography (OCT) images from multiple devices using subjective and quantitative measurements...
  54. pmc Relationship of measures of frailty to visual function: the Beaver Dam Eye Study
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, USA
    Trans Am Ophthalmol Soc 101:191-6; discussion 196-9. 2003
    ..To investigate the association of standard measures of frailty to visual acuity and contrast sensitivity...
  55. ncbi request reprint Attained parental age and children's survival at mid-life ages in a large population
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisc, USA
    Gerontology 53:399-403. 2007
    ..Long-lived persons tend to share a survival advantage with their parents and siblings; however, there is limited information on benefit beyond the extremes of longevity. We evaluated a survival benefit associated with age of parents...
  56. ncbi request reprint Do multiple families alter estimates of risk for age-related cataract in a population-based study? The Beaver Dam Eye Study
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin, USA
    Ophthalmic Epidemiol 10:97-106. 2003
    ....
  57. ncbi request reprint Heritability of risk factors for primary open-angle glaucoma: the Beaver Dam Eye Study
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53726 2336, USA
    Invest Ophthalmol Vis Sci 45:59-62. 2004
    ..To investigate the family aggregation and heritability of risk indicators of primary open-angle glaucoma...
  58. pmc The 25-year cumulative incidence of lower extremity amputations in people with type 1 diabetes
    Karine Sahakyan
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    Diabetes Care 34:649-51. 2011
    ..To examine the 25-year cumulative incidence of lower-extremity amputation (LEA) in people with type 1 diabetes...
  59. ncbi request reprint Associations of visual function with physical outcomes and limitations 5 years later in an older population: the Beaver Dam eye study
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53705 2397, USA
    Ophthalmology 110:644-50. 2003
    ..To examine the association of performance-based measures of visual functioning with the occurrence of falls, fractures, physical outcomes, and limitations in an older population...
  60. ncbi request reprint The comparability of estimates of retroilluminated lens opacities as judged from film-based and digital imaging
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53726, USA
    Am J Ophthalmol 138:668-70. 2004
    ..A digital imaging system is now available for imaging these opacities. We sought to compare gradings of images from both systems...
  61. pmc Serum calcium and breast cancer risk in a prospective cohort study
    Brian L Sprague
    Department of Population Health Sciences and Paul P Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, WI 53726, USA
    Ann Epidemiol 20:82-5. 2010
    ..1(st) quartile) or ionized (HR = 0.85; 95% CI: 0.53, 1.38; 4(th) vs. 1(st) quartile) serum calcium levels. Additionally, we found no evidence for an association among subgroups defined by menopausal status and body mass index...
  62. ncbi request reprint Harmonizing the classification of age-related macular degeneration in the three-continent AMD consortium
    Ronald Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    Ophthalmic Epidemiol 21:14-23. 2014
    ....
  63. ncbi request reprint Relation of Smoking, Drinking, and Physical Activity to Changes in Vision over a 20-Year Period: The Beaver Dam Eye Study
    Ronald Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin Electronic address
    Ophthalmology 121:1220-8. 2014
    ..To describe the relationships of lifestyle characteristics to changes in vision and incidence of visual impairment (VI) over a 20-year period in the Beaver Dam Eye Study (BDES)...
  64. pmc Refraction in adults with diabetes
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, 610 N Walnut St, Fourth Floor, Wisconsin Alumni Research Foundation, Madison, WI 53726 2336, USA
    Arch Ophthalmol 129:56-62. 2011
    ..To examine refraction, change in refraction, and risk factors for change in refraction in adults with type 1 and type 2 diabetes mellitus...
  65. ncbi request reprint Statin use and incident nuclear cataract
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, USA
    JAMA 295:2752-8. 2006
    ..Oxidative stress is believed to play a role in the development of nuclear cataract, but little is known regarding the relationship of statin use and cataract incidence...
  66. ncbi request reprint Complement factor H and hemicentin-1 in age-related macular degeneration and renal phenotypes
    Cheryl L Thompson
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA
    Hum Mol Genet 16:2135-48. 2007
    ..Both genes appear to play a role in both AMD and renal pathophysiology. These findings support evidence for common pathways influencing ocular and renal function and suggest that further work is required on their common determinants...
  67. ncbi request reprint Genetics of pigment changes and geographic atrophy
    Cheryl L Thompson
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106 7281, USA
    Invest Ophthalmol Vis Sci 48:3005-13. 2007
    ..Studies of age-related macular degeneration (AMD) often involve persons with both choroidal neovascularization and geographic atrophy (GA), but few genome-wide scans (GWSs) have discriminated between these two outcomes...
  68. ncbi request reprint Confirmation of linkage to ocular refraction on chromosome 22q and identification of a novel linkage region on 1q
    Alison P Klein
    Departments of Oncology and Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Arch Ophthalmol 125:80-5. 2007
    ....
  69. pmc Identification of novel genetic loci for intraocular pressure: a genomewide scan of the Beaver Dam Eye Study
    Priya Duggal
    Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, USA
    Arch Ophthalmol 125:74-9. 2007
    ..To identify genetic loci that control intraocular pressure (IOP)...
  70. ncbi request reprint The prevalence of refractive errors among adults in the United States, Western Europe, and Australia
    John H Kempen
    Johns Hopkins University School of Medicine, 550 N Broadway, Suite 700, Baltimore, MD 21205, USA
    Arch Ophthalmol 122:495-505. 2004
    ..To estimate the prevalence of refractive errors in persons 40 years and older...
  71. ncbi request reprint Genome-wide linkage study of retinal vessel diameters in the Beaver Dam Eye Study
    Chao Xing
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA
    Hypertension 47:797-802. 2006
    ..In summary, we provide evidence demonstrating that genetic factors independent of hypertension affect retinal vessel diameters...
  72. pmc Dissection of genomewide-scan data in extended families reveals a major locus and oligogenic susceptibility for age-related macular degeneration
    Sudha K Iyengar
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44109 1998, USA
    Am J Hum Genet 74:20-39. 2004
    ..In summary, we have evidence for a major ARMD locus on 15q21, which, coupled with numerous other loci segregating in these families, suggests complex oligogenic patterns of inheritance for ARMD...
  73. ncbi request reprint Genome-wide analyses demonstrate novel loci that predispose to drusen formation
    Gyungah Jun
    Departments of Epidemiology and Biostatistics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 7281, USA
    Invest Ophthalmol Vis Sci 46:3081-8. 2005
    ..To test whether genes for drusen formation are independent of age-related macular degeneration (AMD) pathogenesis...
  74. ncbi request reprint Meta-analysis of genome scans of age-related macular degeneration
    Sheila A Fisher
    Department of Medical and Molecular Genetics, Guy s, King s and St Thomas School of Medicine, King s College London, London SE1 9RT, UK
    Hum Mol Genet 14:2257-64. 2005
    ..Several of the regions identified here showed only weak evidence for linkage in the individual studies. These results will help prioritize regions for future positional and functional candidate gene studies in AMD...
  75. ncbi request reprint Polygenic effects and cigarette smoking account for a portion of the familial aggregation of nuclear sclerosis
    Alison P Klein
    Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, Baltimore, MD, USA
    Am J Epidemiol 161:707-13. 2005
    ..Cigarette smoking was an important covariate in these analyses. Overall, results highlight the complex etiology of nuclear sclerosis...
  76. ncbi request reprint A genetic contribution to intraocular pressure: the beaver dam eye study
    Priya Duggal
    Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland, USA
    Invest Ophthalmol Vis Sci 46:555-60. 2005
    ..IOP is a principal risk factor for primary open-angle glaucoma (POAG) a leading cause of blindness worldwide...
  77. pmc Identification of a major locus for age-related cortical cataract on chromosome 6p12-q12 in the Beaver Dam Eye Study
    Sudha K Iyengar
    Department of Epidemiology and Biostatistics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 101:14485-90. 2004
    ..00005). The current genome scan for age-related cortical cataracts may lead to identification of novel genes, because few regions identified in the current scan have previously been implicated in congenital or age-related cataracts...
  78. pmc A whole-genome screen of a quantitative trait of age-related maculopathy in sibships from the Beaver Dam Eye Study
    James H Schick
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44109 1998, USA
    Am J Hum Genet 72:1412-24. 2003
    ..89 cM), showed the strongest indication of linkage, with a P value of.004. Three other regions, on chromosomes 5, 6, and 15, that were nominally significant at P< or =.01 are also appropriate for fine mapping...
  79. ncbi request reprint Data mining, neural nets, trees--problems 2 and 3 of Genetic Analysis Workshop 15
    Andreas Ziegler
    Institut fur Medizinische Biometrie und Statistik, Universitatsklinikum Schleswig Holstein, Universitat zu Lubeck, Ratzeburger Allee 160, Lubeck, Germany
    Genet Epidemiol 31:S51-60. 2007
    ..However, improved implementations that are able to deal with hundreds of thousands of SNPs at a time are required...
  80. ncbi request reprint The GLC1H glaucoma locus may reflect glaucoma with elevated intraocular pressure
    Priya Duggal
    Arch Ophthalmol 125:1716-7; author reply 1717. 2007