KEVIN SCOTT LEE

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. pmc Protection against focal ischemic injury to the brain by trans-sodium crocetinate. Laboratory investigation
    Hiroaki Manabe
    Department of Neuroscience, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosurg 113:802-9. 2010
  2. ncbi request reprint Differential hydroxylation of salicylate in core and penumbra regions during focal reversible cerebral ischemia
    N J Solenski
    Department of Neurology, University of Virginia, Charlottesville 22908, USA
    Stroke 28:2545-51; discussion 2551-2. 1997
  3. ncbi request reprint A murine model of subarachnoid hemorrhage-induced cerebral vasospasm
    Chih Lung Lin
    Departments of Neuroscience and Neurological Surgery, University of Virginia Health System, Box 801392, Charlottesville, VA 22908, USA
    J Neurosci Methods 123:89-97. 2003
  4. ncbi request reprint Cerebral vasospasm after subarachnoid hemorrhage: putative role of inflammation
    Aaron S Dumont
    Department of Neurological Surgery, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Neurosurgery 53:123-33; discussion 133-5. 2003
  5. ncbi request reprint Monoclonal antibody against E selectin attenuates subarachnoid hemorrhage-induced cerebral vasospasm
    Chih Lung Lin
    Department of Neurosurgery, Kaohsiung Medical University, Kaohsiung 80708, Taiwan, ROC
    Surg Neurol 64:201-5; discussion 205-6. 2005
  6. ncbi request reprint Oral administration of an inhibitor of endothelin-converting enzyme attenuates cerebral vasospasm following experimental subarachnoid haemorrhage in rabbits
    Aij Lie Kwan
    Department of Neurosurgery, Kaohsiung Medical University, No 100 Shih chuan 1st Road, Kaohsiung
    Clin Sci (Lond) 103:414S-417S. 2002
  7. ncbi request reprint Characteristics of hypothermic preconditioning influencing the induction of delayed ischemic tolerance
    Masatoshi Yunoki
    Department of Neuroscience, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    J Neurosurg 97:650-7. 2002
  8. ncbi request reprint Attenuation of hemolysate-induced cerebrovascular endothelial cell injury and of production of endothelin-1 and big endothelin-1 by an endothelin-converting enzyme inhibitor
    Chih Zen Chang
    Department of Neurosurgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, Republic of China
    Surg Neurol 58:181-7; discussion 187-8. 2002
  9. ncbi request reprint GABAergic synaptic inhibition is reduced before seizure onset in a genetic model of cortical malformation
    Stacey A Trotter
    Department of Neuroscience, Health Sciences Center, Neuroscience Graduate Program, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosci 26:10756-67. 2006

Collaborators

Detail Information

Publications9

  1. pmc Protection against focal ischemic injury to the brain by trans-sodium crocetinate. Laboratory investigation
    Hiroaki Manabe
    Department of Neuroscience, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosurg 113:802-9. 2010
    ..The present study examined the ability of TSC to modify oxygenation in ischemic neural tissue and tested the potential neuroprotective effects of TSC in permanent and temporary models of focal cerebral ischemia...
  2. ncbi request reprint Differential hydroxylation of salicylate in core and penumbra regions during focal reversible cerebral ischemia
    N J Solenski
    Department of Neurology, University of Virginia, Charlottesville 22908, USA
    Stroke 28:2545-51; discussion 2551-2. 1997
    ..With use of a reproducible model of in vivo focal ischemia/reperfusion, the time course of salicylate hydroxylation was measured in ischemic core and penumbra regions...
  3. ncbi request reprint A murine model of subarachnoid hemorrhage-induced cerebral vasospasm
    Chih Lung Lin
    Departments of Neuroscience and Neurological Surgery, University of Virginia Health System, Box 801392, Charlottesville, VA 22908, USA
    J Neurosci Methods 123:89-97. 2003
    ..g. genetically-altered animals and gene expression arrays). This model also represents a replicable and inexpensive approach for screening therapeutic candidates...
  4. ncbi request reprint Cerebral vasospasm after subarachnoid hemorrhage: putative role of inflammation
    Aaron S Dumont
    Department of Neurological Surgery, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Neurosurgery 53:123-33; discussion 133-5. 2003
    ..Investigations into the nature of the inflammatory response accompanying SAH are needed to elucidate the precise role(s) of inflammatory events in SAH-induced pathologies...
  5. ncbi request reprint Monoclonal antibody against E selectin attenuates subarachnoid hemorrhage-induced cerebral vasospasm
    Chih Lung Lin
    Department of Neurosurgery, Kaohsiung Medical University, Kaohsiung 80708, Taiwan, ROC
    Surg Neurol 64:201-5; discussion 205-6. 2005
    ..This study was designed to examine the effect of a highly specific antibody, monoclonal anti-E-selectin antibody, on cerebral vasospasm in a new murine SAH model...
  6. ncbi request reprint Oral administration of an inhibitor of endothelin-converting enzyme attenuates cerebral vasospasm following experimental subarachnoid haemorrhage in rabbits
    Aij Lie Kwan
    Department of Neurosurgery, Kaohsiung Medical University, No 100 Shih chuan 1st Road, Kaohsiung
    Clin Sci (Lond) 103:414S-417S. 2002
    ..These findings also reinforce evidence demonstrating that treatment with an ECE-1 inhibitor is a potentially viable therapeutic approach for reducing cerebral vasospasm after SAH...
  7. ncbi request reprint Characteristics of hypothermic preconditioning influencing the induction of delayed ischemic tolerance
    Masatoshi Yunoki
    Department of Neuroscience, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    J Neurosurg 97:650-7. 2002
    ..The purpose of this study was to characterize the parameters of HPC that regulate the induction of delayed tolerance...
  8. ncbi request reprint Attenuation of hemolysate-induced cerebrovascular endothelial cell injury and of production of endothelin-1 and big endothelin-1 by an endothelin-converting enzyme inhibitor
    Chih Zen Chang
    Department of Neurosurgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, Republic of China
    Surg Neurol 58:181-7; discussion 187-8. 2002
    ..The purpose of the present study was to investigate the effects of an ECE inhibitor, CGS 26303, on hemolysate-induced injury of cerebral vessel endothelial cells as well as the production of ET-1 from these cells...
  9. ncbi request reprint GABAergic synaptic inhibition is reduced before seizure onset in a genetic model of cortical malformation
    Stacey A Trotter
    Department of Neuroscience, Health Sciences Center, Neuroscience Graduate Program, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosci 26:10756-67. 2006
    ..Such alterations represent a rational substrate for reduced seizure thresholds associated with certain cortical malformations...

Research Grants20

  1. PREDOCTORAL TRAINING IN NEUROSCIENCE
    Kevin Lee; Fiscal Year: 2007
    ..The program has a strong track record of producing Neuroscience PhDs with careers in all aspects of modern scientific endeavor. ..
  2. Neurological Impact of Cardiopulmonary Bypass Surgery
    Kevin Lee; Fiscal Year: 2007
    ..The results will expand our fundamental understanding of the mechanisms underlying CPB-related injury and will assess a rational candidate therapy for limiting cognitive decline after CPB. ..
  3. Utility of a Novel Carotenoid for Treating Stroke
    Kevin Lee; Fiscal Year: 2009
    ..The overall goal of the studies is to test whether this novel therapeutic approach is effective in protecting the brain during stroke. ..
  4. Utility of a Novel Carotenoid for Treating Stroke
    KEVIN SCOTT LEE; Fiscal Year: 2010
    ..The overall goal of the studies is to test whether this novel therapeutic approach is effective in protecting the brain during stroke. ..
  5. CNS Plasticity of Human Adipo-derived Multipotent Cells
    Kevin Lee; Fiscal Year: 2004
    ..The results of these studies will provide the first evidence of hADC plasticity in the brain and could form the foundation for future cell-based therapies in the CNS. ..
  6. FOREBRAIN ORGANIZATION IN A NOVEL RAT
    Kevin Lee; Fiscal Year: 2003
    ..The proposed studies will provide fundamental insights into the structure, function and development of a seizure-prone brain with band heterotopia. ..
  7. Delayed Tolerance After Hypothermic Preconditioning
    Kevin Lee; Fiscal Year: 2003
    ..This approach will ultimately facilitate the development of novel gene-based therapies for limiting ischemic injury. ..
  8. Utility of a Novel Carotenoid for Treating Stroke
    Kevin Lee; Fiscal Year: 2009
    ..The overall goal of the studies is to test whether this novel therapeutic approach is effective in protecting the brain during stroke. ..