Jay M Lee

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc IL-27 inhibits epithelial-mesenchymal transition and angiogenic factor production in a STAT1-dominant pathway in human non-small cell lung cancer
    Puja Kachroo
    Lung Cancer Research Program, Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA
    J Exp Clin Cancer Res 32:97. 2013
  2. pmc Inflammation in lung carcinogenesis: new targets for lung cancer chemoprevention and treatment
    Jay M Lee
    Division of Cardiothoracic Surgery, Department of Surgery, UCLA Lung Cancer Research Program, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Crit Rev Oncol Hematol 66:208-17. 2008
  3. ncbi request reprint Vitamin D-mediated hypercalcemia and Cushing syndrome as manifestations of malignant pleural mesothelioma
    Jay M Lee
    Division of Thoracic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Endocr Pract 14:1011-6. 2008
  4. doi request reprint Inflammation, epithelial to mesenchymal transition, and epidermal growth factor receptor tyrosine kinase inhibitor resistance
    Kostyantyn Krysan
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Thorac Oncol 3:107-10. 2008
  5. pmc Smoking and lung cancer: the role of inflammation
    Tonya Walser
    Lung Cancer Research Program, Division of Pulmonary and Critical Care Medicine, 37 131 CHS, 10833 Le Conte Avenue, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
    Proc Am Thorac Soc 5:811-5. 2008
  6. ncbi request reprint Development of transcriptomic biomarker signature in human saliva to detect lung cancer
    Lei Zhang
    School of Dentistry and Dental Research Institute, University of California, Los Angeles, 90095, USA
    Cell Mol Life Sci 69:3341-50. 2012
  7. ncbi request reprint Inflammation and lung carcinogenesis: applying findings in prevention and treatment
    Katherine A Peebles
    David Geffen School of Medicine at UCLA, Division of Pulmonary and Critical Care Medicine and Hospitalists, Department of Medicine, UCLA Lung Cancer Research Program, CA, USA
    Expert Rev Anticancer Ther 7:1405-21. 2007
  8. doi request reprint Single-institution, multidisciplinary experience with surgical resection of primary chest wall sarcomas
    Puja Kachroo
    Department of Surgery, Division of Cardiac and Thoracic Surgery, University of California at Los Angeles, Los Angeles, CA, USA
    J Thorac Oncol 7:552-8. 2012
  9. pmc Myeloid suppressor cells and immune modulation in lung cancer
    Minu K Srivastava
    University of California Los Angeles and Veterans Affairs Greater Los Angeles, CA, USA
    Immunotherapy 4:291-304. 2012
  10. pmc Elevated neutrophil gelatinase-associated lipocalin contributes to erlotinib resistance in non-small cell lung cancer
    Kostyantyn Krysan
    Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA Los Angeles, CA
    Am J Transl Res 5:481-96. 2013

Collaborators

Detail Information

Publications23

  1. pmc IL-27 inhibits epithelial-mesenchymal transition and angiogenic factor production in a STAT1-dominant pathway in human non-small cell lung cancer
    Puja Kachroo
    Lung Cancer Research Program, Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA
    J Exp Clin Cancer Res 32:97. 2013
    ..In this study, we investigated the role of IL-27 in regulating EMT and angiogenesis through modulation of the STAT pathways in human non-small cell lung carcinoma (NSCLC) cells...
  2. pmc Inflammation in lung carcinogenesis: new targets for lung cancer chemoprevention and treatment
    Jay M Lee
    Division of Cardiothoracic Surgery, Department of Surgery, UCLA Lung Cancer Research Program, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Crit Rev Oncol Hematol 66:208-17. 2008
    ..The understanding of molecular mechanisms involved in inflammation and lung carcinogenesis provide insight for new drug development that target reversible, non-mutational events in the chemoprevention and treatment of lung cancer...
  3. ncbi request reprint Vitamin D-mediated hypercalcemia and Cushing syndrome as manifestations of malignant pleural mesothelioma
    Jay M Lee
    Division of Thoracic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Endocr Pract 14:1011-6. 2008
    ..To report a case of coincident hypercalcemia and Cushing syndrome arising from mesothelioma...
  4. doi request reprint Inflammation, epithelial to mesenchymal transition, and epidermal growth factor receptor tyrosine kinase inhibitor resistance
    Kostyantyn Krysan
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Thorac Oncol 3:107-10. 2008
    ..Here we focus on the potential contribution of inflammatory mediator-induced resistance to epidermal growth factor receptor tyrosine kinase inhibitors...
  5. pmc Smoking and lung cancer: the role of inflammation
    Tonya Walser
    Lung Cancer Research Program, Division of Pulmonary and Critical Care Medicine, 37 131 CHS, 10833 Le Conte Avenue, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
    Proc Am Thorac Soc 5:811-5. 2008
    ..Full definition of these pathways will afford the opportunity to intervene in specific inflammatory events mediating lung tumorigenesis and resistance to therapy...
  6. ncbi request reprint Development of transcriptomic biomarker signature in human saliva to detect lung cancer
    Lei Zhang
    School of Dentistry and Dental Research Institute, University of California, Los Angeles, 90095, USA
    Cell Mol Life Sci 69:3341-50. 2012
    ..These results poised the salivary biomarkers for the initiation of a multi-center validation in a definitive clinical context...
  7. ncbi request reprint Inflammation and lung carcinogenesis: applying findings in prevention and treatment
    Katherine A Peebles
    David Geffen School of Medicine at UCLA, Division of Pulmonary and Critical Care Medicine and Hospitalists, Department of Medicine, UCLA Lung Cancer Research Program, CA, USA
    Expert Rev Anticancer Ther 7:1405-21. 2007
    ..These newly discovered molecular mechanisms in the pathogenesis of lung cancer provide novel opportunities for targeted therapy and prevention in lung cancer...
  8. doi request reprint Single-institution, multidisciplinary experience with surgical resection of primary chest wall sarcomas
    Puja Kachroo
    Department of Surgery, Division of Cardiac and Thoracic Surgery, University of California at Los Angeles, Los Angeles, CA, USA
    J Thorac Oncol 7:552-8. 2012
    ..Primary chest wall sarcomas are rare mesenchymal tumors and their mainstay of therapy is wide surgical resection. We report our single-institution, multidisciplinary experience with full-thickness resection for primary chest wall sarcomas...
  9. pmc Myeloid suppressor cells and immune modulation in lung cancer
    Minu K Srivastava
    University of California Los Angeles and Veterans Affairs Greater Los Angeles, CA, USA
    Immunotherapy 4:291-304. 2012
    ..Specific genetic signatures in lung cancer modulate the activities of MDSCs and impact tumor progression. Targeting MDSCs may have a long-term antitumor benefit and is at the forefront of anticancer therapeutic strategies...
  10. pmc Elevated neutrophil gelatinase-associated lipocalin contributes to erlotinib resistance in non-small cell lung cancer
    Kostyantyn Krysan
    Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA Los Angeles, CA
    Am J Transl Res 5:481-96. 2013
    ..Correlations between plasma neutrophil gelatinase associated lipocalin (NGAL) levels, erlotinib response and the EGFR mutational status were assessed in advanced stage NSCLC patients treated with erlotinib...
  11. pmc Pre-clinical characterization of GMP grade CCL21-gene modified dendritic cells for application in a phase I trial in non-small cell lung cancer
    Felicita Baratelli
    UCLA Lung Cancer Research Program of the Jonsson Comprehensive Cancer Center, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Los Angeles, CA 90095, USA
    J Transl Med 6:38. 2008
    ..These results have provided the rationale to generate a clinical grade adenoviral vector encoding CCL-21 for ex vivo transduction of human DC in order to assess intratumoral administration in late stage human lung cancer...
  12. pmc Myeloid suppressor cell depletion augments antitumor activity in lung cancer
    Minu K Srivastava
    Department of Medicine, UCLA Lung Cancer Research Program, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America
    PLoS ONE 7:e40677. 2012
    ..We evaluated the mechanistic role of MDSC depletion on antigen presenting cell (APC), NK, T cell activities and therapeutic vaccination responses in murine models of lung cancer...
  13. pmc TLR3 agonists and proinflammatory antitumor activities
    Sherven Sharma
    UCLA Lung Cancer Research Program, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Los Angeles, CA, USA 1 310 478 3711 ext 41863 1 310 268 4807
    Expert Opin Ther Targets 17:481-3. 2013
    ..Herein, we summarize the TLR3 agonists that will hopefully come to clinical fruition...
  14. pmc Snail promotes CXCR2 ligand-dependent tumor progression in non-small cell lung carcinoma
    Jane Yanagawa
    Lung Cancer Research Program, Division of Pulmonary and Critical Care Medicine, 10833 Le Conte Avenue, 37 131 CHS, Los Angeles, CA 90095 1690, USA
    Clin Cancer Res 15:6820-9. 2009
    ..However, other important Snail-dependent malignant phenotypes have not been fully explored. Here, we investigate the contributions of Snail to the progression of non-small cell lung cancer (NSCLC)...
  15. doi request reprint Chest wall sarcomas are accurately diagnosed by image-guided core needle biopsy
    Puja Kachroo
    Division of Cardiac and Thoracic Surgery, Department of Surgery, David Geffen School of Medicine at University of California, Los Angeles, CA, USA
    J Thorac Oncol 7:151-6. 2012
    ..Accurate preoperative diagnosis is a prerequisite in considering investigational or institutional management algorithms that include neoadjuvant treatment. We reviewed our experience using core needle biopsy for chest wall sarcomas...
  16. pmc Surgical management of endobronchial solitary fibrous tumors
    Peter S Pak
    Lung Cancer Research Program of the Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7313, USA
    Ann Thorac Surg 90:659-61. 2010
    ..This report describes the challenging surgical management of an infrequently encountered tumor in a unique location...
  17. ncbi request reprint Adenovirus vector-mediated overexpression of a truncated form of the p65 nuclear factor kappa B cDNA in dendritic cells enhances their function resulting in immune-mediated suppression of preexisting murine tumors
    Jay M Lee
    Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 8:3561-9. 2002
    ..The purpose of this study was to evaluate the effect of the Rel homology domain (RHD) of the transcription factor, nuclear factor kappa B (NF kappa B), on proinflammatory gene expression in bone marrow-derived dendritic cells (BMDCs)...
  18. pmc Proteomic analysis of human saliva from lung cancer patients using two-dimensional difference gel electrophoresis and mass spectrometry
    Hua Xiao
    Dental Research Institute, University of California, Los Angeles, Los Angeles, California 90095, USA
    Mol Cell Proteomics 11:M111.012112. 2012
    ..The discriminatory power of these candidate biomarkers indicate that a simple saliva test might be established for lung cancer clinical screening and detection...
  19. pmc Chemokines: can effector cells be redirected to the site of the tumor?
    Steven M Dubinett
    Department of Medicine, University of California Los Angeles Lung Cancer Research Program, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Cancer J 16:325-35. 2010
    ..We review several areas of chemokine importance in tumor immunity and discuss the experimental evidence that is leading to the clinical use of this cytokine family in new treatment approaches for patients with cancer...
  20. ncbi request reprint Resection of thyroid cancer metastases to the sternum
    Jane Yanagawa
    Lung Cancer Research Program of the Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Thorac Oncol 4:1022-5. 2009
    ..Overall, we demonstrate that radical resection of sternal metastases can be performed safely even in patients with poor prognosis to achieve palliation and potentiation of radioiodine therapy for concurrent metastases...
  21. ncbi request reprint Incidental Mediastinal Dose Does Not Explain Low Mediastinal Node Recurrence Rates in Patients With Early-Stage NSCLC Treated With Stereotactic Body Radiotherapy
    Jean Claude M Rwigema
    Department of Radiation Oncology, Ronald Reagan UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA
    Clin Lung Cancer 15:287-93. 2014
    ..We determined incidental SBRT doses to assess whether this could account for the low rates of recurrence...
  22. ncbi request reprint Adenovirus vector-mediated transfer of the vascular endothelial growth factor cDNA to healing abdominal fascia enhances vascularity and bursting strength in mice with normal and impaired wound healing
    Maneesh Ailawadi
    Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Surgery 131:219-27. 2002
    ..We hypothesized that adenovirus-mediated transfer of the vascular endothelial growth factor (VEGF121) complementary DNA (cDNA) to murine laparotomy fascial wounds would enhance vascularity and bursting strength...
  23. ncbi request reprint Intratumoral expression of macrophage-derived chemokine induces CD4+ T cell-independent antitumor immunity in mice
    Jay M Lee
    Deparment of Cardiothoracic Surgery, Division of Pulmonary and Critical Care Medicine, Sloan Kettering Cancer Center, New York, NY, USA
    J Immunother 26:117-29. 2003
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