James C Lee

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Gene expression profiling of flaxseed in mouse lung tissues-modulation of toxicologically relevant genes
    Floyd Dukes
    Department of Medicine, Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, Philadelphia, PA 19104, USA
    BMC Complement Altern Med 12:47. 2012
  2. doi request reprint Primary graft dysfunction
    James C Lee
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Am Thorac Soc 6:39-46. 2009
  3. doi request reprint Primary graft dysfunction: definition, risk factors, short- and long-term outcomes
    James C Lee
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Semin Respir Crit Care Med 31:161-71. 2010
  4. doi request reprint Primary graft dysfunction
    James C Lee
    Division of Pulmonary, Allergy and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Clin Chest Med 32:279-93. 2011
  5. pmc Clinical risk factors for primary graft dysfunction after lung transplantation
    Joshua M Diamond
    Pulmonary, Allergy and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 187:527-34. 2013
  6. pmc Plasma monocyte chemotactic protein-1 levels at 24 hours are a biomarker of primary graft dysfunction after lung transplantation
    Rupal J Shah
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Transl Res 160:435-42. 2012
  7. pmc Variation in PTX3 is associated with primary graft dysfunction after lung transplantation
    Joshua M Diamond
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, 3400 Spruce St, 8 West Gates, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 186:546-52. 2012
  8. doi request reprint Donor transmission of malignant melanoma in a lung transplant recipient 32 years after curative resection
    Navkaranbir S Bajaj
    University of Alabama, Ryals School of Public Health, Birmingham, AL, USA
    Transpl Int 23:e26-31. 2010
  9. doi request reprint Lung transplantation in autoimmune diseases
    James C Lee
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Clin Chest Med 31:589-603. 2010
  10. pmc A panel of lung injury biomarkers enhances the definition of primary graft dysfunction (PGD) after lung transplantation
    Rupal J Shah
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Heart Lung Transplant 31:942-9. 2012

Collaborators

Detail Information

Publications13

  1. pmc Gene expression profiling of flaxseed in mouse lung tissues-modulation of toxicologically relevant genes
    Floyd Dukes
    Department of Medicine, Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, Philadelphia, PA 19104, USA
    BMC Complement Altern Med 12:47. 2012
    ..We therefore postulated that flaxseed might modulate gene expression of vital signaling pathways, thus interfering with the development of tissue injury...
  2. doi request reprint Primary graft dysfunction
    James C Lee
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Am Thorac Soc 6:39-46. 2009
    ..Finally, we will summarize efforts at finding genetic and molecular markers for PGD and discuss future directions for PGD research...
  3. doi request reprint Primary graft dysfunction: definition, risk factors, short- and long-term outcomes
    James C Lee
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Semin Respir Crit Care Med 31:161-71. 2010
    ..Studies examining the short- and long-term effects of PGD on lung transplant outcomes are reviewed. Lastly, we highlight the emerging concepts in lung transplantation that will potentially impact PGD incidence and outcomes...
  4. doi request reprint Primary graft dysfunction
    James C Lee
    Division of Pulmonary, Allergy and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Clin Chest Med 32:279-93. 2011
    ..This article aims to provide a state-of-the-art review of PGD epidemiology, outcomes, and risk factors, and to summarize current efforts at biomarker development and novel strategies for prevention and treatment...
  5. pmc Clinical risk factors for primary graft dysfunction after lung transplantation
    Joshua M Diamond
    Pulmonary, Allergy and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 187:527-34. 2013
    ..Clinical trial registered with www.clinicaltrials.gov (NCT 00552357)...
  6. pmc Plasma monocyte chemotactic protein-1 levels at 24 hours are a biomarker of primary graft dysfunction after lung transplantation
    Rupal J Shah
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Transl Res 160:435-42. 2012
    ..Persistent elevations in MCP-1 levels at 24 hours are a biomarker of grade 3 PGD post-transplantation. Monocyte chemotaxis may play a role in the pathogenesis of PGD...
  7. pmc Variation in PTX3 is associated with primary graft dysfunction after lung transplantation
    Joshua M Diamond
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, 3400 Spruce St, 8 West Gates, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 186:546-52. 2012
    ..Elevated long pentraxin-3 (PTX3) levels are associated with the development of primary graft dysfunction (PGD) after lung transplantation. Abnormalities in innate immunity, mediated by PTX3 release, may play a role in PGD pathogenesis...
  8. doi request reprint Donor transmission of malignant melanoma in a lung transplant recipient 32 years after curative resection
    Navkaranbir S Bajaj
    University of Alabama, Ryals School of Public Health, Birmingham, AL, USA
    Transpl Int 23:e26-31. 2010
    ....
  9. doi request reprint Lung transplantation in autoimmune diseases
    James C Lee
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Clin Chest Med 31:589-603. 2010
    ..The reasons for this low number are multifactorial. This article reviews issues relevant to all lung transplant candidates and recipients as well as those specific to patients with autoimmune diseases...
  10. pmc A panel of lung injury biomarkers enhances the definition of primary graft dysfunction (PGD) after lung transplantation
    Rupal J Shah
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Heart Lung Transplant 31:942-9. 2012
    ..We aimed to identify combinations of biomarkers to enhance the definition of primary graft dysfunction (PGD) for translational research...
  11. pmc Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice
    James C Lee
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Radiat Res 173:590-601. 2010
    ..Thus dietary curcumin ameliorates radiation-induced pulmonary fibrosis and increases mouse survival while not impairing tumor cell killing by radiation...
  12. pmc Dietary flaxseed prevents radiation-induced oxidative lung damage, inflammation and fibrosis in a mouse model of thoracic radiation injury
    James C Lee
    Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, 19104, USA
    Cancer Biol Ther 8:47-53. 2009
    ..Taken together, these data suggest that dietary flaxseed may be clinically useful as an agent to increase the therapeutic index of thoracic XRT by increasing the radiation tolerance of lung tissues...
  13. ncbi request reprint Dietary flaxseed enhances antioxidant defenses and is protective in a mouse model of lung ischemia-reperfusion injury
    James C Lee
    Department of Medicine, Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, Abramson Research Center, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA
    Am J Physiol Lung Cell Mol Physiol 294:L255-65. 2008
    ..We conclude that dietary FS is protective against IRI in an experimental murine model and that FS affects ROS generation and ROS detoxification via pathways not limited to upregulation of antioxidant enzymes such as HO-1...