Research Topics
Genomes and Genes | Jae Woo LeeSummaryAffiliation: University of California Country: USA Publications
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Publications
Nitric oxide decreases surfactant protein gene expression in primary cultures of type II pneumocytesJae W Lee
Dept of Anesthesiology, University of California San Francisco, CA 94143, USA
Am J Physiol Lung Cell Mol Physiol 288:L950-7. 2005..The results showed that NO mediated the decrease in surfactant protein gene expression at least in part through an increase in endothelin-1 secretion and a decrease in phosphorylated ERK1/2 MAPKs...- Increased pulmonary blood flow does not alter surfactant protein gene expression in lambs within the first week of lifeJae W Lee
Department of Anesthesiology, University of California, CA 94143, USA
Am J Physiol Lung Cell Mol Physiol 286:L1237-43. 2004.... 
beta2 adrenergic agonists in acute lung injury? The heart of the matterJae W Lee
Departments of Anesthesiology and the Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
Crit Care 13:1011. 2009..The authors demonstrate that, in oleic acid lung injury in dogs, the inotropic effect of beta agonists may recruit damaged pulmonary capillaries, leading to increased lung endothelial permeability...- Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lungJae W Lee
Department of Anesthesiology, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 106:16357-62. 2009..In summary, treatment with allogeneic human MSCs or the conditioned medium restores normal fluid balance in an ex vivo perfused human lung injured by E. coli endotoxin... - Potential application of mesenchymal stem cells in acute lung injuryJae Woo Lee
University of California, Anesthesiology, 505 Parnassus Avenue, Box 0648, San Francisco, CA 94143 0648, USA
Expert Opin Biol Ther 9:1259-70. 2009..The review concludes with a discussion of future research directions required for potential clinical trials... - Acute lung injury edema fluid decreases net fluid transport across human alveolar epithelial type II cellsJae W Lee
Department of Anesthesiology, University of California, San Francisco, CA 94143, USA
J Biol Chem 282:24109-19. 2007.... - Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in miceNaveen Gupta
Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
J Immunol 179:1855-63. 2007..In conclusion, treatment with intrapulmonary MSC markedly decreases the severity of endotoxin-induced acute lung injury and improves survival in mice... - Human mesenchymal stem cells reduce mortality and bacteremia in gram-negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytesAnna Krasnodembskaya
Cardiovascular Research Institute and Department of Anesthesiology, University of California San Francisco, 505 Parnassus Ave, CA 94143, USA
Am J Physiol Lung Cell Mol Physiol 302:L1003-13. 2012..Thus intravenous MSC increased survival from gram-negative peritoneal sepsis, in part by a monocyte-dependent increase in bacterial phagocytosis... - Role of CFTR expressed by neutrophils in modulating acute lung inflammation and injury in miceXiao Su
Cardiovascular Research Institute, University of California, San Francisco, HSW 825, 505 Parnassus Ave, San Francisco, CA 94143 0130, USA
Inflamm Res 60:619-32. 2011..In this study, we investigated whether a lack of functional CFTR in neutrophils would promote lipopolysaccharide (LPS)-induced lung inflammation and injury... - Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37Anna Krasnodembskaya
The Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
Stem Cells 28:2229-38. 2010..Human bone marrow-derived MSCs possess direct antimicrobial activity, which is mediated in part by the secretion of human cathelicidin hCAP-18/ LL-37... - Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and ratsXiao Su
Cardiovascular Research Institute, University of California San Francisco, HSW 825, 505 Parnassus Ave, San Francisco, CA 94143 0130, USA
Am J Respir Cell Mol Biol 37:186-92. 2007..These results indicate that activation of alpha7 nAChR may provide a new therapeutic pathway for the treatment of acute lung injury... - Claudin-4 levels are associated with intact alveolar fluid clearance in human lungsDeepti Rokkam
San Francisco VA Medical Center, University of California San Francisco, San Francisco, California, USA
Am J Pathol 179:1081-7. 2011.... - Distribution and surfactant association of carcinoembryonic cell adhesion molecule 6 in human lungCheryl Chapin
Department of Pediatrics, University of California San Francisco, San Francisco, California, USA
Am J Physiol Lung Cell Mol Physiol 302:L216-25. 2012..Production appears to be upregulated during neonatal lung disease, perhaps related to roles of CEACAM6 in surfactant function, cell proliferation, and innate immune defense... 
Mesenchymal stem cells for acute lung injury: preclinical evidenceMichael A Matthay
Department of Medicine, University of California, San Francisco, CA, USA
Crit Care Med 38:S569-73. 2010..Further preclinical studies are needed, as is planning for clinical trials for acute lung injury...- Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungsJames A Frank
Department of Medicine, University of California, San Francisco, California, USA
Am J Physiol Lung Cell Mol Physiol 293:L52-9. 2007..Also, although additional studies are needed, a biological marker of alveolar epithelial injury may be useful clinically in predicting preserved AFC... - Activation of the stress protein response inhibits the STAT1 signalling pathway and iNOS function in alveolar macrophages: role of Hsp90 and Hsp70Marybeth Howard
Laboratory of Surgical Research, Department of Anesthesia, University of California, San Francisco, CA 94110, USA
Thorax 65:346-53. 2010..The activation of the stress protein response (SPR) in alveolar macrophages on iNOS-dependent NO production in response to interferon gamma (IFNgamma), a major cytokine present in the airspace of patients with ALI, was investigated... - Regulated gene expression in cultured type II cells of adult human lungPhilip L Ballard
Department of Pediatrics, University of California San Francisco, San Francisco, USA
Am J Physiol Lung Cell Mol Physiol 299:L36-50. 2010..Our results further define the adult human type II cell molecular phenotype and demonstrate that a subset of genes remains hormone responsive in cultured adult cells... - Therapeutic potential of mesenchymal stem cells for severe acute lung injuryMichael A Matthay
Department of Medicine, University of California, San Francisco, CA 94143 0624, USA
Chest 138:965-72. 2010..There is a dual focus on how to design trials for testing both safety and efficacy... - Airway surface liquid depth measured in ex vivo fragments of pig and human trachea: dependence on Na+ and Cl- channel functionYuanlin Song
Department of Anesthesia and Perioperative Care, Univ of California, San Francisco, 94143 0521, USA
Am J Physiol Lung Cell Mol Physiol 297:L1131-40. 2009..We suggest that CF lung disease may be caused by the inability of CFTR-deficient airways to increase their ASL depth transiently following secretory stimuli that in non-CF airways produce transient increases in ASL depth... - Elevated levels of the receptor for advanced glycation end products, a marker of alveolar epithelial type I cell injury, predict impaired alveolar fluid clearance in isolated perfused human lungsRaphael Briot
University of California, San Francisco, Cardiovascular Research Institute, San Francisco, CA 94143 0624, USA
Chest 135:269-75. 2009..A second objective was to determine whether levels of a marker of endothelial injury, von Willebrand factor antigen (vWF:Ag), are associated with impaired AFC... - Allogeneic human mesenchymal stem cells restore epithelial protein permeability in cultured human alveolar type II cells by secretion of angiopoietin-1Xiaohui Fang
The Cardiovascular Research Institute, San Francisco, California, USA
J Biol Chem 285:26211-22. 2010..This study provides novel evidence for a beneficial effect of MSC on alveolar epithelial permeability to protein... - Concise review: Mesenchymal stem cells for acute lung injury: role of paracrine soluble factorsJae W Lee
Department of Anesthesiology, University of California San Francisco, California 94143, USA
Stem Cells 29:913-9. 2011..This review will focus on recent studies, which support the potential therapeutic use of MSCs in ALI/ARDS, with an emphasis on the role of paracrine soluble factors... - Protein permeability in lung injury: now in real time again?Jae W Lee
J Appl Physiol 102:508-9. 2007 - Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferasesSeunghee Lee
Deparment of Molecular and Cellular Biology, Division of Diabetes, Endocrinology, and Metabolism, and Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 103:15392-7. 2006.... - A regulatory network to segregate the identity of neuronal subtypesSeunghee Lee
Department of Molecular Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Dev Cell 14:877-89. 2008..Thus, our study uncovers a regulatory network to segregate related cell fates, which involves reciprocal feedforward gene regulatory loops...