Jae Woo Lee

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Nitric oxide decreases surfactant protein gene expression in primary cultures of type II pneumocytes
    Jae W Lee
    Dept of Anesthesiology, University of California San Francisco, CA 94143, USA
    Am J Physiol Lung Cell Mol Physiol 288:L950-7. 2005
  2. pmc Allogeneic human mesenchymal stem cells restore epithelial protein permeability in cultured human alveolar type II cells by secretion of angiopoietin-1
    Xiaohui Fang
    The Cardiovascular Research Institute, San Francisco, California, USA
    J Biol Chem 285:26211-22. 2010
  3. ncbi request reprint Increased pulmonary blood flow does not alter surfactant protein gene expression in lambs within the first week of life
    Jae W Lee
    Department of Anesthesiology, University of California, CA 94143, USA
    Am J Physiol Lung Cell Mol Physiol 286:L1237-43. 2004
  4. pmc beta2 adrenergic agonists in acute lung injury? The heart of the matter
    Jae W Lee
    Departments of Anesthesiology and the Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    Crit Care 13:1011. 2009
  5. pmc Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung
    Jae W Lee
    Department of Anesthesiology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:16357-62. 2009
  6. pmc Potential application of mesenchymal stem cells in acute lung injury
    Jae Woo Lee
    University of California, Anesthesiology, 505 Parnassus Avenue, Box 0648, San Francisco, CA 94143 0648, USA
    Expert Opin Biol Ther 9:1259-70. 2009
  7. pmc Acute lung injury edema fluid decreases net fluid transport across human alveolar epithelial type II cells
    Jae W Lee
    Department of Anesthesiology, University of California, San Francisco, CA 94143, USA
    J Biol Chem 282:24109-19. 2007
  8. ncbi request reprint Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice
    Naveen Gupta
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 179:1855-63. 2007
  9. pmc Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37
    Anna Krasnodembskaya
    The Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
    Stem Cells 28:2229-38. 2010
  10. pmc Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats
    Xiao Su
    Cardiovascular Research Institute, University of California San Francisco, HSW 825, 505 Parnassus Ave, San Francisco, CA 94143 0130, USA
    Am J Respir Cell Mol Biol 37:186-92. 2007

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Nitric oxide decreases surfactant protein gene expression in primary cultures of type II pneumocytes
    Jae W Lee
    Dept of Anesthesiology, University of California San Francisco, CA 94143, USA
    Am J Physiol Lung Cell Mol Physiol 288:L950-7. 2005
    ..The results showed that NO mediated the decrease in surfactant protein gene expression at least in part through an increase in endothelin-1 secretion and a decrease in phosphorylated ERK1/2 MAPKs...
  2. pmc Allogeneic human mesenchymal stem cells restore epithelial protein permeability in cultured human alveolar type II cells by secretion of angiopoietin-1
    Xiaohui Fang
    The Cardiovascular Research Institute, San Francisco, California, USA
    J Biol Chem 285:26211-22. 2010
    ..This study provides novel evidence for a beneficial effect of MSC on alveolar epithelial permeability to protein...
  3. ncbi request reprint Increased pulmonary blood flow does not alter surfactant protein gene expression in lambs within the first week of life
    Jae W Lee
    Department of Anesthesiology, University of California, CA 94143, USA
    Am J Physiol Lung Cell Mol Physiol 286:L1237-43. 2004
    ....
  4. pmc beta2 adrenergic agonists in acute lung injury? The heart of the matter
    Jae W Lee
    Departments of Anesthesiology and the Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    Crit Care 13:1011. 2009
    ..The authors demonstrate that, in oleic acid lung injury in dogs, the inotropic effect of beta agonists may recruit damaged pulmonary capillaries, leading to increased lung endothelial permeability...
  5. pmc Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung
    Jae W Lee
    Department of Anesthesiology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:16357-62. 2009
    ..In summary, treatment with allogeneic human MSCs or the conditioned medium restores normal fluid balance in an ex vivo perfused human lung injured by E. coli endotoxin...
  6. pmc Potential application of mesenchymal stem cells in acute lung injury
    Jae Woo Lee
    University of California, Anesthesiology, 505 Parnassus Avenue, Box 0648, San Francisco, CA 94143 0648, USA
    Expert Opin Biol Ther 9:1259-70. 2009
    ..The review concludes with a discussion of future research directions required for potential clinical trials...
  7. pmc Acute lung injury edema fluid decreases net fluid transport across human alveolar epithelial type II cells
    Jae W Lee
    Department of Anesthesiology, University of California, San Francisco, CA 94143, USA
    J Biol Chem 282:24109-19. 2007
    ....
  8. ncbi request reprint Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice
    Naveen Gupta
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 179:1855-63. 2007
    ..In conclusion, treatment with intrapulmonary MSC markedly decreases the severity of endotoxin-induced acute lung injury and improves survival in mice...
  9. pmc Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37
    Anna Krasnodembskaya
    The Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
    Stem Cells 28:2229-38. 2010
    ..Human bone marrow-derived MSCs possess direct antimicrobial activity, which is mediated in part by the secretion of human cathelicidin hCAP-18/ LL-37...
  10. pmc Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats
    Xiao Su
    Cardiovascular Research Institute, University of California San Francisco, HSW 825, 505 Parnassus Ave, San Francisco, CA 94143 0130, USA
    Am J Respir Cell Mol Biol 37:186-92. 2007
    ..These results indicate that activation of alpha7 nAChR may provide a new therapeutic pathway for the treatment of acute lung injury...
  11. pmc Human mesenchymal stem cells reduce mortality and bacteremia in gram-negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytes
    Anna Krasnodembskaya
    Cardiovascular Research Institute and Department of Anesthesiology, University of California San Francisco, 505 Parnassus Ave, CA 94143, USA
    Am J Physiol Lung Cell Mol Physiol 302:L1003-13. 2012
    ..Thus intravenous MSC increased survival from gram-negative peritoneal sepsis, in part by a monocyte-dependent increase in bacterial phagocytosis...
  12. pmc Role of CFTR expressed by neutrophils in modulating acute lung inflammation and injury in mice
    Xiao Su
    Cardiovascular Research Institute, University of California, San Francisco, HSW 825, 505 Parnassus Ave, San Francisco, CA 94143 0130, USA
    Inflamm Res 60:619-32. 2011
    ..In this study, we investigated whether a lack of functional CFTR in neutrophils would promote lipopolysaccharide (LPS)-induced lung inflammation and injury...
  13. pmc Claudin-4 levels are associated with intact alveolar fluid clearance in human lungs
    Deepti Rokkam
    San Francisco VA Medical Center, University of California San Francisco, San Francisco, California, USA
    Am J Pathol 179:1081-7. 2011
    ....
  14. pmc Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs
    James A Frank
    Department of Medicine, University of California, San Francisco, California, USA
    Am J Physiol Lung Cell Mol Physiol 293:L52-9. 2007
    ..Also, although additional studies are needed, a biological marker of alveolar epithelial injury may be useful clinically in predicting preserved AFC...
  15. pmc Distribution and surfactant association of carcinoembryonic cell adhesion molecule 6 in human lung
    Cheryl Chapin
    Department of Pediatrics, University of California San Francisco, San Francisco, California, USA
    Am J Physiol Lung Cell Mol Physiol 302:L216-25. 2012
    ..Production appears to be upregulated during neonatal lung disease, perhaps related to roles of CEACAM6 in surfactant function, cell proliferation, and innate immune defense...
  16. pmc Mesenchymal stem cells for acute lung injury: preclinical evidence
    Michael A Matthay
    Department of Medicine, University of California, San Francisco, CA, USA
    Crit Care Med 38:S569-73. 2010
    ..Further preclinical studies are needed, as is planning for clinical trials for acute lung injury...
  17. pmc Activation of the stress protein response inhibits the STAT1 signalling pathway and iNOS function in alveolar macrophages: role of Hsp90 and Hsp70
    Marybeth Howard
    Laboratory of Surgical Research, Department of Anesthesia, University of California, San Francisco, CA 94110, USA
    Thorax 65:346-53. 2010
    ..The activation of the stress protein response (SPR) in alveolar macrophages on iNOS-dependent NO production in response to interferon gamma (IFNgamma), a major cytokine present in the airspace of patients with ALI, was investigated...
  18. pmc Regulated gene expression in cultured type II cells of adult human lung
    Philip L Ballard
    Department of Pediatrics, University of California San Francisco, San Francisco, USA
    Am J Physiol Lung Cell Mol Physiol 299:L36-50. 2010
    ..Our results further define the adult human type II cell molecular phenotype and demonstrate that a subset of genes remains hormone responsive in cultured adult cells...
  19. pmc Therapeutic potential of mesenchymal stem cells for severe acute lung injury
    Michael A Matthay
    Department of Medicine, University of California, San Francisco, CA 94143 0624, USA
    Chest 138:965-72. 2010
    ..There is a dual focus on how to design trials for testing both safety and efficacy...
  20. pmc Airway surface liquid depth measured in ex vivo fragments of pig and human trachea: dependence on Na+ and Cl- channel function
    Yuanlin Song
    Department of Anesthesia and Perioperative Care, Univ of California, San Francisco, 94143 0521, USA
    Am J Physiol Lung Cell Mol Physiol 297:L1131-40. 2009
    ..We suggest that CF lung disease may be caused by the inability of CFTR-deficient airways to increase their ASL depth transiently following secretory stimuli that in non-CF airways produce transient increases in ASL depth...
  21. pmc Elevated levels of the receptor for advanced glycation end products, a marker of alveolar epithelial type I cell injury, predict impaired alveolar fluid clearance in isolated perfused human lungs
    Raphael Briot
    University of California, San Francisco, Cardiovascular Research Institute, San Francisco, CA 94143 0624, USA
    Chest 135:269-75. 2009
    ..A second objective was to determine whether levels of a marker of endothelial injury, von Willebrand factor antigen (vWF:Ag), are associated with impaired AFC...
  22. pmc Mfge8 suppresses airway hyperresponsiveness in asthma by regulating smooth muscle contraction
    Makoto Kudo
    Lung Biology Center, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 110:660-5. 2013
    ..These data indicate that Mfge8 binding to integrin receptors on ASM opposes the effect of allergic inflammation on RhoA activity and identify a pathway for specific inhibition of ASM hypercontractility in asthma...
  23. pmc Concise review: Mesenchymal stem cells for acute lung injury: role of paracrine soluble factors
    Jae W Lee
    Department of Anesthesiology, University of California San Francisco, California 94143, USA
    Stem Cells 29:913-9. 2011
    ..This review will focus on recent studies, which support the potential therapeutic use of MSCs in ALI/ARDS, with an emphasis on the role of paracrine soluble factors...
  24. ncbi request reprint Protein permeability in lung injury: now in real time again?
    Jae W Lee
    J Appl Physiol 102:508-9. 2007
  25. pmc Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases
    Seunghee Lee
    Deparment of Molecular and Cellular Biology, Division of Diabetes, Endocrinology, and Metabolism, and Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:15392-7. 2006
    ....
  26. pmc A regulatory network to segregate the identity of neuronal subtypes
    Seunghee Lee
    Department of Molecular Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Dev Cell 14:877-89. 2008
    ..Thus, our study uncovers a regulatory network to segregate related cell fates, which involves reciprocal feedforward gene regulatory loops...