Gloria Lee

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. ncbi request reprint The microtubule binding domain of tau protein
    G Lee
    Department of Neurology Neuroscience, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115
    Neuron 2:1615-24. 1989
  2. ncbi request reprint Phosphorylation of tau by fyn: implications for Alzheimer's disease
    Gloria Lee
    Department of Internal Medicine, University of Iowa, Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Neurosci 24:2304-12. 2004
  3. ncbi request reprint Tau and src family tyrosine kinases
    Gloria Lee
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Biochim Biophys Acta 1739:323-30. 2005
  4. ncbi request reprint Tau interacts with src-family non-receptor tyrosine kinases
    G Lee
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Cell Sci 111:3167-77. 1998
  5. ncbi request reprint Tau impacts on growth-factor-stimulated actin remodeling
    Vandana M Sharma
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Cell Sci 120:748-57. 2007
  6. ncbi request reprint Disease-related modifications in tau affect the interaction between Fyn and Tau
    Kiran Bhaskar
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 280:35119-25. 2005
  7. doi request reprint Two motifs within the tau microtubule-binding domain mediate its association with the hsc70 molecular chaperone
    Mitul Sarkar
    Program in Neuroscience and Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
    J Neurosci Res 86:2763-73. 2008
  8. doi request reprint Microtubule-associated protein tau in human prostate cancer cells: isoforms, phosphorylation, and interactions
    Skye Souter
    Program in Molecular and Cellular Biology, Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Cell Biochem 108:555-64. 2009
  9. pmc Tau potentiates nerve growth factor-induced mitogen-activated protein kinase signaling and neurite initiation without a requirement for microtubule binding
    Chad J Leugers
    Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 285:19125-34. 2010
  10. pmc Tau and tauopathies
    Gloria Lee
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
    Prog Mol Biol Transl Sci 107:263-93. 2012

Collaborators

Detail Information

Publications24

  1. ncbi request reprint The microtubule binding domain of tau protein
    G Lee
    Department of Neurology Neuroscience, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115
    Neuron 2:1615-24. 1989
    ..Fragments containing two or one repeat are also capable of binding, indicating that the basic tubulin interacting unit is one repeat...
  2. ncbi request reprint Phosphorylation of tau by fyn: implications for Alzheimer's disease
    Gloria Lee
    Department of Internal Medicine, University of Iowa, Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Neurosci 24:2304-12. 2004
    ..We also found evidence suggesting that differentially phosphorylated tau existed within degenerating neurons. Our data add new support for a role for fyn in the neurodegenerative process...
  3. ncbi request reprint Tau and src family tyrosine kinases
    Gloria Lee
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Biochim Biophys Acta 1739:323-30. 2005
    ..The subsequent finding that tau is tyrosine phosphorylated has led to the observation that tau in neurofibrillary tangles is tyrosine phosphorylated. Therefore, a role for tyrosine kinases such as fyn in neuropathogenesis is predicted...
  4. ncbi request reprint Tau interacts with src-family non-receptor tyrosine kinases
    G Lee
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Cell Sci 111:3167-77. 1998
    ..The tyrosine phosphorylation of tau by fyn may also have a role in neuropathogenesis, as fyn is upregulated in Alzheimer's disease...
  5. ncbi request reprint Tau impacts on growth-factor-stimulated actin remodeling
    Vandana M Sharma
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Cell Sci 120:748-57. 2007
    ..Our results provide evidence that the interaction of tau with Src upregulates tyrosine kinase activity and that this interaction allows tau to impact on growth-factor-induced actin remodeling...
  6. ncbi request reprint Disease-related modifications in tau affect the interaction between Fyn and Tau
    Kiran Bhaskar
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 280:35119-25. 2005
    ..Our data support a role for the Fyn-tau interaction in neurodegeneration...
  7. doi request reprint Two motifs within the tau microtubule-binding domain mediate its association with the hsc70 molecular chaperone
    Mitul Sarkar
    Program in Neuroscience and Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
    J Neurosci Res 86:2763-73. 2008
    ..Our results provide an important stimulus for research into how the hsc70-tau interaction might affect tau fate in normal cells and in disease...
  8. doi request reprint Microtubule-associated protein tau in human prostate cancer cells: isoforms, phosphorylation, and interactions
    Skye Souter
    Program in Molecular and Cellular Biology, Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Cell Biochem 108:555-64. 2009
    ..Our results suggest that tau in prostate cancer cells does not resemble that from normal adult brain and support the hypothesis that tau is a multifunctional protein...
  9. pmc Tau potentiates nerve growth factor-induced mitogen-activated protein kinase signaling and neurite initiation without a requirement for microtubule binding
    Chad J Leugers
    Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 285:19125-34. 2010
    ..Together, these findings indicate a new functional role for Tau in early neuronal development independent of its established role in microtubule stabilization...
  10. pmc Tau and tauopathies
    Gloria Lee
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
    Prog Mol Biol Transl Sci 107:263-93. 2012
    ..This chapter provides an overview of tau structure, functions, and its involvement in neurodegenerative diseases...
  11. pmc Allele-specific silencing of dominant disease genes
    Victor M Miller
    Department of Neurology, Graduate Program in Genetics, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 100:7195-200. 2003
    ..These studies establish that siRNA can be engineered to silence disease genes differing by a single nucleotide and highlight a key role for SNPs in extending the utility of siRNA in dominantly inherited disorders...
  12. ncbi request reprint B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells
    G J Freeman
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115
    J Immunol 143:2714-22. 1989
    ..These results demonstrate that the B7 gene encodes a unique molecule belonging to the Ig superfamily and that B7 expression is limited to normal activated B cells and noncirculating B cell malignancies...
  13. ncbi request reprint The primary structure and heterogeneity of tau protein from mouse brain
    G Lee
    Department of Neurology, Harvard Medical School, Boston, MA 02115
    Science 239:285-8. 1988
    ..These complementary DNAs should enable the study of various functional domains of tau and the study of tau expression in normal and pathological states...
  14. ncbi request reprint Tubulin-independent tau in Alzheimer's disease and cancer: implications for disease pathogenesis and treatment
    S Souter
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Curr Alzheimer Res 7:697-707. 2010
    ..In fact, structural similarities exist between Alzheimer's disease tau and prostate cancer cell tau, raising the possibility that new tau functions uncovered in prostate cancer cells will have relevance to Alzheimer's disease...
  15. pmc Increase in tau tyrosine phosphorylation correlates with the formation of tau aggregates
    Irving E Vega
    Department of Neuroscience, Mayo Clinic College of Medicine, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
    Brain Res Mol Brain Res 138:135-44. 2005
    ..The results suggest that tyrosine phosphorylation is as important as phosphorylation of other residues in tauopathy...
  16. ncbi request reprint Two protein 4.1 domains essential for mitotic spindle and aster microtubule dynamics and organization in vitro
    Sharon Wald Krauss
    Lawrence Berkeley National Laboratory, Life Sciences Division, University of California, Berkeley 94720, USA
    J Biol Chem 279:27591-8. 2004
    ..These investigations underscore an important functional context for protein 4.1 in microtubule morphogenesis and highlight a previously unappreciated role for 4.1 in cell division...
  17. ncbi request reprint Two distinct domains of protein 4.1 critical for assembly of functional nuclei in vitro
    Sharon Wald Krauss
    Department of Subcellular Structure, Life Sciences Division, University of California, Lawrence Berkeley National Laboratory, 94720, USA
    J Biol Chem 277:44339-46. 2002
    ..1R. Our data establish that protein 4.1 is essential for nuclear assembly and identify two distinct 4.1 domains, initially characterized in cytoskeletal interactions, that have crucial and versatile functions in nuclear assembly...
  18. ncbi request reprint Novel secreted isoform of adhesion molecule ICAM-4: potential regulator of membrane-associated ICAM-4 interactions
    Gloria Lee
    Life Sciences Division, University of California, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Blood 101:1790-7. 2003
    ..We postulate that secretion of this newly described isoform, ICAM-4S, may modulate binding of membrane-associated ICAM-4 and could thus play a critical regulatory role in erythroblast molecular attachments...
  19. ncbi request reprint Expression of the ATP-binding cassette membrane transporter, ABCG2, in human and rodent brain microvessel endothelial and glial cell culture systems
    Gloria Lee
    Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    Pharm Res 24:1262-74. 2007
    ..This project investigates the functional expression of endogenous ABCG2 in cultures of human and rodent brain cellular compartments...
  20. pmc Targeted gene deletion demonstrates that the cell adhesion molecule ICAM-4 is critical for erythroblastic island formation
    Gloria Lee
    Life Sciences Division, University of California, Lawrence Berkeley National Laboratory, Bldg 74, 1 Cyclotron Road, Berkeley, CA 94720, USA
    Blood 108:2064-71. 2006
    ....
  21. ncbi request reprint Phosphorylation of STAT3 serine-727 by cyclin-dependent kinase 1 is critical for nocodazole-induced mitotic arrest
    Xiaoqing Shi
    Brain Research Center and Department of Medicine, University of British Columbia, Vancouver, Canada
    Biochemistry 45:5857-67. 2006
    ..Taken together, our observations point to a novel role of STAT3 Ser-727 phosphorylation in control of the onset and maintenance of the M phase during the cell cycle through downregulation of CDK inhibitors...
  22. ncbi request reprint Functional expression and localization of P-glycoprotein in the central nervous system: relevance to the pathogenesis and treatment of neurological disorders
    Gloria Lee
    Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario M5S 2S2, Canada
    Pharm Res 21:1313-30. 2004
    ....
  23. ncbi request reprint Tau protein binds single-stranded DNA sequence specifically--the proof obtained in vitro with non-equilibrium capillary electrophoresis of equilibrium mixtures
    Svetlana M Krylova
    Department of Chemistry, York University, Toronto, Ont, Canada M3J 1P3
    FEBS Lett 579:1371-5. 2005
    ..Moreover, we determined the equilibrium dissociation constants for all tau-DNA complexes studied...

Research Grants16

  1. Tyrosine Phosphorylation in Alzheimer's Disease
    Gloria Lee; Fiscal Year: 2009
    ..The identification of the fyn-tau interaction as a critical event in the neurodegenerative process would suggest new candidate targets for therapeutic interventions. ..
  2. Tyrosine Phosphorylation in Alzheimer's Disease
    Gloria Lee; Fiscal Year: 2007
    ..The identification of the fyn-tau interaction as a critical event in the neurodegenerative process would suggest new candidate targets for therapeutic interventions. ..
  3. PHOSPHORYLATION AND SPATIAL LOCALIZATION OF TAU PROTEIN
    Gloria Lee; Fiscal Year: 2004
    ..Signal transduction pathways involving tau and A-beta may go awry during neurodegenerative diseases, leading to inappropriate cross talk between pathways that may culminate in abnormal tau phosphorylation and polymerization. ..
  4. TYROSINE PHOSPHORYLATION IN ALZHEIMERS DISEASE
    Gloria Lee; Fiscal Year: 2003
    ..Insights into the tyrosine phosphorylation of tau may provide an important step forward in elucidating the pathways leading to neurofibrillary tangle formation in AD. ..
  5. PHOSPHORYLATION AND SPATIAL LOCALIZATION OF TAU PROTEIN
    Gloria Lee; Fiscal Year: 1999
    ..These studies will provide new insights into the function of tau's amino terminus and into tau's role in the transduction of extracellular signals to the cytoskeleton. ..
  6. Tyrosine Phosphorylation in Alzheimer's Disease
    Gloria Lee; Fiscal Year: 2010
    ..The identification of the fyn-tau interaction as a critical event in the neurodegenerative process would suggest new candidate targets for therapeutic interventions. ..