Edward B Lee

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc The neuropathology of obesity: insights from human disease
    Edward B Lee
    Translational Neuropathology Research Laboratory, Division of Neuropathology, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, 605B Stellar Chance Laboratories, 422 Curie Blvd, Philadelphia, PA, 19104, USA
    Acta Neuropathol 127:3-28. 2014
  2. pmc Alteration of hypothalamic cellular dynamics in obesity
    Edward B Lee
    Department of Pathology and Laboratory Medicine, Perelman School of Medicine at University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 122:22-5. 2012
  3. pmc Obesity, leptin, and Alzheimer's disease
    Edward B Lee
    Translational Neuropathology Research Laboratory, Division of Neuropathology, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Ann N Y Acad Sci 1243:15-29. 2011
  4. doi request reprint Thyroid transcription factor 1 expression in sellar tumors: a histogenetic marker?
    Edward B Lee
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19106, USA
    J Neuropathol Exp Neurol 68:482-8. 2009
  5. pmc Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias
    Mark Yarchoan
    3615 Chestnut Street, Philadelphia, PA 19104, USA
    Brain 135:3749-56. 2012
  6. ncbi request reprint Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice
    Edward B Lee
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Biol Chem 281:4292-9. 2006
  7. doi request reprint Development and validation of pedigree classification criteria for frontotemporal lobar degeneration
    Elisabeth M Wood
    Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, Philadelphia
    JAMA Neurol 70:1411-7. 2013
  8. pmc α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies
    Youngshin Lim
    Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 31:10076-87. 2011
  9. pmc Intraneuronal APP, not free Aβ peptides in 3xTg-AD mice: implications for tau versus Aβ-mediated Alzheimer neurodegeneration
    Matthew J Winton
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 31:7691-9. 2011
  10. pmc Phosphorylated tau/amyloid beta 1-42 ratio in ventricular cerebrospinal fluid reflects outcome in idiopathic normal pressure hydrocephalus
    Sunil Patel
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Fluids Barriers CNS 9:7. 2012

Collaborators

Detail Information

Publications26

  1. pmc The neuropathology of obesity: insights from human disease
    Edward B Lee
    Translational Neuropathology Research Laboratory, Division of Neuropathology, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, 605B Stellar Chance Laboratories, 422 Curie Blvd, Philadelphia, PA, 19104, USA
    Acta Neuropathol 127:3-28. 2014
    ....
  2. pmc Alteration of hypothalamic cellular dynamics in obesity
    Edward B Lee
    Department of Pathology and Laboratory Medicine, Perelman School of Medicine at University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 122:22-5. 2012
    ..These findings support the notion that obesity is a disease that affects multiple organs, including the brain, and that disruption of normal brain function leads to abnormal regulation of peripheral metabolism...
  3. pmc Obesity, leptin, and Alzheimer's disease
    Edward B Lee
    Translational Neuropathology Research Laboratory, Division of Neuropathology, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Ann N Y Acad Sci 1243:15-29. 2011
    ..These studies will serve as a framework for understanding the role of adipokines in brain health...
  4. doi request reprint Thyroid transcription factor 1 expression in sellar tumors: a histogenetic marker?
    Edward B Lee
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19106, USA
    J Neuropathol Exp Neurol 68:482-8. 2009
    ..Our observations may have implications for the classification of these rare sellar neoplasms, all the while acknowledging the morphological diversity of pituicyte-related neoplasms...
  5. pmc Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias
    Mark Yarchoan
    3615 Chestnut Street, Philadelphia, PA 19104, USA
    Brain 135:3749-56. 2012
    ....
  6. ncbi request reprint Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice
    Edward B Lee
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Biol Chem 281:4292-9. 2006
    ..These data implicated Abeta oligomers as a pathologic substrate for cognitive decline in Alzheimer disease...
  7. doi request reprint Development and validation of pedigree classification criteria for frontotemporal lobar degeneration
    Elisabeth M Wood
    Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, Philadelphia
    JAMA Neurol 70:1411-7. 2013
    ..There is also great need to develop clinical tools and approaches that will assist clinicians in the identification and counseling of patients with FTLD and their families regarding the likelihood of an identifiable genetic cause...
  8. pmc α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies
    Youngshin Lim
    Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 31:10076-87. 2011
    ..Furthermore, when α-syn expression was suppressed, we observed partial clearing of pre-existing α-syn pathology and reversal of structural synaptic defects, resulting in an improvement in memory function...
  9. pmc Intraneuronal APP, not free Aβ peptides in 3xTg-AD mice: implications for tau versus Aβ-mediated Alzheimer neurodegeneration
    Matthew J Winton
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 31:7691-9. 2011
    ..Although we cannot corroborate the presence of intraneuronal Aβ peptide in 3xTg-AD mice, our findings warrant further study as to the role of aberrant APP accumulation in this unique model of AD...
  10. pmc Phosphorylated tau/amyloid beta 1-42 ratio in ventricular cerebrospinal fluid reflects outcome in idiopathic normal pressure hydrocephalus
    Sunil Patel
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Fluids Barriers CNS 9:7. 2012
    ..abstract:..
  11. pmc Olfactory epithelium amyloid-beta and paired helical filament-tau pathology in Alzheimer disease
    Steven E Arnold
    Alzheimer s Disease Core Center, University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann Neurol 67:462-9. 2010
    ..However, their frequency, abundance, and disease specificity, and the relationships of OE pathology to brain pathology have not been established...
  12. pmc Comparative survey of the topographical distribution of signature molecular lesions in major neurodegenerative diseases
    Steven E Arnold
    Penn Memory Center, Departments of Psychiatry and Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, 19104
    J Comp Neurol 521:4339-55. 2013
    ....
  13. pmc Lack of shunt response in suspected idiopathic normal pressure hydrocephalus with Alzheimer disease pathology
    Roy Hamilton
    Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
    Ann Neurol 68:535-40. 2010
    ....
  14. ncbi request reprint Meningoencephalitis associated with passive immunization of a transgenic murine model of Alzheimer's amyloidosis
    Edward B Lee
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, HUP, Philadelphia, 19104 4283, USA
    FEBS Lett 579:2564-8. 2005
    ..This report indicates that current passive immunization in humans should proceed with careful regard for autoimmune complications...
  15. ncbi request reprint Supranuclear vertical gaze abnormalities in sporadic Creutzfeldt-Jakob disease
    Sashank Prasad
    Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia 19104, United States
    J Neurol Sci 253:69-72. 2007
    ..Both patients were found to have sporadic CJD after genetic testing. Distinguishing familial from sporadic CJD in this setting has important genetic and epidemiological implications...
  16. doi request reprint Hemangiomas of the brachial plexus: a case series
    Nathan J Ranalli
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Neurosurgery 65:A181-8. 2009
    ..We present 5 cases of extraneural hemangiomas causing brachial plexopathy, including pre-, intra-, and postoperative decision making, with an emphasis on diagnostic and management issues as well as outcomes...
  17. doi request reprint Photo essay. MRI and positron emission tomography findings in Heidenhain variant Creutzfeldt-Jakob disease
    Sashank Prasad
    Departments of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Neuroophthalmol 30:260-2. 2010
    ..Nuclear imaging provides a considerably more sensitive measure of neural dysfunction early in the course of this disease...
  18. ncbi request reprint Topography of FUS pathology distinguishes late-onset BIBD from aFTLD-U
    Edward B Lee
    Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA Translational Neuropathology Research Laboratory, 605B Stellar Chance Laboratories, 422 Curie Blvd, Philadelphia, PA 19104, USA Department of Pathology and Laboratory Medicine, Philadelphia, PA, USA
    Acta Neuropathol Commun 1:1-11. 2013
    ..In this study, we report the clinical and pathologic features of three cases of aFTLD-U and two cases of late-onset BIBD with an emphasis on the anatomic distribution of FUS inclusions...
  19. pmc Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansion
    Johannes Brettschneider
    Center for Neurodegenerative Disease Research CNDR, University of Pennsylvania School of Medicine, 3rd Floor Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104, USA
    Acta Neuropathol 123:825-39. 2012
    ..Our study indicates that this pathology is associated with alterations in clinical phenotype, and suggests that the presence of C9ORF72 repeat expansions may indicate a worse prognosis in ALS...
  20. pmc Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration
    Edward B Lee
    Translational Neuropathology Research Laboratory, Division of Neuropathology, Department of Pathology and Laboratory Medicine, University of Pennsylvania, 605B Stellar Chance Laboratories, 422 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Neurosci 13:38-50. 2012
    ..In addition, the distinct possibility of pleotropic or combined effects - in which gains of toxic properties and losses of normal TDP43 functions act together - needs to be considered...
  21. pmc Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice
    Lionel M Igaz
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, and Institute on Aging, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 121:726-38. 2011
    ..Our data suggest that perturbation of endogenous nuclear TDP-43 results in loss of normal TDP-43 function(s) and gene regulatory pathways, culminating in degeneration of selectively vulnerable affected neurons...
  22. pmc Metabolic dysfunction associated with adiponectin deficiency enhances kainic acid-induced seizure severity
    Edward B Lee
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 31:14361-6. 2011
    ..These findings demonstrate that metabolic syndrome modulates the outcome of seizures and brain injury...
  23. ncbi request reprint TDP-43 immunoreactivity in anoxic, ischemic and neoplastic lesions of the central nervous system
    Edward B Lee
    Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Acta Neuropathol 115:305-11. 2008
    ..These findings expand our knowledge of the distribution and localization of TDP-43, and indicate that the TDP-43 inclusions seen in frontotemporal dementias and motor neuron diseases are specific to a neurodegenerative process...
  24. pmc Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model
    Bin Zhang
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3600 Spruce Street, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 102:227-31. 2005
    ..Thus, MT-stabilizing drugs could have therapeutic potential for treating neurodegenerative tauopathies by offsetting losses of tau function that result from the sequestration of this MT-stabilizing protein into filamentous inclusions...
  25. pmc Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease
    Syaun Sung
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Pathol 165:2197-206. 2004
    ....
  26. ncbi request reprint Secretion and intracellular generation of truncated Abeta in beta-site amyloid-beta precursor protein-cleaving enzyme expressing human neurons
    Edward B Lee
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 278:4458-66. 2003
    ..Therefore, we conclude that Abeta11-40/42 is generated prior to deposition in senile plaques and that N-terminally truncated Abeta peptides may contribute to the downstream effects of amyloid accumulation in Alzheimer's disease...