David Lee

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi Characterization of the mouse epidermal growth factor promoter and 5'-flanking region. Role for an atypical TATA sequence
    S E Fenton
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599 7295, USA
    J Biol Chem 271:30870-8. 1996
  2. ncbi TACE/ADAM17 processing of EGFR ligands indicates a role as a physiological convertase
    David C Lee
    Department of Biochemistry and Biophysics, UNC Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7260, USA
    Ann N Y Acad Sci 995:22-38. 2003
  3. ncbi Selective roles for tumor necrosis factor alpha-converting enzyme/ADAM17 in the shedding of the epidermal growth factor receptor ligand family: the juxtamembrane stalk determines cleavage efficiency
    C Leann Hinkle
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 279:24179-88. 2004
  4. pmc Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling
    Leslie F Jackson
    Department of Biochemistry and Biophysics, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    EMBO J 22:2704-16. 2003
  5. ncbi Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability
    Susan Wohler Sunnarborg
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    J Biol Chem 277:12838-45. 2002
  6. ncbi Heparin-binding epidermal growth factor-like growth factor, collateral vessel development, and angiogenesis in skeletal muscle ischemia
    Dan Chalothorn
    Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, NC 27599 7545, USA
    Arterioscler Thromb Vasc Biol 25:1884-90. 2005
  7. pmc Mitochondrial reactive oxygen species mediate GPCR-induced TACE/ADAM17-dependent transforming growth factor-alpha shedding
    Timothy J Myers
    Department of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Mol Biol Cell 20:5236-49. 2009
  8. pmc Heparin-binding epidermal growth factor-like growth factor signaling in flow-induced arterial remodeling
    Hua Zhang
    Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, NC 27599 7545, USA
    Circ Res 102:1275-85. 2008
  9. ncbi Transactivation of epidermal growth factor receptor mediates catecholamine-induced growth of vascular smooth muscle
    Hua Zhang
    Department of Cell and Molecular Physiology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7545, USA
    Circ Res 95:989-97. 2004
  10. ncbi Amphiregulin contributes to the transformed phenotype of human hepatocellular carcinoma cells
    Josefa Castillo
    Division of Hepatology and Gene Therapy, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
    Cancer Res 66:6129-38. 2006

Research Grants

Collaborators

  • Shigeki Higashiyama
  • Terrance G Johns
  • M D Sternlicht
  • ROBERT CHEVALIER
  • N C Partridge
  • Paola Zigrino
  • Richard Fox
  • Roy A Black
  • Susan C Kiley
  • Heike Schäcke
  • D Accili
  • David W Threadgill
  • M Federici
  • G Sesti
  • D Henrion
  • Marco Conti
  • Hua Zhang
  • Carmen Berasain
  • Susan W Sunnarborg
  • Leslie F Jackson
  • Josefa Castillo
  • James E Faber
  • Matias A Avila
  • Jesus Prieto
  • Elena Erroba
  • William E Russell
  • Mary Stevenson
  • Dan Chalothorn
  • Susan Wohler Sunnarborg
  • C Leann Hinkle
  • Timothy J Myers
  • Minnie Hsieh
  • Dominique Chansel
  • Monica Santamaria
  • Claudia Mitchell
  • Alexandre Lautrette
  • Ling Qin
  • Elena R Garcia-Trevijano
  • Paul S Amieux
  • Claus Werner Franzke
  • Leann H Brennaman
  • K Kirk McNaughton
  • Alekos Theologis
  • Sara Panigone
  • Ruby Chen
  • Kathleen Horner
  • Ana Maria Gomez
  • Jean Claude Dussaule
  • Thomas M Coffman
  • Sophie Vandermeersch
  • Pierre Louis Tharaux
  • Sylvain Richard
  • Magali Ciroldi
  • Maria J Perugorria
  • Jean H M Feyen
  • Martine Burtin
  • Jean S Campbell
  • Emanuel DiCicco-Bloom
  • Joseph Tamasi
  • Mary Nivison
  • Gerard Friedlander
  • Nelson Fausto
  • Scott M Moore
  • Liza Raggatt
  • Fabiola Terzi
  • Xin Li
  • Shunqiang Li
  • Rohia Alili
  • David Loiselle
  • Carol E Parker
  • Chunlian Zhang
  • Ting Hu Qiu
  • Cam Patterson
  • Aileen Chang
  • George S Laszlo
  • Beverly J Castner
  • Falk Fahrenholz
  • Raymond J Paxton
  • Mary J Gerhart
  • Thomas Su
  • Douglas G Howe
  • Kaisa Tasanen
  • Leena Bruckner-Tuderman
  • Karl Tryggvason
  • Susan Sunnarborg
  • Rejean L Idzerda
  • Jacques J Peschon
  • Cornelia Mauch
  • G Stanley McKnight
  • S E Fenton

Detail Information

Publications22

  1. ncbi Characterization of the mouse epidermal growth factor promoter and 5'-flanking region. Role for an atypical TATA sequence
    S E Fenton
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599 7295, USA
    J Biol Chem 271:30870-8. 1996
    ..These data suggest that the TTTAAA sequence functions as an atypical TATA box...
  2. ncbi TACE/ADAM17 processing of EGFR ligands indicates a role as a physiological convertase
    David C Lee
    Department of Biochemistry and Biophysics, UNC Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7260, USA
    Ann N Y Acad Sci 995:22-38. 2003
    ..The implications of these results for the biology of the EGF family and TACE are discussed...
  3. ncbi Selective roles for tumor necrosis factor alpha-converting enzyme/ADAM17 in the shedding of the epidermal growth factor receptor ligand family: the juxtamembrane stalk determines cleavage efficiency
    C Leann Hinkle
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 279:24179-88. 2004
    ..These results indicate that efficient TACE cleavage is determined by a combination of stalk length and scissile bond sequence...
  4. pmc Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling
    Leslie F Jackson
    Department of Biochemistry and Biophysics, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    EMBO J 22:2704-16. 2003
    ..These results suggest that cardiac valvulogenesis is dependent on EGFR activation by TACE-derived soluble HB-EGF, and that EGFR signaling is required to regulate bone morphogenetic protein signaling in this context...
  5. ncbi Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability
    Susan Wohler Sunnarborg
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    J Biol Chem 277:12838-45. 2002
    ..Collectively, these data support a broad role for TACE in the regulated shedding of EGFR ligands...
  6. ncbi Heparin-binding epidermal growth factor-like growth factor, collateral vessel development, and angiogenesis in skeletal muscle ischemia
    Dan Chalothorn
    Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, NC 27599 7545, USA
    Arterioscler Thromb Vasc Biol 25:1884-90. 2005
    ..We examined the hypothesis that HB-EGF participates in angiogenesis and collateral growth in ischemia...
  7. pmc Mitochondrial reactive oxygen species mediate GPCR-induced TACE/ADAM17-dependent transforming growth factor-alpha shedding
    Timothy J Myers
    Department of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Mol Biol Cell 20:5236-49. 2009
    ..These results reveal an essential role for mitochondrial ROS in regulating GPCR-induced growth factor shedding...
  8. pmc Heparin-binding epidermal growth factor-like growth factor signaling in flow-induced arterial remodeling
    Hua Zhang
    Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, NC 27599 7545, USA
    Circ Res 102:1275-85. 2008
    ..These findings suggest that HB-EGF signaling is required for low flow-induced hypertrophic remodeling and may participate in vascular wall disease and remodeling...
  9. ncbi Transactivation of epidermal growth factor receptor mediates catecholamine-induced growth of vascular smooth muscle
    Hua Zhang
    Department of Cell and Molecular Physiology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7545, USA
    Circ Res 95:989-97. 2004
    ..This trophic pathway may link sympathetic activity to arterial wall growth in adaptive remodeling and hypertrophic disease...
  10. ncbi Amphiregulin contributes to the transformed phenotype of human hepatocellular carcinoma cells
    Josefa Castillo
    Division of Hepatology and Gene Therapy, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
    Cancer Res 66:6129-38. 2006
    ..These observations suggest that AR is involved in the acquisition of neoplastic traits in the liver and thus constitutes a novel therapeutic target in human hepatocarcinoma...
  11. pmc Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin
    Mark D Sternlicht
    Department of Anatomy, University of California, 513 Parnassus Ave, San Francisco, CA 94143 0452, USA
    Development 132:3923-33. 2005
    ..Thus, ADAM17 plays a crucial role in mammary morphogenesis by releasing AREG from mammary epithelial cells, thereby eliciting paracrine activation of stromal EGFR and reciprocal responses that regulate mammary epithelial development...
  12. ncbi Novel role for amphiregulin in protection from liver injury
    Carmen Berasain
    Division of Hepatology and Gene Therapy, Centro de Investigación Médica Aplicada, Facultad de Medicina, Universidad de Navarra, Pio XII, 55, 31008 Pamplona, Spain
    J Biol Chem 280:19012-20. 2005
    ..These results show that amphiregulin is a protective factor induced in response to liver damage and that it may be therapeutic in liver diseases...
  13. ncbi Epidermal growth factor potentiates renal cell death in hydronephrotic neonatal mice, but cell survival in rats
    Susan C Kiley
    Department of Pediatrics, University of Virginia, Charlottesville, Virginia 22908, USA
    Kidney Int 68:504-14. 2005
    ..Epidermal growth factor (EGF) markedly attenuates tubular apoptosis induced by unilateral ureteral obstruction (UUO) in the neonatal rat, and reduces apoptosis induced by mechanical stretch of cultured rat tubular cells...
  14. ncbi Amphiregulin: an early trigger of liver regeneration in mice
    Carmen Berasain
    Division of Hepatology and Gene Therapy, Cntro de Investigción Médica Aplicada, Facultad e Medicina, Universidad de Navarra, Pamplona, Spain
    Gastroenterology 128:424-32. 2005
    ..We have investigated the expression of amphiregulin in liver injury and its role during liver regeneration after partial hepatectomy...
  15. ncbi Amphiregulin is a novel growth factor involved in normal bone development and in the cellular response to parathyroid hormone stimulation
    Ling Qin
    Physiology and Biophysics and Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Biol Chem 280:3974-81. 2005
    ..Moreover, AR null mice displayed significantly less tibial trabecular bone than wild-type mice. Taken together, we have identified a novel growth factor that is PTH-regulated and appears to have an important role in bone metabolism...
  16. ncbi Increased basal cAMP-dependent protein kinase activity inhibits the formation of mesoderm-derived structures in the developing mouse embryo
    Paul S Amieux
    Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    J Biol Chem 277:27294-304. 2002
    ..Our results demonstrate that unregulated PKA activity negatively affects growth factor-mediated mesoderm formation during early mouse development...
  17. pmc Transmembrane collagen XVII, an epithelial adhesion protein, is shed from the cell surface by ADAMs
    Claus Werner Franzke
    Department of Dermatology, University of Munster, D 48149 Munster, Germany
    EMBO J 21:5026-35. 2002
    ..Functionally, release of the ectodomain of collagen XVII from the cell surface was associated with altered keratinocyte motility in vitro...
  18. pmc Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha
    Massimo Federici
    Center for Atherosclerosis, Policlinico Tor Vergata University Hospital, Rome, Italy
    J Clin Invest 115:3494-505. 2005
    ..Our results suggest that an interplay between reduced insulin action and unchecked TACE activity promotes diabetes and vascular inflammation...
  19. ncbi Heparin-binding epidermal growth factor-like growth factor links hepatocyte priming with cell cycle progression during liver regeneration
    Claudia Mitchell
    Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Biol Chem 280:2562-8. 2005
    ..Moreover, we show that hepatocyte DNA replication was delayed in HB-EGF knock-out mice. In summary, we show that HB-EGF is a key factor for hepatocyte progression through G(1)/S transition during liver regeneration...
  20. ncbi Heparin binding EGF is necessary for vasospastic response to endothelin
    Dominique Chansel
    INSERM U702 Hôpital Tenon Université Pierre et Marie Curie, Paris, France
    FASEB J 20:1936-8. 2006
    ..This functional cascade requires modulation of agonist-induced calcium transient by EGFR and PI3K with extremely fast kinetics, suggesting a novel paradigm for GPCR-mediated calcium signaling, which may offer future therapeutic targets...
  21. pmc Luteinizing hormone-dependent activation of the epidermal growth factor network is essential for ovulation
    Minnie Hsieh
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5317, USA
    Mol Cell Biol 27:1914-24. 2007
    ....
  22. ncbi Angiotensin II and EGF receptor cross-talk in chronic kidney diseases: a new therapeutic approach
    Alexandre Lautrette
    INSERM U426, Hopital Necker Enfants Malades, IFR 94, Universite Paris 5, 149 rue de Sevres, 75015 Paris, France
    Nat Med 11:867-74. 2005
    ..These findings indicate a crucial role for AngII-dependent EGFR transactivation in renal deterioration and identify in TACE inhibitors a new therapeutic strategy for preventing progression of chronic renal diseases...

Research Grants34

  1. REGULATION OF TRANSFORMING GROWTH FACTORS
    David Lee; Fiscal Year: 1993
    ..Finally, establish an endometrial culture system with which to study the mechanism by which estrogen enhances expression of this gene...
  2. REGULATION OF TRANSFORMING GROWTH FACTORS
    David Lee; Fiscal Year: 2001
    ....
  3. REGULATION OF TRANSFORMING GROWTH FACTORS
    David Lee; Fiscal Year: 2003
    ..abstract_text> ..
  4. ERBB REGULATION OF BREAST DEVELOPMENT AND TUMORIGENESI
    David Lee; Fiscal Year: 2004
    ..The ability of ERBB4 to suppress TGF-alpha-induced mammary tumorigenesis will then be tested in bitransgenic mice harboring both receptor chimera and TGF-alpha transgenes. ..
  5. REGULATION OF TRANSFORMING GROWTH FACTORS
    David Lee; Fiscal Year: 1991
    ....