Daniel C Lee

Summary

Affiliation: University of South Florida
Country: USA

Publications

  1. pmc LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice
    Daniel C Lee
    Byrd Alzheimer s Institute, Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33612, USA
    J Neuroinflammation 7:56. 2010
  2. pmc Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
    Maj Linda B Selenica
    Department of Molecular Pharmacology and Physiology, USF Health Byrd Alzheimer s Institute, University of South Florida, Tampa, FL 33613, USA
    Neurodegener Dis 11:165-81. 2013
  3. pmc Diverse activation of microglia by chemokine (C-C motif) ligand 2 overexpression in brain
    Maj Linda B Selenica
    Department of Molecular Pharmacology and Physiology, Byrd Alzheimer Institute, University of South Florida, Tampa, FL, USA
    J Neuroinflammation 10:86. 2013
  4. doi request reprint Chronological age impacts immunotherapy and monocyte uptake independent of amyloid load
    Qingyou Li
    USF Health Byrd Alzheimer s Institute, Tampa, FL 33613, USA
    J Neuroimmune Pharmacol 7:202-14. 2012
  5. pmc Intracranial injection of AAV expressing NEP but not IDE reduces amyloid pathology in APP+PS1 transgenic mice
    Nikisha Carty
    University of South Florida College of Medicine, Byrd Alzheimer s Institute, Department of Molecular Pharmacology and Physiology, Tampa, Florida, United States of America
    PLoS ONE 8:e59626. 2013
  6. pmc Aging enhances classical activation but mitigates alternative activation in the central nervous system
    Daniel C Lee
    Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA
    Neurobiol Aging 34:1610-20. 2013
  7. doi request reprint Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy
    Kevin R Nash
    Molecular Pharmacology and Physiology Department, Byrd Alzheimer Institute, University of South Florida, Tampa, FL, USA
    Neurobiol Aging 34:1540-8. 2013
  8. pmc Trafficking CD11b-positive blood cells deliver therapeutic genes to the brain of amyloid-depositing transgenic mice
    Lori Lebson
    Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, Florida 33612, USA
    J Neurosci 30:9651-8. 2010
  9. pmc Chemical manipulation of hsp70 ATPase activity regulates tau stability
    Umesh K Jinwal
    Departments of Molecular Medicine, USF Health Byrd Alzheimer s Institute, University of South Florida, Tampa, Florida 33613, USA
    J Neurosci 29:12079-88. 2009

Collaborators

Detail Information

Publications9

  1. pmc LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice
    Daniel C Lee
    Byrd Alzheimer s Institute, Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33612, USA
    J Neuroinflammation 7:56. 2010
    ....
  2. pmc Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
    Maj Linda B Selenica
    Department of Molecular Pharmacology and Physiology, USF Health Byrd Alzheimer s Institute, University of South Florida, Tampa, FL 33613, USA
    Neurodegener Dis 11:165-81. 2013
    ..We aimed to investigate the influence of oligomeric forms of β-amyloid (Aβ) and the influence of the duration of exposure on the development of tau phosphorylation...
  3. pmc Diverse activation of microglia by chemokine (C-C motif) ligand 2 overexpression in brain
    Maj Linda B Selenica
    Department of Molecular Pharmacology and Physiology, Byrd Alzheimer Institute, University of South Florida, Tampa, FL, USA
    J Neuroinflammation 10:86. 2013
    ..The chemokine (C-C motif) ligand 2 (CCL2) is a monocyte chemoattractant protein that mediates macrophage recruitment and migration during peripheral and central nervous system (CNS) inflammation...
  4. doi request reprint Chronological age impacts immunotherapy and monocyte uptake independent of amyloid load
    Qingyou Li
    USF Health Byrd Alzheimer s Institute, Tampa, FL 33613, USA
    J Neuroimmune Pharmacol 7:202-14. 2012
    ..We conclude that preclinical studies should be conducted in aged animal models as well as young mice to better prepare for unintended consequences in the human trial...
  5. pmc Intracranial injection of AAV expressing NEP but not IDE reduces amyloid pathology in APP+PS1 transgenic mice
    Nikisha Carty
    University of South Florida College of Medicine, Byrd Alzheimer s Institute, Department of Molecular Pharmacology and Physiology, Tampa, Florida, United States of America
    PLoS ONE 8:e59626. 2013
    ..As such, they may be considered reasonable candidates for gene therapy trials in AD...
  6. pmc Aging enhances classical activation but mitigates alternative activation in the central nervous system
    Daniel C Lee
    Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA
    Neurobiol Aging 34:1610-20. 2013
    ..Importantly, selective transcripts were induced at all ages by CKT-1, whereas selective gene transcripts induced by CKT-2 decreased with age suggesting an age-related reduction in the IL-4/ IL-13 signaling pathway...
  7. doi request reprint Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy
    Kevin R Nash
    Molecular Pharmacology and Physiology Department, Byrd Alzheimer Institute, University of South Florida, Tampa, FL, USA
    Neurobiol Aging 34:1540-8. 2013
    ..These data argue that agonism at fractalkine receptors might be an excellent target for therapeutic intervention in tauopathies, including those associated with amyloid deposition...
  8. pmc Trafficking CD11b-positive blood cells deliver therapeutic genes to the brain of amyloid-depositing transgenic mice
    Lori Lebson
    Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, Florida 33612, USA
    J Neurosci 30:9651-8. 2010
    ..Moreover, these data support the results from bone marrow grafts that circulating CD11b+ cells can enter the CNS without requiring the use of lethal irradiation...
  9. pmc Chemical manipulation of hsp70 ATPase activity regulates tau stability
    Umesh K Jinwal
    Departments of Molecular Medicine, USF Health Byrd Alzheimer s Institute, University of South Florida, Tampa, Florida 33613, USA
    J Neurosci 29:12079-88. 2009
    ..These findings reveal an entirely novel path toward therapeutic intervention of tauopathies by inhibition of the previously untargeted ATPase activity of Hsp70...