Affiliation: University of Iowa
Kerov V, Laird J, Joiner M, Knecht S, Soh D, Hagen J, et al
. α2δ-4 Is Required for the Molecular and Structural Organization of Rod and Cone Photoreceptor Synapses. J Neurosci. 2018;38:6145-6160 pubmed publisher
..Our results suggest that alterations in presynaptic Ca2+ signaling and photoreceptor synapse structure may contribute to vision impairment in humans with mutations in the CACNA2D4 gene encoding α2δ-4. ..
Williams B, Haeseleer F, Lee A. Splicing of an automodulatory domain in Cav1.4 Ca2+ channels confers distinct regulation by calmodulin. J Gen Physiol. 2018;150:1676-1687 pubmed publisher
..4Δex47 to be modulated by a wider range of synaptic Ca2+ concentrations than K1591X; this may distinguish the normal physiological function of Cav1.4Δex47 from the pathological consequences of K1591X. ..
Garza López E, Lopez J, Hagen J, Sheffer R, Meiner V, Lee A. Role of a conserved glutamine in the function of voltage-gated Ca2+ channels revealed by a mutation in human CACNA1D. J Biol Chem. 2018;293:14444-14454 pubmed publisher
..Our results reveal a critical extracellular determinant of current density for all Cav family members and of voltage-dependent inactivation of Cav1.3 and Cav2.1 channels. ..
Lee A, Fakler B, Kaczmarek L, Isom L. More than a pore: ion channel signaling complexes. J Neurosci. 2014;34:15159-69 pubmed publisher
..Molecular and functional dissection of the ion channel proteome/interactome has yielded new insights into the composition of ion channel complexes and how their dysregulation leads to human disease. ..
Yang T, Choi J, Soh D, Tobin K, Joiner M, Hansen M, et al
. CaBP1 regulates Cav1 L-type Ca2+ channels and their coupling to neurite growth and gene transcription in mouse spiral ganglion neurons. Mol Cell Neurosci. 2018;88:342-352 pubmed publisher
..Our findings establish a role for CaBP1 as an essential regulator of Cav1 channels in SGNs and their coupling to downstream pathways controlling activity-dependent transcription and neurite growth. ..
Yang T, Britt J, Cintrón Pérez C, Vázquez Rosa E, Tobin K, Stalker G, et al
. Ca2+-Binding Protein 1 Regulates Hippocampal-dependent Memory and Synaptic Plasticity. Neuroscience. 2018;380:90-102 pubmed publisher
..Moreover, hippocampal long-term potentiation was significantly reduced in C-KO mice. We conclude that CaBP1 is required for cellular mechanisms underlying optimal encoding of hippocampal-dependent spatial and fear-related memories. ..
Yang T, Hu N, Pangrsic T, Green S, Hansen M, Lee A. Functions of CaBP1 and CaBP2 in the peripheral auditory system. Hear Res. 2018;364:48-58 pubmed publisher
..Our results reveal requirements for CaBP1 and CaBP2 in the peripheral auditory system and highlight the diverse modes by which CaBPs influence sensory processing. ..
Inagaki A, Frank C, Usachev Y, Benveniste M, Lee A. Pharmacological correction of gating defects in the voltage-gated Ca(v)2.1 Ca²? channel due to a familial hemiplegic migraine mutation. Neuron. 2014;81:91-102 pubmed publisher
..Our results reveal a mechanism by which a Ca(v)2.1 gating modifier can ameliorate defects associated with a disease-causing mutation in Ca(v)2.1. ..
Joiner M, Lee A. Voltage-Gated Cav1 Channels in Disorders of Vision and Hearing. Curr Mol Pharmacol. 2015;8:143-8 pubmed
..This review will cover advances in our understanding of the function of Cav1 channels at sensory ribbon synapses, and how dysregulation of these channels leads to disorders of vision and hearing. ..