A S Lee

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint GRP78 induction in cancer: therapeutic and prognostic implications
    Amy S Lee
    Department of Biochemistry and Molecular Biology, University of Southern California Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
    Cancer Res 67:3496-9. 2007
  2. ncbi request reprint The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress
    Amy S Lee
    Department of Biochemistry and Molecular Biology and the USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089 9176, USA
    Methods 35:373-81. 2005
  3. ncbi request reprint The glucose-regulated proteins: stress induction and clinical applications
    A S Lee
    University of Southern California Norris Comprehensive Cancer Center, Dept of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089 9176, USA
    Trends Biochem Sci 26:504-10. 2001
  4. pmc Identification of TFII-I as the endoplasmic reticulum stress response element binding factor ERSF: its autoregulation by stress and interaction with ATF6
    R Parker
    Department of Biochemistry and Molecular Biology and the USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California 90089 9176, USA
    Mol Cell Biol 21:3220-33. 2001
  5. pmc The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells
    J Li
    Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA
    Cell Death Differ 15:1460-71. 2008
  6. pmc Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis
    M Wang
    Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90089 9176, USA
    Cell Death Differ 17:488-98. 2010
  7. ncbi request reprint YY1 as a regulator of replication-dependent hamster histone H3.2 promoter and an interactive partner of AP-2
    F Wu
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089-9176, USA
    J Biol Chem 276:28-34. 2001
  8. pmc The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies
    B Luo
    Department of Biochemistry and Molecular Biology, University of Southern California USC Norris Comprehensive Cancer Center, Keck School of Medicine of USC, Los Angeles, CA 90089 9176, USA
    Oncogene 32:805-18. 2013
  9. pmc ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1
    M Li
    Department of Biochemistry and Molecular Biology, and the USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California 90089 9176, USA
    Mol Cell Biol 20:5096-106. 2000
  10. ncbi request reprint GRP78/BiP inhibits endoplasmic reticulum BIK and protects human breast cancer cells against estrogen starvation-induced apoptosis
    Yong Fu
    Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
    Cancer Res 67:3734-40. 2007

Collaborators

Detail Information

Publications47

  1. ncbi request reprint GRP78 induction in cancer: therapeutic and prognostic implications
    Amy S Lee
    Department of Biochemistry and Molecular Biology, University of Southern California Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
    Cancer Res 67:3496-9. 2007
    ..Furthermore, the recent discovery of GRP78 on the cell surface of cancer cells but not in normal tissues suggests that targeted therapy against cancer via surface GRP78 may be feasible...
  2. ncbi request reprint The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress
    Amy S Lee
    Department of Biochemistry and Molecular Biology and the USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089 9176, USA
    Methods 35:373-81. 2005
    ..This can be achieved by measuring the Grp78 promoter activity or by measuring the level of Grp78 transcripts or GRP78 protein. These techniques can be applied to tissue culture cells as well as tissues and organs...
  3. ncbi request reprint The glucose-regulated proteins: stress induction and clinical applications
    A S Lee
    University of Southern California Norris Comprehensive Cancer Center, Dept of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089 9176, USA
    Trends Biochem Sci 26:504-10. 2001
    ..The elucidation of Grp function and regulation opens up new therapeutic approaches to diseases associated with ER stress and cancer...
  4. pmc Identification of TFII-I as the endoplasmic reticulum stress response element binding factor ERSF: its autoregulation by stress and interaction with ATF6
    R Parker
    Department of Biochemistry and Molecular Biology and the USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California 90089 9176, USA
    Mol Cell Biol 21:3220-33. 2001
    ..We further discovered that TFII-I is an interactive protein partner of ATF6 and that optimal stimulation of ERSE by ATF6 requires TFII-I...
  5. pmc The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells
    J Li
    Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA
    Cell Death Differ 15:1460-71. 2008
    ..Thus, these studies uncover 3-MA as an inhibitor of UPR activation and establish GRP78 as a novel obligatory component of autophagy in mammalian cells...
  6. pmc Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis
    M Wang
    Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90089 9176, USA
    Cell Death Differ 17:488-98. 2010
    ..Our studies uncover a novel link between GRP78 depletion and reduction in cytosolic ubiquitination and establish a novel mouse model of accelerated cerebellar degeneration with basic and clinical applications...
  7. ncbi request reprint YY1 as a regulator of replication-dependent hamster histone H3.2 promoter and an interactive partner of AP-2
    F Wu
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089-9176, USA
    J Biol Chem 276:28-34. 2001
    ....
  8. pmc The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies
    B Luo
    Department of Biochemistry and Molecular Biology, University of Southern California USC Norris Comprehensive Cancer Center, Keck School of Medicine of USC, Los Angeles, CA 90089 9176, USA
    Oncogene 32:805-18. 2013
    ..In summary, perturbance of ER homeostasis has critical roles in tumorigenesis, and therapeutic modulation of ER chaperones and/or UPR components presents potential antitumor treatments...
  9. pmc ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1
    M Li
    Department of Biochemistry and Molecular Biology, and the USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California 90089 9176, USA
    Mol Cell Biol 20:5096-106. 2000
    ..The requirement for a high-affinity NF-Y site for ATF6 but not human Ire1p activity suggests that they stimulate the ERSE through diverse pathways...
  10. ncbi request reprint GRP78/BiP inhibits endoplasmic reticulum BIK and protects human breast cancer cells against estrogen starvation-induced apoptosis
    Yong Fu
    Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
    Cancer Res 67:3734-40. 2007
    ....
  11. pmc Role of the unfolded protein response regulator GRP78/BiP in development, cancer, and neurological disorders
    Miao Wang
    Department of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, USC Norris Comprehensive Cancer Center, Los Angeles, California 90089 9176, USA
    Antioxid Redox Signal 11:2307-16. 2009
    ..Mouse models also reveal that GRP78 controls maturation and secretion of neuronal factors for proper neural migration and offers neuroprotection...
  12. ncbi request reprint ER stress and cancer
    Amy S Lee
    Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90089 9176, USA
    Cancer Biol Ther 5:721-2. 2006
  13. pmc The Par-4-GRP78 TRAIL, more twists and turns
    Amy S Lee
    Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Cancer Biol Ther 8:2103-5. 2009
    ..In this journal club, we discuss some open questions and how these new findings integrate with current understanding of GRP78 function in vivo...
  14. pmc miR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer
    S F Su
    1 Department of Urology, Los Angeles, CA, USA 2 Program in Genetic, Molecular, and Cellular Biology, Los Angeles, CA, USA
    Oncogene 32:4694-701. 2013
    ..Together, our results indicate that the delivery of co-transcribed miRNAs can efficiently suppress GRP78 levels and GRP78-mediated chemoresistance, and suggest that this strategy holds therapeutic potential. ..
  15. pmc Regulation of PERK signaling and leukemic cell survival by a novel cytosolic isoform of the UPR regulator GRP78/BiP
    Min Ni
    Department of Biochemistry and Molecular Biology and the USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America
    PLoS ONE 4:e6868. 2009
    ..Our study further reveals a novel survival mechanism in leukemic cells and other cell types where GRP78va is expressed...
  16. ncbi request reprint Transcriptional regulation of the Grp78 promoter by endoplasmic reticulum stress: role of TFII-I and its tyrosine phosphorylation
    Min Hong
    Department of Biochemistry and Molecular Biology and the University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California 90089 9176, USA
    J Biol Chem 280:16821-8. 2005
    ..Our studies provide a molecular link that connects the c-Src tyrosine kinase transduction pathway to ER stress-induced transcriptional activation of Grp78 mediated by TFII-I...
  17. pmc Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium
    Yong Fu
    Department of Biochemistry, University of Southern California Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, CA 90089 9176, USA
    Proc Natl Acad Sci U S A 105:19444-9. 2008
    ..Thus, inactivation of GRP78 may represent a previously undescribed approach to stop prostate cancer and potentially other cancers resulting from the loss of PTEN tumor suppression and/or activation of the oncogenic AKT...
  18. pmc Targeted mutation of the mouse Grp94 gene disrupts development and perturbs endoplasmic reticulum stress signaling
    Changhui Mao
    Department of Biochemistry and Molecular Biology, University of Southern California Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    PLoS ONE 5:e10852. 2010
    ..Furthermore, from analysis of microarray database and immunohistochemical staining, we present predictions where GRP94 may play an important role in specific adult organ homeostasis and function...
  19. ncbi request reprint Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation
    Ramachandra K Reddy
    Department of Biochemistry and Molecular Biology and the USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90089 9176, USA
    J Biol Chem 278:20915-24. 2003
    ..Lastly, a GRP78 mutant deleted of its ATP binding domain fails to bind procaspase-7 and loses its protective effect against etoposide-induced apoptosis...
  20. pmc Endoplasmic reticulum stress induction of the Grp78/BiP promoter: activating mechanisms mediated by YY1 and its interactive chromatin modifiers
    Peter Baumeister
    Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, Keck School of Medicine, 1441 Eastlake Ave, Room 5308, MC 9176, Los Angeles, CA 90089 9176, USA
    Mol Cell Biol 25:4529-40. 2005
    ..A model for the ER stress-mediated transcription factor binding and chromatin modifications at the Grp78 promoter leading to its activation is proposed...
  21. pmc ER chaperones in mammalian development and human diseases
    Min Ni
    Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, 1441 Eastlake Ave, Los Angeles, CA 90089 9176, United States
    FEBS Lett 581:3641-51. 2007
    ....
  22. pmc Constitutive nucleosome depletion and ordered factor assembly at the GRP78 promoter revealed by single molecule footprinting
    Einav Nili Gal-Yam
    Department of Urology, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
    PLoS Genet 2:e160. 2006
    ..Studying the positioning of nucleosomes and transcription factors at the single promoter level provides a powerful tool to gain novel insights into the transcriptional process in eukaryotes...
  23. pmc GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development
    Shengzhan Luo
    Department of Biochemistry and Molecular Biology and the USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089 9176, USA
    Mol Cell Biol 26:5688-97. 2006
    ..These findings provide the first evidence that GRP78 is essential for embryonic cell growth and pluripotent cell survival...
  24. pmc Cell surface relocalization of the endoplasmic reticulum chaperone and unfolded protein response regulator GRP78/BiP
    Yi Zhang
    Departments of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089 9176, USA
    J Biol Chem 285:15065-75. 2010
    ..We also identified the exposure of multiple domains of GRP78 on the cell surface and determined that binding of extracellular GRP78 to the cell surface is unlikely. A new topology model for cell surface GRP78 is presented...
  25. ncbi request reprint Stress induction of GRP78/BiP and its role in cancer
    Jianze Li
    Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, 90089 9176, USA
    Curr Mol Med 6:45-54. 2006
    ..This review summarizes the transcriptional regulation of Grp78, the molecular basis for the cytoprotective function of GRP78 and its role in cancer progression, drug resistance and potential future cancer therapy...
  26. ncbi request reprint In vivo regulation of Grp78/BiP transcription in the embryonic heart: role of the endoplasmic reticulum stress response element and GATA-4
    Changhui Mao
    Department of Biochemistry and Molecular Biology, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90089 9176, USA
    J Biol Chem 281:8877-87. 2006
    ..These results suggest that during early heart organogenesis, Grp78 can be activated through cooperation between the cell type-specific transcription factors and ERSE-binding factors...
  27. pmc Stress chaperone GRP78/BiP confers chemoresistance to tumor-associated endothelial cells
    Jenilyn J Virrey
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089 9176, USA
    Mol Cancer Res 6:1268-75. 2008
    ..Our findings provide the proof of principle that targeting GRP78 will sensitize the tumor vasculature to chemotherapeutic drugs, thus enhancing the efficacy of these drugs in combination therapy for glioma treatment...
  28. ncbi request reprint The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas
    Peter Pyrko
    Department of Pathology, and University of Southern California Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    Cancer Res 67:9809-16. 2007
    ....
  29. ncbi request reprint Cancer-inducible transgene expression by the Grp94 promoter: spontaneous activation in tumors of various origins and cancer-associated macrophages
    Ramachandra K Reddy
    Department of Biochemistry and Molecular Biology, University of Southern California Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90089 9176, USA
    Cancer Res 62:7207-12. 2002
    ....
  30. ncbi request reprint Endoplasmic reticulum stress triggers an acute proteasome-dependent degradation of ATF6
    Min Hong
    Department of Biochemistry and Molecular Biology and the USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California 90089 9176, USA
    J Cell Biochem 92:723-32. 2004
    ..Further, inhibition of proteasome activity can result in chaperone protein gene induction through stabilization of p90ATF6 as well as accumulation of malfolded proteins...
  31. ncbi request reprint Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements
    Shengzhan Luo
    Department of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, Los Angeles, California 90089 9176, USA
    J Biol Chem 278:37375-85. 2003
    ..Our studies resolve a mechanism responsible for inhibition of Grp78 mRNA induction by ER stress in cells that are functionally null for PERK or devoid of eIF2alpha phosphorylation...
  32. ncbi request reprint The endoplasmic reticulum chaperone glycoprotein GRP94 with Ca(2+)-binding and antiapoptotic properties is a novel proteolytic target of calpain during etoposide-induced apoptosis
    R K Reddy
    Department of Biochemistry, USC Norris Comprehensive Cancer Center, University of Southern California School of Medicine, Los Angeles, California 90033, USA
    J Biol Chem 274:28476-83. 1999
    ..Our studies provide new evidence that the cytoprotective GRP94, as in the case of the antiapoptotic protein Bcl-2, can be targets of proteolytic cleavage themselves during the apoptotic process...
  33. ncbi request reprint Underglycosylation of ATF6 as a novel sensing mechanism for activation of the unfolded protein response
    Min Hong
    Department of Biochemistry and Molecular Biology and the University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California 90089 9176, USA
    J Biol Chem 279:11354-63. 2004
    ....
  34. pmc Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance
    Risheng Ye
    Department of Biochemistry and Molecular Biology, University of Southern California Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Diabetes 59:6-16. 2010
    ..To investigate the role of the endoplasmic reticulum (ER) chaperone glucose-regulated protein (GRP) 78/BiP in the pathogenesis of obesity, insulin resistance, and type 2 diabetes...
  35. doi request reprint Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development
    Dezheng Dong
    Department of Biochemistry and Molecular Biology, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, California 90089 9176, USA
    Cancer Res 68:498-505. 2008
    ....
  36. ncbi request reprint Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53
    Jianze Li
    Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089 9176, USA
    J Biol Chem 281:7260-70. 2006
    ..Our results provide new evidence that, in MEFs, in addition to PUMA, p53 and NOXA are novel components of the ER stress-induced apoptotic pathway, and both contribute to ER stress-induced apoptosis...
  37. ncbi request reprint Spontaneous and controllable activation of suicide gene expression driven by the stress-inducible grp78 promoter resulting in eradication of sizable human tumors
    Dezheng Dong
    Department of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089 9176, USA
    Hum Gene Ther 15:553-61. 2004
    ..Thus, transcriptional control through the use of the Grp78 promoter offers multiple novel approaches for human cancer gene therapy...
  38. ncbi request reprint Vascular targeting and antiangiogenesis agents induce drug resistance effector GRP78 within the tumor microenvironment
    Dezheng Dong
    Department of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, Los Angeles, California 90089 9176, USA
    Cancer Res 65:5785-91. 2005
    ..Our studies imply that antivascular and antiangiogenesis therapy that results in severe glucose and oxygen deprivation will induce GRP78 expression that could lead to drug resistance...
  39. ncbi request reprint Expression of stress response protein Grp78 is associated with the development of castration-resistant prostate cancer
    Llana Pootrakul
    Department of Pathology, University of Southern California, Keck School of Medicine USC Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA
    Clin Cancer Res 12:5987-93. 2006
    ..We investigated the role of Grp78 in prostate cancer progression and the development of castration resistance, where cancer cells continue to survive despite the stress of an androgen-starved environment...
  40. ncbi request reprint GRP78 as a novel predictor of responsiveness to chemotherapy in breast cancer
    Eunjung Lee
    Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90089 9176, USA
    Cancer Res 66:7849-53. 2006
    ..82; P = 0.010). The use of GRP78 as a predictor for chemoresponsiveness and the potential interaction of GRP78 and/or the UPR pathways with taxanes warrant larger studies...
  41. ncbi request reprint Glucose regulated proteins in cancer progression, drug resistance and immunotherapy
    Yong Fu
    Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90089 9176, USA
    Cancer Biol Ther 5:741-4. 2006
    ..These and other new developments on the role of GRP78, GRP94 and GRP170 in cancer progression and therapy are discussed in this review...
  42. ncbi request reprint Transgenic mouse model for monitoring endoplasmic reticulum stress in vivo
    Changhui Mao
    Nat Med 10:1013-4; author reply 1014. 2004
  43. ncbi request reprint Glucose-regulated protein GRP78 is up-regulated in prostate cancer and correlates with recurrence and survival
    Siamak Daneshmand
    Section of Urologic Oncology, Division of Urology, Oregon Health and Science University, Portland, OR 97239, USA
    Hum Pathol 38:1547-52. 2007
    ..The intensity of expression is significantly associated with survival and clinical recurrence. GRP78 has considerable potential not only as a prognostic indicator but also as a potential therapeutic target...
  44. ncbi request reprint Endoplasmic reticulum stress
    Gabor Banhegyi
    Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Puskin utca 9, 1088, Budapest, Hungary
    Ann N Y Acad Sci 1113:58-71. 2007
    ..Certain components of the ER stress response machinery are identified as biomarkers of the diseases or as possible targets for therapeutic intervention...
  45. pmc Requirement of the p38 mitogen-activated protein kinase signalling pathway for the induction of the 78 kDa glucose-regulated protein/immunoglobulin heavy-chain binding protein by azetidine stress: activating transcription factor 6 as a target for stress-i
    Shengzhan Luo
    Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles 90089 9176, USA
    Biochem J 366:787-95. 2002
    ..We propose that phosphorylation of ATF6 is a novel mechanism for augmenting its potential as a transcription activator...
  46. pmc ATF6 modulates SREBP2-mediated lipogenesis
    Lingfang Zeng
    Division of Biomedical Sciences, University of California, Riverside, Riverside, CA 92521 0121, USA
    EMBO J 23:950-8. 2004
    ..As a functional consequence, the lipogenic effect of SREBP2(N) in liver cells was suppressed by ATF6(N). Our results provide a novel mechanism by which ATF6 antagonizes SREBP2 to regulate the homeostasis of lipid and glucose...
  47. ncbi request reprint Enhanced photodynamic therapy efficacy with inducible suicide gene therapy controlled by the grp promoter
    Marian C Luna
    Clayton Center for Ocular Oncology, Childrens Hospital Los Angeles, California 90027, USA
    Cancer Res 62:1458-61. 2002
    ..Our results confirm that the grp promoter was able to effectively function as a molecular switch for the inducible expression of the HSV-tk gene after exposure to PDT...