Affiliation: University of Toledo
- Bone and fat: a relationship of different shadesBeata Lecka-Czernik
Department of Orthopaedic Surgery, University of Toledo Health Science Campus, Toledo, OH 43614, United States Department of Physiology and Pharmacology, University of Toledo Health Science Campus, Toledo, OH 43614, United States Center for Diabetes and Endocrine Research, University of Toledo Health Science Campus, Toledo, OH 43614, United States Electronic address
Arch Biochem Biophys 561:124-9. 2014..Therefore, better understanding of regulatory axes between bone and fat may provide the basis for development of strategies which will treat these diseases simultaneously and improve health and life quality of elderly. ..
- PPARgamma2 Regulates a Molecular Signature of Marrow Mesenchymal Stem CellsK R Shockley
The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
PPAR Res 2007:81219. 2007..These observations may have important therapeutic consequences and indicate a need for more detailed studies of PPARgamma2 role in stem cell biology...
- Marrow fat metabolism is linked to the systemic energy metabolismBeata Lecka-Czernik
Department of Orthopaedic Surgery, University of Toledo Health Sciences Campus, Toledo, OH 43614, USA
Bone 50:534-9. 2012..These functions may include a role in bone energy maintenance and endocrine activities to serve osteogenesis during bone remodeling and bone healing...
- Aleglitazar, a dual PPARα and PPARγ agonist for the potential oral treatment of type 2 diabetes mellitusBeata Lecka-Czernik
University of Toledo, College of Medicine, Department of Orthopaedic Surgery, 3000 Arlington Avenue, Toledo, OH 43614, USA
IDrugs 13:793-801. 2010..A phase III clinical trial was also ongoing in patients with T2DM who had recently experienced a cardiac event...
- Bone loss in diabetes: use of antidiabetic thiazolidinediones and secondary osteoporosisBeata Lecka-Czernik
Department of Orthopaedic Surgery, Center for Diabetes and Endocrine Research, University of Toledo Medical Center, OH, 43614, USA
Curr Osteoporos Rep 8:178-84. 2010..We also suggest a possible orthopedic complication, not yet supported by clinical studies, of delayed fracture healing in T2DM patients on TZD therapy...
- PPARs in bone: the role in bone cell differentiation and regulation of energy metabolismBeata Lecka-Czernik
Departments of Orthopaedic Surgery and Physiology and Pharmacology, Center for Diabetes and Endocrine Research, University of Toledo Medical Center, 3000 Arlington Avenue, Toledo, OH, 43614, USA
Curr Osteoporos Rep 8:84-90. 2010..We also discuss the role of bone fat in modulation of bone marrow microenvironment and its possible contribution to the systemic regulation of energy metabolism...
- Bone as a target of type 2 diabetes treatmentBeata Lecka-Czernik
Department of Orthopaedic Surgery, University of Toledo Medical Center, Center for Diabetes and Endocrine Research, Toledo, OH 43614, USA
Curr Opin Investig Drugs 10:1085-90. 2009..In summary, bone is a target of certain antidiabetic therapies and, therefore, caution is necessary in the choice of treatment for patients who are at risk of skeletal complications...
- β-catenin directly sequesters adipocytic and insulin sensitizing activities but not osteoblastic activity of PPARγ2 in marrow mesenchymal stem cellsSima Rahman
Department of Orthopaedic Surgery, University of Toledo College of Medicine, Toledo, Ohio, United States of America
PLoS ONE 7:e51746. 2012..In conclusion, β-catenin and PPARγ2 are in cross-talk which results in sequestration of pro-adipocytic and insulin sensitizing activity. The anti-osteoblastic activity of PPARγ2 is independent of this interaction...
- Strain-specific effects of rosiglitazone on bone mass, body composition, and serum insulin-like growth factor-ICheryl L Ackert-Bicknell
The Jackson Laboratory, Bar Harbor, Maine 04609, USA
Endocrinology 150:1330-40. 2009..The divergent skeletal responses to rosiglitazone in this study suggest the existence of a strong genetic background effect...
- Inducible brown adipose tissue, or beige fat, is anabolic for the skeletonSima Rahman
Departments of Orthopaedic Surgery, University ofToledo Health Sciences Campus, Toledo, OH 43614, USA
Endocrinology 154:2687-701. 2013..Conversely, CM derived from cells overexpressing IGFBP2 or WNT10b restored osteoblastic activity in recipient cells. In conclusion, beige fat secretes endocrine/paracrine activity that is beneficial for the skeleton...
- A chromosomal inversion within a quantitative trait locus has a major effect on adipogenesis and osteoblastogenesisCheryl L Ackert-Bicknell
The Jackson Laboratory, Bar Harbor, ME 04609, USA
Ann N Y Acad Sci 1116:291-305. 2007..Rather, 6T demonstrates that disordered regulation of gene expression by genomic rearrangement can have a profound effect on a complex trait, such as BMD, and that genomic rearrangement can supersede the effects of various alleles...
- Polycaprolactone nanofiber interspersed collagen type-I scaffold for bone regeneration: a unique injectable osteogenic scaffoldNuray Baylan
Department of Bioengineering, College of Engineering, University of Toledo, Toledo, OH 43606, USA
Biomed Mater 8:045011. 2013....
- Peroxisome proliferator-activated receptor delta agonist attenuates nicotine suppression effect on human mesenchymal stem cell-derived osteogenesis and involves increased expression of heme oxygenase-1Dong Hyun Kim
Department of Physiology and Pharmacology, University of Toledo College of Medicine, Toledo, OH 43614, USA
J Bone Miner Metab 31:44-52. 2013..This offers insight into both how nicotine affects bone remodeling and a therapeutic approach to prevent fracture and osteoporosis in smokers...
- Skeletal aging and the adipocyte program: New insights from an "old" moleculeBeata Lecka-Czernik
Department of Orthopaedic Surgery, Center for Diabetes and Endocrine Research, University of Toledo Medical Center, Toledo, Ohio, USA
Cell Cycle 9:3648-54. 2010..In this Extra View we discuss the interactive role of three molecules, PPARγ, nocturnin and IGF-I in regulating stem cell fate in the marrow and the potential implications of this network for understanding cellular aging...
- Partial agonist, telmisartan, maintains PPARγ serine 112 phosphorylation, and does not affect osteoblast differentiation and bone massVipula Kolli
Department of Orthopaedic Surgery, University of Toledo College of Medicine, Toledo, Ohio, United States of America Center for Diabetes and Endocrine Research, University of Toledo College of Medicine, Toledo, Ohio, United States of America
PLoS ONE 9:e96323. 2014..They also suggest a relationship between PPARγ fat "browning" activity and a lack of anti-osteoblastic activity. ..
- An overview of recent advances in designing orthopedic and craniofacial implantsVenkata P Mantripragada
Biomedical Engineering Program, The University of Toledo, Toledo, Ohio, 43614 5807
J Biomed Mater Res A 101:3349-64. 2013..Recent advances in orthobiologics are proving interesting as well. This paper thus deals with the latest improvements being made to the existing implant materials and includes new materials being introduced in the field of biomaterials...
- PPARgamma2 nuclear receptor controls multiple regulatory pathways of osteoblast differentiation from marrow mesenchymal stem cellsKeith R Shockley
The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
J Cell Biochem 106:232-46. 2009....
- PPAR gamma-2 expression in marrow stroma during agingBeata Lecka Czernik; Fiscal Year: 2005..Such intervention may slow down or even prevent age-related bone loss. ..
- Bone loss with aging occurs due to increased PPAR-g activity in marrow stem cellsBEATA ANNA LECKA CZERNIK; Fiscal Year: 2010..Completion of the above aims should enable us to determine the role of PPARg in this process and will allow designing therapeutic interventions that will selectively block PPARg anti-osteoblastic activity. ..