James Lechleiter

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. ncbi request reprint Ca2+ wave dispersion and spiral wave entrainment in Xenopus laevis oocytes overexpressing Ca2+ ATPases
    J D Lechleiter
    Department of Molecular Medicine Institute of Biotechnology, University of Texas HSC, San Antonio 78245, USA
    Biophys Chem 72:123-9. 1998
  2. pmc The trifunctional protein mediates thyroid hormone receptor-dependent stimulation of mitochondria metabolism
    E Sandra Chocron
    Departments of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Mol Endocrinol 26:1117-28. 2012
  3. pmc Multi-photon laser scanning microscopy using an acoustic optical deflector
    James D Lechleiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 78229, USA
    Biophys J 83:2292-9. 2002
  4. pmc Novel redox-dependent regulation of NOX5 by the tyrosine kinase c-Abl
    Amina El Jamali
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Free Radic Biol Med 44:868-81. 2008
  5. ncbi request reprint Multiphoton laser scanning microscopy as a tool for Xenopus oocyte research
    Angela M Prouty
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, USA
    Methods Mol Biol 322:87-101. 2006
  6. pmc Nontranscriptional modulation of intracellular Ca2+ signaling by ligand stimulated thyroid hormone receptor
    Nuttawut Saelim
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 78229, USA
    J Cell Biol 167:915-24. 2004
  7. ncbi request reprint Purinergic receptor-stimulated IP3-mediated Ca2+ release enhances neuroprotection by increasing astrocyte mitochondrial metabolism during aging
    Jun Wu
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Neurosci 27:6510-20. 2007
  8. pmc Chemical calcium indicators
    R Madelaine Paredes
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Methods 46:143-51. 2008
  9. pmc Modeling the dependence of the period of intracellular Ca2+ waves on SERCA expression
    Martin Falcke
    Hahn Meitner Institute, 14109 Berlin, Germany
    Biophys J 85:1474-81. 2003
  10. ncbi request reprint Amphetamine-induced dopamine efflux. A voltage-sensitive and intracellular Na+-dependent mechanism
    Habibeh Khoshbouei
    Department of Molecular Physiology and Biophysics and the Center for Molecular Neuroscience, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 278:12070-7. 2003

Collaborators

  • Patricia Camacho
  • Wei Zheng
  • WILLIAM NAUSEEF
  • Robert A Clark
  • A J Valente
  • Martin Falcke
  • JONATHAN JAVITCH
  • Jun Wu
  • Nuttawut Saelim
  • E Sandra Chocron
  • R Madelaine Paredes
  • Amina El Jamali
  • Da Ting Lin
  • Angela M Prouty
  • Habibeh Khoshbouei
  • Aurelio Galli
  • Lucia Carvelli
  • Jamal A Ibdah
  • Xuguang Zhu
  • Naomi L Sayre
  • Lily Q Dong
  • Sheue yann Cheng
  • Deborah Holstein
  • Maria J Gamez
  • Doran W Pearson
  • Julie C Etzler
  • Lora Talley Watts
  • Stuart Conway
  • J Deborah Holstein
  • Geeta Upadhyay
  • Elizabeth Muller
  • Linu M John
  • Jeong Soon Park
  • Yidong Bai
  • Hongwei Wang
  • Richard Z Lin
  • Namita Sen
  • Jasmine V Ferrer
  • Jose A MorĂ³n
  • Toni S Shippenberg
  • Kristopher M Kahlig
  • Lisa M Ballou
  • Eileen M Lafer
  • L M Fredrik Leeb-Lundberg
  • Gerald Merrill

Detail Information

Publications11

  1. ncbi request reprint Ca2+ wave dispersion and spiral wave entrainment in Xenopus laevis oocytes overexpressing Ca2+ ATPases
    J D Lechleiter
    Department of Molecular Medicine Institute of Biotechnology, University of Texas HSC, San Antonio 78245, USA
    Biophys Chem 72:123-9. 1998
    ..In oocytes exhibiting both spiral and target patterns of Ca2+ release, spiral waves had higher frequencies and showed entrainment of the surrounding regions. These properties are characteristic of a classical excitable medium [4-6]...
  2. pmc The trifunctional protein mediates thyroid hormone receptor-dependent stimulation of mitochondria metabolism
    E Sandra Chocron
    Departments of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Mol Endocrinol 26:1117-28. 2012
    ..We suggest that T(3)-induced increases in mitochondrial metabolism are at least in part mediated by a T(3)-shortened TR isoform-dependent stabilization of the MTP complex, which appears to lower MTP subunit turnover...
  3. pmc Multi-photon laser scanning microscopy using an acoustic optical deflector
    James D Lechleiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 78229, USA
    Biophys J 83:2292-9. 2002
    ..The end result is an AOD-based multi-photon microscope that is capable of rapid imaging of physiological events as well as slow detection of weakly fluorescent biological samples...
  4. pmc Novel redox-dependent regulation of NOX5 by the tyrosine kinase c-Abl
    Amina El Jamali
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Free Radic Biol Med 44:868-81. 2008
    ..Our data demonstrate for the first time that NOX5 is activated by c-Abl through a Ca(2+)-mediated, redox-dependent signaling pathway and suggest a functional association between NOX5 NADPH oxidase and c-Abl...
  5. ncbi request reprint Multiphoton laser scanning microscopy as a tool for Xenopus oocyte research
    Angela M Prouty
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, USA
    Methods Mol Biol 322:87-101. 2006
    ..The practical application of imaging oocytes is demonstrated with specific examples...
  6. pmc Nontranscriptional modulation of intracellular Ca2+ signaling by ligand stimulated thyroid hormone receptor
    Nuttawut Saelim
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 78229, USA
    J Cell Biol 167:915-24. 2004
    ..We conclude that T3-bound mitochondrial targeted TRs acutely modulate IP3-mediated Ca2+ signaling by increasing mitochondrial metabolism independently of transcriptional activity...
  7. ncbi request reprint Purinergic receptor-stimulated IP3-mediated Ca2+ release enhances neuroprotection by increasing astrocyte mitochondrial metabolism during aging
    Jun Wu
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Neurosci 27:6510-20. 2007
    ..These data also reveal a signaling pathway that can rapidly respond to central energy needs throughout the aging process...
  8. pmc Chemical calcium indicators
    R Madelaine Paredes
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Methods 46:143-51. 2008
    ..Recent technical advances that permit in vivo Ca2+ measurements will also be discussed...
  9. pmc Modeling the dependence of the period of intracellular Ca2+ waves on SERCA expression
    Martin Falcke
    Hahn Meitner Institute, 14109 Berlin, Germany
    Biophys J 85:1474-81. 2003
    ..These simulations are supported by experimental data demonstrating higher luminal Ca(2+) levels, decreased periods, increased amplitude, and increased velocity of Ca(2+) waves in response to increased SERCA density...
  10. ncbi request reprint Amphetamine-induced dopamine efflux. A voltage-sensitive and intracellular Na+-dependent mechanism
    Habibeh Khoshbouei
    Department of Molecular Physiology and Biophysics and the Center for Molecular Neuroscience, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 278:12070-7. 2003
    ..Second, because of this AMPH-induced inward current, Na(+) becomes more available intracellularly to the DAT, thereby enhancing DAT-mediated reverse transport of DA...
  11. ncbi request reprint PI 3-kinase regulation of dopamine uptake
    Lucia Carvelli
    Department of Pharmacology, MC 7764, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Neurochem 81:859-69. 2002
    ....

Research Grants13

  1. In vivo neuroprotective role of astrocyte mitochondrial metabolism during aging
    James D Lechleiter; Fiscal Year: 2010
    ..These pathways should also serve as an attractive therapeutic targets to address many neuropathological processes, including stroke and dementias. ..
  2. Molecular Control of Intracellular Ca++Release Patterns
    James Lechleiter; Fiscal Year: 2006
    ..Finally, dysfunctional mitochondria, which accumulate with age and/or oxidative stress are promising targets for therapeutic intervention in degenerative diseases. ..
  3. MOLECULAR CONTROL OF INTRACELLULAR CA++ RELEASE PATTERNS
    James Lechleiter; Fiscal Year: 2001
    ..And finally, functional defects in either CaBPs or mitochondria can lead to pathogenic disorders such as neurodegenerative diseases (Alzheimer s; Parkinson's and Huntington's), epilepsy and seizures. ..
  4. In vivo neuroprotective role of astrocyte mitochondrial metabolism during aging
    James Lechleiter; Fiscal Year: 2009
    ..These pathways should also serve as an attractive therapeutic targets to address many neuropathological processes, including stroke and dementias. ..