James Lechleiter

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. ncbi request reprint Ca2+ wave dispersion and spiral wave entrainment in Xenopus laevis oocytes overexpressing Ca2+ ATPases
    J D Lechleiter
    Department of Molecular Medicine Institute of Biotechnology, University of Texas HSC, San Antonio 78245, USA
    Biophys Chem 72:123-9. 1998
  2. pmc Nontranscriptional modulation of intracellular Ca2+ signaling by ligand stimulated thyroid hormone receptor
    Nuttawut Saelim
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 78229, USA
    J Cell Biol 167:915-24. 2004
  3. pmc Purinergic receptor stimulation reduces cytotoxic edema and brain infarcts in mouse induced by photothrombosis by energizing glial mitochondria
    Wei Zheng
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 5:e14401. 2010
  4. pmc Calcineurin interacts with PERK and dephosphorylates calnexin to relieve ER stress in mammals and frogs
    Mariana Bollo
    Instituto de Investigación Médica Mercedes y Martín Ferreyra INIMEC CONICET, Cordoba, Argentina
    PLoS ONE 5:e11925. 2010
  5. pmc The trifunctional protein mediates thyroid hormone receptor-dependent stimulation of mitochondria metabolism
    E Sandra Chocron
    Departments of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Mol Endocrinol 26:1117-28. 2012
  6. pmc Multi-photon laser scanning microscopy using an acoustic optical deflector
    James D Lechleiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 78229, USA
    Biophys J 83:2292-9. 2002
  7. pmc A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis
    Jeong Soon Park
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 78229, USA
    Hum Mol Genet 18:1578-89. 2009
  8. pmc Novel redox-dependent regulation of NOX5 by the tyrosine kinase c-Abl
    Amina El Jamali
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Free Radic Biol Med 44:868-81. 2008
  9. pmc Nuclear suppression of mitochondrial defects in cells without the ND6 subunit
    Jian Hong Deng
    Department of Cellular and Structural Biology, University of Texas Health Sciences Center at San Antonio, San Antonio, TX 78229, USA
    Mol Cell Biol 26:1077-86. 2006
  10. pmc Glutathione peroxidase 4 differentially regulates the release of apoptogenic proteins from mitochondria
    Hanyu Liang
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
    Free Radic Biol Med 47:312-20. 2009

Collaborators

  • Jun Wu
  • Yidong Bai
  • Wei Zheng
  • Patricia Camacho
  • Murat Digicaylioglu
  • Jianxin Lu
  • Qitao Ran
  • Hongzhi Li
  • Andrej Musatov
  • A J Valente
  • Robert A Clark
  • WILLIAM NAUSEEF
  • JONATHAN JAVITCH
  • Martin Falcke
  • Deborah Holstein
  • Jeong Soon Park
  • Lora Talley Watts
  • R Madelaine Paredes
  • Nuttawut Saelim
  • E Sandra Chocron
  • Mariana Bollo
  • Hanyu Liang
  • Amina El Jamali
  • Jian Hong Deng
  • Angela M Prouty
  • Habibeh Khoshbouei
  • Aurelio Galli
  • Lucia Carvelli
  • Shane Sprague
  • R Justin Garling
  • David Jimenez
  • Jamal A Ibdah
  • Xuguang Zhu
  • Naomi L Sayre
  • Lily Q Dong
  • Sheue yann Cheng
  • Nadezhda Zheleznova
  • RuiHua Xiang
  • Susan L Naylor
  • Arlan Richardson
  • Tiffany McDonald-Marsh
  • Youngmok Charles Jang
  • Janice J Deng
  • Wook Song
  • Lokendra Kumar Sharma
  • Holly Van Remmen
  • Maria J Gamez
  • Doran W Pearson
  • Julie C Etzler
  • Da Ting Lin
  • Youfen Li
  • Peiqing Hu
  • Linu M John
  • Hongwei Wang
  • Richard Z Lin
  • Namita Sen
  • Jasmine V Ferrer
  • Jose A Morón
  • Toni S Shippenberg
  • Kristopher M Kahlig
  • Lisa M Ballou
  • Eileen M Lafer
  • L M Fredrik Leeb-Lundberg
  • Gerald Merrill

Detail Information

Publications17

  1. ncbi request reprint Ca2+ wave dispersion and spiral wave entrainment in Xenopus laevis oocytes overexpressing Ca2+ ATPases
    J D Lechleiter
    Department of Molecular Medicine Institute of Biotechnology, University of Texas HSC, San Antonio 78245, USA
    Biophys Chem 72:123-9. 1998
    ..In oocytes exhibiting both spiral and target patterns of Ca2+ release, spiral waves had higher frequencies and showed entrainment of the surrounding regions. These properties are characteristic of a classical excitable medium [4-6]...
  2. pmc Nontranscriptional modulation of intracellular Ca2+ signaling by ligand stimulated thyroid hormone receptor
    Nuttawut Saelim
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 78229, USA
    J Cell Biol 167:915-24. 2004
    ..We conclude that T3-bound mitochondrial targeted TRs acutely modulate IP3-mediated Ca2+ signaling by increasing mitochondrial metabolism independently of transcriptional activity...
  3. pmc Purinergic receptor stimulation reduces cytotoxic edema and brain infarcts in mouse induced by photothrombosis by energizing glial mitochondria
    Wei Zheng
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 5:e14401. 2010
    ..Enhancement of this energy source could have similar protective benefits for a wide range of brain injuries...
  4. pmc Calcineurin interacts with PERK and dephosphorylates calnexin to relieve ER stress in mammals and frogs
    Mariana Bollo
    Instituto de Investigación Médica Mercedes y Martín Ferreyra INIMEC CONICET, Cordoba, Argentina
    PLoS ONE 5:e11925. 2010
    ..Work from our group has shown that cytosolic phosphorylation of calnexin (CLNX) controls Ca2+ uptake into the ER via the sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) 2b...
  5. pmc The trifunctional protein mediates thyroid hormone receptor-dependent stimulation of mitochondria metabolism
    E Sandra Chocron
    Departments of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Mol Endocrinol 26:1117-28. 2012
    ..We suggest that T(3)-induced increases in mitochondrial metabolism are at least in part mediated by a T(3)-shortened TR isoform-dependent stabilization of the MTP complex, which appears to lower MTP subunit turnover...
  6. pmc Multi-photon laser scanning microscopy using an acoustic optical deflector
    James D Lechleiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 78229, USA
    Biophys J 83:2292-9. 2002
    ..The end result is an AOD-based multi-photon microscope that is capable of rapid imaging of physiological events as well as slow detection of weakly fluorescent biological samples...
  7. pmc A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis
    Jeong Soon Park
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 78229, USA
    Hum Mol Genet 18:1578-89. 2009
    ..Our results indicate that the mtDNA mutations might play an important role in the early stage of cancer development, possibly through alteration of ROS generation and apoptosis...
  8. pmc Novel redox-dependent regulation of NOX5 by the tyrosine kinase c-Abl
    Amina El Jamali
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Free Radic Biol Med 44:868-81. 2008
    ..Our data demonstrate for the first time that NOX5 is activated by c-Abl through a Ca(2+)-mediated, redox-dependent signaling pathway and suggest a functional association between NOX5 NADPH oxidase and c-Abl...
  9. pmc Nuclear suppression of mitochondrial defects in cells without the ND6 subunit
    Jian Hong Deng
    Department of Cellular and Structural Biology, University of Texas Health Sciences Center at San Antonio, San Antonio, TX 78229, USA
    Mol Cell Biol 26:1077-86. 2006
    ..Our results suggest that change(s) in the expression of a certain nucleus-encoded factor(s) can compensate for the absence of the ND6 or ND5 subunit...
  10. pmc Glutathione peroxidase 4 differentially regulates the release of apoptogenic proteins from mitochondria
    Hanyu Liang
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
    Free Radic Biol Med 47:312-20. 2009
    ..These data suggest that Gpx4 differentially regulates apoptogenic protein release owing to its inner membrane location in mitochondria and its ability to repair cardiolipin peroxidation...
  11. doi request reprint Purinergic 2Y1 receptor stimulation decreases cerebral edema and reactive gliosis in a traumatic brain injury model
    Lora Talley Watts
    Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio School of Medicine, TX 78229 3904, USA
    J Neurotrauma 30:55-66. 2013
    ..We suggest that enhancing astrocyte mitochondrial metabolism offers a promising neuroprotective strategy for a broad range of brain injuries...
  12. ncbi request reprint Multiphoton laser scanning microscopy as a tool for Xenopus oocyte research
    Angela M Prouty
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, USA
    Methods Mol Biol 322:87-101. 2006
    ..The practical application of imaging oocytes is demonstrated with specific examples...
  13. pmc Chemical calcium indicators
    R Madelaine Paredes
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Methods 46:143-51. 2008
    ..Recent technical advances that permit in vivo Ca2+ measurements will also be discussed...
  14. ncbi request reprint Purinergic receptor-stimulated IP3-mediated Ca2+ release enhances neuroprotection by increasing astrocyte mitochondrial metabolism during aging
    Jun Wu
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Neurosci 27:6510-20. 2007
    ..These data also reveal a signaling pathway that can rapidly respond to central energy needs throughout the aging process...
  15. pmc Modeling the dependence of the period of intracellular Ca2+ waves on SERCA expression
    Martin Falcke
    Hahn Meitner Institute, 14109 Berlin, Germany
    Biophys J 85:1474-81. 2003
    ..These simulations are supported by experimental data demonstrating higher luminal Ca(2+) levels, decreased periods, increased amplitude, and increased velocity of Ca(2+) waves in response to increased SERCA density...
  16. ncbi request reprint Amphetamine-induced dopamine efflux. A voltage-sensitive and intracellular Na+-dependent mechanism
    Habibeh Khoshbouei
    Department of Molecular Physiology and Biophysics and the Center for Molecular Neuroscience, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 278:12070-7. 2003
    ..Second, because of this AMPH-induced inward current, Na(+) becomes more available intracellularly to the DAT, thereby enhancing DAT-mediated reverse transport of DA...
  17. ncbi request reprint PI 3-kinase regulation of dopamine uptake
    Lucia Carvelli
    Department of Pharmacology, MC 7764, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Neurochem 81:859-69. 2002
    ....

Research Grants13

  1. In vivo neuroprotective role of astrocyte mitochondrial metabolism during aging
    James D Lechleiter; Fiscal Year: 2010
    ..These pathways should also serve as an attractive therapeutic targets to address many neuropathological processes, including stroke and dementias. ..
  2. In vivo neuroprotective role of astrocyte mitochondrial metabolism during aging
    James Lechleiter; Fiscal Year: 2009
    ..These pathways should also serve as an attractive therapeutic targets to address many neuropathological processes, including stroke and dementias. ..
  3. Molecular Control of Intracellular Ca++Release Patterns
    James Lechleiter; Fiscal Year: 2006
    ..Finally, dysfunctional mitochondria, which accumulate with age and/or oxidative stress are promising targets for therapeutic intervention in degenerative diseases. ..
  4. Molecular Control of Intracellular Ca++Release Patterns
    James Lechleiter; Fiscal Year: 2005
    ..Finally, dysfunctional mitochondria, which accumulate with age and/or oxidative stress are promising targets for therapeutic intervention in degenerative diseases. ..
  5. Molecular Control of Intracellular Ca++Release Patterns
    James Lechleiter; Fiscal Year: 2004
    ..Finally, dysfunctional mitochondria, which accumulate with age and/or oxidative stress are promising targets for therapeutic intervention in degenerative diseases. ..
  6. Molecular Control of Intracellular Ca++Release Patterns
    James Lechleiter; Fiscal Year: 2003
    ..Finally, dysfunctional mitochondria, which accumulate with age and/or oxidative stress are promising targets for therapeutic intervention in degenerative diseases. ..
  7. MOLECULAR CONTROL OF INTRACELLULAR CA++ RELEASE PATTERNS
    James Lechleiter; Fiscal Year: 2001
    ..And finally, functional defects in either CaBPs or mitochondria can lead to pathogenic disorders such as neurodegenerative diseases (Alzheimer s; Parkinson's and Huntington's), epilepsy and seizures. ..
  8. MOLECULAR CONTROL OF INTRACELLULAR CA++ RELEASE PATTERNS
    James Lechleiter; Fiscal Year: 2000
    ..And finally, functional defects in either CaBPs or mitochondria can lead to pathogenic disorders such as neurodegenerative diseases (Alzheimer s; Parkinson's and Huntington's), epilepsy and seizures. ..
  9. MOLECULAR CONTROL OF INTRACELLULAR CA++ RELEASE PATTERNS
    James Lechleiter; Fiscal Year: 1999
    ..And finally, functional defects in either CaBPs or mitochondria can lead to pathogenic disorders such as neurodegenerative diseases (Alzheimer s; Parkinson's and Huntington's), epilepsy and seizures. ..
  10. In vivo neuroprotective role of astrocyte mitochondrial metabolism during aging
    James Lechleiter; Fiscal Year: 2009
    ..These pathways should also serve as an attractive therapeutic targets to address many neuropathological processes, including stroke and dementias. ..