Research Topics
| James LechleiterSummaryAffiliation: University of Texas Health Science Center Country: USA Publications
Research Grants
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Detail Information
Publications
Ca2+ wave dispersion and spiral wave entrainment in Xenopus laevis oocytes overexpressing Ca2+ ATPasesJ D Lechleiter
Department of Molecular Medicine Institute of Biotechnology, University of Texas HSC, San Antonio 78245, USA
Biophys Chem 72:123-9. 1998..In oocytes exhibiting both spiral and target patterns of Ca2+ release, spiral waves had higher frequencies and showed entrainment of the surrounding regions. These properties are characteristic of a classical excitable medium [4-6]...
The trifunctional protein mediates thyroid hormone receptor-dependent stimulation of mitochondria metabolismE Sandra Chocron
Departments of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
Mol Endocrinol 26:1117-28. 2012..We suggest that T(3)-induced increases in mitochondrial metabolism are at least in part mediated by a T(3)-shortened TR isoform-dependent stabilization of the MTP complex, which appears to lower MTP subunit turnover...- Multi-photon laser scanning microscopy using an acoustic optical deflectorJames D Lechleiter
Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 78229, USA
Biophys J 83:2292-9. 2002..The end result is an AOD-based multi-photon microscope that is capable of rapid imaging of physiological events as well as slow detection of weakly fluorescent biological samples... - Novel redox-dependent regulation of NOX5 by the tyrosine kinase c-AblAmina El Jamali
Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
Free Radic Biol Med 44:868-81. 2008..Our data demonstrate for the first time that NOX5 is activated by c-Abl through a Ca(2+)-mediated, redox-dependent signaling pathway and suggest a functional association between NOX5 NADPH oxidase and c-Abl... - Multiphoton laser scanning microscopy as a tool for Xenopus oocyte researchAngela M Prouty
Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, USA
Methods Mol Biol 322:87-101. 2006..The practical application of imaging oocytes is demonstrated with specific examples... - Nontranscriptional modulation of intracellular Ca2+ signaling by ligand stimulated thyroid hormone receptorNuttawut Saelim
Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 78229, USA
J Cell Biol 167:915-24. 2004..We conclude that T3-bound mitochondrial targeted TRs acutely modulate IP3-mediated Ca2+ signaling by increasing mitochondrial metabolism independently of transcriptional activity... - Purinergic receptor-stimulated IP3-mediated Ca2+ release enhances neuroprotection by increasing astrocyte mitochondrial metabolism during agingJun Wu
Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
J Neurosci 27:6510-20. 2007..These data also reveal a signaling pathway that can rapidly respond to central energy needs throughout the aging process... - Chemical calcium indicatorsR Madelaine Paredes
Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
Methods 46:143-51. 2008..Recent technical advances that permit in vivo Ca2+ measurements will also be discussed... - Modeling the dependence of the period of intracellular Ca2+ waves on SERCA expressionMartin Falcke
Hahn Meitner Institute, 14109 Berlin, Germany
Biophys J 85:1474-81. 2003..These simulations are supported by experimental data demonstrating higher luminal Ca(2+) levels, decreased periods, increased amplitude, and increased velocity of Ca(2+) waves in response to increased SERCA density... - Amphetamine-induced dopamine efflux. A voltage-sensitive and intracellular Na+-dependent mechanismHabibeh Khoshbouei
Department of Molecular Physiology and Biophysics and the Center for Molecular Neuroscience, Vanderbilt University, Nashville, Tennessee 37232, USA
J Biol Chem 278:12070-7. 2003..Second, because of this AMPH-induced inward current, Na(+) becomes more available intracellularly to the DAT, thereby enhancing DAT-mediated reverse transport of DA... - PI 3-kinase regulation of dopamine uptakeLucia Carvelli
Department of Pharmacology, MC 7764, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
J Neurochem 81:859-69. 2002....
Research Grants
- In vivo neuroprotective role of astrocyte mitochondrial metabolism during agingJames D Lechleiter; Fiscal Year: 2010..These pathways should also serve as an attractive therapeutic targets to address many neuropathological processes, including stroke and dementias. ..
- Molecular Control of Intracellular Ca++Release PatternsJames Lechleiter; Fiscal Year: 2006..Finally, dysfunctional mitochondria, which accumulate with age and/or oxidative stress are promising targets for therapeutic intervention in degenerative diseases. ..
- MOLECULAR CONTROL OF INTRACELLULAR CA++ RELEASE PATTERNSJames Lechleiter; Fiscal Year: 2001..And finally, functional defects in either CaBPs or mitochondria can lead to pathogenic disorders such as neurodegenerative diseases (Alzheimer s; Parkinson's and Huntington's), epilepsy and seizures. ..
- In vivo neuroprotective role of astrocyte mitochondrial metabolism during agingJames Lechleiter; Fiscal Year: 2009..These pathways should also serve as an attractive therapeutic targets to address many neuropathological processes, including stroke and dementias. ..