Dan I Lebovic

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi Peritoneal macrophages induce RANTES (regulated on activation, normal T cell expressed and secreted) chemokine gene transcription in endometrial stromal cells
    Dan I Lebovic
    Reproductive Endocrinology Division, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan 48109 0276, USA
    J Clin Endocrinol Metab 89:1397-401. 2004
  2. ncbi Peroxisome proliferator-activated receptor-gamma induces regression of endometrial explants in a rat model of endometriosis
    Dan I Lebovic
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Michigan, Ann Arbor, Michigan 48109 0276, USA
    Fertil Steril 82:1008-13. 2004
  3. ncbi PPAR-gamma receptor ligand induces regression of endometrial explants in baboons: a prospective, randomized, placebo- and drug-controlled study
    Dan I Lebovic
    Reproductive Endocrinology Division, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Fertil Steril 88:1108-19. 2007
  4. ncbi Peroxisome proliferator-activated receptor-(gamma) receptor ligand partially prevents the development of endometrial explants in baboons: a prospective, randomized, placebo-controlled study
    Dan I Lebovic
    Department of Obstetrics and Gynecology, University of Wisconsin, USA
    Endocrinology 151:1846-52. 2010
  5. ncbi Public perceptions of endometriosis: perspectives from both genders
    Divya K Shah
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Acta Obstet Gynecol Scand 89:646-50. 2010
  6. ncbi Thiazolidinediones decrease vascular endothelial growth factor (VEGF) production by human luteinized granulosa cells in vitro
    Divya K Shah
    Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI 48109, USA
    Fertil Steril 93:2042-7. 2010
  7. ncbi Altered expression of a cell-cycle suppressor gene, Tob-1, in endometriotic cells by cDNA array analyses
    Dan I Lebovic
    Reproductive Endocrinology Division, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, USA
    Fertil Steril 78:849-54. 2002
  8. ncbi Use of a flexible cannula to bypass an obstructing fibroid during a first-trimester surgical abortion. A case report
    Vanessa K Dalton
    Department of Obstetrics and Gynecology, University of Michigan Medical School, Ann Arbor, MI 48109 027, USA
    J Reprod Med 48:551-2. 2003
  9. ncbi Periodontal disease and endometriosis: analysis of the National Health and Nutrition Examination Survey
    Shahryar K Kavoussi
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Michigan Endometriosis Center, Ann Arbor, Michigan 48109, USA
    Fertil Steril 91:335-42. 2009
  10. ncbi Thiazolidinediones as therapy for endometriosis: a case series
    Molly B Moravek
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Mich USA
    Gynecol Obstet Invest 68:167-70. 2009

Research Grants

  1. Endometriosis: Immunomodulation and Allo-autoimmunity
    Dan Lebovic; Fiscal Year: 2007

Collaborators

Detail Information

Publications19

  1. ncbi Peritoneal macrophages induce RANTES (regulated on activation, normal T cell expressed and secreted) chemokine gene transcription in endometrial stromal cells
    Dan I Lebovic
    Reproductive Endocrinology Division, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan 48109 0276, USA
    J Clin Endocrinol Metab 89:1397-401. 2004
    ..We postulate that PFM stimulation of RANTES production by ESC could lead to a self-propagating recruitment of inflammatory cells that contribute to the development and progression of endometriotic lesions...
  2. ncbi Peroxisome proliferator-activated receptor-gamma induces regression of endometrial explants in a rat model of endometriosis
    Dan I Lebovic
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Michigan, Ann Arbor, Michigan 48109 0276, USA
    Fertil Steril 82:1008-13. 2004
    ..To determine the effects of a thiazolidinedione, ciglitazone, in a rat model of endometriosis...
  3. ncbi PPAR-gamma receptor ligand induces regression of endometrial explants in baboons: a prospective, randomized, placebo- and drug-controlled study
    Dan I Lebovic
    Reproductive Endocrinology Division, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Fertil Steril 88:1108-19. 2007
    ..To determine the effects of a thiazolidinedione (TZD) agonist of peroxisome proliferator-activated receptor (PPAR)-gamma, rosiglitazone, in a baboon model of established endometriosis...
  4. ncbi Peroxisome proliferator-activated receptor-(gamma) receptor ligand partially prevents the development of endometrial explants in baboons: a prospective, randomized, placebo-controlled study
    Dan I Lebovic
    Department of Obstetrics and Gynecology, University of Wisconsin, USA
    Endocrinology 151:1846-52. 2010
    ..Using this animal model, we have shown that thiazolidinedione is a promising drug for preventive treatment of endometriosis...
  5. ncbi Public perceptions of endometriosis: perspectives from both genders
    Divya K Shah
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Acta Obstet Gynecol Scand 89:646-50. 2010
    ..There is a paucity of data, however, surrounding perceptions of endometriosis in the general population. This study aims to assess knowledge of endometriosis among individuals of both genders...
  6. ncbi Thiazolidinediones decrease vascular endothelial growth factor (VEGF) production by human luteinized granulosa cells in vitro
    Divya K Shah
    Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI 48109, USA
    Fertil Steril 93:2042-7. 2010
    ..To determine the effect of thiazolidenedione derivatives (TZDs) on vascular endothelial growth factor (VEGF) production by human luteinized granulosa cells and the morphologic development of murine embryos...
  7. ncbi Altered expression of a cell-cycle suppressor gene, Tob-1, in endometriotic cells by cDNA array analyses
    Dan I Lebovic
    Reproductive Endocrinology Division, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, USA
    Fertil Steril 78:849-54. 2002
    ..These findings are the first to associate IL-1beta with an alteration of cell-cycle gene expression in cells derived from endometriotic implants...
  8. ncbi Use of a flexible cannula to bypass an obstructing fibroid during a first-trimester surgical abortion. A case report
    Vanessa K Dalton
    Department of Obstetrics and Gynecology, University of Michigan Medical School, Ann Arbor, MI 48109 027, USA
    J Reprod Med 48:551-2. 2003
    ..Uterine fibroids can pose a significant obstacle in surgical abortions...
  9. ncbi Periodontal disease and endometriosis: analysis of the National Health and Nutrition Examination Survey
    Shahryar K Kavoussi
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Michigan Endometriosis Center, Ann Arbor, Michigan 48109, USA
    Fertil Steril 91:335-42. 2009
    ....
  10. ncbi Thiazolidinediones as therapy for endometriosis: a case series
    Molly B Moravek
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Mich USA
    Gynecol Obstet Invest 68:167-70. 2009
    ..The aim of this study was to provide preliminary data about the effectiveness of a TZD in treating endometriosis-related pain...
  11. ncbi Development and prevention of postsurgical adhesions in a chimeric mouse model of experimental endometriosis
    Jennifer L Herington
    Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Women s Reproductive Health Research Center, Nashville, Tennessee, USA
    Fertil Steril 95:1295-301.e1. 2011
    ..To examine the impact of a recent surgery on development of endometriosis-related adhesions in a chimeric model and to determine the therapeutic efficacy of pioglitazone (PIO)...
  12. ncbi Endometrioma complicated by tubo-ovarian abscess in a woman with bacterial vaginosis
    Shahryar K Kavoussi
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI 48109-0276, USA
    Infect Dis Obstet Gynecol 2006:84140. 2006
    ..Therefore, aggressive treatment of BV in patients with known advanced-stage endometriosis may be considered to prevent superinfected endometriomas...
  13. ncbi Expression of mannose-binding lectin in the peritoneal fluid of women with and without endometriosis
    Shahryar K Kavoussi
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Michigan Endometriosis Center, Ann Arbor, Michigan, USA
    Fertil Steril 85:1526-8. 2006
    ..Mannose-binding lectin (MBL) modulates inflammation and usually enhances clearance of apoptotic cells. We observed that the concentration and total amount of peritoneal fluid MBL does not differ in patients with and without endometriosis...
  14. ncbi Endometriosis-associated nerve fibers and pain
    Melissa G Medina
    Department of Obstetrics and Gynecology, University of Michigan, 600 Highland Avenue, Ann Arbor, MI 57392, USA
    Acta Obstet Gynecol Scand 88:968-75. 2009
    ..A direct result of specific nerve fiber detection within eutopic endometrial layers points to the use of a minimally invasive endometrial biopsy technique in reducing delay in diagnosis and subsequent possible preservation of fertility...
  15. ncbi Intrauterine adhesions after manual vacuum aspiration for early pregnancy failure
    Vanessa K Dalton
    Department of Obstetrics and Gynecology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Fertil Steril 85:1823.e1-3. 2006
    ..To describe the occurrence of intrauterine adhesions after manual vacuum aspiration for early pregnancy failure...
  16. ncbi Epithelial neutrophil-activating peptide 78 concentrations are elevated in the peritoneal fluid of women with endometriosis
    Michael D Mueller
    Department of Obstetrics and Gynecology, Inselspital, University of Bern, Bern, Switzerland
    Fertil Steril 79:815-20. 2003
    ..To investigate the presence of epithelial neutrophil-activating peptide 78 (ENA-78) in peritoneal fluid of women with and without endometriosis and to identify the cells that produce this inflammatory protein...
  17. ncbi Long-term progestin treatment inhibits RANTES (regulated on activation, normal T cell expressed and secreted) gene expression in human endometrial stromal cells
    Dong Zhao
    Center for Reproductive Science, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California-San Francisco, Box 0556, San Francisco, CA 94143-0556, USA
    J Clin Endocrinol Metab 87:2514-9. 2002
    ..The clinical effectiveness of chronic progestin treatment in endometriosis-associated pelvic pain may be attributed to its inhibition of RANTES production and its suppression of inflammatory responses in the pelvis...
  18. ncbi Angiogenic effects of norplant contraception on endometrial histology and uterine bleeding
    Elizabeth A Pritts
    Center for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, 513 Parnassus, Health Sciences West 1656, University of California, San Francisco, San Francisco, California 94143-0556, USA
    J Clin Endocrinol Metab 90:2142-7. 2005
    ..Irregular bleeding with Norplant use appears to reflect paracrine-mediated effects on vascular function by angiogenic factors, such as VEGF...
  19. ncbi Angiogenic factors in endometriosis
    Robert N Taylor
    Center for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, 94143 0556, USA
    Ann N Y Acad Sci 955:89-100; discussion 118, 396-406. 2002
    ..We postulate that interference with angiogenic principles expressed in the peritoneum may constitute novel therapeutic opportunities for the prevention, amelioration, or treatment of pelvic endometriosis...

Research Grants2

  1. Endometriosis: Immunomodulation and Allo-autoimmunity
    Dan Lebovic; Fiscal Year: 2007
    ..Ultimately, the study will lead to a program that will substantially improve the outcome for women with endometriosis. ..