Larry J Leamy

Summary

Affiliation: University of North Carolina at Charlotte
Country: USA

Publications

  1. pmc Analysis of quantitative trait locus effects on the size and shape of mandibular molars in mice
    Michael Scott Workman
    Department of Biology, University of North Carolina, Charlotte, North Carolina 28223, USA
    Genetics 160:1573-86. 2002
  2. ncbi request reprint Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on molar development among non-resistant inbred strains of mice: a geometric morphometric analysis
    James M Keller
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    Growth Dev Aging 71:3-16. 2008
  3. ncbi request reprint Quantitative trait loci for fluctuating asymmetry of discrete skeletal characters in mice
    L J Leamy
    Department of Biology, University of North Carolina at Charlotte 28223, USA
    Heredity (Edinb) 80:509-18. 1998
  4. pmc Genetic variance and covariance patterns for body weight and energy balance characters in an advanced intercross population of mice
    Larry J Leamy
    Department of Biology, University of North Carolina at Charlotte, 28223, USA
    Genet Sel Evol 37:151-73. 2005
  5. ncbi request reprint Quantitative trait loci for directional but not fluctuating asymmetry of mandible characters in mice
    L J Leamy
    Department of Biology, University of North Carolina at Charlotte 28223, USA
    Genet Res 76:27-40. 2000
  6. ncbi request reprint An epistatic genetic basis for fluctuating asymmetry of tooth size and shape in mice
    L J Leamy
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    Heredity (Edinb) 94:316-25. 2005
  7. ncbi request reprint Size and fluctuating asymmetry of morphometric characters in mice: their associations with inbreeding and t-haplotype
    L J Leamy
    Department of Biology, University of North Carolina at Charlotte, 28223, USA
    Evolution 55:2333-41. 2001
  8. ncbi request reprint An epistatic genetic basis for fluctuating asymmetry of mandible size in mice
    Larry J Leamy
    Department of Biology, University of North Carolina, Charlotte 28223, USA
    Evolution 56:642-53. 2002
  9. ncbi request reprint Pleiotropy of quantitative trait loci for organ weights and limb bone lengths in mice
    Larry J Leamy
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    Physiol Genomics 10:21-9. 2002
  10. pmc Quantitative trait loci for physical activity traits in mice
    J Timothy Lightfoot
    Department of Kinesiology, University of North Carolina, Charlotte, NC 28223, USA
    Physiol Genomics 32:401-8. 2008

Research Grants

Detail Information

Publications30

  1. pmc Analysis of quantitative trait locus effects on the size and shape of mandibular molars in mice
    Michael Scott Workman
    Department of Biology, University of North Carolina, Charlotte, North Carolina 28223, USA
    Genetics 160:1573-86. 2002
    ....
  2. ncbi request reprint Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on molar development among non-resistant inbred strains of mice: a geometric morphometric analysis
    James M Keller
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    Growth Dev Aging 71:3-16. 2008
    ..The C3H/HeJ and CBA/J strains appeared to be the most sensitive to the disruption of molar development via TCDD and the C57BL/6J strain appeared to be the least sensitive...
  3. ncbi request reprint Quantitative trait loci for fluctuating asymmetry of discrete skeletal characters in mice
    L J Leamy
    Department of Biology, University of North Carolina at Charlotte 28223, USA
    Heredity (Edinb) 80:509-18. 1998
    ....
  4. pmc Genetic variance and covariance patterns for body weight and energy balance characters in an advanced intercross population of mice
    Larry J Leamy
    Department of Biology, University of North Carolina at Charlotte, 28223, USA
    Genet Sel Evol 37:151-73. 2005
    ..The independence of body weight and adiposity suggests that this advanced intercross population is ideal for a comprehensive discovery of genes controlling regulation of mammalian adiposity that are distinct from those for body weight...
  5. ncbi request reprint Quantitative trait loci for directional but not fluctuating asymmetry of mandible characters in mice
    L J Leamy
    Department of Biology, University of North Carolina at Charlotte 28223, USA
    Genet Res 76:27-40. 2000
    ..The QTLs for DA were similar in location to those affecting the size of several of the mandible characters, although they accounted for an average of only 1% of the total phenotypic variation in DA...
  6. ncbi request reprint An epistatic genetic basis for fluctuating asymmetry of tooth size and shape in mice
    L J Leamy
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    Heredity (Edinb) 94:316-25. 2005
    ....
  7. ncbi request reprint Size and fluctuating asymmetry of morphometric characters in mice: their associations with inbreeding and t-haplotype
    L J Leamy
    Department of Biology, University of North Carolina at Charlotte, 28223, USA
    Evolution 55:2333-41. 2001
    ..These combined results suggest that FA is not a generally sensitive proxy measure for fitness, but can be associated with fitness reductions for certain genetic stressors...
  8. ncbi request reprint An epistatic genetic basis for fluctuating asymmetry of mandible size in mice
    Larry J Leamy
    Department of Biology, University of North Carolina, Charlotte 28223, USA
    Evolution 56:642-53. 2002
    ....
  9. ncbi request reprint Pleiotropy of quantitative trait loci for organ weights and limb bone lengths in mice
    Larry J Leamy
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    Physiol Genomics 10:21-9. 2002
    ..The direction of the effect of these QTLs was almost always consistent within and between characters, with little evidence for antagonistic pleiotropy...
  10. pmc Quantitative trait loci for physical activity traits in mice
    J Timothy Lightfoot
    Department of Kinesiology, University of North Carolina, Charlotte, NC 28223, USA
    Physiol Genomics 32:401-8. 2008
    ..1, DIST13.1, SPD13.1, and SPD9.1 were subsequently replicated by haplotype association mapping. The results of this study suggest a genetic basis of voluntary activity in mice and provide a foundation for future candidate gene studies...
  11. pmc Genetic variation for body weight change in mice in response to physical exercise
    Larry J Leamy
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    BMC Genet 10:58. 2009
    ....
  12. pmc A search for quantitative trait loci controlling within-individual variation of physical activity traits in mice
    Larry J Leamy
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    BMC Genet 11:83. 2010
    ....
  13. doi request reprint Genetic differences in sensitivity to alterations of mandible structure caused by the teratogen 2,3,7,8-tetrachlorodibenzo-p-dioxin
    James M Keller
    University of North Carolina, Charlotte, 28223, USA
    Toxicol Pathol 36:1006-13. 2008
    ....
  14. pmc An epistatic genetic basis for physical activity traits in mice
    Larry J Leamy
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    J Hered 99:639-46. 2008
    ....
  15. pmc Exercise and diet affect quantitative trait loci for body weight and composition traits in an advanced intercross population of mice
    Larry J Leamy
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    Physiol Genomics 44:1141-53. 2012
    ..It was concluded that the indirect effects of these QTLs provide an underlying genetic basis for the considerable variability in weight or fat loss typically found among individuals on the same diet and/or exercise regimen...
  16. pmc Genetic variation in the pleiotropic association between physical activity and body weight in mice
    Larry J Leamy
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    Genet Sel Evol 41:41. 2009
    ....
  17. ncbi request reprint 2,3,7,8-Tetrachlorodibenzo-p-dioxin affects fluctuating asymmetry of molar shape in mice, and an epistatic interaction of two genes for molar size
    J M Keller
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    Heredity 98:259-67. 2007
    ..We concluded that although TCDD may be affecting the expression of some genes governing the development of molars in our population of mice, FA of molar size and shape is not a particularly sensitive indicator of this effect...
  18. ncbi request reprint Quantitative trait loci associated with maximal exercise endurance in mice
    J Timothy Lightfoot
    Department of Kinesiology, University of North Carolina Charlotte, Charlotte, North Carolina 28223, USA
    J Appl Physiol 103:105-10. 2007
    ....
  19. ncbi request reprint The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on molar and mandible traits in congenic mice: a test of the role of the Ahr locus
    James M Keller
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223 0001, USA
    Toxicology 242:52-62. 2007
    ..These results suggest that the effects of TCDD on molar and mandible shape are influenced by the Ahr genotype but that males and females differ in sensitivity to both of these effects...
  20. doi request reprint Epistatic interactions of genes influence within-individual variation of physical activity traits in mice
    Larry J Leamy
    Department of Biology, University of North Carolina, Charlotte, NC 28223, USA
    Genetica 139:813-21. 2011
    ..It was concluded that epistasis is more important than single-locus effects of genes on activity traits at specific ages and it is therefore an essential component of the genetic architecture of physical activity...
  21. pmc Qualitative effects of dioxin on molars vary among inbred mouse strains
    J M Keller
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223 0001, USA
    Arch Oral Biol 52:450-4. 2007
    ..We evaluated the effects of different levels of the potent environmental toxicant and teratogen, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), on molar development in mice in six inbred strains, all with TCDD responsive Ahr alleles...
  22. doi request reprint A search for quantitative trait loci exhibiting imprinting effects on mouse mandible size and shape
    L J Leamy
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    Heredity (Edinb) 101:518-26. 2008
    ..We concluded that genomic imprinting has a negligible effect on these specific morphometric traits, and that maternal genetic effects may account for many of the previously reported instances of apparent genomic imprinting...
  23. ncbi request reprint 2,3,7,8-tetrachlorodibenzo-p-dioxin affects size and shape, but not asymmetry, of mandibles in mice
    D E Allen
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    Ecotoxicology 10:167-76. 2001
    ..We found no detectable effect of TCDD on levels of FA in either size or shape of the mandible, but TCDD did produce a significant decrease in mandible size, and a significant effect on the overall shape...
  24. ncbi request reprint The influence of hybridization between African and European honeybees, Apis mellifera, on asymmetries in wing size and shape
    S S Schneider
    Department of Biology, University of North Carolina, Charlotte, North Carolina 28223, USA
    Evolution 57:2350-64. 2003
    ....
  25. pmc Quantitative trait loci for bone mineral density and femoral morphology in an advanced intercross population of mice
    Larry J Leamy
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    Bone 55:222-9. 2013
    ..Several QTLs showed significant interactions with sex, although only two QTLs interacted with diet, both affecting only mice fed the high-fat diet...
  26. pmc Sex-, diet-, and cancer-dependent epistatic effects on complex traits in mice
    Larry J Leamy
    Department of Biology, University of North Carolina at Charlotte Charlotte, NC, USA
    Front Genet 2:71. 2011
    ..It was concluded that this context-dependency of epistatic effects is an important component of the genetic architecture of complex traits such as those contributing to weight and obesity...
  27. ncbi request reprint Measurement precision of body composition variables using the lunar DPX-L densitometer
    G M Kiebzak
    Miller Orthopaedic Clinic, Charlotte, NC 28203, USA
    J Clin Densitom 3:35-41. 2000
    ..We conclude that the measurement precision of total and regional body composition variables was generally comparable to the precision limits typically associated with lumbar spine and proximal femur BMD data...
  28. pmc Epistatic pleiotropy and the genetic architecture of covariation within early and late-developing skull trait complexes in mice
    Jason B Wolf
    Faculty of Life Sciences, University of Manchester, UK
    Genetics 171:683-94. 2005
    ..Nearly all single-locus and epistatic pleiotropic effects contributed positive components to covariances between traits, suggesting that genetic integration in the skull is achieved by a complex combination of pleiotropic effects...
  29. ncbi request reprint The contribution of epistatic pleiotropy to the genetic architecture of covariation among polygenic traits in mice
    Jason B Wolf
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    Evol Dev 8:468-76. 2006
    ..Thus, although epistatic pleiotropy made a smaller contribution than single-locus pleiotropy, it clearly made a significant contribution to the genetic architecture of variation/covariation...
  30. pmc Integration and modularity of quantitative trait locus effects on geometric shape in the mouse mandible
    Christian Peter Klingenberg
    School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    Genetics 166:1909-21. 2004
    ....

Research Grants1

  1. EFFECTS OF DIOXIN ON TOOTH AND MANDIBLE TRAITS IN MICE
    Larry Leamy; Fiscal Year: 2005
    ..The identification of such genes should allow us to test for potential effects of this toxicant, even at prevailing levels of exposure in human populations, on a myriad of human diseases. ..