Douglas Leaman

Summary

Affiliation: University of Toledo
Country: USA

Publications

  1. ncbi request reprint Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection
    Yaping Sun
    Department of Biological Sciences, University of Toledo, Toledo, Ohio 43606, USA
    J Biol Chem 280:15561-8. 2005
  2. doi request reprint Recent progress in oligonucleotide therapeutics: antisense to aptamers
    Douglas W Leaman
    The University of Toledo, Department of Biological Sciences, Toledo, OH 43606, USA 1 419 530 1555 1 419 530 7737
    Expert Opin Drug Discov 3:997-1009. 2008
  3. ncbi request reprint 2-5A antisense treatment of respiratory syncytial virus
    Douglas W Leaman
    Department of Biological Sciences, University of Toledo, Toledo, Ohio 43606, USA
    Curr Opin Pharmacol 5:502-7. 2005
  4. ncbi request reprint Targeted therapy of respiratory syncytial virus in African green monkeys by intranasally administered 2-5A antisense
    Douglas W Leaman
    Ridgeway Biosystems Inc, 9500 Euclid Avenue, NE50, Cleveland, Ohio 44195, USA
    Virology 292:70-7. 2002
  5. ncbi request reprint Identification of X-linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis
    Douglas W Leaman
    Department of Biological Sciences, University of Toledo, Toledo, Ohio 43606, USA
    J Biol Chem 277:28504-11. 2002
  6. ncbi request reprint Overcoming resistance to interferon-induced apoptosis of renal carcinoma and melanoma cells by DNA demethylation
    Frederic J Reu
    Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Clin Oncol 24:3771-9. 2006
  7. pmc Expression of RASSF1A, an epigenetically silenced tumor suppressor, overcomes resistance to apoptosis induction by interferons
    Frederic J Reu
    The Cleveland Clinic Foundation Taussig Cancer Center, Cleveland, Ohio 44195, USA
    Cancer Res 66:2785-93. 2006
  8. ncbi request reprint IFN-beta pretreatment sensitizes human melanoma cells to TRAIL/Apo2 ligand-induced apoptosis
    Mamta Chawla-Sarkar
    Center for Drug Discovery and Development, Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Immunol 169:847-55. 2002
  9. ncbi request reprint Novel growth and death related interferon-stimulated genes (ISGs) in melanoma: greater potency of IFN-beta compared with IFN-alpha2
    Douglas W Leaman
    Department of Biological Sciences, University of Toledo, OH 43606, USA
    J Interferon Cytokine Res 23:745-56. 2003
  10. ncbi request reprint Ectopic expression of toll-like receptor-3 (TLR-3) overcomes the double-stranded RNA (dsRNA) signaling defects of P2.1 cells
    Yaping Sun
    Department of Biological Sciences, University of Toledo, Toledo, OH 43606, USA
    J Interferon Cytokine Res 24:350-61. 2004

Collaborators

  • Hagen Cramer
  • Paul F Torrence
  • Ernest Borden
  • Wei Ding
  • Robert Silverman
  • Subha Sen
  • Taolin Yi
  • Marcia F McInerney
  • M Grace
  • Yaping Sun
  • Frederic J Reu
  • Mamta Chawla-Sarkar
  • Diana L Brassard
  • Koichi Sairyo
  • Soo In Bae
  • Normand Beaulieu
  • Jayashree M Paranjape
  • Leonid Cherkassky
  • A Robert MacLeod
  • Mohammad K Mohammad
  • Sagartirtha Sarkar
  • Marc M Delorenzo
  • Keyur Vyas
  • Barbara S Jacobs
  • Ian A Cowgill
  • Robert Booth
  • Suneeth E Mohan
  • Jean Thomas
  • Vijay K Goel
  • Ashok Biyani
  • Nabil A Ebraheim
  • Daniel J Lindner
  • Brandon Slotterbeck
  • Ratan R Maitra
  • Da Xu
  • Donald R Rempinski
  • Soon Cheol Hong
  • Hermann von Grafenstein
  • Mark W Fox
  • James Okicki
  • Michael Morran
  • David M Kushner
  • Daniel Lindner
  • Debabrata Mukherjee
  • Norman Ratliff
  • Mary Rayborn
  • Parames Sil
  • Joe Hollyfield
  • Jeffrey Spond
  • Federico Goodsaid
  • Sean Gavor
  • Stuart Cox
  • Annitta Morehead
  • Ronald Bordens
  • David Young
  • Sudhiranjan Gupta
  • George R Stark
  • Ralph J Tuthill
  • Moitreyee Chatterjee-Kishore

Detail Information

Publications17

  1. ncbi request reprint Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection
    Yaping Sun
    Department of Biological Sciences, University of Toledo, Toledo, Ohio 43606, USA
    J Biol Chem 280:15561-8. 2005
    ..Together, these data suggest that Noxa is an important component of the innate immune response of cells to viral infection, leading to enhanced cellular apoptosis that may play a role in limiting viral dissemination...
  2. doi request reprint Recent progress in oligonucleotide therapeutics: antisense to aptamers
    Douglas W Leaman
    The University of Toledo, Department of Biological Sciences, Toledo, OH 43606, USA 1 419 530 1555 1 419 530 7737
    Expert Opin Drug Discov 3:997-1009. 2008
    ..Conclusion: Although a variety of technological issues continue to hamper antisense progress towards the clinic, advances in stabilization and delivery have provided new hope for using nucleic acids as drugs...
  3. ncbi request reprint 2-5A antisense treatment of respiratory syncytial virus
    Douglas W Leaman
    Department of Biological Sciences, University of Toledo, Toledo, Ohio 43606, USA
    Curr Opin Pharmacol 5:502-7. 2005
    ..Thus, targeted approaches to block RSV replication, including humanized monoclonal antibodies and nucleic acid-based strategies (antisense and RNA interference), have emerged as potentially viable drug development options...
  4. ncbi request reprint Targeted therapy of respiratory syncytial virus in African green monkeys by intranasally administered 2-5A antisense
    Douglas W Leaman
    Ridgeway Biosystems Inc, 9500 Euclid Avenue, NE50, Cleveland, Ohio 44195, USA
    Virology 292:70-7. 2002
    ..When administered intranasally to RSV-infected African green monkeys, this chimera reduced nasal RSV replication by up to four log(10) units in a dose- and time-dependent manner...
  5. ncbi request reprint Identification of X-linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis
    Douglas W Leaman
    Department of Biological Sciences, University of Toledo, Toledo, Ohio 43606, USA
    J Biol Chem 277:28504-11. 2002
    ..These results suggested that IFN-dependent induction of XAF1 strongly influenced cellular sensitivity to the proapoptotic actions of TRAIL...
  6. ncbi request reprint Overcoming resistance to interferon-induced apoptosis of renal carcinoma and melanoma cells by DNA demethylation
    Frederic J Reu
    Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Clin Oncol 24:3771-9. 2006
    ..Thus, inhibitors of DNMT1 may have clinical relevance for immune modulation by augmentation of cytokine effects and/or expression of tumor-associated antigens...
  7. pmc Expression of RASSF1A, an epigenetically silenced tumor suppressor, overcomes resistance to apoptosis induction by interferons
    Frederic J Reu
    The Cleveland Clinic Foundation Taussig Cancer Center, Cleveland, Ohio 44195, USA
    Cancer Res 66:2785-93. 2006
    ..Results identified RASSF1A as regulated by IFNs and participating in IFN-induced apoptosis at least in part by sensitization to TRAIL...
  8. ncbi request reprint IFN-beta pretreatment sensitizes human melanoma cells to TRAIL/Apo2 ligand-induced apoptosis
    Mamta Chawla-Sarkar
    Center for Drug Discovery and Development, Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Immunol 169:847-55. 2002
    ..Thus, in vitro IFN-beta and TRAIL/Apo2L combination treatment had more potent apoptotic and anti-growth effects when compared with either cytokine alone in melanoma cells lines...
  9. ncbi request reprint Novel growth and death related interferon-stimulated genes (ISGs) in melanoma: greater potency of IFN-beta compared with IFN-alpha2
    Douglas W Leaman
    Department of Biological Sciences, University of Toledo, OH 43606, USA
    J Interferon Cytokine Res 23:745-56. 2003
    ..The diversity of stimulated genes suggests the full therapeutic potential of IFN regulation of gene expression has yet to be realized...
  10. ncbi request reprint Ectopic expression of toll-like receptor-3 (TLR-3) overcomes the double-stranded RNA (dsRNA) signaling defects of P2.1 cells
    Yaping Sun
    Department of Biological Sciences, University of Toledo, Toledo, OH 43606, USA
    J Interferon Cytokine Res 24:350-61. 2004
    ....
  11. ncbi request reprint Lumbar ligamentum flavum hypertrophy is due to accumulation of inflammation-related scar tissue
    Koichi Sairyo
    Spine Research Center, Department of Bioengineering and Orthopedics, University of Toledo, Toledo, OH 43606, USA
    Spine (Phila Pa 1976) 32:E340-7. 2007
    ..A histologic, biologic, and immunohistochemical assessment using human samples of the lumbar ligamentum flavum...
  12. ncbi request reprint Human telomerase RNA degradation by 2'-5'-linked oligoadenylate antisense chimeras in a cell-free system, cultured tumor cells, and murine xenograft models
    Jayashree M Paranjape
    Department of Cancer Biology and Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA
    Oligonucleotides 16:225-38. 2006
    ....
  13. ncbi request reprint Biologic activity of polyethylene glycol12000-interferon-alpha2b compared with interferon-alpha2b: gene modulatory and antigrowth effects in tumor cells
    Keyur Vyas
    Cleveland Clinic Taussig Cancer Center and Lerner Research Institute, Ohio, USA
    J Immunother 26:202-11. 2003
    ..Therefore, although the specific activity of IFN-alpha2b is approximately three times greater than PEG-IFN-alpha2b, the two preparations have identical in vitro biologic activities when applied to cells at equivalent antiviral units...
  14. ncbi request reprint Dysregulated Toll-like receptor expression and signaling in bone marrow-derived macrophages at the onset of diabetes in the non-obese diabetic mouse
    Mohammad K Mohammad
    Department of Medicinal and Biological Chemistry, College of Pharmacy, University of Toledo, 2801 West Bancroft Street, Toledo, OH 43606 3390, USA
    Int Immunol 18:1101-13. 2006
    ....
  15. ncbi request reprint Cardiac overexpression of myotrophin triggers myocardial hypertrophy and heart failure in transgenic mice
    Sagartirtha Sarkar
    Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Biol Chem 279:20422-34. 2004
    ..Knowledge of the changes that take place as a result of overexpression of myotrophin at both the cellular and molecular levels will suggest novel strategies for treatment to prevent hypertrophy and its progression to heart failure...
  16. ncbi request reprint Resistance to interferons in melanoma cells does not correlate with the expression or activation of signal transducer and activator of transcription 1 (Stat1)
    Mamta Chawla-Sarkar
    Center for Drug Discovery and Development, Taussig Cancer Center, Cleveland, OH 44195, USA
    J Interferon Cytokine Res 22:603-13. 2002
    ..Cellular resistance to IFNs likely results from defective quantitative or qualitative expression of specific ISGs...
  17. ncbi request reprint Regulation of gene expression by pegylated IFN-alpha2b and IFN-alpha2b in human peripheral blood mononuclear cells
    Diana L Brassard
    Department of Biotechnology, Schering Plough Research Institute, Union, NJ 07083, USA
    J Interferon Cytokine Res 24:455-69. 2004
    ....

Research Grants12

  1. Impact of the interferon regulated proteins XAF1 and ZNF313 on innate immunity
    Douglas Leaman; Fiscal Year: 2007
    ....
  2. Molecular Mediators of Interferon induced Apoptosis
    Douglas Leaman; Fiscal Year: 2005
    ..The results of these studies should provide important information on the molecular details of antitumor activity of IFNs that can be used to identify or develop targeted therapeutics that augment IFN effects. ..
  3. 2-5A Antisense Targeting of Telomerase RNA
    Douglas Leaman; Fiscal Year: 2003
    ..These studies will also impact other antisense products under development by improving the effectiveness of the 2-A antisense technology. ..
  4. Impact of the interferon regulated proteins XAF1 and ZNF313 on innate immunity
    Douglas W Leaman; Fiscal Year: 2010
    ....