Sancy Leachmann

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. pmc Future perspectives in melanoma research. Meeting report from the "Melanoma research: a bridge from Naples to the World. Napoli, December 5th-6th 2011"
    Paolo A Ascierto
    Department of Melanoma, Sarcoma, and Head and Neck Disease, Istituto Nazionale Tumori Fondazione Pascale, Naples, Italy
    J Transl Med 10:83. 2012
  2. pmc Therapeutic siRNAs for dominant genetic skin disorders including pachyonychia congenita
    Sancy A Leachman
    Department of Dermatology and Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, United States
    J Dermatol Sci 51:151-7. 2008
  3. ncbi request reprint Clinical and pathological features of pachyonychia congenita
    Sancy A Leachman
    Department of Dermatology, University of Utah Health Sciences Center, Salt Lake City, Utah 84112 5550, USA
    J Investig Dermatol Symp Proc 10:3-17. 2005
  4. ncbi request reprint Pharmacogenetic candidate genes for melanoma
    Christopher Hull
    University of Utah School of Medicine
    Pharmacogenomics 4:753-65. 2003
  5. pmc First-in-human mutation-targeted siRNA phase Ib trial of an inherited skin disorder
    Sancy A Leachman
    Department of Dermatology, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112 5550, USA
    Mol Ther 18:442-6. 2010
  6. pmc Selection criteria for genetic assessment of patients with familial melanoma
    Sancy A Leachman
    Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112 5550, USA
    J Am Acad Dermatol 61:677.e1-14. 2009
  7. doi request reprint Melanoma mimic: a case of multiple pagetoid Spitz nevi
    Kalynne Harris
    Department of Dermatology, University of Utah, Salt Lake City, UT 84112, USA
    Arch Dermatol 148:370-4. 2012
  8. pmc Melanocortin 1 receptor genotype: an important determinant of the damage response of melanocytes to ultraviolet radiation
    Ana Luisa Kadekaro
    Department of Dermatology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0592, USA
    FASEB J 24:3850-60. 2010
  9. doi request reprint Sampling of melanocytic nevi for research purposes: a prospective, pilot study to determine effect on diagnosis
    Scott R Florell
    The Melanoma Program, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84132, USA
    J Am Acad Dermatol 59:814-21. 2008
  10. doi request reprint CDKN2A/p16 genetic test reporting improves early detection intentions and practices in high-risk melanoma families
    Lisa G Aspinwall
    Department of Psychology, University of Utah, 380 South 1530 East, Room 502, Salt Lake City, UT 84112 0251, USA
    Cancer Epidemiol Biomarkers Prev 17:1510-9. 2008

Detail Information

Publications48

  1. pmc Future perspectives in melanoma research. Meeting report from the "Melanoma research: a bridge from Naples to the World. Napoli, December 5th-6th 2011"
    Paolo A Ascierto
    Department of Melanoma, Sarcoma, and Head and Neck Disease, Istituto Nazionale Tumori Fondazione Pascale, Naples, Italy
    J Transl Med 10:83. 2012
    ....
  2. pmc Therapeutic siRNAs for dominant genetic skin disorders including pachyonychia congenita
    Sancy A Leachman
    Department of Dermatology and Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, United States
    J Dermatol Sci 51:151-7. 2008
    ..If clinical efficacy is ultimately demonstrated, this "first-in-skin" siRNA may herald a paradigm shift in the treatment of dominant-negative genetic disorders...
  3. ncbi request reprint Clinical and pathological features of pachyonychia congenita
    Sancy A Leachman
    Department of Dermatology, University of Utah Health Sciences Center, Salt Lake City, Utah 84112 5550, USA
    J Investig Dermatol Symp Proc 10:3-17. 2005
    ..Possible pathogenic mechanisms are discussed with respect to the clinicopathologic and genetic correlations observed...
  4. ncbi request reprint Pharmacogenetic candidate genes for melanoma
    Christopher Hull
    University of Utah School of Medicine
    Pharmacogenomics 4:753-65. 2003
    ..This review will summarize the genetics of melanoma with the goal of providing insights into potential pharmacogenetic candidate genes...
  5. pmc First-in-human mutation-targeted siRNA phase Ib trial of an inherited skin disorder
    Sancy A Leachman
    Department of Dermatology, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112 5550, USA
    Mol Ther 18:442-6. 2010
    ..The callus regression seen on the patient's siRNA-treated foot appears sufficiently promising to warrant additional studies of siRNA in this and other dominant-negative skin diseases...
  6. pmc Selection criteria for genetic assessment of patients with familial melanoma
    Sancy A Leachman
    Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112 5550, USA
    J Am Acad Dermatol 61:677.e1-14. 2009
    ..The work summarized in this review should help identify individuals who are appropriate candidates for referral for genetic consultation and possible testing...
  7. doi request reprint Melanoma mimic: a case of multiple pagetoid Spitz nevi
    Kalynne Harris
    Department of Dermatology, University of Utah, Salt Lake City, UT 84112, USA
    Arch Dermatol 148:370-4. 2012
    ..Differentiating Spitz nevi from melanoma can be difficult. Pagetoid spread of melanocytes is among the features making diagnosis difficult. Rare reports of isolated pagetoid Spitz nevi exist...
  8. pmc Melanocortin 1 receptor genotype: an important determinant of the damage response of melanocytes to ultraviolet radiation
    Ana Luisa Kadekaro
    Department of Dermatology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0592, USA
    FASEB J 24:3850-60. 2010
    ..Our findings highlight the molecular mechanisms by which the melanocortin 1 receptor genotype controls genomic stability of and the mutagenic effect of ultraviolet radiation on human melanocytes...
  9. doi request reprint Sampling of melanocytic nevi for research purposes: a prospective, pilot study to determine effect on diagnosis
    Scott R Florell
    The Melanoma Program, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84132, USA
    J Am Acad Dermatol 59:814-21. 2008
    ..Withholding portions of fresh nevus tissue for molecular studies could result in the loss of important diagnostic material...
  10. doi request reprint CDKN2A/p16 genetic test reporting improves early detection intentions and practices in high-risk melanoma families
    Lisa G Aspinwall
    Department of Psychology, University of Utah, 380 South 1530 East, Room 502, Salt Lake City, UT 84112 0251, USA
    Cancer Epidemiol Biomarkers Prev 17:1510-9. 2008
    ....
  11. ncbi request reprint Protein phosphorylation in irradiated human melanoma cells
    Raymond L Warters
    Department of Radiation Oncology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    Radiat Res 168:535-44. 2007
    ..Characterization of these phosphoproteins will require greater enrichment of low-abundance proteins...
  12. ncbi request reprint Melanoma cells express elevated levels of phosphorylated histone H2AX foci
    Raymond L Warters
    Department of Radiation Oncology, University of Utah Health Sciences Center, Salt Lake City, Utah 85132, USA
    J Invest Dermatol 124:807-17. 2005
    ....
  13. ncbi request reprint Novel application of a fibrin cell block method to evaluate melanocytic cell populations
    Scott R Florell
    Department of Dermatology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Pigment Cell Res 16:662-9. 2003
    ..Preparation of a FCB followed by immunohistochemical staining is an easy and inexpensive way to confirm melanocytic lineage, estimate population purity, and provide a permanent archive of cultured cells...
  14. doi request reprint The nuclear matrix shell proteome of human epidermis
    Raymond L Warters
    Department of Radiation Oncology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, United States
    J Dermatol Sci 58:113-22. 2010
    ..Proteomic approaches have identified cancer specific biomarker proteins in the nuclear matrix fraction of cancer cells. We wanted to determine whether a similar approach could be used to investigate melanoma biomarkers...
  15. ncbi request reprint Longitudinal assessment of the nevus phenotype in a melanoma kindred
    Scott R Florell
    The Melanoma Program, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112 5550, USA
    J Invest Dermatol 123:576-82. 2004
    ..Continued accumulation of nevi in mutation carriers supports a nevogenic role for this CDKN2A mutation. An intermediate nevus phenotype in non-carrier family members suggests the presence of additional modifier genes...
  16. ncbi request reprint Histopathologic recognition of involved margins of lentigo maligna excised by staged excision: an interobserver comparison study
    Scott R Florell
    Department of Dermatology, University of Utah Health Sciences Center, 30 North 1900 East, Salt Lake City, UT 84132 2409, USA
    Arch Dermatol 139:595-604. 2003
    ....
  17. ncbi request reprint Evaluation of a 7-day continuous intravenous infusion of decitabine: inhibition of promoter-specific and global genomic DNA methylation
    Wolfram E Samlowski
    Huntsman Cancer Institute and the Department of Internal Medicine Oncology, University of Utah, Salt Lake City, UT 84112 5550, USA
    J Clin Oncol 23:3897-905. 2005
    ..A clinical study was designed to examine the molecular effects and toxicity of a continuous 1-week intravenous infusion of decitabine in solid tumor patients...
  18. ncbi request reprint Treatment of pachyonychia congenita
    Leonard M Milstone
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520 8059, USA
    J Investig Dermatol Symp Proc 10:18-20. 2005
    ..pachyonychia.org/Registry.html)...
  19. ncbi request reprint Proliferative nodules in congenital melanocytic nevi: a clinicopathologic and immunohistochemical analysis
    Mark D Herron
    Department of Dermatology, University of Utah School of Medicine, 100 North Medical Drive, Salt Lake City, UT 84113, USA
    Am J Surg Pathol 28:1017-25. 2004
    ..These findings underscore the similarities between PNs and the underlying CMN and suggest that maturational, proliferative, and apoptotic processes are involved in their clinical evolution...
  20. ncbi request reprint Molecular classification of melanoma using real-time quantitative reverse transcriptase-polymerase chain reaction
    Tracey B Lewis
    Research and Development, ARUP Laboratories Inc, Salt Lake City, Utah, USA
    Cancer 104:1678-86. 2005
    ..Molecular methods are more sensitive in detecting occult lymph node metastases compared with standard histopathology and are reported to have utility in clinical diagnostics...
  21. doi request reprint A unique genome-wide association analysis in extended Utah high-risk pedigrees identifies a novel melanoma risk variant on chromosome arm 10q
    Craig Teerlink
    Division of Genetic Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Hum Genet 131:77-85. 2012
    ..Our approach illustrates an example of using high-risk pedigrees for the identification of new melanoma predisposition variants...
  22. ncbi request reprint Population-based assessment of non-melanoma cancer risk in relatives of cutaneous melanoma probands
    April A Larson
    Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA
    J Invest Dermatol 127:183-8. 2007
    ..The increased risks for five additional cancer types in first-degree relatives of melanoma cases suggest that individuals with a family history of melanoma should strictly adhere to recommended screenings for all cancers...
  23. ncbi request reprint Clinical germline genetic testing for melanoma
    Christopher B Hansen
    Department of Dermatology, University of Utah, UT 84112, USA
    Lancet Oncol 5:314-9. 2004
    ....
  24. ncbi request reprint Melanoma genetics: a review of genetic factors and clinical phenotypes in familial melanoma
    Lana Pho
    Department of Dermatology, University of Utah Health Sciences Center, Salt Lake City, 84112, USA
    Curr Opin Oncol 18:173-9. 2006
    ..The clinical phenotypes of familial melanoma syndromes and genetic and environmental interactions are reviewed to summarize the current status of the field and to identify gaps in molecular and clinical investigations...
  25. pmc N-acetylcysteine protects melanocytes against oxidative stress/damage and delays onset of ultraviolet-induced melanoma in mice
    Murray A Cotter
    Department of Dermatology, Huntsman Cancer Institute, Salt Lake City, Utah 84112, USA
    Clin Cancer Res 13:5952-8. 2007
    ..We evaluated whether the thiol antioxidant N-acetylcysteine (NAC) could protect melanocytes from UV-induced oxidative stress/damage in vitro and from UV-induced melanoma in vivo...
  26. doi request reprint Responses of human cells to ZnO nanoparticles: a gene transcription study
    Philip J Moos
    Department of Pharmacology and Toxicology, University of Utah, 30 S 2000 East, Salt Lake City, Utah 84112, USA
    Metallomics 3:1199-211. 2011
    ..This provides some of the first data on the effects of commercial metal oxide nanoparticles on human colon-derived and skin-derived cells...
  27. doi request reprint Patterns of photoprotection following CDKN2A/p16 genetic test reporting and counseling
    Lisa G Aspinwall
    Department of Psychology, University of Utah, Salt Lake City, Utah, USA
    J Am Acad Dermatol 60:745-57. 2009
    ..The impact of melanoma genetic testing and counseling on photoprotective behaviors is unknown...
  28. doi request reprint Reflectance spectrophotometer: the dermatologists' sphygmomanometer for skin phototyping?
    Lynn K Pershing
    Department of Dermatology, University of Utah, Salt Lake City, Utah 84108 1806, USA
    J Invest Dermatol 128:1633-40. 2008
    ..Thus, RS assessment of constitutive skin color at the upper volar arm provides a quick, noninvasive, precise, and accurate method to objectively determine SPT...
  29. ncbi request reprint Multiple primary melanomas in a CDKN2A mutation carrier exposed to ionizing radiation
    Mark J Eliason
    Department of Dermatology, Health Sciences Center, University of Utah, Salt Lake City, UT 84112 5550, USA
    Arch Dermatol 143:1409-12. 2007
    ..We describe a patient from a familial melanoma pedigree with 7 primary melanomas on the right side of her body, the first occurring 5 years after exposure to atmospheric nuclear bomb testing in the 1950s...
  30. ncbi request reprint Biochemotherapy of metastatic melanoma in patients with or without recently diagnosed brain metastases
    Martin Majer
    Multidisciplinary Melanoma Program, Huntsman Cancer Institute, Salt Lake City, Utah, USA
    Cancer 110:1329-37. 2007
    ....
  31. ncbi request reprint Pancreatic carcinoma surveillance in patients with familial melanoma
    Jana Foley Parker
    Department of Dermatology and Huntsman Cancer Institute and the Divisions of Gastroenterology and Oncology, University of Utah, Salt Lake City, Utah 84112, USA
    Arch Dermatol 139:1019-25. 2003
    ..To determine the optimal methods for pancreatic adenocarcinoma surveillance in high-risk patients with familial melanoma and cyclin-dependent kinase inhibitor 2A (CDKN2A) mutations...
  32. ncbi request reprint Population-based analysis of prognostic factors and survival in familial melanoma
    Scott R Florell
    Department of Dermatology, Melanoma Program, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA
    J Clin Oncol 23:7168-77. 2005
    ..We sought to determine whether melanomas that occur in a familial setting demonstrate different prognostic and survival statistics relative to sporadic melanoma...
  33. ncbi request reprint Population-based prevalence of CDKN2A mutations in Utah melanoma families
    Mark J Eliason
    Department of Dermatology, University of Utah Health Sciences Center, Salt Lake City, Utah, USA
    J Invest Dermatol 126:660-6. 2006
    ..We observed a significantly elevated rate of pancreatic cancer in one of four families with a deleterious CDKN2A mutation...
  34. pmc Activation of dual apoptotic pathways in human melanocytes and protection by survivin
    Tong Liu
    Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, 84112, USA
    J Invest Dermatol 126:2247-56. 2006
    ....
  35. ncbi request reprint Vulvar melanoma: diffuse melanosis and metastasis to the placenta
    April Alexander
    Department of Dermatology, University of Utah, Salt Lake City, Utah 84112 5550, USA
    J Am Acad Dermatol 50:293-8. 2004
    ..Pregnancy does not alter the incidence or prognosis of melanoma; however, patients with a poor prognosis or high recurrence risk should be informed of potential pregnancy complications associated with melanoma recurrence or metastasis...
  36. ncbi request reprint Metastatic melanoma in pregnancy: risk of transplacental metastases in the infant
    April Alexander
    Department of Dermatology, University of Utah, 2000 Circle of Hope, Room 5242, Salt Lake City, UT 84112 5550, USA
    J Clin Oncol 21:2179-86. 2003
    ..Although metastases to the fetus via the placenta are rare, melanoma is the most common culprit. When it occurs, maternally derived melanoma metastasis in the infant is almost invariably fatal...
  37. ncbi request reprint Management of melanoma during pregnancy
    Sancy A Leachman
    University of Utah Health Sciences Center, Department of Dermatology, and Huntsman Cancer Institute Melanoma Program, University of Utah, Salt Lake City, UT, USA
    Dermatol Nurs 19:145-52, 161. 2007
    ..Treatment of early-stage melanoma is the same irrespective of whether or not the patient is pregnant. Chemotherapeutic regimens for metastatic disease administered during pregnancy have not demonstrated significant efficacy...
  38. doi request reprint Paternal germ cell mosaicism in autosomal dominant pachyonychia congenita
    Lana N Pho
    Department of Dermatology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Arch Dermatol 147:1077-80. 2011
    ....
  39. ncbi request reprint The use of dermatologic drugs in pregnancy and lactation
    Sancy A Leachman
    Tom C Mathews Jr Familial Melanoma Research Clinic, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Suite 5242, Salt Lake City, UT 84112, USA
    Dermatol Clin 24:167-97, vi. 2006
    ..A discussion of the necessity of considering stages of childbearing in choosing drug therapies introduces the tables. A summary list of cautions spells out the steps physicians should take in treating women of childbearing age...
  40. ncbi request reprint Motivating factors for attendance of skin cancer screenings
    Tyler R Call
    Huntsman Cancer Institute, Salt Lake City, Utah 84112, USA
    J Am Acad Dermatol 51:642-4. 2004
    ..Little is known about targeting these subgroups. This study investigates the attendance motivations of screening participants, including men 50 years of age and older, who are at heightened risk...
  41. ncbi request reprint Single-nucleotide-specific siRNA targeting in a dominant-negative skin model
    Robyn P Hickerson
    TransDerm Inc, Santa Cruz, California, USA
    J Invest Dermatol 128:594-605. 2008
    ..These results suggest that efficient delivery of these "designer siRNAs" may allow effective treatment of numerous genetic disorders including PC...
  42. pmc Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma-prone families from three continents
    Alisa M Goldstein
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20892 7236, USA
    J Med Genet 44:99-106. 2007
    ....
  43. ncbi request reprint The genetic basis of pachyonychia congenita
    Frances J D Smith
    Epithelial Genetics Group, Human Genetics Unit, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    J Investig Dermatol Symp Proc 10:21-30. 2005
    ..Understanding the genetic basis of these disorders allows better counseling for patients and paves the way for therapy development...
  44. ncbi request reprint Nevus distribution in a Utah melanoma kindred with a temperature-sensitive CDKN2A mutation
    Scott R Florell
    J Invest Dermatol 125:1310-2. 2005
  45. ncbi request reprint High-risk melanoma susceptibility genes and pancreatic cancer, neural system tumors, and uveal melanoma across GenoMEL
    Alisa M Goldstein
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20892 7236, USA
    Cancer Res 66:9818-28. 2006
    ..This GenoMEL study provides the most extensive characterization of mutations in high-risk melanoma susceptibility genes in families with three or more melanoma patients yet available...
  46. doi request reprint Increased melanocytic nevi and nevus density in a G-34T CDKN2A/p16 melanoma-prone pedigree
    Scott R Florell
    J Invest Dermatol 128:2122-5. 2008
  47. ncbi request reprint Failure to detect differences in proliferation status of nevi from CDKN2A mutation carriers and non-carriers
    Scott R Florell
    J Invest Dermatol 118:386-7. 2002
  48. pmc Absence of senescence-associated beta-galactosidase activity in human melanocytic nevi in vivo
    Murray A Cotter
    J Invest Dermatol 127:2469-71. 2007

Research Grants2